Article
Food Science & Technology
Qianmin Lin, Bingbing Song, Yingxiong Zhong, Huan Yin, Ziyu Li, Zhuo Wang, Kit-Leong Cheong, Riming Huang, Saiyi Zhong
Summary: As an acidic polysaccharide, Hyaluronic acid (HA) is commonly found in the form of Sodium Hyaluronate (SH) and has various applications such as knee repair, oral treatment, skincare, and food additive. This study examines the anti-aging activity of SH as a food additive by treating C. elegans with SH and assessing lifespan indicators and gene expression. The results show that SH extends lifespan, increases antioxidant enzyme levels, decreases oxidative stress markers, improves athletic ability, and regulates gene expression associated with aging and oxidative stress.
Article
Biology
Monica Garcia Silva, Paulo Nunes, Paula Oliveira, Rita Ferreira, Margarida Fardilha, Daniel Moreira-Goncalves, Jose Alberto Duarte, Maria Manuel Oliveira, Francisco Peixoto
Summary: This study demonstrates the lifelong benefits of aerobic exercise in preventing age-related consequences on liver function and antioxidant activity. The duration of the training protocol might be more critical for the adaptive response than exercise intensity. Regular aerobic exercise can prevent mitochondrial dysfunction and loss of antioxidant system efficacy in the liver associated with aging.
Article
Biochemistry & Molecular Biology
Marta Budkowska, Elzbieta Cecerska-Heryc, Zuzanna Marcinowska, Aldona Siennicka, Barbara Dolegowska
Summary: This study aimed to investigate the activity of several enzymes related to oxidative stress and the concentration of glutathione in the circadian rhythm. The results showed that the activity of these enzymes and the concentration of glutathione peaked at 2 a.m. during sleep. This suggests that the processes maintaining the redox balance are intensified during sleep, thus reducing oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Shiva Ganjali, Reihaneh Keshavarz, Susan Hosseini, Atena Mansouri, Massimo R. Mannarino, Matteo Pirro, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: This study revealed significant differences in oxidant/antioxidant markers between FH patients and healthy individuals, as well as between HoFH and HeFH patients. These differences may be strongly associated with plasma LDL-C levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Physics, Multidisciplinary
J. Misek, J. Jakus, K. Hamza Sladicekova, L. Zastko, M. Veternik, V. Jakusova, I. Belyaev
Summary: Cell phones expose significant parts of the human brain and head to extremely low frequency (ELF) magnetic fields (MF) classified by the IARC as a 2B carcinogen. Measurements and simulations showed that the ELF MF emitted by cell phones can reach levels comparable to those known to induce biological and health effects, including carcinogenesis. Understanding the exposure and combined effects of radiofrequency and ELF electromagnetic fields is important for future studies.
FRONTIERS IN PHYSICS
(2023)
Article
Plant Sciences
Satish Kumar Sanwal, Parveen Kumar, Hari Kesh, Vijai Kishor Gupta, Arvind Kumar, Ashwani Kumar, Babu Lal Meena, Giuseppe Colla, Mariateresa Cardarelli, Pradeep Kumar
Summary: Salinity stress significantly reduces plant height, stem numbers, and tuber yield in potato varieties. Salt-tolerant genotypes exhibit better performance under salt stress due to a strong antioxidant defense system and osmotic adjustment, suggesting their potential for breeding new high-yielding, salt-tolerant lines. Specific physiological and biochemical traits were identified as predominant for tuber yield under salt stress, providing insights for further genetic and molecular studies on salt tolerance in potato.
Article
Environmental Sciences
Sukhchain Kaur, Neha Garg, Rubal Rubal, Monisha Dhiman
Summary: Heavy metal exposure is correlated with hypertension and is associated with altered lipid profiles, cardiac markers, oxidative stress markers, and heavy metal concentrations exceeding permissible limits.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Cristiane de Freitas Rodrigues, Jean Ramos Boldori, Marcell Valandro Soares, Sabrina Somacal, Tatiana Emanuelli, Aryele Izaguirry, Francielli Weber Santos Cibin, Paula Rossini Augusti, Cristiane Casagrande Denardin
Summary: Goji berry juice exerts toxic effects on Caenorhabditis elegans, promoting premature aging. Further studies in mammals are needed before its consumption can be recommended.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Chandra Sekhar Arigela, Giribabu Nelli, Siew Hua Gan, Kuttulebbai Nainamohamed Salam Sirajudeen, Kumarathevan Krishnan, Nurhanan Abdul Rahman, Visweswara Rao Pasupuleti
Summary: Bitter gourd honey (BGH) shows potential anti-oxidative, anti-inflammatory, and anti-apoptotic effects in the treatment of diabetes, reducing liver and kidney damage and increasing levels of antioxidant enzymes.
