Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Elvira Brauner, Youn-Hee Lim, Trine Koch, Cecilie S. Uldbjerg, Laura S. Gregersen, Marc K. Pedersen, Hanne Frederiksen, Jorgen H. Petersen, Brent A. Coull, Anna-Maria Andersson, Martha Hickey, Niels E. Skakkebaek, Russ Hauser, Anders Juul
Summary: Evidence suggests that maternal exposure to environmental endocrine disrupting chemicals (EDCs) is associated with a higher risk of testicular cancer in male offspring, particularly nonseminomas. Further research is needed to explore the complexity of this field and the potential impact of prenatal EDC exposures on testicular cancer risk.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Environmental Sciences
ZhiChao Dang, Maria Arena, Aude Kienzler
Summary: This study summarized and evaluated the effects of TDCs on fish thyroid sensitive endpoints, including thyroid hormones, gene expression, and other aspects. The findings suggest that changes in thyroid sensitive endpoints may be influenced by various factors, such as the balance of different processes and environmental factors.
ENVIRONMENTAL POLLUTION
(2021)
Review
Environmental Sciences
ZhiChao Dang
Summary: Both AMA and LAGDA are used to detect thyroid-mediated modality and adversity based on morphological changes during thyroid hormone-dependent metamorphosis. The EU Guidance recommends their use for investigating the effects of thyroid hormone system disrupting chemicals. However, there is debate over the necessity of using LAGDA as a follow-up to positive AMA results. This study analyzes the similarities, differences, and sensitivity of these two assays in detecting TDCs.
ENVIRONMENTAL POLLUTION
(2022)
Review
Endocrinology & Metabolism
Wiwat Rodprasert, Jorma Toppari, Helena E. Virtanen
Summary: Endocrine disrupting chemicals, particularly antiandrogenic EDCs, may impact male reproductive health, especially when exposed during fetal development at the sensitive 'masculinization programming window'.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Saerom Kim, Hye Sook Min, Won Jin Lee, Seung-Ah Choe
Summary: This study investigated the differences in personal care product (PCP) use and exposure to endocrine disrupting chemicals (EDCs) based on occupation and gender. It found that women used body and makeup products more frequently than men, and had higher urinary levels of EDCs in all occupation groups. However, for men, the differences in urinary concentration of EDCs across occupation groups were not observed. These findings suggest the need for interventions to reduce EDC exposure, particularly for women in clerical, service, and sales occupations.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Immacolata Cristina Nettore, Fabiana Franchini, Giuseppe Palatucci, Paolo Emidio Macchia, Paola Ungaro
Summary: Research has shown a possible association between obesity and endocrine-disrupting chemicals, which can interfere with energy metabolism and adipose tissue structure regulation. Early exposure to these chemicals may induce epigenetic modifications, making individuals susceptible to obesity and other diseases.
Article
Engineering, Environmental
Longyao Xu, Yu Hu, Qingqing Zhu, Chunyang Liao Guibin, Guibin Jiang
Summary: This study investigated the concentrations and exposure risks of five groups of EDCs in urines from general populations in three cities with different economic levels in China. Results showed significant differences in the levels of target compounds among different cities, with exposure correlated with gender, age, body mass index, education level, occupation, and diet.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Endocrinology & Metabolism
Vasantha Padmanabhan, Wenhui Song, Muraly Puttabyatappa
Summary: Exposure to endocrine-disrupting chemicals (EDCs) in the environment can disrupt the maternal-fetal environment and lead to adverse pregnancy outcomes. Research focuses on the effects of EDCs, the role of environmental and lifestyle factors, related mechanisms, and future research directions.
