Article
Public, Environmental & Occupational Health
Yuanyuan Xu, Hongjie Shi, Xiaoxiao Dong, Chengyuan Ding, Sushu Wu, Xin Li, Hongying Zhang, Mengkai Qiao, Xiaoshan Li, Zhengping Zhu
Summary: This study aimed to understand the prevalence and transmission of transmitted drug resistance (TDR) among ART-naive HIV-1-infected individuals in Nanjing. The overall prevalence of TDR in Nanjing was 7.8%, with nearly half of TDR individuals included in transmission clusters. It is crucial to sustain and expand HIV drug-resistance prevention, monitoring, and response efforts in Nanjing to reduce the prevalence and transmission of TDR.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Virology
Huangbo Yuan, Zhenqiu Liu, Xuefu Wu, Mingshan Wu, Qiwen Fang, Xin Zhang, Tingting Shi, Damien C. Tully, Tiejun Zhang
Summary: The study found a low prevalence of TDR HIV in China over the last two decades. However, the rate of TDR HIV has been increasing since 2010, with persistent circulation of drug resistance mutations and expansion of drug resistance reservoirs, potentially compromising the efficacy of antiretroviral therapy programs.
ARCHIVES OF VIROLOGY
(2021)
Article
Infectious Diseases
Benjamin M. Wenk, Herbert A. Mbunkah, Ndi N. Nsanwe, Eyongetah T. Mbu, Lydia M. Besong, Bella A. Sama, Emmanuel Orock, Christine Leemann, Karin J. Metzner
Summary: This study investigated the prevalence of pretreatment HIV-1 resistance to INSTIs in Cameroon and found a low resistance rate. However, a majority of individuals carried polymorphic accessory INSTI drug resistance mutations, which may require further studies to assess their impact on INSTI-based ART regimens.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Barbara Rossetti, Massimiliano Fabbiani, Domenico Di Carlo, Francesca Incardona, Ana Abecasis, Perpetua Gomes, Anna Maria Geretti, Carole Seguin-Devaux, Federico Garcia, Rolf Kaiser, Sara Modica, Adrian Shallvari, Anders Sonnerborg, Maurizio Zazzi
Summary: This large multi-cohort study indicates high effectiveness of elvitegravir- or dolutegravir-based first-line ART in routine practice across Europe. Factors such as baseline viral load and CD4 cell count can affect the treatment outcomes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Clinical Neurology
Ruili Li, Yuxun Gao, Wei Wang, Zengxin Jiao, Bo Rao, Guangxue Liu, Hongjun Li
Summary: This study investigated the effects of early HIV infection and combination antiretroviral therapy (cART) on gray matter structural covariance networks using graph theoretical analysis. The results showed a decrease in information transfer efficiency in sensory regions and a compensatory increase in the frontal lobe in early HIV+ individuals. HIV+/cART+ individuals exhibited a less specialized regional segregation function but a stronger global integration function in the network.
FRONTIERS IN NEUROLOGY
(2022)
Article
Infectious Diseases
Rui Li, Chuan Song, Danying Chen, Cuilin Li, Yu Hao, Hui Zeng, Junyan Han, Hongxin Zhao
Summary: This study investigated the prevalence, patterns, associated risk factors, and predicted drug sensitivity of transmitted drug resistance (TDR) in ART-naive patients with HIV/AIDS in Beijing from 2015 to 2018. The overall prevalence of TDR was 6.68%, with the lowest resistance observed for nucleoside reverse transcriptase inhibitors (NRTIs) and the highest resistance observed for non-nucleoside reverse transcriptase inhibitors (NNRTIs). Patients aged 40-59 years and those with the CRF08_BC subtype were identified as having a higher risk for drug resistance mutation.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Infectious Diseases
Xianwu Pang, Kailing Tang, Qin He, Jinghua Huang, Ningye Fang, Xinjuan Zhou, Qiuying Zhu, Xiuling Wu, Zhiyong Shen, Shujia Liang
Summary: The study found a TDR prevalence of 7.21% among newly diagnosed HIV-1 individuals in Guangxi. Being unmarried and having the CRF08_BC subtype were significantly associated with TDR prevalence.
