Review
Oncology
Funmilayo O. Adeshakin, Adeleye O. Adeshakin, Lukman O. Afolabi, Dehong Yan, Guizhong Zhang, Xiaochun Wan
Summary: Cancer cells develop mechanisms to resist anoikis, promoting invasion and metastasis. Understanding the mechanisms driving anoikis resistance is crucial for preventing tumor progression and metastasis, with metabolic pathways playing a key role in helping cells evade anoikis.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Sana Khurshid Baba, Sadaf Khursheed Baba, Rashid Mir, Imadeldin Elfaki, Naseh Algehainy, Mohammad Fahad Ullah, Jameel Barnawi, Faisal H. Altemani, Mohammad Alanazi, Syed Khalid Mustafa, Tariq Masoodi, Ammira S. Alshabeeb Akil, Ajaz A. Bhat, Muzafar A. Macha
Summary: Cancer metastasis, responsible for 90% of cancer-related deaths, is a complex process involving the spread and colonization of cancer cells in distant organs. Long non-coding RNAs (lncRNAs) play a critical role in this process by regulating signaling pathways and modulating key molecules. Understanding the molecular basis of lncRNA involvement in cancer metastasis could lead to new therapeutic and diagnostic approaches for metastatic disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Qi Lu, Li Wang, Yabiao Gao, Ping Zhu, Luying Li, Xue Wang, Youping Jin, Xiuling Zhi, Jerry Yu, Xin Li, Xingjun Qin, Ping Zhou
Summary: The study revealed that lncRNA APOC1P1-3 promotes breast cancer metastasis by regulating apoptosis and anoikis resistance-related protein expression. It acts as a sponge to block the inhibition of Bcl-2 by specifically binding to miRNA-188-3p.
CANCER CELL INTERNATIONAL
(2021)
Review
Cell Biology
Farzad Sattari Fard, Nazila Jalilzadeh, Amir Mehdizadeh, Fakhrosadat Sajjadian, Kobra Velaei
Summary: The development of effective cancer treatments requires a detailed understanding of cellular mechanisms involved in cancer progression and metastasis. Anoikis, a special type of apoptosis induced by loss of anchorage, is a driving mechanism in cancer metastasis. This review discusses the mechanisms of gaining anoikis/anoikis resistance phenotype in tumor cells and highlights the significance of anoikis in malignancies for cancer diagnosis and therapy development.
CELL BIOLOGY INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Tai-Na Wu, Hui-Ming Chen, Lie-Fen Shyur
Summary: Triple-negative breast cancer is typically treated with chemotherapy, but drug resistance often leads to poor prognosis. Abnormal tumor metabolism and immune cells in the tumor microenvironment may impact tumor growth and resistance to treatment. Phytochemicals have the potential to alter tumor metabolism and reprogram the tumor microenvironment, potentially suppressing cancer metastasis and overcoming chemoresistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Roger Carles-Fontana, Nigel Heaton, Elena Palma, Shirin Khorsandi
Summary: Mitochondria are important organelles involved in cellular processes and are altered in pathological states, including cancer. Cancer cells adapt different strategies to generate sufficient energy for their high proliferation rates, often mediated by extracellular signals such as extracellular vesicles (EVs). This review discusses EV-mediated mitochondrial reprogramming mechanisms that support cancer survival and progression, as well as the potential of using EVs as delivery vectors for targeting mitochondria in cancer therapy.
