Article
Biochemistry & Molecular Biology
Lijuan Ma, Jing Li, Yuan Yuan, Wenwen Chen, Jun Zhao
Summary: The MTHFR 677TT variant, gender, folate, and Vit B12 were identified as risk factors for the occurrence of H-type hypertension. Folate level decreased with the C to T substitution of the MTFHR C677T gene, while Vit B12 level was not associated with the gene. These factors should be considered in the prevention and treatment of hypertension.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Xue Wu, Kai Liu, Xinke Zhao, Xiaowei Zhang, Huan Guo, Hugang Jiang, Juan Chang, Xinfang Lv, Xiang Gao, Xiaodong Zhi, Chunzhen Ren, Qilin Chen, Yufang Liang, Yingdong Li
Summary: This study evaluated the relationship between polymorphisms in the MTHFR gene and CHD in the Gansu region of China. The findings suggest that the TT genotype of the MTHFR C677T locus is closely associated with an increased risk of CHD.
DNA AND CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Malgorzata Wrzosek, Klaudia Slusarczyk
Summary: This study examined the influence of the MTHFR C677T variant on BMI and its role as a risk factor for obesity. The results showed that the MTHFR 677TT genotype is not directly related to a higher BMI in Polish adults but has a detrimental effect on folate concentrations in individuals with high BMI values.
Article
Medicine, General & Internal
Qi Zhang, Jinran Lin, Zhenghua Zhang, Ling Han, Qiong Huang, Jie Zhu, Bing Wang, Xu Fang, Zhizhong Zheng, Nikhil Yawalkar, Jun Liang, Kexiang Yan
Summary: This study investigated the effect of MTHFR gene polymorphism and folic acid supplementation on serum homocysteine levels in psoriatic patients. The results showed that individuals with the TT genotype of MTHFR rs1801133 had higher serum homocysteine levels and better treatment response. Sex and genotype were significantly associated with serum homocysteine levels. Folic acid supplementation only decreased homocysteine levels in male patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Si-ying Li, He-shou Lei, Xiao-yun Wu, Kai Li, Zhi-min Liu, Jian-hui Lu, Xiao-yun Chen
Summary: This study explored the relationship between cognitive impairment after general anesthesia and rs55763075 polymorphisms. Patients with AA genotype showed lower MMSE scores, decreased MTHFR mRNA expression, and reduced MTHFR protein expression compared to patients with GG/GA genotypes. The study also demonstrated that the minor allele (A) of rs55763075 polymorphisms affected the binding of miR-34b to MTHFR mRNA, leading to decreased folic acid levels in AA-genotyped patients.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Lei Chen, Chunhua Wu, Zhaoying Dong, Shanshan Cao, Ning Ren, Xiaoyan Yan
Summary: This study investigated the association of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms with small vessel disease (SVD) risk. The findings revealed that SVD patients had elevated plasma total homocysteine (tHcy) levels and decreased folate levels. Significant differences were observed in the rs1801133 (C677T) gene polymorphism, with higher tHcy levels in individuals carrying the TT allele. The rs1801131 (A1298C) polymorphism was not associated with tHcy levels or SVD risk. Therefore, elevated plasma tHcy levels are closely associated with the development of SVD, while MTHFR gene polymorphisms are not a risk factor for SVD.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Dengyu Ji, Chenghua Luo, Jing Liu, Yan Cao, Jiangxu Wu, Wenjing Yan, Ke Xue, Jiayin Chai, Xinyu Zhu, Ye Wu, Huirong Liu, Wen Wang
Summary: The study identified that hydrogen sulfide (H2S) could enhance the bioactivity of MTHFR through S-sulfhydration, offering a potential therapeutic strategy for hyperhomocysteinemia (HHcy).
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Nutrition & Dietetics
Yanfei Zhang, Chenhong Gu, Ying Lei, Jingwen Wang, Leiqin Sun, Junwei Fan, Yanlin Wang, Xiaoqing Zhang
Summary: This study aimed to explore the effects of one-carbon metabolic (OCM) indicators on pregnancy-induced hypertension (PIH) and preeclampsia (PE) in pregnant women who were supplemented with folate and vitamin B12. The results showed that high homocysteine, high folate status, and high BMI were independent risk factors for PIH in pregnant women with MTHFR CC genotype. Additionally, low folate levels were identified as an independent risk factor for the progression from PIH to PE.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Justyna Piechocka, Monika Wyszczelska-Rokiel, Rafal Glowacki
Summary: This report presents a method for simultaneous determination of plasma HPPTCA and total low molecular-weight thiols content. The assay is based on HPLC-UV, involving disulfides reduction, derivatization, and sample deproteinization. The HPLC-UV assay provides a complementary tool for routine clinical analysis and facilitates further studies on the role of aminothiols and HPPTCA in living systems.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Shona M. Richardson, Piera M. Marchetti, Michael A. Herrera, Dominic J. Campopiano
Summary: A unique di-domain biocatalyst (PtTamH) has been discovered, which can convert fatty acids to amines and has potential applications. Moreover, the structural organization of PtTamH has been revealed.
