Journal
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
Volume 42, Issue 6, Pages 575-579Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijantimicag.2013.08.014
Keywords
Vibrio parahaemolyticus; qnrVC6; bla(PER-1); Multidrug resistance; Novel integron
Funding
- Chinese National Key Basic Research and Development (973) Program [2013CB127200]
- Research Fund for the Control of Infectious Diseases from the Food and Health Bureau, Government of Hong Kong SAR [K-ZJG2]
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Vibrio parahaemolyticus is a major causative agent of gastroenteritis and is the leading cause of food-borne illness in Hong Kong. Recent studies of resistance to extended-spectrum beta-lactams and fluoroquinolones in V. parahaemolyticus have caused huge concern. This work reports the characterisation of a multidrug resistance conjugative plasmid in V. parahaemolyticus isolated from shrimp samples from Hong Kong. The plasmid is ca. 200 kb and carries multidrug resistance genes, including a novel plasmid-mediated quinolone resistance gene qnrVC6 surrounded by several known and novel insertion sequence (IS) elements, an extended-spectrum beta-lactamase gene bla(PER-1) mediated by ISCR1, and a ca. 3-kb four-gene cassette (aacA3, catB2, dfrA1 and aadA1) class 1 integron. Transmission of this multidrug resistance conjugative plasmid among Vibrio spp. would compromise the effectiveness of Vibrio infection control and pose a huge threat to public health. (C) 2013 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
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