Article
Biochemistry & Molecular Biology
Jakub Rok, Zuzanna Rzepka, Mateusz Maszczyk, Artur Beberok, Dorota Wrzesniok
Summary: Minocycline, a semisynthetic tetracycline antibiotic, not only exhibits antibacterial activity but also shows antioxidative effects. Long-term use of minocycline may cause skin hyperpigmentation. Research indicates that minocycline induces oxidative stress in human melanocytes but can also increase cell viability and mitigate oxidative stress when exposed to hydrogen peroxide and UVA radiation. Additionally, the different impact of minocycline on CAT activity compared to other tetracyclines may be attributed to the binding site location.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Khadija Sossey Alaoui, Bernard Tychon, Sandrine Joachim, Alain Geffard, Katherine Nott, Sebastien Ronkart, Jean-Marc Porcher, Remy Beaudouin, Christelle Robert, Marie-Laure Fauconnier, Matthew Saive
Summary: The study aimed to assess the toxicity of a mixture of five pharmaceutical drugs using Fontinalis antipyretica as a bioindicator and bioaccumulator. Results showed that only carbamazepine and irbesartan were accumulated by the species, with bioaccumulation levels increasing with exposure time. Antioxidant enzymes were sensitive to the drug mixture, with higher activity observed in plants exposed to higher concentrations. Chlorophyll content decreased in exposed plants, but photosynthetic activity was restored after 5 months. Morphological characteristics were less impacted by the treatment.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Mohammad Hasan Saberi, Seraj Bita
Summary: In this study, the immunotoxicity of silver nanoparticles on whiteleg shrimp was assessed by monitoring the activity of certain enzymes, as well as the changes in antioxidant capacity and oxidative damage markers. It was found that silver nanoparticles caused severe immunotoxicity in the hepatopancreas tissue of whiteleg shrimp through the suppression of certain enzymes and antioxidant capacity.
MARINE POLLUTION BULLETIN
(2023)
Review
Oncology
Felix M. Onyije, Ann Olsson, Dan Baaken, Friederike Erdmann, Martin Stanulla, Daniel Wollschlaeger, Joachim Schuez
Summary: Leukemia is the most common type of cancer in children worldwide. This umbrella review examines the environmental risk factors and the risk of childhood acute lymphoblastic leukemia (ALL). Only low doses of ionizing radiation in early childhood and maternal exposure to general pesticides during pregnancy showed convincing evidence of an association with childhood ALL.
Article
Environmental Sciences
Yu Ji, Yanfang Ren, Chuan Han, Wenjia Zhu, Jinyu Gu, Junyu He
Summary: The research demonstrated that exogenous application of GB could improve plant growth and development of pakchoi under lead stress by enhancing antioxidative enzyme activities and reducing oxidative stress and lead accumulation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Claudia Rebeca Rivera-Yanez, Porfirio Alonso Ruiz-Hurtado, Maria Isabel Mendoza-Ramos, Julia Reyes-Reali, Gina Stella Garcia-Romo, Glustein Pozo-Molina, Aldo Arturo Resendiz-Albor, Oscar Nieto-Yanez, Adolfo Rene Mendez-Cruz, Claudia Fabiola Mendez-Catala, Nelly Rivera-Yanez
Summary: Skin is the main external organ that needs protection from various harmful agents. There are skin disorders that lack effective and accessible treatment. Flavonoids from propolis have beneficial effects on skin diseases, with antioxidant and anti-inflammatory properties that help control and regulate cellular and biochemical changes caused by these diseases.
