Journal
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
Volume 33, Issue 9, Pages 627-635Publisher
WICHTIG EDITORE
DOI: 10.1177/039139881003300908
Keywords
Device; Biofilm; Infection
Categories
Funding
- TYRX, Inc.
- WuXi AppTec, Inc.
Ask authors/readers for more resources
Purpose: Device-related infections represent a significant clinical challenge. Once established, these infections prove difficult to treat with existing antibiotic regimens, compromising the health of device recipients, and usually requiring surgical intervention to resolve. The purpose of this study was to determine the ability of the AIGIS(RX)(R) Anti-Bacterial envelope to reduce the formation of bacterial biofilm on implanted pacing devices. Methods: An infection was established in a rabbit model by creating bilateral subcutaneous implant pockets, into which a pacing device with or without AIGIS(RX)(R) was placed. The incisions were closed, and a defined dose of bacteria was infused into each implant pocket. After seven days, devices were explanted and assessed for viable bacteria by a sonication/vortex procedure to quantify bacteria, and by imaging of the device surface by scanning electron microscopy and laser scanning confocal microscopy. Results: The presence of the AIGIS(RX)(R) envelope eliminated recoverable, viable bacteria from the explanted devices using a vortex/sonication technique from in vivo models of Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus capitis, and Escherichia coli infections. Scanning electron microscopy and confocal microscopy demonstrate greatly reduced biological material on the pacemaker surfaces in the presence of the AIGIS(RX)(R) envelope compared to untreated controls. Conclusion: These results demonstrate that in this animal model, the AIGIS(RX)(R) device reduces the formation of adherent bacteria and reduces bioburden on implanted, infected pacemaker devices.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available