Article
Pharmacology & Pharmacy
Virginia Barreto Lordello, Andreia Bagliotti Meneguin, Sarah Raquel de Annunzio, Maria Pia Taranto, Marlus Chorilli, Carla Raquel Fontana, Daniela Cardoso Umbelino Cavallini
Summary: The orodispersible film developed in this study successfully delivered probiotic Enterococcus faecium CRL 183 into the oral cavity, demonstrating good antifungal activity against Candida albicans and reducing biofilm formation.
Article
Microbiology
Angela Maione, Marianna Imparato, Annalisa Buonanno, Federica Carraturo, Antonetta Schettino, Maria Teresa Schettino, Marilena Galdiero, Elisabetta de Alteriis, Marco Guida, Emilia Galdiero
Summary: Candida albicans is a common microorganism in the human microbiota that can cause vulvovaginal infections. The development of drug resistance in C. albicans isolates is a complication that requires new therapeutic strategies. The study found that phenyllactic acid (PLA) has strong antifungal and antivirulence activities against C. albicans, including reducing biofilm formation and affecting gene expression. PLA shows promise as a novel and safe antifungal agent for the treatment of vulvovaginal candidiasis.
Article
Infectious Diseases
Yu Wang, Zejun Pei, Zaixiang Lou, Hongxin Wang
Summary: The study demonstrated the inhibitory and eradicating effects of cordycepin on Candida albicans biofilms, reducing their metabolic activity and damaging the biofilm structure. Furthermore, cordycepin showed low acute toxicity in mice, suggesting its safety as a potential antifungal agent.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Chemistry, Medicinal
Hitoshi Kamauchi, Yu Kimura, Mikoto Ushiwatari, Mitsuaki Suzuki, Taishi Seki, Koichi Takao, Yoshiaki Sugita
Summary: Thirty-five pyridone derivatives were synthesized using domino-Knoevenagel-electrocyclic reactions on various polycyclic pyridone scaffolds. These compounds were tested for anti-fungal activities against Candida albicans. Among them, compound 6d showed both anti-hyphal and biofilm inhibition activities.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Natalia Gomez-Casanova, Angela Martin-Serrano Ortiz, Irene Heredero-Bermejo, Javier Sanchez-Nieves, Jose Luis Copa-Patino, F. Javier de la Mata
Summary: The development of biofilms on different surfaces is a significant public health issue, and the resistance to antimicrobial drugs necessitates the search for compounds that can prevent cell adhesion and establishment of these complex communities. Zwitterionic modification of nanomaterials shows promise in preventing microbial adhesion and inhibiting biofilm formation in Candida albicans, Staphylococcus aureus, and Pseudomonas aeruginosa.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Materials Science, Coatings & Films
F. S. da Silva, A. C. A. de Paula e Silva, P. A. Barbugli, N. Cinca, S. Dosta, I. G. Cano, J. M. Guilemany, C. E. Vergani, A. Benedetti
Summary: In this study, the cold gas spray (CGS) technique was used to produce copper surfaces with anti-biofilm and biocompatibility properties. The physical characteristics of the copper coating, antimicrobial effects against various strains, and biocompatibility with human monocytes were investigated. Results showed that the copper coatings effectively inhibited the adhesion and viability of bacteria and fungi, while maintaining a high cell viability rate and similar cell labeling as standard culture conditions.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Chemistry, Applied
Ruilian Li, Limeng Zhu, Dongdong Liu, Wenjing Wang, Chen Zhang, Siming Jiao, Jinhua Wei, Lishi Ren, Yuchen Zhang, Xun Gou, Xianghua Yuan, Yuguang Du, Zhuo A. Wang
Summary: The study demonstrated that a cell wall polymer analog, HCOS, showed apparent antifungal activity against Candida strains, especially those in biofilm. Mechanistic studies suggested that HCOS exerts its activity by interfering with the connection and assembly of cell wall polysaccharides.
