Article
Microbiology
Jana Hagen, Peter Sarkies, Murray E. Selkirk
Summary: The use of a pseudotyped viral vector has successfully enabled genetic manipulation of parasitic nematodes, including gene silencing and expression of exogenous genes. This method holds promise for advancing research on the complex biology of nematode parasites and identifying new targets for infection control.
Article
Parasitology
Aya Masuda, Judith E. Allen, Jos G. M. Houdijk, Spiridoula Athanasiadou
Summary: The study found that dietary protein supplementation during pregnancy and lactation enhances Th2 immunity in rats, leading to increased splenic macrophage populations following reinfection with N. brasiliensis, helping to reduce the degree of immunity relaxation.
Article
Multidisciplinary Sciences
Brock Kingstad-Bakke, Woojong Lee, Shaswath S. Chandrasekar, David J. Gasper, Cristhian Salas-Quinchucua, Thomas Cleven, Jeremy A. Sullivan, Adel Talaat, Jorge E. Osorio, M. Suresh
Summary: The study found that mucosal or parenteral immunization effectively controlled the virus and protected the lungs from damage with or without neutralizing antibodies. The protection provided by mucosal memory CD8 T cells was largely redundant in the presence of neutralizing antibodies, but unhelped mucosal memory CD8 T cells provided no protection against the homologous SARS-CoV-2 without CD4 T cells and neutralizing antibodies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biotechnology & Applied Microbiology
Jiri Mestecky
Summary: Extensive experiments have shown the protective effect of polyclonal or monoclonal antibodies administered through the mucosal route in animal models, highlighting the importance of producing antibodies of desired specificity and selecting suitable delivery systems to effectively prevent mucosally acquired infectious diseases in humans.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2022)
Article
Immunology
Ji Eun Oh, Eric Song, Miyu Moriyama, Patrick Wong, Sophia Zhang, Ruoyi Jiang, Shirin Strohmeier, Steven H. Kleinstein, Florian Krammer, Akiko Iwasaki
Summary: Research shows that intranasal immunization induces local IgA secretion in the bronchoalveolar space, providing effective protection against respiratory virus infections; single-cell RNA sequencing reveals a heterogeneous population of IgA-expressing cells within the respiratory mucosa, including tissue-resident memory B cells, plasmablasts, and plasma cells.
SCIENCE IMMUNOLOGY
(2021)
Article
Immunology
Yarden Golan, Mary Prahl, Arianna G. Cassidy, Caryl Gay, Alan H. B. Wu, Unurzul Jigmeddagva, Christine Y. Lin, Veronica J. Gonzalez, Emilia Basilio, Megan A. Chidboy, Lakshmi Warrier, Sirirak Buarpung, Lin Li, Amy P. Murtha, Ifeyinwa V. Asiodu, Nadav Ahituv, Valerie J. Flaherman, Stephanie L. Gaw
Summary: The study found that COVID-19 mRNA vaccines generated robust immune responses in both plasma and milk of lactating individuals, with significant transfer of antibodies to milk for potential protection of infants. No severe adverse events were reported in the cohort, indicating the safety and efficacy of vaccination during lactation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Denise Fiorelli, Beatrice Francavilla, Andrea Magrini, Stefano Di Girolamo, Sergio Bernardini, Marzia Nuccetelli
Summary: The aim of this study was to evaluate the accuracy of two diagnostic immunoassays for COVID-19 (ELISA for IgA-S1 and chemiluminescent assay for IgG-RBD) on serum, saliva, and nasal secretions. Data demonstrate that the developed method can provide accurate and reliable results for the detection of anti-SARS-CoV-2 mucosal specific antibodies (IgA-S1 and IgG-RBD) on saliva and nasal secretions, either after COVID-19 infection or in vaccinated subjects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Plant Sciences
Bin Guo, Borong Lin, Qiuling Huang, Zhiwen Li, Kan Zhuo, Jinling Liao
Summary: This study found that the effector MeTCTP of Meloidogyne enterolobii can form homodimers and bind calcium ions, leading to inhibition of cytosolic free calcium concentration and suppression of plant immune responses. These findings reveal a novel mechanism used by plant pathogens to suppress plant immunity.
PLANT CELL AND ENVIRONMENT
(2022)
Article
Fisheries
Fatou Ndoye Fall, Shuoli Ma, Javad Sahandi, Chukwuma Kenneth Chibuikem, Mingzhu Pan, Bwebwe Botaa Tabuariki, Yanlin Guo, Kangsen Mai, Wenbing Zhang
Summary: This study investigated the effects of dietary protein level, water temperature, and their interactions on the growth performance, innate immunity, and disease resistance of abalone. The results showed that a protein level of 27.53% significantly improved the weight gain rate and shell length increment of abalones at both 17°C and 23°C water temperatures. This protein level also enhanced the enzymatic activities and reduced oxidative stress markers in abalones. Furthermore, it down-regulated the expression of pro-inflammatory and apoptotic genes, and increased immune parameters in abalones. Additionally, the 27.53% protein level enhanced disease resistance in abalones after Vibrio challenge at 17°C water temperature.
