Journal
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
Volume 42, Issue 4, Pages 535-542Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.biocel.2009.10.014
Keywords
Fibrocyte; Fibrosis
Categories
Funding
- NCI NIH HHS [R01 CA087879-09, R01 CA087879] Funding Source: Medline
- NHLBI NIH HHS [R01 HL073848, K23 HL097074-02, K23 HL097074-01, K23 HL097074, R01 HL066027, R01 HL066027-10] Funding Source: Medline
- NIDDK NIH HHS [P30 DK067629] Funding Source: Medline
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Regeneration and fibrosis are integral parts of the recovery process following tissue injury, and impaired regulation of these mechanisms is a hallmark of many chronic diseases. A population of bone marrow-derived mesenchymal progenitor cells known as fibrocytes, play an important role in tissue remodeling and fibrosis in both physiologic and pathologic settings. In this review we summarize the key concepts regarding the pathophysiology of wound healing and fibrosis, and present data to support the contention that circulating fibrocytes are important in both normal repair process and aberrant healing and fibrotic damage associated with a diverse set of disease states. (C) 2009 Elsevier Ltd. All rights reserved.
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