Article
Public, Environmental & Occupational Health
Scott J. Swartz, Libby M. Morimoto, Todd P. Whitehead, Mindy C. DeRouen, Xiaomei Ma, Rong Wang, Joseph L. Wiemels, Katherine A. McGlynn, Robert Gunier, Catherine Metayer
Summary: The incidence of testicular germ cell tumors (TGCT) is increasing in the United States, particularly among Latinos, and prenatal exposure to acephate and malathion was associated with TGCT risk among Latinos while carbaryl was associated with TGCT risk among non-Latinos in California. These findings suggest a potential link between exposure to these pesticides and the rise in TGCT risk among Latinos.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Environmental Sciences
Sherly Antony, Sham Antony, Sharrel Rebello, Sandhra George, Devika T. Biju, R. Reshmy, Aravind Madhavan, Parameswaran Binod, Ashok Pandey, Raveendran Sindhu, Mukesh Kumar Awasthi
Summary: Endocrine Disrupting Chemicals (EDCs) pose a serious threat to the health and future of humans and the ecosystem. This review provides an overview of various EDCs, their toxic effects, and both conventional and modern remediation methods. The use of sustainable approaches like bioremediation has shown positive impacts in controlling EDC pollution.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Viviana Ramirez, Yolanda Galvez-Ontiveros, Pablo Jose Gonzalez-Domenech, Miguel Angel Baca, Lourdes Rodrigo, Ana Rivas
Summary: The study aimed to review limited literature on the effects of postnatal exposure to EDC on child neurodevelopment and behavior. While some research suggests a relationship between postnatal EDC exposure and adverse neurobehavioral outcomes in children, the underlying mechanisms of action remain unclear.
ENVIRONMENTAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Yan Yan, Fengjun Guo, Kexin Liu, Rixin Ding, Yichao Wang
Summary: Endocrine-disrupting chemicals (EDCs) are naturally occurring or artificial substances released into the environment. Humans are exposed to EDCs through ingestion, inhalation, and skin contact, and they are found in everyday household items. EDCs have negative effects on health, including cancer, cardiovascular risk, and reproductive disorders, and the placenta is particularly sensitive to their impact. This review evaluates the effects of various EDCs on placental development and function, identifies knowledge gaps, and guides future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Leonardo Trasande, Robert M. Sargis
Summary: Rapidly advancing evidence indicates that synthetic chemicals in the environment contribute to disease and disability across the lifespan. Endocrine-disrupting chemicals (EDCs) have a substantial impact on chronic diseases in adulthood, especially metabolic, cardiovascular, and reproductive conditions. The mortality and economic costs of exposure to certain phthalates are significant. Low-income and minority populations are disproportionately affected by these exposures. Government action is necessary to limit hazardous exposures and screen new chemicals. Routine healthcare should include guidance to reduce EDC exposures.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Environmental Sciences
Eliska Sychrova, Affiefa Yawer, Petra Laboha, Amrita Basu, Aneta Dydowiczova, Ishita Virmani, Pavel Babica, Iva Sovadinova
Summary: This study developed a 3D scaffold-free spheroid model to assess the hazards of chemicals on male reproductive health. The results showed that testicular toxicity was influenced by both the type of culture and the duration of exposure, with benzo[a]pyrene and triclocarban being the most active compounds.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Article
Ophthalmology
Diana C. Schmidt, Line Kessel, Daniella Bach-Holm, Katharina M. Main, Dorte A. Larsen, Regitze Bangsgaard
Summary: This study aimed to investigate the prevalence and risk factors of hypothalamus-pituitary-adrenal axis suppression in infants receiving glucocorticoid eye drops. The results showed that high daily glucocorticoid doses per weight were associated with HPA axis suppression in infants. Monitoring is necessary for infants receiving glucocorticoids after ocular surgery.
ACTA OPHTHALMOLOGICA
(2023)
Article
Environmental Sciences
Marie Tysman, Jorma Toppari, Katharina M. Main, Annika Adamsson, Christine Wohlfahrt-Veje, Jean-Philippe Antignac, Bruno Le Bizec, Eliisa Loyttyniemi, Niels E. Skakkebaek, Helena E. Virtanen
Summary: Hypospadias is a congenital malformation of the penile urethra, and the etiology is mostly unknown. This study investigated the association between hypospadias and exposure to persistent organic pollutants (POPs) through breast milk. The study included Danish and Finnish mother-son pairs, and breast milk samples were analyzed for various classes of POPs. The results did not show any significant associations between POP concentrations and hypospadias in either country. This study provides information on quantitative exposures but does not support a direct link between hypospadias and POP exposure.
