Article
Cell Biology
Weiyuan Huang, Yue Ke, Jianping Zhu, Shuai Liu, Jin Cong, Hailin Ye, Yanwu Guo, Kewan Wang, Zhenhai Zhang, Wenxiang Meng, Tian-Ming Gao, Heiko J. Luhmann, Werner Kilb, Rongqing Chen
Summary: Depolarization-induced shunting inhibition (DShI) mediates non-synaptic, neuronal intrinsic short-term plasticity, which suppresses action potential generation and postsynaptic responses. The TRESK channel significantly contributes to DShI and may represent a therapeutic target for antiepileptic drugs.
Article
Clinical Neurology
Miklos Lengyel, Dominika Hajdu, Alice Dobolyi, Judit Rosta, Gabor Czirjak, Maria Dux, Peter Enyedi
Summary: The study found that inhibition of TRESK increased TRPV1-mediated calcium signal in dorsal root ganglion neurons and potentiated capsaicin-induced increases in calcitonin gene-related peptide release and meningeal blood flow. Activation of TRESK decreased capsaicin sensitivity in sensory neurons, leading to an attenuation of capsaicin-induced increase in meningeal blood flow. In animals lacking TRESK, TRPV1-mediated nociceptive reactions were not affected by TRESK modulators.
Review
Neurosciences
Niklas Huntemann, Stefan Bittner, Stefanie Bock, Sven G. Meuth, Tobias Ruck
Summary: The TRESK and TREK channels, although structurally and pharmacologically different, are functionally more closely related than previously thought. Recent studies suggest that assembling TRESK and TREK subunits can lead to the formation of heterodimeric channels with different properties, enhancing functional diversity. Their involvement in migraine, pain syndromes, and (neuro-)inflammatory processes highlights the potential for innovative therapeutic strategies, but also reveals obstacles in therapy development for these diseases.
NEUROSCIENCE LETTERS
(2022)
Article
Clinical Neurology
Shahram Bahrami, Guy Hindley, Bendik Slagsvold Winsvold, Kevin S. O'Connell, Oleksandr Frei, Alexey Shadrin, Weiqiu Cheng, Francesco Bettella, Linn Rodevand, Ketil J. Odegaard, Chun C. Fan, Matti J. Pirinen, Heidi M. Hautakangas, Anders M. Dale, Srdjan Djurovic, Olav B. Smeland, Ole A. Andreassen
Summary: Migraine shows a certain level of shared genetic basis with bipolar disorder, depression, and schizophrenia, with some shared genetic loci. It is less polygenic compared to mental disorders and shares variants with intelligence and educational attainment. Specific loci were identified that are jointly associated with migraine and depression, as well as with migraine and schizophrenia, implicating shared molecular mechanisms and highlighting candidate migraine genes for further research.
Article
Clinical Neurology
Brittany L. Mitchell, Santiago Diaz-Torres, Svetlana Bivol, Gabriel Cuellar-Partida, Zachary F. Gerring, Nicholas G. Martin, Sarah E. Medland, Katrina L. Grasby, Dale R. Nyholt, Miguel E. Renteria
Summary: This study explores the genetic relationship between migraine risk and brain morphometry using genome-wide association studies. The researchers found a negative genetic correlation between migraine risk and intracranial volume, and identified shared genomic regions between migraine and various brain structures. Additionally, evidence of a causal relationship between smaller brain volumes and increased migraine risk was discovered. These findings contribute to the understanding of the genetic basis for migraine and potential therapeutic targets.