Meeting Abstract
Biochemistry & Molecular Biology
Virginio Bignotti, Silvano Santini, Valeria Cordone, Valeria Panella, Mahmut Mijit, Pierpaolo Aimola, Stefano Falone, Fernanda Amicarelli
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Francesca Lombardi, Silvano Santini, Paola Palumbo, Valeria Cordone, Virginio Bignotti, Valeria Panella, Giovanna Di Emidio, Carla Tatone, Maurizio Giuliani, Stefano Falone, Benedetta Cinque, Fernanda Amicarelli, Maria Grazia Cifone
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Simone Guarnieri, Caterina Morabito, Michele Bevere, Paola Lanuti, Maria A. Mariggio
Summary: The study found that simulated microgravity slowed cell proliferation and decreased metabolic activity, along with increased levels of intracellular reactive oxygen species and calcium ions. The presence of an antioxidant, N-acetylcysteine, counteracted the effects of simulated microgravity.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Chemistry, Multidisciplinary
Rosa Mancinelli, Ester Sara Di Filippo, Margherita Tumedei, Mariangela Marrone, Antonella Fontana, Valeria Ettorre, Silvia Giordani, Michele Baldrighi, Giovanna Iezzi, Adriano Piattelli, Stefania Fulle
Summary: Equine bone blocks with G-N2 and G-N10 coatings, along with melatonin, were found to enhance cell adhesion and increase osteogenic potential of hDPSCs, suggesting a promotion of the osteogenic process.
APPLIED SCIENCES-BASEL
(2021)
Review
Biochemistry & Molecular Biology
Rosa Mancinelli, Franco Checcaglini, Francesco Coscia, Paola Gigliotti, Stefania Fulle, Giorgio Fano-Illic
Summary: In the last decade, evidence has emerged showing the importance of myokines released from skeletal muscle in impacting various biological functions. Specific myokines such as irisin have unique roles in modulating oxidative stress. Understanding the role of myokines in skeletal muscle aging processes can help in comprehending the regulatory mechanisms of muscle cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Raffaella Franciotti, Pamela Pignatelli, Claudia Carrarini, Federica Maria Romei, Martina Mastrippolito, Antonella Gentile, Rosa Mancinelli, Stefania Fulle, Adriano Piattelli, Marco Onofrj, Maria Cristina Curia
Summary: This study aimed to quantify Porphyromonas gingivalis (Pg) abundance in the oral cavity of neurodegenerative disease patients and found that Pg levels were significantly higher in neurodegenerative disease patients compared to other groups. The results also showed a strong correlation between Pg abundance in the oral cavity and antibody levels in patients, suggesting that oral pathogens may induce an antibody systemic response that influences disease progression.
Article
Dentistry, Oral Surgery & Medicine
Margherita Tumedei, Rosa Mancinelli, Ester Sara Di Filippo, Mariangela Marrone, Giovanna Iezzi, Adriano Piattelli, Stefania Fulle
Summary: This study evaluated the osteogenic differentiation of hDPSCs stimulated by melatonin on equine bone blocks. The results showed that melatonin and equine bone blocks increased the osteogenic potential of hDPSCs and regulated the expression of miRNAs and genes related to osteogenesis. These findings suggest that hDPSCs/equine bone block and melatonin could be a promising biocomplex for bone regeneration with potential clinical application.
INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY
(2022)
Review
Cell Biology
Michele Bevere, Caterina Morabito, Maria A. Mariggio, Simone Guarnieri
Summary: This review provides an overview of the key hallmarks of cardiomyocytes in physiological and pathological conditions, highlighting the metabolic aspects, cellular structures, intracellular calcium homeostasis, and intracellular zinc balance. These components are strongly linked to each other through intracellular ROS management, and their imbalance can lead to cardiovascular diseases.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Cell Biology
Michele Bevere, Caterina Morabito, Simone Guarnieri, Maria A. Mariggio
Summary: This study investigated the impact of GAP43 on cardiac tissue and found that its absence led to morphological changes and signs of hypertrophy in the hearts of knockout mice. This suggests that GAP43 may play a significant role in the functional processes of cardiac muscle.
HISTOCHEMISTRY AND CELL BIOLOGY
(2022)
Review
Cell Biology
Marco Ponzetti, Nadia Rucci, Stefano Falone
Summary: Disruption of redox homeostasis and RNA methylome-dependent control of gene expression play critical roles in cancer resistance to treatment. However, little research has focused on the involvement of redox-dependent or -responsive signaling pathways in the epitranscriptome-directed adaptations underlying acquired and/or innate resistance traits in cancer. This review summarizes the current understanding of this topic and provides new perspectives for delaying or preventing refractory cancer and tumor recurrence.
