Article
Biochemistry & Molecular Biology
Datu Agasi Mohd Kamal, Siti Fatimah Ibrahim, Azizah Ugusman, Mohd Helmy Mokhtar
Summary: This study found aberrant expression of sex steroid receptors in polycystic ovary syndrome and demonstrated that Kelulut honey treatment can normalize the expression of these receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Margherita Corti, Stefano Lorenzetti, Alessandro Ubaldi, Romano Zilli, Daniele Marcoccia
Summary: The role of endocrine disruptors in the human prostate gland is overlooked, but they can influence the homeostasis and diseases of the prostate, including prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Demitria M. Vasilatis, Christopher A. Lucchesi, Paramita M. Ghosh
Summary: Dogs naturally develop prostate cancer similar to aggressive forms found in humans. Prostate cancer samples in dogs often lack androgen receptor (AR), which can enhance our understanding of AR-indifferent prostate cancer in humans. This review highlights the molecular similarities between dog and human prostate cancer variants, suggesting the potential use of dogs as pre-clinical animal models for developing new therapies and diagnostics that can benefit both species.
Article
Oncology
Anthony D. Elias, Nicole S. Spoelstra, Alyse W. Staley, Sharon Sams, Lyndsey S. Crump, Gregory A. Vidal, Virginia F. Borges, Peter Kabos, Jennifer R. Diamond, Elena Shagisultanova, Anosheh Afghahi, Jose Mayordomo, Tessa McSpadden, Gloria Crawford, Angelo D'Alessandro, Kathryn L. Zolman, Adrie van Bokhoven, Yonghua Zhuang, Rosa I. Gallagher, Julia D. Wulfkuhle, Emanuel F. Petricoin III, Dexiang Gao, Jennifer K. Richer
Summary: This clinical trial examined the combination of fulvestrant and enzalutamide for women with metastatic ER+/HER2- breast cancer. The results showed that the combination therapy had manageable side effects and a clinical benefit rate of 25% in heavily pretreated patients.
Editorial Material
Cell Biology
Li Xin
Summary: EZH2 has been shown to promote the development of castration-resistant prostate cancer (CRPC) by interacting with the androgen receptor (AR) to reprogram its transcriptional activity, facilitating the transition of CRPC into a lineage infidelity state.
NATURE CELL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Amani A. Mahbub, Akhmed Aslam, Mohamed E. Elzubier, Mohamed El-Boshy, Abdelghany H. Abdelghany, Jawwad Ahmad, Shakir Idris, Riyad Almaimani, Aiman Alsaegh, Mahmoud Zaki El-Readi, Mohammed A. Baghdadi, Bassem Refaat
Summary: The study found that the individual use of E2 and P4 can inhibit the development of colorectal cancer, showing good anti-tumor effects in male mice and cell experiments. The combination of the two shows a stronger anti-cancer effect.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Haozhe Zhang, Yi Zhou, Zengzhen Xing, Rajiv Kumar Sah, Junqi Hu, Hailiang Hu
Summary: This review discusses the close relationship between the evolution of prostate cancer and androgen levels and the status of the androgen receptor. It also explores how alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tae Jin Kim, Young Hwa Lee, Kyo Chul Koo
Summary: The androgen receptor (AR) plays a crucial role in the development and progression of prostate cancer (PCa), and treatment for hormone-sensitive prostate cancer (HSPC) relies heavily on androgen deprivation therapy (ADT). Despite most patients progressing to castration-resistant prostate cancer (CRPC), studies suggest that manipulating alternative molecular pathways can help improve current treatments and develop novel therapies for CRPC management.
Article
Oncology
Xiaolei Shi, Abderrahman Day, Hannah E. Bergom, Sydney Tape, Sylvan C. Baca, Zoi E. Sychev, Gabrianne Larson, Asha Bozicevich, Justin M. Drake, Nicholas Zorko, Jinhua Wang, Charles J. Ryan, Emmanuel S. Antonarakis, Justin Hwang
Summary: The study identifies B7-H3 as an immune checkpoint overexpressed in prostate cancer, particularly in metastatic castration-resistant prostate cancer (mCRPC). Enzalutamide-resistant mCRPC cells show increased expression of B7-H3, and it is associated with resistance signaling pathways. The gene network of B7-H3 is strongly correlated with androgen receptor (AR) and its co-factors, suggesting potential therapeutic targets for mCRPC.