AQUACULTURE REPORTS
(2023)
Article
Environmental Sciences
Marcia Regina Faita, Adriana Chaves, Caio Cezar Guedes Correa, Vanildo Silveira, Rubens Onofre Nodari
Summary: This study reveals that glyphosate-based herbicides can affect the protein composition of royal jelly, specifically leading to a reduction in the accumulation of Major royal jelly protein 3 (MRJP3). These changes may have negative effects on the nutrition and social immunity of bees.
Article
Multidisciplinary Sciences
Eleanor Brindle, Lorraine Lillis, Rebecca Barney, Pooja Bansil, Sonja Y. Hess, K. Ryan Wessells, Cesaire T. Ouedraogo, Francisco Arredondo, Mikaela K. Barker, Neal E. Craft, Christina Fischer, James L. Graham, Peter J. Havel, Crystal D. Karakochuk, Mindy Zhang, Ei-Xia Mussai, Carine Mapango, Jody M. Randolph, Katherine Wander, Christine M. Pfeiffer, Eileen Murphy, David S. Boyle
Summary: This study evaluated the performance characteristics and comparability of immunoassay methods for quantifying seven biomarkers across different laboratories. Results showed acceptable precision and linearity in a single lab, with generally good agreement in biomarker results between labs.
Article
Medicine, Research & Experimental
Livia Casciola-Rosen, David R. Thiemann, Felipe Andrade, Maria Trejo-Zambrano, Elissa K. Leonard, Jamie B. Spangler, Nicole E. Skinner, Justin Bailey, Srinivasan Yegnasubramanian, Rulin Wang, Ajay M. Vaghasia, Anuj Gupta, Andrea L. Cox, Stuart C. Ray, Raleigh M. Linville, Zhaobin Guo, Peter C. Searson, Carolyn E. Machamer, Stephen Desiderio, Lauren M. Sauer, Oliver Laeyendecker, Brian T. Garibaldi, Li Gao, Mahendra Damarla, Paul M. Hassoun, Jody E. Hooper, Christopher A. Mecoli, Lisa Christopher-Stine, Laura Gutierrez-Alamillo, Qingyuan Yang, David Hines, William A. Clarke, Richard E. Rothman, Andrew Pekosz, Katherine Zj Fenstermacher, Zitong Wang, Scott L. Zeger, Antony Rosen
Summary: This study identifies anti-ACE2 IgM as a mechanism-based biomarker strongly associated with severe clinical outcomes in SARS-CoV-2 infection, with therapeutic implications.
Article
Microbiology
Gabriel Diem, Michael Jaeger, Stefanie Dichtl, Angelika Bauer, Cornelia Lass-Floerl, Markus Reindl, Doris Wilflingseder, Wilfried Posch
Summary: This study investigated the immune responses to SARS-CoV-2 variants in vaccinated and/or convalescent individuals. The results showed that current COVID-19 vaccines induce strong humoral immunity, but the neutralizing effectiveness against novel variants is reduced. Therefore, it is suggested to adjust the vaccine strategy to include mucosal booster vaccinations to establish robust immunity against emerging SARS-CoV-2 variants.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Daigo Tsubokawa, Taisei Kikuchi, Jae Man Lee, Takahiro Kusakabe, Yasuhiko Yamamoto, Haruhiko Maruyama
Summary: Parasitic helminths can disrupt host protective immunity by targeting the RAGE receptor, and the EF-hand Ca2+-binding protein venestatin secreted by Strongyloides venezuelensis plays a key role in this immune evasion process. Venestatin binds to RAGE and suppresses inflammatory responses, facilitating larval migration from the skin to the lungs. These findings suggest that targeting the anti-inflammatory mechanism of venestatin may offer new therapeutic approaches for RAGE-mediated inflammatory diseases.
