Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 44, Issue 2, Pages 147-160Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2013.08.002
Keywords
Toxoplasma gondii; Rhoptry; Rhoptry neck; Host-pathogen interaction
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Funding
- American Heart Association
- Knights Templar Eye Foundation, USA
- A*STAR NSS, Singapore
- Cancer Research Institute, USA
- Charles A. King Trust, USA
- National Institutes of Health, USA [R01-AI080621]
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The rhoptries are key secretory organelles from apicomplexan parasites that contain proteins involved in invasion and modulation of the host cell. Some rhoptry proteins are restricted to the posterior bulb (ROPs) and others to the anterior neck (RONs). As many rhoptry proteins have been shown to be key players in Toxoplasma invasion and virulence, it is important to identify, understand and characterise the biological function of the components of the rhoptries. In this report, we identified putative novel rhoptry genes by identifying Toxoplasma genes with similar cyclical expression profiles as known rhoptry protein encoding genes. Using this approach we identified two new rhoptry bulb (ROP47 and ROP48) and one new rhoptry neck protein (RON12). ROP47 is secreted and traffics to the host cell nucleus, RON12 was not detected at the moving junction during invasion. Deletion of ROP47 or ROP48 in a type II strain did not show major influence in in vitro growth or virulence in mice. (C) 2013 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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