Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 49, Issue -, Pages 64-68Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2014.01.002
Keywords
Cholesterol; Cholesterol transport; Steroidogenic acute regulatory lipid; transfer domain; StarD4 subfamily; Sterols
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Funding
- NIDDK NIH HHS [R01 DK082464, DK082464] Funding Source: Medline
- BLRD VA [I01 BX000197] Funding Source: Medline
- VA [5I01BX000197-02, 550118, 5I01BX000197-07, 852483] Funding Source: Federal RePORTER
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Cholesterol levels in the body are maintained through the coordinated regulation of its uptake, synthesis, distribution, storage and efflux. However, the way cholesterol is sorted within cells remains poorly defined. The discovery of the newly described StarD4 subfamily, part of the steroidogenic acute regulatory lipid transfer (START) domain family of proteins, affords an opportunity for the study of intracellular cholesterol movement, metabolism and its disorders. The three members of this intracellular subfamily of proteins (StarD4, StarD5 and StarD6) have a similar lipid binding pocket specific for sterols (cholesterol in particular), but differing regulation and localization. The ability to bind and transport cholesterol through a non-vesicular mean suggests that they play a previously unappreciated role in cholesterol homeostasis. (C) 2014 Elsevier Ltd. All rights reserved.
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