Article
Immunology
Kai Su, Yawen Wang, Chen Yuan, Yanan Zhang, Yanrui Li, Tanqing Li, Qinye Song
Summary: S1-BLPs vaccine can stimulate intestinal mucosal immune response, and intranasal administration is more effective than intramuscular administration in inducing specific antibodies and Th cell immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
P. Sakkas, S. Smith, T. R. Hill, I. Kyriazakis
Article
Agriculture, Dairy & Animal Science
S. Stavrakakis, F. Loisel, P. Sakkas, N. Le Floc'h, I Kyriazakis, G. Stewart, L. Montagne
Article
Agriculture, Dairy & Animal Science
Anne M. S. Huting, Panagiotis Sakkas, Ilias Kyriazakis
JOURNAL OF ANIMAL SCIENCE
(2019)
Article
Biotechnology & Applied Microbiology
Jolinda Pollock, Michael R. Hutchings, Kate E. K. Hutchings, David L. Gally, Jos G. M. Houdijk
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Agriculture, Dairy & Animal Science
Oluyinka A. Olukosi, Robin L. Walker, Jos G. M. Houdijk
Article
Biotechnology & Applied Microbiology
Tim Giles, Tommy van Limbergen, Panagiotis Sakkas, Lily Quinn, Aouatif Belkhiri, Dominiek Maes, Ilias Kyriazakis, Paul Barrow, Neil Foster
Article
Medicine, Research & Experimental
Enrica E. K. Tan, Richard A. Hopkins, Chrissie K. Lim, Saumya S. Jamuar, Christina Ong, Koh C. Thoon, Mark J. A. Koh, Eun Mong Shin, Derrick W. Q. Lian, Madhushanee Weerasooriya, Christopher Z. W. Lee, Andreas Alvin Pumomo Soetedjo, Chang Siang Lim, Veonice B. Au, Edmond Chua, Hui Yin Lee, Leigh Ann Jones, Sharmy S. James, Nivashini Kaliaperumal, Jeffery Kwok, Ee Shien Tan, Biju Thomas, Lynn Xue Wu, Lena Ho, Anna Marie Fairhurst, Florent Ginhoux, Adrian K. K. Teo, Yong Liang Zhang, Kok Huar Ong, Weimiao Yu, Byrappa Venkatesh, Vinay Tergaonkar, Bruno Reversade, Keh Chuang Chin, Ah Moy Tan, Woei Kang Liew, John E. Connolly
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Agriculture, Dairy & Animal Science
A. O. Lala, A. O. Oso, E. L. K. Osafo, J. G. M. Houdijk, D. O. Eyarefe
Article
Agriculture, Dairy & Animal Science
James Taylor, Panagiotis Sakkas, Ilias Kyriazakis
Summary: The study found that modern broilers have a strong ability to adapt to insufficient feed energy content by increasing feed intake. Different feed volumes have varying effects on the feed intake and performance of broilers, with no specific bulk dimension identified to predict feed intake.
Article
Agriculture, Dairy & Animal Science
James Taylor, Panagiotis Sakkas, Ilias Kyriazakis
Summary: The study investigated the role of diet composition in pathogen-induced anorexia and infection outcomes in broilers. The findings suggest that infection affects food intake, and different dietary components can influence the extent of anorexia and infection outcomes.
Article
Veterinary Sciences
Ilias Giannenas, Panagiotis Sakkas, Georgios A. Papadopoulos, Ioannis Mitsopoulos, Ioanna Stylianaki, Stella Dokou, Vasileios Tsiouris, Theodora Papagrigoriou, Marina Panheleux, Fabrice Robert, Vasileios A. Bampidis
Summary: Supplementation with the plant extract combination PHYTO improved egg production rate, feed efficiency, reduced stress hormone levels, liver enzyme activity, and lipid peroxidation concentration in blood, while enhancing intestinal health and eggshell quality in laying hens.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Multidisciplinary Sciences
Farina Khattak, Salvatore Galgano, Jos Houdijk
Summary: This study aimed to assess the robustness of culture-based and molecular biology methods for quantification of total bacterial concentration and Campylobacter jejuni (C. jejuni) in caecal content. The results showed that storage time affected the output of culture-based analyses but had minimal impact on qPCR results. It was suggested that biological samples should be stored at -80 degrees C to avoid temporal-dependent effects on C. jejuni concentrations.
Article
Agriculture, Dairy & Animal Science
M. A. Hussein, F. Khattak, L. Vervelde, S. Athanasiadou, J. G. M. Houdijk
Summary: The effects of amino acid supplementation on broilers placed on recycled litter were investigated. The results showed that placement on recycled litter improved growth performance, while amino acid supplementation did not significantly increase growth performance.
Article
Microbiology
Salvatore Galgano, Helen Kettle, Andrew Free, Jos G. M. Houdijk
Summary: The swine gut microbiota is a complex ecosystem that can be influenced by both external and internal factors. Targeting the core microbiota could lead to more precise and long-lasting effects, but the metabolic role and relationship with other microbial communities are currently unclear.
Article
Agriculture, Dairy & Animal Science
Adebukunola Olufunmilayo Lala, Abimbola Oladele Oso, Emmanuel Lartey Osafo, Jos G. M. Houdijk
ANIMAL SCIENCE JOURNAL
(2020)