Article
Nutrition & Dietetics
Alexandros S. Zervas, Pavlos P. Lelovas, Antonios Galanos, Dimitrios Galanis, Maria Makropoulou, Stavros Beteinakis, Anastasia Patsaki, Christina Passali, Stavros K. Kourkoulis, Aggeliki Triantafyllou, Efstathios Chronopoulos, Alexios L. Skaltsounis, Ismene A. Dontas
Summary: The study found that administration of olive wastewater extract for 6 months protected tibial bone mineral density loss in comparison with the untreated ovariectomised group without causing adverse effects.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Tiansong Yang, Qingyong Wang, Yuanyuan Qu, Chuwen Feng, Chaoran Li, Yan Yang, Zhongren Sun, Tahani A. Alahmadi, Sulaiman A. Alharbi, Shengyong Bao
Summary: Rhaponticin has therapeutic potential for osteoporosis in OVX rats, preventing bone density loss and improving bone microarchitecture, while also positively impacting body indices, bone turnover markers, inflammatory markers, and more.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Food Science & Technology
Xiaojie Qin, Qingshan Shen, Yujie Guo, Xia Li, Jiqian Liu, Mengliang Ye, Hang Wang, Wei Jia, Chunhui Zhang
Summary: The study showed that smaller particle sizes of YBP significantly increased water holding capacity and protein solubility, promoting protein digestion. However, different particle sizes had a weak effect on the anti-osteoporosis activity of YBP.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Hussein Sakr, Zenat Khired, Marzieh Moghadas
Summary: This study examined the effect of a wheat grain diet on bone turnover markers in rats. The results showed that rats fed whole or refined grains had lower bone density and mineral content compared to the control group. Additionally, levels of bone turnover indicators in the blood were altered, indicating a decrease in bone turnover and mass with a grain diet.
Article
Nutrition & Dietetics
Nasser M. Al-Daghri, Syed Danish Hussain, Abdullah M. Alnaami, Naji Aljohani, Shaun Sabico
Summary: Osteoporosis is a significant public health concern in Saudi Arabia, particularly among the aging population. This study examined the association between dietary calcium intake and osteoporosis risk in Saudi adults. Results showed that the overall mean calcium intake was very low and that certain dietary factors, such as tea intake and consumption of fish and eggs, were associated with a lower risk of osteoporosis.
Article
Biochemistry & Molecular Biology
Ewa Jowko, Barbara Dlugolecka, Igor Cieslinski, Jadwiga Kotowska
Summary: The aim of this study was to identify relevant factors that affect bone mineral content (BMC) and bone mineral density (BMD) in young, healthy men reaching peak bone mass. The results showed that age, BMI, engaging in combat and team sports at a competitive level, and certain genetic polymorphisms were significant predictors of BMD/BMC at different skeletal sites. Specifically, the SOD2 AG genotype was associated with lower BMC values, while the VDR FokI GG genotype was associated with lower BMD. However, the CALCR AG genotype was linked to higher arm BMD. These findings suggest that sports training may mitigate the negative impact of genetic factors on bone tissue and reduce the risk of osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Elham Kazemian, Ali Pourali, Fatemeh Sedaghat, Mehrdad Karimi, Vahid Basirat, Zohreh Sajadi Hezaveh, Sayed Hossein Davoodi, Michael F. Holick
Summary: A systematic review and meta-analysis evaluated the effects of vitamin D-3 supplementation on bone health in adults. The results showed a protective effect of vitamin D-3 supplementation on bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip. Dose-response analysis revealed a linear relationship between vitamin D-3 supplementation doses and BMD. However, no significant effect of vitamin D-3 supplementation on whole-body or total hip BMD was found. The relationship between vitamin D-3 supplement doses and markers of bone turnover was nonlinear.