CARBOHYDRATE POLYMERS
(2022)
Article
Pharmacology & Pharmacy
Sara M. M. Hashem, Mary K. K. Gad, Hend M. M. Anwar, Neveen M. M. Saleh, Rehab N. N. Shamma, Noha I. I. Elsherif
Summary: The aim of this study was to design colloidal carriers called ufasomes that could encapsulate itraconazole and improve its penetration. A factorial design was used to investigate the effect of three independent factors on the encapsulation efficiency, particle size, and zeta potential. The optimized ufasomes had high encapsulation efficiency, small particle size, and negative zeta potential.
Article
Microbiology
Emerenziana Ottaviano, Giovanna Baron, Laura Fumagalli, Jessica Leite, Elisa Adele Colombo, Angelica Artasensi, Giancarlo Aldini, Elisa Borghi
Summary: The study demonstrated the efficacy of urinary cranberry metabolites VAL and 4-HBA in inhibiting Candida adhesion and biofilm formation in vitro. These metabolites interfered with yeast adhesion by modulating key gene expression, leading to a significant reduction in biofilm biomass and metabolic activity. The findings suggest that VAL and 4-HBA could be potential targets for drug development in preventing genitourinary Candida infections.
Article
Microbiology
Carola Parolin, Vanessa Croatti, Luca Laghi, Barbara Giordani, Maria Rosaria Tondi, Priscilla Romina De Gregorio, Claudio Foschi, Beatrice Vitali
Summary: The study reveals that vaginal Lactobacillus strains are capable of forming biofilms, with L. plantarum strains demonstrating the strongest biofilm production and effective inhibition against Candida. Additionally, the mode of biofilm/planktonic growth impacts Lactobacillus metabolism, particularly nitrogen and amino acid pathways, while anti-Candida activity is linked to carbohydrate metabolism. This highlights the complex interplay between microbial growth mode, metabolism, and functional properties, emphasizing the importance of biofilm formation by healthy human microbiota in microbial physiology and host-microbiota interactions.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Food Science & Technology
Quan Lin, Yanxin Li, Maokun Sheng, Jiaman Xu, Xiaoyan Xu, Jintae Lee, Yulong Tan
Summary: In recent years, there has been an increasing trend in Candida contamination caused by Candida mastitis, which has a significant impact on the hygienic quality of raw milk and dairy products. The biofilm produced by Candida albicans plays a critical role in fungal infection by protecting the fungus from host defense and drug attacks. Therefore, finding effective means to reduce the biofilm and drug resistance of Candida albicans has become an urgent problem. This study investigated the anti-biofilm effect of berberine-loaded chitosan nanoparticles on Candida albicans and explored the antifungal mechanism of released berberine.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Abdullah A. Al-Ghanayem
Summary: Lemongrass oil exhibits antifungal and anti-biofilm activity against Candida albicans, with no cytotoxic effect on HaCaT keratinocytes at lower concentrations.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Infectious Diseases
Shuai Wang, Peng Wang, Jun Liu, Chunxia Yang, Qiangyi Wang, Mingze Su, Ming Wei, Li Gu
Summary: This study compared the effects of different essential fatty acids (EFAs) on the biofilm formation and eradication of C. albicans. The results suggest that EPA and AA may serve as potential new antifungal agents for the treatment of clinical infections caused by C. albicans biofilms.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Biochemistry & Molecular Biology
Juliana Ribeiro Reynaldo, Katia Monteiro Novack, Lucas Resende Dutra Sousa, Paula Melo de Abreu Vieira, Tatiane Roquete Amparo, Gustavo Henrique Bianco de Souza, Luiz Fernando Medeiros Teixeira, Ana Paula Moreira Barboza, Bernardo Ruegger Almeida Neves, Meiry Edivirges Alvarenga, Felipe Terra Martins, Viviane Martins Rebello dos Santos
Summary: In this study, the incorporation of ketoconazole into copolymers was evaluated for its release profile, anti-Candida albicans activity, and cytotoxicity. The results showed that the drug incorporated in copolymers and its derivatives exhibited an immediate release profile, demonstrated activity against Candida albicans, and were non-toxic to human cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Bruna L. R. Silva, Gisele Simao, Carmem D. L. Campos, Cinara R. A. V. Monteiro, Laryssa R. Bueno, Gabriel B. Ortis, Saulo J. F. Mendes, Israel Viegas Moreira, Daniele Maria-Ferreira, Eduardo M. Sousa, Flavia C. B. Vidal, Cristina de Andrade Monteiro, Valerio Monteiro-Neto, Elizabeth S. Fernandes
Summary: This study investigated the in silico and antifungal activities of sulforaphane (SFN) against Candida albicans. SFN showed antimicrobial potential, high gastrointestinal absorption, good oral availability, and exhibited antifungal activity against C. albicans. SFN prevented biofilm and hyphae formation and showed additive/synergistic effects when used in combination with fluconazole (FLZ). These findings highlight the potential of SFN as an adjuvant therapy to FLZ in the clinical treatment of Candida infections.