Article
Clinical Neurology
Line Pickering, Katharina M. M. Main, Ulla Feldt-Rasmussen, Astrid Sehested, Rene Mathiasen, Marianne Klose, Rikke Ibsen, Jakob Kjellberg, Poul Jennum
Summary: This nationwide prospective cohort study in Denmark aimed to evaluate survival distributions, long-term socioeconomic consequences, and health care costs in patients with childhood and adolescent onset of brain tumours. The study found that the probability of mortality was highest during the first year after tumour diagnosis. In young adulthood, the patients had negative long-term socioeconomic consequences, such as lower educational levels, employment rates, and higher health care costs.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Environmental Sciences
Louise Scheutz Henriksen, Hanne Frederiksen, Niels Jorgensen, Anders Juul, Niels E. Skakkebaek, Jorma Toppari, Jorgen Holm Petersen, Katharina M. Main
Summary: This study aimed to explore if there is an association between fetal phthalate exposure and markers of testicular function in young adult men. The results showed that higher maternal phthalate exposure was associated with higher luteinizing hormone (LH) but unchanged testosterone in adult sons. Additionally, higher maternal exposure was associated with lower total and free testosterone/LH ratios in adult sons.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Endocrinology & Metabolism
Marie Lindhardt Ljubicic, Trine Holm Johannsen, Margit Bistrup Fischer, Emmie N. Upners, Alexander S. Busch, Katharina M. Main, Anna-Maria Andersson, Casper P. Hagen, Anders Juul
Summary: The ratio between luteinizing hormone (LH) and follicle-stimulating hormone (FSH) has been found to be a reliable marker for sex determination in healthy infants. However, its role in patients with differences of sex development (DSD) remains unclear. This retrospective study aimed to describe LH/FSH in infants with DSD and found that the ratio sometimes corresponds to the assigned sex, but not in all cases.
ENDOCRINE CONNECTIONS
(2023)
Article
Anesthesiology
Gitte K. Vesterlund, Hans-Christian Thorsen-Meyer, Morten H. Moller, Soren Brunak, Thomas Strom, Anders Perner, Benjamin S. Kaas-Hansen
Summary: This study aimed to describe abnormal serum levels of magnesium, phosphate, and zinc in Danish ICU patients and assess their associations with outcomes. The results showed that most ICU patients had low serum levels of magnesium, phosphate, or zinc, and some received supplementation. However, the associations between serum levels and clinical outcomes were inconclusive due to insufficient data.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Louise Laub Asserhoj, Ikram Mizrak, Gerda Ferja Heldarskard, Tine Dalsgaard Clausen, Eva R. Hoffmann, Gorm Greisen, Katharina M. Main, Per Lav Madsen, Rikke Beck Jensen, Anja Pinborg
Summary: The study found that BMI in childhood does not differ between children conceived after frozen embryo transfer (FET), fresh embryo transfer (fresh-ET), or natural conception (NC). Previous studies have shown that high childhood BMI is strongly associated with obesity, cardiometabolic disease, and mortality in adulthood. Children conceived after FET have a higher risk of being born large for gestational age (LGA), which is associated with an increased risk of childhood obesity. The study suggests that ART-induced epigenetic variations may influence fetal size at birth as well as BMI and health later in life.
HUMAN REPRODUCTION
(2023)
Article
Endocrinology & Metabolism
Jakob Albrethsen, Peter Busch Ostergren, Pernille Badsberg Norup, Jens Sonksen, Mikkel Fode, Caroline Kistorp, Nikolai B. Nordsborg, Sara Amalie Solheim, Jakob Morkeberg, Katharina M. Main, Anders Juul
Summary: This study aimed to investigate the changes in serum insulin-like factor 3 (INSL3) concentration during hypothalamus-pituitary-testicular suppression. The results showed that INSL3 levels decreased during experimental testicular suppression and returned to baseline levels after release of suppression. Similarly, INSL3, testosterone, and LH concentrations decreased during therapeutic hormonal hypothalamus-pituitary-testicular suppression in transgender girls and patients with prostate cancer. Therefore, INSL3 can serve as a sensitive marker of testicular suppression and complement testosterone measurement in male reproductive disorders.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hans Valdemar Lopez Krabbe, Jorgen Holm Petersen, Louise Laub Asserhoj, Trine Holm Johannsen, Peter Christiansen, Rikke Beck Jensen, Line Hartvig Cleemann, Casper P. Hagen, Laerke Priskorn, Niels Jorgensen, Katharina M. Main, Anders Juul, Lise Aksglaede
Summary: Adult patients with Klinefelter syndrome (KS) exhibit variable phenotypes and a high risk of metabolic disorders. Most adults require testosterone replacement therapy (TRT), but its use during puberty is debated. This study found that patients with KS have unfavorable body composition and impaired bone mineral status already during childhood and adolescence. Further research is needed to evaluate the effects of TRT during puberty on these parameters.
