Article
Endocrinology & Metabolism
Mathis Grossmann, Channa N. Jayasena, Bradley D. Anawalt
Summary: Although testosterone replacement therapy is commonly used for men with classical hypogonadism, its role in age-related decline of testosterone remains unclear due to limited evidence from long-term clinical trials. However, men aged 50 years and above with comorbidities and higher body mass index often exhibit symptoms of androgen deficiency and low testosterone levels. Clinicians face a challenging dilemma in initiating testosterone therapy and must carefully assess the benefits and risks based on limited clinical trial data. In this article, a practical approach to the assessment and management of such men is presented using a case scenario.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Urology & Nephrology
Kajal Khodamoradi, Alexandra Dullea, Katherine Campbell, Christian Ramsoomair, Roei Golan, Ranjith Ramasamy
Summary: This study aimed to measure androgen receptor (AR) signaling levels in corpus cavernosal tissue of males with different serum testosterone (T) levels. The results showed no significant difference in VEGF expression above a serum T level of 200 ng/dl. Therefore, there may be a saturation level of approximately 200 ng/dl that fully saturates tissue androgen receptors and results in optimal male function.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Endocrinology & Metabolism
Maria Santa Rocca, Giovanni Minervini, Cinzia Vinanzi, Alberto Bottacin, Federica Lia, Carlo Foresta, Maria Pennuto, Alberto Ferlin
Summary: This study evaluated the frequency and type of androgen receptor (AR) gene variants in a large cohort of infertile males. The study found that patients with AR gene variants had lower sperm count, higher testosterone concentration, and higher androgen sensitivity index compared to patients without variants. Two novel potentially pathogenic AR variants were identified. Based on these findings, AR sequencing is suggested as a routine genetic test in cases of idiopathic oligozoospermia with high testosterone levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Andrology
Robert Bozick
Summary: This study examines the relationship between men's testosterone levels and their sexual behaviors, finding that this relationship is contingent upon age, with positive correlation among younger men and negative correlation among older men.
Article
Endocrinology & Metabolism
Jean-Marc Kaufman
Summary: The diagnosis of hypogonadism in ageing men requires attention to symptom specificity and measurement of serum testosterone levels. The diagnostic approach to late onset hypogonadism is similar to other forms of hypogonadism, but with a focus on avoiding overdiagnosis.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Andrology
Alexander W. Pastuszak, Marc Gittelman, James P. Tursi, Jonathan S. Jaffe, David Schofield, Martin M. Miner
Summary: Endogenous diurnal testosterone variation decreases naturally with age. Men with testosterone deficiency lack diurnal testosterone variation and exhibit a flatter testosterone profile compared to men with normal testosterone levels. Some testosterone replacement options provide intraday testosterone level variations similar to normal circadian secretion, while others provide a flatter exposure profile reflective of depot release, and some exceed the frequency and physiological range of natural diurnal testosterone variation.
Review
Urology & Nephrology
Eduardo P. Miranda, Elizabeth Schofield, Kazuhito Matsushita, Darren J. Katz, Christian J. Nelson, Nicole Benfante, John P. Mulhall
Summary: This study aimed to investigate the impact of testosterone therapy on luteinizing hormone (LH) levels and analyze predictors of LH suppression. The study found that while 73% of patients had at least one LH level below 1 IU/ml during treatment, only 22% of patients maintained LH suppression throughout the treatment. Intramuscular route, baseline LH level, and estradiol were significant predictors of LH suppression.
JOURNAL OF SEXUAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Nandini Shankara-Narayana, Lance Brooker, Catrin Goebel, Naomi Speers, David J. Handelsman
Summary: The drug history of androgen abuse in a high-risk population can be objectively validated using urine mass spectrometry tests, and serum luteinizing hormone (LH) has high discriminatory power in distinguishing between current and noncurrent androgen use.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Urology & Nephrology
Jeremy M. Auerbach, Odinachi Moghalu, Rupam Das, Joshua Horns, Alexander Campbell, James Hotaling, Alexander W. Pastuszak
Summary: This study investigated the current diagnosis and treatment trends of hypogonadism in adult men in the United States using a commercial insurance database. Results revealed higher incidence rates among men aged 35-44 and those living in the Southern United States, with an increasing prevalence of HG and decreasing treatment rates. Further research is needed to understand the factors driving the observed decline in healthcare utilization among men with hypogonadism.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2022)
Article
Geriatrics & Gerontology
Seema D. Sharma, Michael J. Cook, Leen Antonio, Evelien Gielen, Gyorgy Bartfai, Felipe F. Casanueva, Ilpo T. Huhtaniemi, Mario Maggi, Margus Punab, Giulia Rastrelli, Jolanta Slowikowska-Hilczer, Jos Tournoy, Dirk Vanderschueren, Frederick C. Wu, Terence W. O'Neill
Summary: There is an association between sleep quality and duration with frailty, and testosterone levels do not influence this association.
Article
Multidisciplinary Sciences
Anna Ksiazek, Marek Medras, Aleksandra Zagrodna, Malgorzata Slowinska-Lisowska, Felicja Lwow
Summary: This study did not find a significant relationship between deficient and insufficient levels of vitamin D and androgen levels in young, healthy men.
SCIENTIFIC REPORTS
(2021)
Review
Urology & Nephrology
Jose M. Flores, Helen L. Bernie, Eduardo Miranda, Bruno Nascimento, Elizabeth Schofield, Nicole Benfante, Sigrid Carlsson, John P. Mulhall
Summary: This study evaluates the relationship between testosterone (T) and prostate-specific antigen (PSA) in patients with prostate cancer (PC). The results suggest a significant association between low T levels and PSA levels below 4 ng/mL and 2 ng/mL, indicating the importance of measuring T levels in the diagnosis and treatment of PC.
JOURNAL OF SEXUAL MEDICINE
(2022)
Article
Oncology
Jane C. Figueiredo, Gillian Gresham, Elizabeth L. Barry, Leila A. Mott, Michael N. Passarelli, Patrick T. Bradshaw, Carlton W. Anderson, John A. Baron
Summary: This study investigated the relationship between sex hormone levels and risk of colorectal precursors in 925 men. The findings fill the gap in the research on sex hormones in men.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Endocrinology & Metabolism
David J. Handelsman, Mathis Grossmann, Bu B. Yeap, Bronwyn G. A. Stuckey, Nandini Shankara-Narayana, Ann J. Conway, Warrick J. Inder, Robert Mclachlan, Carolyn Allan, Alicia J. Jenkins, David Jesudason, Karen Bracken, Gary A. Wittert
Summary: The T4DM study shows that testosterone treatment for men with impaired glucose tolerance or newly diagnosed diabetes reduces the risk of diabetes and improves sleep apnea diagnosis during the study period, but these effects disappear after the study. There is also evidence of androgen dependence in some men receiving prolonged injectable testosterone treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Maria Gabriela Figueiredo, Thiago Gagliano-Juca, Shehzad Basaria
Summary: This article reviews the pharmacokinetics and safety of subcutaneous testosterone therapy and provides guidance for clinicians on counseling and managing patients who choose this route. Limited evidence suggests that subcutaneous administration results in comparable pharmacokinetics and testosterone levels as intramuscular injection. The subcutaneous route is easier for self-administration and has the potential to improve patient adherence.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