Review
Biochemistry & Molecular Biology
Kathryn Frost, Amy J. Naylor, Helen M. McGettrick
Summary: Bone remodelling is a dynamically regulated process involving osteoblasts, osteoclasts, and their progenitors. Dysregulation of bone remodelling can lead to disorders like osteoporosis and Paget's disease. The sphingosine-1-phosphate (S1P) signaling pathway has been identified as an important regulator of bone remodelling and inflammatory responses. This review discusses the role of S1P in bone homeostasis and disease, highlighting its potential as a biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Kazuyoshi Shigehara, Kouji Izumi, Yoshifumi Kadono, Atsushi Mizokami
Summary: Bone fracture due to osteoporosis is a significant issue for elderly men, and testosterone replacement therapy has shown benefits in improving bone mineral density in symptomatic hypogonadal men with osteopenia.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Alicia R. Jones, Koen Simons, Susan Harvey, Vivian Grill
Summary: Individuals with primary hyperparathyroidism have reduced cortical bone mineral density, but relatively preserved trabecular bone density. However, their fracture risk is still increased. Trabecular bone score may provide a more accurate assessment of bone quality and fracture risk. This study compared the effectiveness of bone mineral density and trabecular bone score in describing bone quality in patients with primary hyperparathyroidism, and also evaluated changes in trabecular bone score following parathyroidectomy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Geriatrics & Gerontology
Xiaowen Zhang, Warrington W. Q. Hsu, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Annie W. C. Kung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: This study investigated the relationship between bone mineral density (BMD) and the risk of incident dementia, and found that higher BMD was associated with a reduced risk of dementia, particularly in women. Further research is needed to evaluate the clinical usefulness of BMD in predicting and managing dementia.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Marta Galvez-Fernandez, Maria Grau-Perez, Tamara Garcia-Barrera, Sara Ramirez-Acosta, Jose L. Gomez-Ariza, Beatriz Perez-Gomez, Inaki Galan-Labaca, Ana Navas-Acien, Josep Redon, Laisa S. Briongos-Figuero, Antonio Duenas-Laita, Jose Luis Perez-Castrillon, Maria Tellez-Plaza, Juan Carlos Martin-Escudero
Summary: The study evaluated the association between arsenic, cadmium, and selenium biomarkers with bone mineral density. Results showed that selenium was associated with BMD-related disease, while arsenic and cadmium were not. The non-linear association of selenium with BMD-related disease included a strong positive association with osteoporosis-related bone fractures risk at higher selenium exposure levels.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Endocrinology & Metabolism
Chin-Hao Hsu, Sheng-Feng Sung, Hsin-Yi Yang, Wan-Ting Huang, Cheng-Yang Hsieh
Summary: Despite being at higher risk, stroke survivors are less likely to receive bone mineral density testing and osteoporosis treatment compared to non-stroke patients. Factors such as female sex, osteoporosis, prior BMD testing, and low-trauma fractures after stroke increase the likelihood of receiving these measures, while greater stroke severity reduces the likelihood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Ming Qin, Yue Gao, Meichen Zhang, Junhua Wu, Yang Liu, Yuting Jiang, Xiaodi Zhang, Xin Wang, Yanmei Yang, Yanhui Gao
Summary: This study investigates the effects of fluorine and ADAMTS14_rs4747096 on bone mineral density (BMD). The findings suggest that fluoride exposure and mutation G allele in ADAMTS14_rs4747096 may be risk factors for decreased BMD, and there is an interaction between the two influencing factors.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Endocrinology & Metabolism
Y. Zhang, Z. Tian, S. Ye, Q. Mu, X. Wang, S. Ren, X. Hou, W. Yu, J. Guo
Summary: The study found that individuals with Down syndrome have significantly lower bone mineral density in total body and different regions (hip, lumbar spine, and femoral neck) compared to controls. It also showed a decreasing trend in lumbar spine volumetric bone mineral density and an elevated femoral neck volumetric bone mineral density in Down syndrome individuals versus controls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)