NPJ PRECISION ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yuliang Wang, Weijie Gao, Youjia Li, Sin Ting Chow, Wenjuan Xie, Xingxing Zhang, Jianfu Zhou, Franky Leung Chan
Summary: Prostate cancer relies on the androgen receptor-mediated signaling for growth, making hormone or androgen-deprivation therapy a key treatment option. Despite its effectiveness in locally advanced or metastatic cases, most patients will develop resistance, leading to castration-resistant disease or even a more aggressive androgen-independent subtype. These newly identified orphan nuclear receptors (ONRs) have shown potential as biomarkers and therapeutic targets in advanced prostate cancer.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Review
Developmental Biology
Andrew Pletcher, Maho Shibata
Summary: This article discusses the research progress in prostate organogenesis, focusing on the new findings related to androgen regulation, epithelial cell origins, and cellular heterogeneity.
Article
Urology & Nephrology
Yiming Gong, Liancheng Fan, Xiaochen Fei, Yinjie Zhu, Xinxing Du, Yuman He, Jiahua Pan, Baijun Dong, Wei Xue
Summary: The study explored the genomic features of prostate cancer metastases in different sites, revealing distinct genetic profiles and alterations, including low AR alterations in pulmonary metastasis and high DNA damage response pathway deficiencies in hepatic metastasis. PTEN alterations were found to be more prevalent in viscerally metastatic prostate cancer. These findings suggest potential therapeutic targets in visceral metastatic prostate cancer.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, Research & Experimental
Sue Jin Moon, Byong Chang Jeong, Hwa Jin Kim, Joung Eun Lim, Hye-Jeong Kim, Ghee Young Kwon, Joshua A. Jackman, Jeong Hoon Kim
Summary: The study identified BCT as a potent inhibitor targeting both AR-FL and AR-V7 activities in CRPC, effectively suppressing tumor growth and metastasis. Mechanistically, BCT disrupts the interaction of HSP90 with AR-FL/AR-V7, leading to their degradation and showing promising therapeutic potential against CRPC.
Article
Oncology
Zemin Hou, Shengsong Huang, Zhenfei Li
Summary: Androgens are crucial in the development of prostate cancer, and targeting steroidogenesis and the androgen receptor has been effective in delaying disease progression. New generation androgen receptor pathway inhibitors like abiraterone and enzalutamide continue to emphasize the role of the androgen-AR axis, even in cases of resistance. The importance of this axis in managing the disease after resistance to current treatments, particularly in neuroendocrine prostate cancer, remains uncertain.
Article
Oncology
Emanuele Perrone, Riccardo Tudisco, Pia Clara Pafundi, Davide Guido, Alessandra Ciucci, Enrica Martinelli, Gian Franco Zannoni, Alessia Piermattei, Saveria Spadola, Giulia Ferrante, Claudia Marchetti, Giovanni Scambia, Anna Fagotti, Daniela Gallo
Summary: This study explored the relationship between hormone receptor status and BRCA1/2 mutation in high-grade serous ovarian carcinoma (HGSOC) patients. The results showed interesting differences in receptor expression patterns and their association with outcomes between BRCA-mutated and BRCA wild-type women. The findings suggest a potential role of estrogen-mediated pathways in BRCA1/2-associated HGSOC tumorigenesis, revealing a possible therapeutic potential for targeting this interaction.
Article
Clinical Neurology
Melanie S. Askari, Laura Helena Andrade, Alexandre Chiavegatto Filho, Camila Magalhaes Silveira, Erica Siu, Yuan-Pang Wang, Maria Carmen Viana, Silvia S. Martins
JOURNAL OF AFFECTIVE DISORDERS
(2017)
Article
Endocrinology & Metabolism
Raquel S. Campello, Luciana A. Fatima, Joao Nilton Barreto-Andrade, Thais F. Lucas, Rosana C. Mori, Catarina S. Porto, Ubiratan F. Machado
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Rafael de Souza Silva, Ana Paola G. Lombardi, Deborah Simao de Souza, Carolina M. Vicente, Catarina S. Porto
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2018)
Article
Cell Biology
Deborah S. Souza, Ana Paola G. Lombardi, Carolina M. Vicente, Thais Fabiana G. Lucas, Adolfo G. Erustes, Gustavo J. S. Pereira, Catarina S. Porto
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Article
Medicine, General & Internal
Carolina Hanna Chaim, Erica Rosanna Siu, Carlos Felipe Cavalcanti Carvalho, Fernanda Piotto Frallonardo, Flavia Ismael, Arthur Guerra de Andrade, Antonio Ventriglio, Julio Torales, Dinesh Bhugra, Joao Mauricio Castaldelli-Maia
SAO PAULO MEDICAL JOURNAL
(2019)
Article
Endocrinology & Metabolism
Ana Paola G. Lombardi, Carolina M. Vicente, Catarina S. Porto
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Ana Paola G. Lombardi, Renan P. Cavalheiro, Catarina S. Porto, Carolina M. Vicente
Summary: This study demonstrates that ER activates rapid response molecules such as SRC and PI3K/AKT to enhance the tumorigenic potential of prostate cancer cells, increasing cell proliferation, migration, invasion, and tumor formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Carolina Hanna Chaim, Geilson Lima Santana, Paula de Vries Albertin, Camila Magalhaes Silveira, Erica Rosanna Siu, Maria Carmen Viana, Wang Yuan Pang, Laura Helena Andrade
Summary: The study found high comorbidity between alcohol use disorders and personality disorders, particularly with Cluster B personality disorders. Cluster B personality disorders showed significant associations with alcohol consumption and disorders, especially more severe cases.