Article
Biotechnology & Applied Microbiology
F. Hubert, M. -H. Rodier, A. Minoza, V. Portet-Sulla, E. Cateau, K. Brunet
Summary: Candida auris, an emerging species responsible for life-threatening infections, has shown resistance to most antifungal drugs and persistence in hospital environments. This study explored interactions between C. auris and two free-living amoeba species, demonstrating that the amoebas can promote yeast survival and proliferation while also internalizing viable C. auris. This suggests that a water environmental reservoir of C. auris may be considered through free-living amoebas, potentially leading to contamination of hospital water networks.
LETTERS IN APPLIED MICROBIOLOGY
(2021)
Article
Critical Care Medicine
Jean-Pierre Gangneux, Eric Dannaoui, Arnaud Fekkar, Charles-Edouard Luyt, Francoise Botterel, Nicolas De Prost, Jean-Marc Tadie, Florian Reizine, Sandrine Houze, Jean-Francois Timsit, Xavier Iriart, Beatrice Riu-Poulenc, Boualem Sendid, Saad Nseir, Florence Persat, Florent Wallet, Patrice Le Pape, Emmanuel Canet, Ana Novara, Melek Manai, Estelle Cateau, Arnaud W. Thille, Sophie Brun, Yves Cohen, Alexandre Alanio, Bruno Megarbane, Muriel Cornet, Nicolas Terzi, Lionel Lamhaut, Estelle Sabourin, Guillaume Desoubeaux, Stephan Ehrmann, Christophe Hennequin, Guillaume Voiriot, Gilles Nevez, Cecile Aubron, Valerie Letscher-Bru, Ferhat Meziani, Marion Blaize, Julien Mayaux, Antoine Monsel, Frederique Boquel, Florence Robert-Gangneux, Yves Le Tulzo, Philippe Seguin, Helene Guegan, Brice Autier, Matthieu Lesouhaitier, Romain Pelletier, Sorya Belaz, Christine Bonnal, Antoine Berry, Jordan Leroy, Nadine Francois, Jean-Christophe Richard, Sylvie Paulus, Laurent Argaud, Damien Dupont, Jean Menotti, Florent Morio, Marie Soulie, Carole Schwebel, Cecile Garnaud, Juliette Guitard, Solene Le Gal, Dorothee Quinio, Jeff Morcet, Bruno Laviolle, Jean-Ralph Zahar, Marie-Elisabeth Bougnoux
Summary: This study demonstrates a high prevalence of invasive pulmonary aspergillosis and candidemia in mechanically ventilated patients with severe COVID-19, and a high mortality associated with pr/pb CAPA. These findings highlight the importance of active surveillance for fungal pathogens in patients with severe COVID-19.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Kevin Brunet, Julien Verdon, Ali Ladram, Simon Arnault, Marie-Helene Rodier, Estelle Cateau
Summary: This study evaluated the activity of a frog antimicrobial peptide (AMP), [K-3]temporin-SHa, against yeasts and moulds, particularly Candida albicans. The results showed that [K-3]temporin-SHa had fungicidal activity against several yeasts and displayed rapid killing effect against C. albicans. Additionally, [K-3]temporin-SHa demonstrated synergistic effect with amphotericin B against C. albicans.
CANADIAN JOURNAL OF MICROBIOLOGY
(2022)
Article
Mycology
Guillaume Desoubeaux, Alix T. Coste, Christine Imbert, Christophe Hennequin
Summary: Candida auris is an emerging yeast species with a high prevalence of multi-drug resistance. It has the ability to survive on surfaces for more than two weeks, leading to large outbreaks primarily through nosocomial transmissions. The rapid global spread of C. auris poses a significant public health threat.
