Article
Polymer Science
Annalisa La Gatta, Emiliano Bedini, Maria Aschettino, Rosario Finamore, Chiara Schiraldi
Summary: This study investigated the rheological properties and stability of four available HA-BDDE hydrogels and their relationship to the type and degree of HA structural modification. The results showed that most of the HA in the gels was branched, and there was no correlation between the conventionally measured rheological properties and the chemical data. The hydration process and the amount of crosslinked HA significantly affected the rheology of the gels. These findings contribute to a better understanding of these gels and provide valuable information for their design and characterization.
Article
Polymer Science
Petra Sedova, Radovan Buffa, Tereza Koci, Lenka Kovarova, Jiri Bednarik, Hana Vagnerova, Vladimir Velebny
Summary: The study investigates the kinetics of gelation and mechanical properties of hydrogels prepared by crosslinking of aldehyde-modified N-acetylglucosamine. The results suggest that the hydrophobic character of the linker affects the mechanical stiffness of the hydrogel.
EXPRESS POLYMER LETTERS
(2022)
Review
Polymer Science
Xuan Mu, Francesca Agostinacchio, Ning Xiang, Ying Pei, Yousef Khan, Chengchen Guo, Peggy Cebe, Antonella Motta, David L. Kaplan
Summary: Protein-based inks for 3D printing offer unique material characteristics that match specific tissue properties, promote implant-host integration, and serve as an interface between technology and biology. Despite challenges like concentration and structural hierarchy, exploiting the biological, chemical, and physical features of protein-based inks holds key opportunities for tissue engineering and regenerative medicine. Advances in photo-crosslinking mechanisms and rheological principles are enhancing the design and development of protein-based inks for a promising spectrum of biomedical research.
PROGRESS IN POLYMER SCIENCE
(2021)
Article
Chemistry, Applied
Katerina Lehka, Jana Starigazdova, Jiri Mrazek, Kristina Nesporova, Matej Simek, Vojtech Pavlik, Josef Chmelar, Martin Cepa, Martin Eugenio Barrios-Llerena, Anna Kocurkova, Eva Krivakova, Ludmila Koukalova, Lukas Kubala, Vladimir Velebny
Summary: The foreign body response (FBR) is a series of reactions that occur after the implantation of biomaterials, leading to the formation of a fibrotic capsule and health complications. The severity of the FBR is influenced by the physicochemical characteristics of the implant, implantation method, and immune system activation. In this study, we present an in vitro model that evaluates protein sorption and cell adhesion on implanted materials to assess their potential to induce FBR in the peritoneum. Our model demonstrated that fibrinogen plays a crucial role in driving cell adhesion, while surface hydrophobicity/hydrophilicity and quantity of adsorbed proteins were not determining factors. The dissolution rate of the material was found to be a crucial factor in inducing long-term cell adhesion and FBR. This model helps predict the probability of FBR without the need for in vivo animal testing.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Fuchao Zhan, Jing Li, Mahmoud Youssef, Bin Li
Summary: The interaction among SC/TA/OSA-Starch and the foam properties was investigated, showing that OSA-Starch can influence the formation of soluble complexes at different pH levels. It was found that OSA-Starch plays a role in promoting foam formation by advancing the diffusion of SC-based complexes to the air/water interface. The shear-thickening properties of the foam stabilized by SC/TA/OSA-Starch contribute to foam stability.
FOOD HYDROCOLLOIDS
(2021)
Article
Chemistry, Applied
Tingting Wu, Nico Kummer, Kevin J. De France, Silvia Campioni, Zhihui Zeng, Gilberto Siqueira, Jie Dong, Gustav Nystrom
Summary: Biohybrid colloids were fabricated by electrostatic complexation of TO-CNF and HEWL, with physical colloidal complexes formed at low TO-CNF concentrations. By increasing HEWL loading and adjusting pH, the gelation and rheology of the colloidal complexes can be modulated, demonstrating the potential for tunability in these hybrid colloids.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Silvia John Mushi, Wanli Kang, Hongbin Yang, Zhe Li, Kenzhebek Ibrashev, Miras Issakhov, Petro Ezekiel Mabeyo
Summary: The addition of phthalic acid (OPA) significantly improves the viscoelasticity and viscosity properties of OAPB viscoelastic micelle solutions, forming a micellar network that transforms transparent viscous water into a viscoelastic fluid.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Pavla Hajovska, Martin Chytil, Michal Kalina
Summary: The research found that mixed hyaluronan-albumin hydrogels have lower crosslink density, higher equilibrium swelling ratio, and significantly different microstructure compared to albumin samples. Increasing the ionic strength of the samples can raise the denaturation temperature of albumin.
