Review
Oncology
Francesca Magnoni, Virgilio Sacchini, Paolo Veronesi, Beatrice Bianchi, Elisa Bottazzoli, Valentina Tagliaferri, Erica Mazzotta, Giulia Castelnovo, Giulia Deguidi, Elisabetta Maria Cristina Rossi, Giovanni Corso
Summary: The optimal surgical approach to hereditary breast cancer and the management of patients carrying mutations in high-penetrance genes are significant current clinical and scientific issues. Studies have shown that breast-conserving surgery is oncologically safe in BRCA carriers in terms of overall survival, despite an increased risk of ipsilateral recurrence.
Article
Oncology
Hakyoung Kim, Sae Byul Lee, Seok-Jin Nam, Eun Sook Lee, Byeong-Woo Park, Ho Yong Park, Hyouk Jin Lee, Jisun Kim, Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn
Summary: This study evaluated the long-term outcomes of Korean women with early breast cancer undergoing breast-conserving surgery plus radiotherapy or total mastectomy. Findings showed that the breast-conserving surgery plus radiotherapy group had better overall survival and breast cancer-specific survival than the total mastectomy group in both the Korean Breast Cancer Registry and Asan Medical Center cohorts. The results suggest that breast-conserving surgery plus radiotherapy is at least equivalent to total mastectomy in terms of overall survival and may influence treatment decisions for early breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Jiameng Liu, Zhanlin Zhu, Zhipeng Hua, Weijie Lin, Yiyin Weng, Juli Lin, Hehui Mao, Lifen Lin, Xuming Chen, Jujiang Guo
Summary: The aim of this study is to identify risk factors for refusal of radiotherapy after breast-conserving surgery. The study found that patients with old age, low income, divorce, white race, advanced stage, and no chemotherapy were more likely to refuse radiotherapy.
RADIATION ONCOLOGY
(2023)
Review
Oncology
Caiqin Mo, Weihong Ruan, Junyu Lin, Huaying Chen, Xiangjin Chen
Summary: Repeat breast-conserving surgery (RBCS) has a higher secondary local recurrence rate compared to salvage mastectomy (SM) for patients with ipsilateral breast tumour recurrence (IBTR), but it does not significantly affect survival rates. RBCS may be considered as an alternative method for IBTR patients after breast-conserving surgery (BCS).
FRONTIERS IN ONCOLOGY
(2021)
Article
Health Care Sciences & Services
Alba Di Leone, Antonio Franco, Francesca Zotta, Lorenzo Scardina, Margherita Sicignano, Enrico Di Guglielmo, Virginia Castagnetta, Stefano Magno, Daniela Terribile, Alejandro Martin Sanchez, Gianluca Franceschini, Riccardo Masetti
Summary: Triple-negative breast cancer (TNBC) refers to a subtype of breast cancer that lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). A population-based study was conducted to compare the outcomes of breast-conserving surgery (BCS) and mastectomy (M) in 289 TNBC patients. The study found no significant differences in locoregional disease-free survival, distant disease-free survival, and overall survival between the two surgical treatments. These findings suggest that TNBC should not be considered a contraindication for breast-conserving surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Yu-Chun Song, Zhou Huang, Hui Fang, Yu Tang, Hao Jing, Yong-Wen Song, Jing Jin, Yue-Ping Liu, Bo Chen, Yuan Tang, Shu-Nan Qi, Ning-Ning Lu, Ning Li, Ye-Xiong Li, Shu-Lian Wang
Summary: This study compares the recurrence and survival outcomes between breast-conserving surgery (BCS) and mastectomy after neoadjuvant chemotherapy (NACT). The results show that there is no significant difference in the 5-year locoregional recurrence rate, distant metastasis rate, and disease-free survival rate between the BCS and mastectomy groups. However, the BCS group has significantly higher 5-year breast cancer-specific survival rate and overall survival rate compared to the mastectomy group. Multivariate analysis also demonstrates that BCS significantly improves breast cancer-specific survival and overall survival.