JOURNAL DE MYCOLOGIE MEDICALE
(2022)
Article
Microbiology
Stephane Bretagne, Karine Sitbon, Marie Desnos-Ollivier, Dea Garcia-Hermoso, Valerie Letscher-Bru, Sophie Cassaing, Laurence Millon, Florent Morio, Jean-Pierre Gangneux, Lilia Hasseine, Loic Favennec, Estelle Cateau, Eric Bailly, Maxime Moniot, Julie Bonhomme, Nicole Desbois-Nogard, Taieb Chouaki, Andre Paugam, Bernard Bouteille, Marc Pihet, Frederic Dalle, Odile Eloy, Milene Sasso, Magalie Demar, Patricia Mariani-Kurkdjian, Vincent Robert, Olivier Lortholary, Francoise Dromer
Summary: The epidemiology of invasive fungal diseases (IFDs) is difficult to determine due to diagnostic challenges. This study emphasizes the importance of active surveillance by mycologists and clinicians to understand global incidence and main IFDs. The findings show an increase in yeast fungemia and a higher prevalence of IFDs in older individuals. Despite advancements in diagnostic tools and antifungal drugs, global survival rates for IFDs have not improved.
Article
Infectious Diseases
Estelle Cateau, Antoine Leclerc, Noemie Cartier, Isabel Valsecchi, Eric Bailly, Ronan Le Senechal, Margaux Becerra, Brice Le Gallou, Rose-Anne Lavergne, Adelaide Chesnay, Jean-Patrice Robin, Carolyn Cray, Nicolas Goddard, Milan Thorel, Jacques Guillot, Baptiste Mulot, Guillaume Desoubeaux
Summary: The incidence of aspergillosis in the penguin population of a French zoo was found elevated, mostly in juveniles. The fungal contamination was high in the surrounding environment, especially at the end of summer. Globally, a great level of genetic diversity was observed, except for one clonal strain.
Article
Mycology
Luc Deroche, Julien Buyck, Estelle Cateau, Blandine Rammaert, Sandrine Marchand, Kevin Brunet
Summary: K. bovina is a yeast species related to bloodstream infections, and its genome has not been published yet.
Article
Microbiology
Seinde Toure, Marion Millot, Lucie Ory, Catherine Roullier, Zineb Khaldi, Valentin Pichon, Marion Girardot, Christine Imbert, Lengo Mambu
Summary: Endolichenic fungi from lichens produce diverse bioactive metabolites, with a new oxygenated fatty acid identified in Preussia persica showing interesting anti-biofilm activity against Candida albicans yeasts.
Article
Infectious Diseases
Adelaide Chesnay, Adelin Pastuszka, Lucie Richard, Agnes Beby-Defaux, Estelle Cateau, Cecile Le Brun, Guillaume Desoubeaux, Philippe Lanotte
Summary: In a retrospective study, sequencing was used to analyze Trichomonas vaginalis-positive specimens. The study found that the majority of T. vaginalis-positive genital and pharyngeal specimens actually contained T. tenax.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2022)
Article
Microbiology
Mohammed Benlaassri, Florine Ecale, Alexandre Crepin, Marie-Helene Rodier, Nicolas Venisse, Estelle Cateau
Summary: In this study, the reciprocal interactions between three parabens and yeasts from the human cutaneous mycobiota were explored in vitro. The results showed that ethylparaben completely inhibited the growth of Cryptococcus uniguttulatus and Rhodotorula mucilaginosa, while methylparaben and propylparaben had no effect on these two fungi. Candida parapsilosis and R. mucilaginosa were found to degrade propylparaben, while C. uniguttulatus did not degrade any paraben.