Article
Cell Biology
Manipa Saha, Neha Deshpande, Abhinav Dubey, Debnath Pal, Hanudatta S. Atreya, Annapoorni Rangarajan
Summary: Adherent cells rely on attachment to the matrix for survival, while detachment leads to apoptosis. Solid tumors must acquire the ability to survive matrix-detachment stress to metastasize. AMPK activity is elevated in matrix-deprived cells, causing increased ATP levels and upregulation of proline metabolism, promoting survival.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Guo-Dong Huang, Fan-Fan Chen, Ji-Hu Yang, Guo-Xu Ma, Zi-Jun Liao, Wei-Ping Li, Zong-Yang Li, Lei Chen
Summary: The study discovered that moschamindole exhibits potential cytotoxic effects on chemoresistant glioblastoma cells by inducing apoptosis signals and disrupting mitochondrial function. Moschamindole inhibits oxidative folding of mitochondrial intermembrane space proteins and disrupts energy metabolism by associating with mitochondrial oxidative respiration. Overexpression of Mia40 can reverse moschamindole-induced apoptosis and is correlated with chemoresistance in glioblastoma, suggesting a potential personalized treatment approach based on mitochondrial characteristics and Mia40 expression.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Junjie Xu, Lin Ji, Yeling Ruan, Zhe Wan, Zhongjie Lin, Shunjie Xia, Liye Tao, Junhao Zheng, Liuxin Cai, Yifan Wang, Xiao Liang, Xiujun Cai
Summary: The study investigated the role of ROS in sorafenib resistance, showing suppressed ROS levels in sorafenib-resistant HCC cells, along with reduced mitochondria numbers likely caused by accelerated degradation of PGC1 beta. Mechanistic dissection revealed that UBQLN1 induced PGC1 beta degradation to attenuate mitochondrial biogenesis and ROS production in sorafenib-resistant cells. Clinical investigations further indicated that higher UBQLN1 levels led to worse recurrence-free survival in patients.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Agriculture, Dairy & Animal Science
Victoria Favorit, Wendy R. Hood, Andreas N. Kavazis, Patricia Villamediana, Kang Nian Yap, Hailey A. Parry, Amy L. Skibiel
Summary: Lactation requires increased nutrient and energy usage. Mitochondrial efficiency and biogenesis in the liver are positively associated with milk yield, while skeletal muscle mitochondrial efficiency remains consistent but experiences oxidative damage.
Review
Pharmacology & Pharmacy
Andrea Cunha, Patricia M. A. Silva, Bruno Sarmento, Odilia Queiros
Summary: The Warburg effect is a metabolic shift that leads to acidification of the tumor microenvironment and increased drug resistance. The metabolic differences between cancer and normal cells provide a strategy for new therapies, and nanodrug delivery systems can overcome multidrug resistance.
Review
Oncology
Aysooda Hosseinzadeh, Faezeh Poursoleiman, Akram Naghdipour Biregani, Ahmad Esmailzadeh
Summary: Despite the complexity of cancer, natural flavonoids have shown potential as therapeutic agents by inhibiting metastasis and inducing cell death in cancer cells. This review discusses the dynamic relationship between metastasis, autophagy, anoikis, and the effects of flavonoids, suggesting that they can be effective in targeting both sensitive and resistant cancer cells.
CANCER CELL INTERNATIONAL
(2023)
Article
Cell Biology
Min Shi, Zhao-Yun Li, Li-Ming Zhang, Xiao-Yu Wu, Shi-Hao Xiang, Yu-Gang Wang, Ya-Qiong Zhang
Summary: The research identified hsa_circ_0007456 as a promising biomarker for HCC, with its downregulation affecting the susceptibility of HCC cells to NK cells. Through modulation of the miR-6852-3p/ICAM-1 axis, hsa_circ_0007456 plays a crucial role in NK cell cytotoxicity towards HCC cells.
CELL DEATH & DISEASE
(2021)
Article
Genetics & Heredity
Yu Xiao, Han Zhou, Yiran Chen, Libin Liu, Qian Wu, Hui Li, Peicheng Lin, Jinluan Li, Junxin Wu, Lirui Tang
Summary: This study investigates the relationship between anoikis-related genes (ARGs), immune infiltration, and prognosis in colorectal cancer (CRC). It was found that high expression of ARGs is associated with poor prognosis in CRC and plays important roles in the immune microenvironment. The findings of this study contribute to the development of more effective immunotherapy techniques.
FRONTIERS IN GENETICS
(2023)
Review
Biochemistry & Molecular Biology
Rindert Missiaen, Nicholas P. Lesner, M. Celeste Simon
Summary: The role of hypoxia-inducible factors (HIFs) in regulating tumor cell metabolism under hypoxia has been extensively studied, but their role in regulating nutrient fates in tumor and stromal cells is not well understood. HIF and nutrients in the tumor microenvironment (TME) can influence the metabolism of stromal and immune cells, as well as tumor cells. This review discusses how HIF-mediated mechanisms regulate nutrient sensing and availability in the TME, the competition for nutrients, and the metabolic crosstalk between tumor and stromal cells.
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