Article
Biochemistry & Molecular Biology
Irene Simonetta, Renata Riolo, Federica Todaro, Antonino Tuttolomondo
Summary: Migraine is a hereditary disease characterized by one-sided or bilateral pain that worsens with physical activity, accompanied by symptoms such as nausea, vomiting, photophobia, and phonophobia. The pathogenesis and mechanism of migraine are still unclear, but research has shown the involvement of various brain areas and the trigeminovascular system. Genetic and environmental factors play important roles in the development and exacerbation of migraine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Elena Crespo, Anna Vidal-Alabro, Thomas Jouve, Pere Fontova, Maik Stein, Sonila Mocka, Maria Meneghini, Anett Sefrin, Petra Hruba, Montserrat Goma, Alba Torija, Laura Donadeu, Alex Fava, Josep M. Cruzado, Edoardo Melilli, Francesc Moreso, Ondrej Viklicky, Frederike Bemelman, Petra Reinke, Josep Grinyo, Nuria Lloberas, Oriol Bestard
Summary: This study investigated how functional TAC-CYP3A genetic variants influence the risk of biopsy-proven acute rejection (BPAR) in kidney transplant patients. The results showed that different genetic variants impacted TAC exposure levels and predicted the occurrence of BPAR. Combining genetic variants with other clinical and immunological risk factors may improve the prediction of rejection risk.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Mona Ameri Chalmer, Andreas Hoiberg Rasmussen, Lisette J. A. Kogelman, Jes Olesen, Thomas Folkmann Hansen
Summary: This study found no aggregation of chronic migraine in families with a clustering of migraine. No specific rare variants gave rise to migraine chronification, suggesting that migraine chronification is caused by environmental factors rather than genetic factors. Chronic migraine was not associated with a higher polygenic risk score.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Cell Biology
Amalie Clement, Song Guo, Inger Jansen-Olesen, Sarah Louise Christensen
Summary: Migraine is a leading cause of disability globally, significantly impacting the lives of those affected. ATP-sensitive potassium (K-ATP) channels have been found to play a role in migraine pathophysiology. However, the development of better treatment options has faced challenges due to species differences in the efficacy and specificity of pharmacological tools targeting K-ATP channel subtypes.
Review
Medicine, Research & Experimental
Johra Khan, Lubna Ibrahim Al Asoom, Ahmad Al Sunni, Nazish Rafique, Rabia Latif, Seham Al Saif, Noor B. Almandil, Dana Almohazey, Sayed AbdulAzeez, J. Francis Borgio
Summary: Migraine is a neurological ailment characterized by severe unilateral headache and associated symptoms. The pathogenesis of migraine involves intracranial network activation leading to trigemino-vascular system sensitization and inflammatory reaction. Genetic factors may play a significant role in individual susceptibility to migraine.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Eleonora Spekker, Tamas Kortesi, Laszlo Vecsei
Summary: Migraine is a chronic neurological disorder affecting 12% of the population. Activation of the trigeminal system releases neuropeptides, leading to inflammation and sensitization. Recent studies have highlighted the role of TRP channels in pain disorders, including migraines, and their potential for therapeutic targeting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Palvi Gotra, Nidhi Bhardwaj, Abhilash Ludhiadch, Gagandeep Singh, Anjana Munshi
Summary: Epilepsy and migraine share common clinical and pathophysiological mechanisms, with genetic variations playing a role in susceptibility. Alterations in ion channel-encoding genes may be a common risk factor for both conditions. The potential for targeting common genes and molecular mechanisms in future treatment strategies is discussed.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Clinical Neurology
Lou Grangeon, Kristin Sophie Lange, Marta Waliszewska-Prosol, Dilara Onan, Karol Marschollek, Wietse Wiels, Petr Mikulenka, Fatemeh Farham, Cedric Gollion, Anne Ducros
Summary: Migraine is a complex brain disorder caused by a combination of genetic and environmental factors. Monogenic migraines, such as familial hemiplegic migraine and migraine with aura associated with hereditary small-vessel disorders, involve genes that affect neurons, glial cells, and blood vessels, leading to increased susceptibility to cortical spreading depression. Genome-wide association studies have identified multiple variants that contribute to migraine risk, although individually each variant only has a small effect. These variants are part of complex networks of molecular abnormalities, mainly affecting neurons or blood vessels. Genetics research has also revealed shared genetic factors between migraine and other conditions like depression and high blood pressure. More research is needed to map all the susceptibility loci for migraine and understand how these genetic variants lead to migraine.
JOURNAL OF HEADACHE AND PAIN
(2023)
Review
Physiology
Andrew F. Russo, Debbie L. Hay
Summary: Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological functions. It acts through various receptors and is associated with disease states such as migraine. Therapeutics targeting the CGRP axis have shown success in bench-to-bedside translation. This review provides a comprehensive overview of CGRP's regulation, expression, physiological actions, and potential therapeutic targeting in various systems and diseases.
PHYSIOLOGICAL REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Areeba Nisar, Zubair Ahmed, Hsiangkuo Yuan
Summary: Migraine is a debilitating neurological condition that affects many patients' quality of life. Despite the success of new therapies, not all patients benefit significantly. Understanding the mechanisms involved in migraine can lead to the discovery of novel therapeutic targets for improved treatment options.
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)