FRONTIERS IN ONCOLOGY
(2023)
Article
Dermatology
Andrew Chen, John G. Albertini, Jeremy S. Bordeaux, Michael W. Chen, Jonathan L. Cook, Caryn Davidson, Katelyn C. Donnelly, Irfan I. Galaria, Catherine M. Hannan, Jonathan Kantor, Daniel L. Kapp, Naomi Lawrence, Clifford W. Lober, Lauren D. Loeding, Alexander Miller, Daniel T. Ness, Rogerio Neves, Peter C. Revenaugh, Peter Setabutr, Sunil S. Tholpady, Travis T. Tollefson, Marta J. Van Beek, Paul R. Weiss, Murad Alam
Summary: A multi-disciplinary work group comprising stakeholders from diverse backgrounds was convened to develop guidelines for the management of reconstruction after skin cancer resection, aiming to improve patient care. The investigation focused on common elements in the reconstructive process and highlighted the need for additional methodologically robust studies to guide clinical practice.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Surgery
Andrew Chen, John G. Albertini, Jeremy S. Bordeaux, Michael W. Chen, Jonathan L. Cook, Caryn Davidson, Katelyn C. Donnelly, Irfan I. Galaria, Catherine M. Hannan, Jonathan Kantor, Daniel L. Kapp, Naomi Lawrence, Clifford W. Lober, Lauren D. Loeding, Alexander Miller, Daniel T. Ness, Rogerio I. Neves, Peter C. Revenaugh, Peter Setabutr, Sunil S. Tholpady, Travis T. Tollefson, Marta J. Van Beek, Paul R. Weiss, Murad Alam
Summary: A multi-disciplinary work group convened to develop guidelines for the management of reconstruction after skin cancer resection, focusing on common elements in the process and utilizing the Grading of Recommendations Assessment, Development, and Evaluation methodology to rate the quality of relevant scientific research. Insufficient evidence was found in some cases, highlighting the need for more methodologically robust studies to guide clinical practice.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2021)
Article
Oncology
M. Luke Marinovich, Christobel M. Saunders, Gavin Pereira, Nehmat Houssami
Summary: This study investigated whether the introduction of the 2014 surgical margins guideline was associated with a reduction in reoperation rates for breast cancer patients in Western Australia. The results showed that the post-guideline reoperation rates did decrease, but this decline was already observed before the guideline was introduced.
Review
Oncology
Mohammed Tarek Hasan, Mohamed Hamouda, Mohammad. K. El Khashab, Ahmed Bostamy Elsnhory, Abdullah Mohamed Elghamry, Obada Atef Hassan, Aya Mamdouh Fayoud, Abdelrahman H. Hafez, Mohammed Al-kafarna, Abdulrahman Ibrahim Hagrass, Randa Kamal Rabea, Mohamed Ibrahim Gbreel
Summary: This study compared conventional breast-conserving surgery (CBCS) with oncoplastic breast-conserving surgery (OPBCS) for breast cancer interventions. The results showed that OPBCS was significantly better than CBCS in most outcomes. However, there was no significant difference between the two techniques in terms of local recurrence, surgical margins, and risk of mastectomy. Overall, oncoplastic surgery is recommended for females with breast cancer.
Article
Oncology
Mingdi Zhang, Kejin Wu, Peng Zhang, Maoli Wang, Fang Bai, Hongliang Chen
Summary: BCS shows independent favorable prognostic factor and can be acceptable and preferable alternative to mastectomy for well-selected early-stage T1 or T2 CLBC patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Yun Wang, Jingjing Shen, Peihua Gu, Zhongming Wang
Summary: Adjuvant radiotherapy is integral to breast cancer treatment after breast-conserving surgery. Advances in radiotherapy technology have allowed for comparison of various techniques and improved segmentation times. Precision radiotherapy must be individually evaluated based on clinical evidence and patient factors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Zhi-Hong Sun, Chuang Chen, Xin-Wen Kuang, Jun-Long Song, Sheng-Rong Sun, Wei-Xing Wang
Summary: This study found that, compared to mastectomy, breast-conserving therapy (BCT) can provide better breast cancer-specific survival and overall survival benefits in young white patients under 40 with early-stage breast cancer, especially in the 36 to 40 years age group.