Article
Cell Biology
Carla Macheroni, Thais Fabiana Gameiro Lucas, Deborah Simao Souza, Carolina Meloni Vicente, Gustavo Jose da Silva Pereira, Itabajara da Silva Vaz Junior, Maria Aparecida Juliano, Catarina Segreti Porto
Summary: This study investigated the expression of estrogen receptors in human testicular embryonal carcinoma NT2/D1 cells and their effects on cell proliferation. The results showed that estrogen receptors were mainly located in the nuclei, while a splice variant was found in the perinuclear region and cytoplasm. Activation of estrogen receptors increased the expression of cell cycle proteins and promoted cell proliferation. Additionally, estrogen induced an increase in cell number and viability, and this effect was blocked by estrogen receptor antagonists.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Neurosciences
Angelica Jardim Costa, Rafaela Brito Oliveira, Patricia Wachilewski, Michelle Sayuri Nishino, Taysa Bervian Bassani, Roberta Sessa Stilhano, Janete Maria Cerutti, Bruno Nozima, Catarina Segreti Porto, Gustavo Jose da Silva Pereira, Ana Lopez Ramirez, Soraya Soubhi Smaili, Rodrigo Portes Ureshino
Summary: Alzheimer's disease (AD) is a neurodegenerative disease associated with aging, which is more common in women than men. Hormone replacement therapy, particularly estrogen, has been shown to reduce memory loss in menopausal women by inducing autophagy to remove protein aggregates. This study found that 17β-estradiol induces autophagy by activating AMPK, independent of mTOR signals. Furthermore, it was discovered that 17β-estradiol increases LC3-II levels and clears tau protein through autophagy.
Article
Biochemistry & Molecular Biology
N. O. Maruyama, H. F. Estrela, E. B. Oliveira Sales, T. F. Lucas, C. S. Porto, C. T. Bergamaschi, R. R. Campos
Summary: In this study, the effects of 17β-estradiol on sympathetic vasomotor activity and blood pressure in a hypertensive rat model were investigated. The expression of estrogen receptors in the rostral ventrolateral medulla (RVLM) was also studied. The results showed that microinjection of 17β-estradiol into the RVLM led to a greater reduction in mean arterial pressure and renal sympathetic nerve activity in control rats compared to hypertensive rats. The expression levels of estrogen receptors GPER and ERα were significantly higher in the RVLM of hypertensive rats. Chronic treatment with losartan reduced the expression levels of estrogen receptors in hypertensive rats.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Deborah Simao Souza, Carla Macheroni, Gustavo Jose Silva Pereira, Carolina Meloni Vicente, Catarina Segreti Porto
Summary: Prostate cancer is the most common cancer among men worldwide, and hormone-related factors, such as androgens, estrogens, and their receptors, play a crucial role in its development and progression. Galectin-3, a family of proteins, is involved in various stages of tumor development and progression, but its expression regulation is still poorly understood. This review focuses on the interplay between Galectin-3 and estrogen receptor signaling pathways in prostate cancer cells and proposes a molecular mechanism involving ER, Galectin-3, and beta-catenin in the modulation of nuclear transcriptional events. Further understanding of the role of Galectin-3 and ER in prostate cancer could lead to the discovery of new drug targets to treat castration-resistant prostate cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Carla Macheroni, Thais Fabiana Gameiro Lucas, Catarina Segreti Porto
Article
Substance Abuse
Daniela Cristina Belchior Mota, Camila Magalhaes Silveira, Erica Siu, Henrique Pinto Gomide, Laura Helena Andrade Guerra, Telmo Mota Ronzani, Brian Rush
JOURNAL OF STUDIES ON ALCOHOL AND DRUGS
(2019)
Review
Cell Biology
Guilherme O. Barbosa, Nilva K. Cervigne, Hernandes F. Carvalho, Taize M. Augusto
CELL BIOLOGY INTERNATIONAL
(2017)