Article
Chemistry, Physical
Jose Rafael Guzman-Sepulveda, Mahed Batarseh, Ruitao Wu, William M. DeCampli, Aristide Dogariu
Summary: Traditional blood properties are evaluated using bulk, low-frequency indicators that cannot differentiate the contributions of red blood cells and plasma to global rheology. However, by probing the viscoelasticity of their environment, red blood cells may provide a solution for determining plasma properties experimentally and offer possibilities for real-time information.
Article
Mechanics
D. Singhal, M. A. Kanso, S. J. Coombs, A. J. Giacomin
Summary: In this study, general expressions for the complex viscosity of poly[ n]catenane suspensions were obtained using general rigid bead-rod theory. The research found that the parts of the complex viscosity for intersecting and interlocking rings matched and showed good agreement with measurements for molten intersecting polystyrene poly[1,3]catenanes.
Article
Chemistry, Multidisciplinary
Shiyu Wu, Zhengjie Shan, Lv Xie, Mengxi Su, Peisheng Zeng, Peina Huang, Lingchan Zeng, Xinyue Sheng, Zhipeng Li, Gucheng Zeng, Zhuofan Chen, Zetao Chen
Summary: Research has shown that clot-immune responses can be regulated by tuning the mesoporous pore sizes, which in turn reduces inflammation of macrophages.
Article
Chemistry, Applied
Jingbo Liu, Jiale Chai, Ting Zhang, Yixin Yuan, Ramesh Kumar Saini, Menglei Xu, Shanle Li, Xiaomin Shang
Summary: The complexation between ovalbumin (OVA) and highly charged dextran sulfate (DS) is mainly driven by strong electrostatic interactions, with the addition of salt having diverse effects on coacervate formation. Isothermal titration calorimetry (ITC) results show that DS binds to native OVA through electrostatic forces, forming coacervates with high viscoelasticity.
FOOD HYDROCOLLOIDS
(2021)
Review
Mechanics
Randy H. Ewoldt, Chaimongkol Saengow
Summary: Taking a step away from Newtonian fluid behavior opens up a wide range of possibilities in terms of non-Newtonian fluid properties. This complexity introduces challenges that need to be addressed. The article explores useful rheological complexity, organizing principles, and design methods to answer questions related to the utility and attainment of non-Newtonian properties.
ANNUAL REVIEW OF FLUID MECHANICS
(2022)
Article
Biochemistry & Molecular Biology
Wenshan Duan, Lei Chen, Fei Liu, Xiefei Li, Yongyan Wu, Lujie Cheng, Junmei Liu, Chao Ai, Qun Huang, Yan Zhou
Summary: A novel binary complex consisting of ovalbumin (OVA) and fucoidan (FUC) was obtained through electrostatic self-assembly. The self-assembly properties and formation mechanism of the OVA-FUC complex were investigated by altering pH value and polysaccharides proportion. The optimal conditions for preparing soluble OVA-FUC binary complex were determined, and the complex exhibited good amphiphilicity and could be used as a pH-controlled emulsifier in functional food systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Antonella Di Savino, Johannes M. Foerster, G. Matthias Ullmann, Marcellus Ubbink
Summary: Optimal charge distribution is important for efficient formation of protein complexes, as electrostatic interactions guide encounter complex formation. However, introducing extra charged patches on a protein surface does not necessarily reduce productive encounters. A complex with a high population of encounter complex may be more affected by suboptimal charge distribution, as demonstrated in interactions between cytochrome c mutants and wild-type or variant cytochrome c peroxidases.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)