Article
Oncology
Huanzuo Yang, Mengxue Qiu, Yu Feng, Nan Wen, Jiao Zhou, Xiangquan Qin, Juan Li, Xinran Liu, Xiaodong Wang, Zhenggui Du
Summary: This study aimed to develop an individualized nomogram to identify early-stage HER2+ patients who could omit radiotherapy after breast-conserving surgery. The results showed that radiotherapy could significantly improve the overall survival and breast cancer-specific survival of HER2+ early-stage breast cancer patients. For high-risk patients, radiotherapy is an essential component of cancer therapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Shi-Ping Yang, Lu-Lu Tan, Ping Zhou, Chen-Lu Lian, San-Gang Wu, Zhen-Yu He
Summary: The study aimed to evaluate the association between adjuvant radiotherapy (RT) after breast-conserving surgery (BCS) and survival among elderly breast cancer patients. The results showed that patients who received adjuvant RT had better breast cancer-specific survival (BCSS) and overall survival (OS) compared to those without RT.
FRONTIERS IN ONCOLOGY
(2022)
Article
Anesthesiology
Takeshi Umegaki, Susumu Kunisawa, Kota Nishimoto, Yasufumi Nakajima, Takahiko Kamibayashi, Yuichi Imanaka
Summary: This study compared the risk of postoperative paraplegia between open surgical descending aortic repair and thoracic endovascular aortic repair (TEVAR) in patients with thoracic aortic disease. The results showed no statistical differences in the risk of paraplegia between the two surgery types.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2022)
Article
Medicine, General & Internal
Hiroyuki Seto, Naoto Ishimaru, Jun Ohnishi, Yohei Kanzawa, Takahiro Nakajima, Toshio Shimokawa, Yuichi Imanaka, Saori Kinami
Summary: This study evaluated the effectiveness of a multidisciplinary team deprescribing intervention in reducing polypharmacy and potentially inappropriate medications in elderly orthopedic inpatients. The intervention resulted in a significant reduction in the number of prescribed medicines and potentially inappropriate medications, as well as a decrease in certain adverse events.
Article
Surgery
Susumu Kunisawa, Haku Ishida, Hiroshi Ikai, Hiroaki Nagano, Toshiyoshi Fujiwara, Hideki Ohdan, Yoshiyuki Fujiwara, Yoshitsugu Tajima, Tomio Ueno, Yoshinori Fujiwara, Mitsuo Shimada, Yasuyuki Suzuki, Yuji Watanabe, Kazuhiro Hanazaki, Yoshihiro Kakeji, Hiraku Kumamaru, Arata Takahashi, Hiroaki Miyata, Yuichi Imanaka
Summary: This study aimed to improve healthcare quality in Western Japan by analyzing the association between hospital characteristics and surgical outcomes. The findings suggest that consolidating and centralizing hospitals based solely on case volume does not lead to significant improvement in surgical outcomes.
Article
Orthopedics
Ayako Tsunemitsu, Takahiko Tsutsumi, Sakiko Inokuma, Tatsuya Kobayashi, Yuichi Imanaka
Summary: Hospitalist co-management of patients with vertebral compression fractures showed a significantly higher rate of initiation of osteoporosis treatment compared to conventional orthopedic surgeon-led care. However, there were no significant differences between the two groups in terms of length of hospital stay, preventable complications during hospitalization, and 30-day readmission.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2023)
Article
Multidisciplinary Sciences
Yu Ohki, Yuichi Ikeda, Susumu Kunisawa, Yuichi Imanaka
Summary: This study explores the contribution of medical cooperation among providers in a series of medical services to the quality of healthcare. The results reveal that medical providers with higher levels of cooperation can reduce the duration of hospital stay.
Article
Cardiac & Cardiovascular Systems
Tetsuji Morishita, Daisuke Takada, Jung-ho Shin, Susumu Kunisawa, Kiyohide Fushimi, Yuichi Imanaka
Summary: The revision of reimbursement policy in Japan in 2018 led to a significant reduction in elective PCI procedures per month, highlighting the importance of documenting ischaemia in patients with stable angina prior to the procedure.