Editorial Material
Chemistry, Multidisciplinary
Maria A. Mariggio, Giulia Ricci
APPLIED SCIENCES-BASEL
(2022)
Editorial Material
Oncology
Antonio Giordano, Nadia Rucci, Stefano Falone
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Felice Lorusso, Antonio Scarano, Stefania Fulle, Luca Valbonetti, Rosa Mancinelli, Ester Sara Di Filippo
Summary: This study analyzed the effects of three natural compounds (resveratrol, curcumin, and apigenin) on the gene expression of human dental pulp stem cells and evaluated their healing effects on critical-size defects in rat calvaria. The results showed that these compounds had positive effects on gene expression and apigenin exhibited the most significant bone healing effects. This study provides new possibilities for promoting bone regeneration through nutraceutical supplementation.
Article
Cell Biology
Marika Berardini, Luisa Gesualdi, Caterina Morabito, Francesca Ferranti, Anna Reale, Michele Zampieri, Katsiaryna Karpach, Antonella Tinari, Lucia Bertuccini, Simone Guarnieri, Angela Catizone, Maria A. Mariggio, Giulia Ricci
Summary: The study shows that simulated microgravity exposure can lead to accumulation of reactive oxygen species in TCam-2 cells, along with increased protein and lipid oxidation, and altered mitochondria structure. However, the cells are capable of triggering compensatory mechanisms to overcome the effects of altered gravitational force.
Article
Oncology
Marco Ponzetti, Argia Ucci, Chiara Puri, Luca Giacchi, Irene Flati, Daria Capece, Francesca Zazzeroni, Alfredo Cappariello, Nadia Rucci, Stefano Falone
Summary: This study investigated the effects of osteoblast-derived extracellular vesicles (OB-EVs) on the phenotype, energy metabolism, and oxidative status of osteosarcoma cells. The results showed that OB-EVs reduced the aggressiveness and viability of osteosarcoma cells through redox-dependent signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kun He, Mengyi Xie, Weifeng Hong, Yonghe Li, Yaolin Yin, Xiaojin Gao, Yi He, Yu Chen, Chuan You, Jingdong Li
Summary: Centromere protein L (CENPL) is overexpressed in hepatocellular carcinoma (HCC) and is associated with poor patient prognosis. Upregulation of CENPL promotes tumor proliferation and glycolysis in HCC cells by activating the MEK1/2-ERK1/2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Yingzi Wang, Haozhong Huang, Huimin Weng, Chunsen Jia, Bin Liao, Yang Long, Fengxu Yu, Yongmei Nie
Summary: Talin protein plays a crucial role in transmitting mechanical forces by connecting the extracellular matrix to the cytoskeleton. It converts mechanical signals into biochemical signals and serves as diagnostic, therapeutic, and prognostic indicators in diseases.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Review
Biochemistry & Molecular Biology
Hema Saranya Ilamathi, Marc Germain
Summary: Mitochondria are the central metabolic hubs in cells, relying on proteins encoded by nuclear DNA and mitochondrial DNA (mtDNA) for their function. The maintenance and distribution of mtDNA are crucial for proper mitochondrial function and are associated with mitochondrial diseases. mtDNA is organized into nucleoids that dynamically move and interact with each other. The replication and distribution of mtDNA nucleoids are regulated by the complex interplay of mitochondrial dynamics, ER-mitochondria contact sites, and cytoskeletal networks.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
K. K. Sruthi, Sirisha Natani, Ramesh Ummanni
Summary: The overexpression of TPD52 is associated with the emergence of neuroendocrine prostate cancer (NEPC). TPD52 activates the NF-kappa B - STAT3 axis to induce neuroendocrine differentiation (NED) of prostate cancer cells. Therapeutic targeting of TPD52 is important for the treatment of prostate cancer.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Cui Li, Feifan Xiang, Yuqi Gong, Yi Fu, Ge Chen, Zhi Wang, Zhong Li, Daiqing Wei
Summary: Our study demonstrates the significant role of tumor-derived microparticles (T-MPs) in osteosarcoma metastasis and immune response. T-MPs promote macrophage polarization and stimulate migration and chemoresistance of osteosarcoma cells, thereby affecting the progression of osteosarcoma.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2024)