Article
Chemistry, Physical
Natalia N. Kuranova, Daria Petrova, Maksim N. Zavalishin, Aleksei N. Kiselev, George A. Gamov
Summary: Hydrazones and Schiff bases are potent metal chelators with various biological activities. This paper collects protonation constant data of these compounds and proposes a chemometric model to describe the protolytic equilibria constants.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Nutrition & Dietetics
Rima Obeid, Ines Warnke, Anja Wittke, Igor Bendik, Barbara Troesch, Rotraut Schoop, Christina Hecht, Johann Demmelmair, Berthold Koletzko
Summary: This study investigated the association between infant's MTHFR C677T genotype, the dietary folate source, and concentrations of folate markers in the blood. The results showed that the use of infant formula with 5-MTHF increased the concentrations of RBC folate and plasma pABG in infants. Over time, the plasma concentrations of 5-MTHF and pABG also significantly increased in breastfed infants. However, carriers of the TT genotype still had lower pABG concentrations compared to carriers of the CC genotype, and it is unclear whether these differences have any clinical relevance.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Masaki Nakano, Yukio Nakamura, Tomohiko Urano, Akiko Miyazaki, Takako Suzuki, Kazuki Watanabe, Jun Takahashi, Masataka Shiraki
Summary: The study found a significant association between circulating homocysteine and MTHFR C677T variant with the prevalence and progression of spinal OA. These factors could serve as potential interventional targets for preventing and improving clinical outcomes of OA.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Nutrition & Dietetics
Long Zhou, Hui Huang, Xiaoxiao Wen, Yu Chen, Jie Liao, Fuli Chen, Liancheng Zhao, Mingjiang Liu, Jianhong Tao, Gang Li
Summary: This study found that elevated levels of red blood cell folate are associated with an increased risk of cardiovascular mortality among hypertensive patients with elevated homocysteine, while serum folate has no such effects.
FRONTIERS IN NUTRITION
(2022)
Article
Dermatology
Maria Celia B. Hughes, Annika Antonsson, Astrid J. Rodriguez-Acevedo, Upekha E. Liyanage, Adele C. Green, Jolieke C. van der Pols
Summary: This study found that consumption of dark green leafy vegetables may lower the risk of cutaneous squamous cell carcinoma, especially in individuals with specific genotypes. The findings suggest that gene polymorphisms related to folate metabolism should be considered when assessing the relationship between green leafy vegetables and cancer risk.
Letter
Rheumatology
Han-You Mo, Xiao-Huan Chen, James Cheng Chung Wei, Hsin-Hua Chen
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Ping-Hao Chiang, Po-Chung Ju, Yun-Chi Chiang, James Cheng-Chung Wei
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Xiao-Huan Chen, James Cheng Chung Wei, Han-You Mo, Hsin-Hua Chen
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Dermatology
Shuo-Yan Gau, Chien-Ying Lee, Yu-Hsiang Kuan, Kevin Sheng-Kai Ma, James Cheng-Chung Wei
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Editorial Material
Clinical Neurology
Pei-Yun Shih, Su-Boon Yong, Chin-Ming Liu, James Cheng-Chung Wei
CURRENT ALZHEIMER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Thomas Yen-Ting Chen, Shiow-Ing Wang, Yao-Min Hung, Joshua J. Hartman, Renin Chang, James Cheng-Chung Wei
Summary: This study found that HPV vaccination is associated with a lower risk of COVID-19. Recent HPV vaccination was significantly associated with a lower incidence and hospitalization risk of COVID-19.
Letter
Pharmacology & Pharmacy
Qiang Tong, Shiow-Ing Wang, James Cheng-Chung Wei, Sheng-Ming Dai
Article
Allergy
Yu-Chuan Chang, Meng-Che Wu, Hsing-Ju Wu, Pei-Lun Liao, James Cheng-Chung Wei
Summary: This study aimed to investigate the association between prenatal antibiotic use and childhood atopic dermatitis (AD). A population-based cohort study using data collected from the Taiwan Maternal and Child Health Database from 2009 to 2016 was performed. The results showed a slight positive association between maternal antibiotic use during pregnancy and childhood AD, particularly in the first and second trimesters. The risk increased by 8% when the exposure to antibiotics was >= 5 courses.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Letter
Rheumatology
Ting-Hsun Lin, James Cheng-Chung Wei
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Letter
Rheumatology
Wen-Jiun Lin, Po-Cheng Shih, Shih James Cheng-Chung Wei
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Editorial Material
Immunology
Jin-Xian Huang, James Cheng-Chung Wei
Article
Rheumatology
Kai-Jun Zhu, Wei Feng, Xiao-Na Ma, Pei-Lun Liao, Chang-Song Lin, Jing-Yang Huang, James Cheng-Chung Wei, Qiang Xu
Summary: Previous studies have shown that the use of proton pump inhibitors (PPIs) increases the risk of gout, but there is a lack of epidemiological research investigating this association. This population-based case-control study from Taiwan aimed to explore the potential impact of PPI treatment on the risk of developing gout. The results indicated that Esomeprazole increased the risk of gout, particularly within 30 days of PPI treatment, and the risk was higher among female and middle-aged users compared to others.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2023)
Article
Rheumatology
Jih-Jin Tsai, Li-Teh Liu, Chun-Hong Chen, Liang-Jen Chen, Shiow-Ing Wang, James Cheng-Chung Wei
Summary: This study aimed to investigate the role of rheumatoid arthritis (RA) with biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARD) exposure in COVID-19 outcomes. The results showed that RA patients using JAK inhibitors (JAKi) had higher risks of hospitalization, mortality, and composite adverse outcomes compared to TNF-alpha inhibitors (TNFi).
Article
Dentistry, Oral Surgery & Medicine
Hsin-Hsin Huang, Kevin Sheng-Kai Ma, Min-You Wu, Yao-Min Hung, Chien-Han Tsao, James Cheng-Chung Wei, Wei-Sheng Wen, Yu-Hsun Wang, Shih-Yen Hung, Max Min Chao
Summary: This study found that patients with obstructive sleep apnea (OSA) had significantly higher risk of developing flavor disorder (FD) during a 15-year follow-up period, especially in female patients.
CLINICAL ORAL INVESTIGATIONS
(2023)
Letter
Rheumatology
Chun-Lin Su, Jhih-Wei Chen, James Cheng-Chung Wei
ANNALS OF THE RHEUMATIC DISEASES
(2023)