Article
Geriatrics & Gerontology
Koji Hara, Takayo Nakabe, Masayuki Tanaka, Yuichi Imanaka
Summary: The study found that the quality of life of long-term care service users is generally lower, especially for females and those under 65 years old with specific diseases. Additionally, as the level of care required increased, the quality of life gradually decreased. Therefore, monitoring users' quality of life is an important quality indicator for care.
Article
Medicine, General & Internal
Osamu Hamada, Takahiko Tsutsumi, Yuichi Imanaka
Summary: This study examined the impact of the hospitalist system on the quality of care and healthcare economics in a Japanese population using treatment of urinary tract infection as an example. The results showed that the hospitalist system was associated with a shorter length of stay and improved quality of care, but there was no significant difference in hospital costs. Overall, the hospitalist system has great potential for positive impact in Japan.
Article
Multidisciplinary Sciences
Yoshito Hirota, Jung-ho Shin, Noriko Sasaki, Susumu Kunisawa, Kiyohide Fushimi, Yuichi Imanaka
Summary: This study aimed to develop and validate prediction models for the discharge destination of elderly patients with aspiration pneumonia. The results showed that the developed models and nomograms could facilitate the early implementation of discharge planning, providing accurate arrangements for patient discharge.
Article
Multidisciplinary Sciences
Mikako Yoshikawa, Etsu Goto, Jung-ho Shin, Yuichi Imanaka
Summary: This study investigates the status of older adults with dementia in different regions of Japan and calculates Dementia-free Life Expectancy. It finds regional disparities and reveals that socioeconomic conditions are more closely related to Dementia-free Life Expectancy than urbanicity and health services-related factors.
Article
Multidisciplinary Sciences
Takuya Higuchi, Jung-ho Shin, Daisuke Takada, Tetsuji Morishita, Susumu Kunisawa, Yuichi Imanaka
Summary: Since the outbreak of COVID-19, the Japanese Guide has been published to provide guidance on the use of steroids for COVID-19 treatment. This study aimed to examine the impact of the Japanese Guide on the prescription trends of steroids for COVID-19 inpatients in Japan.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Hiroyuki Nagano, Jung -ho Shin, Susumu Kunisawa, Kiyohide Fushimi, Miki Nagao, Yuichi Imanaka
Summary: A shortage of cefazolin occurred in Japan in 2019. This study compared the impact of the shortage on the selection of parenteral antibiotics at affected and non-affected hospitals. The results showed that hospitals with shortage had a significant increase in the use of broader-spectrum beta-lactams and clindamycin.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Gastroenterology & Hepatology
Hiromitsu Kinoshita, Tatsuto Nishigori, Susumu Kunisawa, Koya Hida, Hisahiro Hosogi, Susumu Inamoto, Hiroaki Hata, Ryo Matsusue, Yuichi Imanaka, Kazutaka Obama, Yumi Matsumura
Summary: This study aims to evaluate the accuracy of extracting patients who underwent GI cancer surgery and postoperative complications from Japanese administrative claims data. The method was validated using data from Kyoto University Hospital and two other hospitals, and the results showed that it accurately identified postoperative complications requiring interventions. This study is of great importance for hospital quality improvement or large-scale comparison studies among nationwide hospitals.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Surgery
Hiromitsu Kinoshita, Tatsuto Nishigori, Takayo Nakabe, Norihiro Shimoike, Keiko Sato, Yuichi Imanaka, Kazutaka Obama, Yumi Matsumura
Summary: This study aimed to investigate factors related to postoperative decision regret in patients undergoing surgery for gastrointestinal cancer. The study found that preoperative trust in physician and postoperative complications were significantly associated with postoperative decision regret. The occurrence of postoperative complications may lead to regret over the choice of surgery, but trust in the physician may help reduce feelings of regret.
Article
Endocrinology & Metabolism
Kenta Minato, Jung-ho Shin, Susumu Kunisawa, Kiyohide Fushimi, Yuichi Imanaka
Summary: During the first wave of the COVID-19 epidemic, the total number of patients with major fragility fractures started to decline before the state of emergency was declared, rather than immediately after it.
ARCHIVES OF OSTEOPOROSIS
(2023)