ENDOCRINE CONNECTIONS
(2023)
Article
Environmental Sciences
Nina Vogel, Rosa Lange, Phillipp Schmidt, Laura Rodriguez Martin, Sylvie Remy., Andrea Springer, Vladimira Puklova, Milena Cerna, Peter Rudnai, Szilvia Kozepesy, Beata Janasik, Danuta Ligocka, Lucia Fabelova, Branislav Kolena, Ida Petrovicova, Michal Jajcaj, Milada Estokova, Marta Esteban-Lopez, Argelia Castano, Janja Snoj Tratnik, Anja Stajnko, Lisbeth E. Knudsen, Jorma Toppari, Katharina M. Main, Anders Juul, Anna-Maria Andersson, Niels Jorgensen, Hanne Frederiksen, Cathrine Thomsen, Amrit Kaur Sakhi, Agneta Akesson, Christina Hartmann, Marie Christine Dewolf, Gudrun Koppen, Pierre Biot, Elly Den Hond, Stefan Voorspoels, Liese Gilles, Eva Govarts, Aline Murawski, Antje Gerofke, Till Weber, Maria Ruether, Arno C. Gutleb, Cedric Guignard, Tamar Berman, Holger M. Koch, Marike Kolossa-Gehring
Summary: Phthalates are widely used as plasticizers and can have negative impacts on reproductive functions. However, existing human biomonitoring studies on internal exposure to phthalates in Europe differ in many aspects, making comparability challenging. The HBM4EU initiative gathered data from 29 studies across Europe to describe the general population's exposure to phthalates from 2005 to 2019. This study is an important step towards making internal exposures to phthalates comparable across countries and provides suggestions for improved harmonization in future studies.
Article
Chemistry, Medicinal
Vanille Lejal, Natacha Cerisier, David Rouquie, Olivier Taboureau
Summary: Drug-induced liver injury (DILI) is a significant problem in drug development, and predicting DILI compounds is a challenge. This study explores the cell morphological perturbations induced by DILI compounds and identifies gene expression signatures associated with DILI. Machine learning models utilizing cell morphological signatures show promising performance in predicting DILI risk. Overall, this study demonstrates the utility of combining high-content screening/imaging with transcriptomics data for comprehensive toxicity assessment in drug discovery.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Article
Environmental Sciences
Katherine Svensson, Chris Gennings, Christian Lindh, Hannu Kiviranta, Panu Rantakokko, Sverre Wikstrom, Carl-Gustaf Bornehag
Summary: This study found an association between prenatal exposure to a mixture of EDCs and lower BMI and overweight in girls, with non-significant associations among boys. Chemicals of concern for girls included phthalates, non-phthalate plasticizers, bisphenols, PAHs, and PFAS.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Clinical Neurology
Siri A. Vulpius, Sebastian Werge, Isabella Friis Jorgensen, Troels Siggaard, Jorge Hernansanz Biel, Gitte M. Knudsen, Soren Brunak, Lars H. Pinborg
Summary: This study demonstrates that text mining of clinical notes can improve the accuracy of epilepsy diagnosis and classification of different epilepsy types for patients. It suggests that combining population-based health registries with electronic health records can be crucial for future precision medicine development for epilepsy patients.
Article
Endocrinology & Metabolism
Amanda Cleemann Wang, Casper P. Hagen, Trine Holm Johannsen, Andre Greger Madsen, Line Hartvig Cleemann, Peter Christiansen, Katharina M. Main, Anders Juul, Rikke Beck Jensen
Summary: Differentiation between girls with ICPP and PT can be supported by individual clinical and biochemical parameters. However, dimension reduction of clinical and hormonal profiles by PCA improved the diagnostic value, which in the future may support the diagnostic process as a supplement to the GnRH test in evaluation of pubertal disorders.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Casper P. P. Hagen, Margit Bistrup Fischer, Gylli Mola, Theis Bech Mikkelsen, Line Hartvig Cleemann, Claus Hojbjerg Gravholt, Mette H. H. Viuff, Anders Juul, Anette Tonnes Pedersen, Katharina Maria Main
Summary: Turner syndrome (TS) is a chromosomal disorder characterized by the absence of the second X chromosome, affecting about 1 in 2500 female births. TS is associated with primary ovarian insufficiency (POI), with only a small percentage of women achieving pregnancy without egg donation. This review evaluates the clinical use of ovarian function markers in TS patients and reports on the transition from pediatric to gynecological and adult endocrinological care in a Danish center.
FRONTIERS IN ENDOCRINOLOGY
(2023)