FEMS MICROBIOLOGY LETTERS
(2023)
Article
Infectious Diseases
Guillaume Hamion, Willy Aucher, Charles Tardif, Julie Miranda, Caroline Rouger, Christine Imbert, Marion Girardot
Summary: Invasive plants produce bioactive metabolites that can efficiently colonize non-native territories. This study found that extracts from certain invasive plants can inhibit the formation of biofilms by Staphylococcus aureus and Candida albicans. Betulinic acid, identified as the most correlated compound, showed promising antibiofilm activity against both strains of bacteria. The combination of chemical and biological data through a bioactivity-based molecular networking approach can help identify potential antibiofilm compounds.
Article
Microbiology
Pierrette Fleurat-Lessard, Estelle Luini, Sylvain La Camera, Florence Thibault, Gabriel Roblin, Jean-Marc Berjeaud
Summary: In esca disease affecting grapevines, the fungi Phaeomoniella chlamydospora and Phaeoacremonium minimum obtain nutrition from xylem sap and enzymatic breakdown residues. The secretion of lignin peroxidase, manganese peroxidase, and laccase by these fungi was quantified in infected woody tissues, and it was found that Phaeoacremonium minimum had higher enzyme detection. The supply of different carbohydrates had differential effects on fungal growth and polypeptide secretion, suggesting a potential influence on the aggressiveness of these pathogens.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sufi Desrini, Julien Ducloux, Guillaume Hamion, Charles Bodet, Jerome Labanowski, Mustofa Mustofa, Titik Nuryastuti, Christine Imbert, Marion Girardot
Summary: The extracts of five invasive plants were investigated for their antifungal and antibiofilm activities against various Candida species. The study found that the ethanol and ethanol-water extracts of Reynoutria japonica leaves and Baccharis halimifolia effectively inhibited the growth of Candida albicans and the formation of its biofilm. The essential oil of B. halimifolia leaves, particularly the compound β-caryophyllene oxide, showed the strongest activity against mature biofilms of C. albicans. This study highlighted the antibiofilm potential of B. halimifolia and its essential oil.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Integrative & Complementary Medicine
Sufi Desrini, Marion Girardot, Christine Imbert, Mustofa Mustofa, Titik Nuryastuti
Summary: This study screened the effects of five invasive plants growing in Indonesia against Candida albicans biofilms, and found that one of the plants had strong antibiofilm activity. The ethyl acetate fraction of this plant showed the most potent antibiofilm activity against 24 h old biofilm of C. albicans.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Article
Parasitology
Nicolas Argy, Celine Nourrisson, Ahmed Aboubacar, Philippe Poirier, Stephane Valot, Adrien Laude, Guillaume Desoubeaux, Christelle Pomares, Marie Machouart, Yohann Le Govic, Frederic Dalle, Francoise Botterel, Nathalie Bourgeois, Estelle Cateau, Marion Leterrier, Patrice Le Pape, Florent Morio, Sandrine Houze
Summary: Commercial multiplex PCR assay panels show high sensitivity and specificity for parasitological diagnosis, serving as a complement to traditional microscopic examination methods. However, the PCR procedure and analytical performance for each specific protist may vary depending on the multiplex PCR assay, which should be considered when implementing a PCR-based diagnostic approach.
Review
Infectious Diseases
Allison M. Hitchcock, Wesley D. Kufel, Keri A. Mastro Dwyer, Eric F. Sidman
Summary: Lenacapavir is a novel HIV-1 treatment option for patients with multidrug-resistant (MDR) HIV-1 infection. It has a favorable pharmacokinetic profile and has shown good tolerability and efficacy in clinical trials.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
Article
Infectious Diseases
Roberta Gagliardini, Alessandro Tavelli, Stefano Rusconi, Sergio Lo Caputo, Vincenzo Spagnuolo, Maria Mercedes Santoro, Andrea Costantini, Alessandra Vergori, Franco Maggiolo, Andrea Giacomelli, Giulia Burastero, Giordano Madeddu, Eugenia Quiros Roldan, Antonella d'Arminio Monforte, Andrea Antinori, Alessandro Cozzi-Lepri
Summary: This study evaluated multiple treatment failures to modern antiretroviral therapy in HIV-infected individuals and found that approximately 4% of them were difficult to treat. The difficult to treat group, compared to the non-difficult to treat group, was characterized by older age, higher prevalence of AIDS, lower CD4+ cell count, and higher risk of treatment failure.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2024)