BMC INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Xiu Liu, Dong Wang, Jing Hu, Chang Song, Lingjie Liao, Yi Feng, Dan Li, Hui Xing, Yuhua Ruan
Summary: This study examines the changes in HIV-1 subtypes, sub-subtypes, and transmitted drug resistance (TDR) among previously untreated Chinese individuals diagnosed with HIV infection. The prevalence of certain subtypes/sub-subtypes has declined, while others have increased. The prevalence of TDR has also significantly increased. Measures to control TDR transmission are urgently needed in China.
Review
Hematology
Antonino Carbone, Emanuela Vaccher, Annunziata Gloghini
Summary: HIV infection increases the risk of cancer, especially lymphomas. The treatment for HIV-associated lymphomas has improved with the introduction of modern therapies, but there is still a need for the development of new treatment strategies.
Article
Multidisciplinary Sciences
Jie Jia, Yu Zhao, Ji-Qun Yang, Dan-Feng Lu, Xiu-Ling Zhang, Jun-Hong Mao, Kun-Hua Wang, Jian-Hua Wang, Yi-Qun Kuang
Summary: Incomplete immune reconstitution can occur in HIV-infected patients despite achieving viral suppression with antiretroviral therapy (ART). A study found that immune non-responders had decreased diversity in B cell receptor repertoire and disrupted cell cycle of B cells. These findings provide important insights into the role of B cell-mediated immune response in immune reconstitution following HIV infection.
Article
Infectious Diseases
Zhuoqun Sun, Yun Lan, Shujia Liang, Jing Wang, Mingjian Ni, Xia Zhang, Fengting Yu, Meiling Chen, Hanxi Zhang, Liting Yan, Weiping Cai, Guanghua Lan, Ye Ma, Fujie Zhang
Summary: This study evaluated the prevalence and characteristics of doravirine resistance and cross-resistance in patients who failed first-line ART in China. The results showed a high prevalence of doravirine cross-resistance, with significant differences between genotypes and provinces. Doravirine should not be used without genotypic resistance testing, and it is not recommended for people who have failed first-line NNRTI-based ART.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Salvatore Martini, Paolo Maggi, Cristina Gervasoni, Lorenzo Onorato, Sergio Ferrara, Loredana Alessio, Chiara Bellacosa, Vincenzo Esposito, Giovanni Di Filippo, Addolorata Masiello, Adelaide Maddaloni, Simona Madonia, Giovanna D'Alessio, Viviana Rizzo, Nicola Coppola
Summary: This study suggests an association between TAF and hypercholesterolemia in HIV-naive patients.
Article
Psychiatry
Wei Hua, Sen Wang, Xi Wang, Ying Shao, Yali Wang, Jiangzhu Ye, Bin Su, Taiyi Jiang, Tong Zhang, Hao Wu, An Liu, Qunhui Li, Supriya D. Mahajan, Zaicun Li, Lijun Sun, Lili Dai
Summary: The study found that the prevalence of anxiety, depression, and sleep disturbances decreased significantly after 12 months of EFV treatment, indicating a positive impact on improving neuropsychiatric adverse events. Additionally, risk factors such as low education level, low income, unemployment, divorce, and WHO III/IV stages were associated with severe neuropsychiatric disorders.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Peter Vanes Ebasone, Nasheeta Peer, Anastase Dzudie, Andre Pascal Kengne
Summary: This protocol aims to estimate the global prevalence of selected cardiometabolic risk factors in ART-naive PLHIV and their association with HIV specific factors. The study will conduct a systematic search and analysis of observational studies to collect relevant data.
Article
Multidisciplinary Sciences
Md Nasir Uddin, Abrar Faiyaz, Lu Wang, Yuchuan Zhuang, Kyle D. Murray, Maxime Descoteaux, Madalina E. Tivarus, Miriam T. Weber, Jianhui Zhong, Xing Qiu, Giovanni Schifitto
Summary: Initiation of cART reduces inflammation in HIV-infected individuals, as shown by decreased extracellular free water (FW) levels in grey and white matter. FW levels correlated positively with neurofilament light chain (NfL) and negatively with CD4 counts. Both FW and NfL decreased after 12 weeks of cART treatment, suggesting that FW could be a biomarker for monitoring HIV-associated neuroinflammation. Long-term follow-up at 1 and 2 years showed no significant differences in FW levels between HIV-infected and uninfected individuals, indicating that cART helps control neuroinflammation.
SCIENTIFIC REPORTS
(2021)