Article
Immunology
Raymundo Coate, Miguel angel Alonso-Diaz, Moises Martinez-Velazquez, Edgar Castro-Saines, Ruben Hernandez-Ortiz, Rodolfo Lagunes-Quintanilla
Summary: Rhipicephalus microplus has significant economic impact on cattle production in tropical and subtropical countries. The use of acaricides as a control method has led to increased resistance and contamination. Anti-tick vaccines based on the Bm86 antigen are a sustainable solution, but their efficacy can vary depending on geographic strains.
Article
Parasitology
Glen A. Scoles, Hala E. Hussein, Cassandra L. Olds, Kathleen L. Mason, Sara K. Davis
Summary: Vaccination with antibodies against RmAQP2 can reduce the number of cattle fever ticks on cattle, but the mechanism of action has not been confirmed. Further research is needed to determine the mechanism and whether these vaccine targets can be effective components of an anti-tick vaccine cocktail.
PARASITES & VECTORS
(2022)
Article
Microbiology
Paul Franck Adjou Moumouni, Souichirou Naomasa, Bumduuren Tuvshintulga, Nariko Sato, Kiyoshi Okado, Weiqing Zheng, Seung-Hun Lee, Juan Mosqueda, Hiroshi Suzuki, Xuenan Xuan, Rika Umemiya-Shirafuji
Summary: In this study, a homologue of Rhipicephalus microplus ATAQ in H. longicornis (HlATAQ) was identified, characterized, and evaluated for its immunogenic potential. HlATAQ was found to be involved in blood-feeding and oviposition processes in the tick's midgut and Malpighian tubules. Silencing of HlATAQ did not result in significant phenotypic changes.
Article
Microbiology
Alina Rodriguez-Mallon
Summary: The presence of species with genetic resistance or acquired resistance to ticks in nature has led to considering vaccination as an alternative to chemical control of ticks. The purification and characterization of the Bm86 antigen in 1989 was a significant development in tick vaccine research. Previous studies on cattle immunization against Rhipicepahalus microplus ticks using tick gut extracts showed successful results, demonstrating the feasibility of using antigens other than salivary-gland-derived molecules for anti-tick immunity. The practical application of an anti-tick vaccine required the isolation and identification of the Bm86 protein, which is still the basis for commercially available tick vaccines.
Review
Immunology
Charles Ndawula
Summary: Ticks are blood-sucking ectoparasites capable of transmitting various pathogens, and while the predominant method of control is the use of acaricides, there are concerns over resistance and residue accumulation. Anti-tick cattle vaccination is seen as a sustainable alternative, but often shows lower efficacy compared to the Bm86-based vaccines. Current approaches to assess vaccine effectiveness and potential bottlenecks are examined in this review, along with a proposed model to aid in the assessment process.
Article
Microbiology
Patricia Paulino, Gabriela Vitari, Antonio Rezende, Joana Couto, Sandra Antunes, Ana Domingos, Maristela Peckle, Carlos Massard, Flavio Araujo, Huarrisson Santos
Summary: This study characterized the sialotranscriptome profile of Rhipicephalus (Boophilus) microplus in response to Theileria equi and identified genes with differential genomic expression. The analysis revealed potential targets in the tick-protozoan interactions, providing valuable information for future studies and biotechnological applications.
Article
Entomology
Christine Maritz-Olivier, Mariette Ferreira, Nicholas A. Olivier, Jan Crafford, Christian Stutzer
Summary: Control of complex parasites remains challenging, and current vaccines and drugs are the preferred integrated control strategy. Developing multicomponent vaccines for endo- and ectoparasites is necessary, but understanding of tick biology is insufficient. Identifying new acaricide targets is crucial due to acaricide resistance, and targeting large protein families and intracellular proteins for vaccine and drug design has limitations. Bm86-based vaccines may reduce tick fecundity by disrupting bloodmeal uptake and digestion.
EXPERIMENTAL AND APPLIED ACAROLOGY
(2023)
Article
Plant Sciences
Veli Vural Uslu, Athanasios Dalakouras, Victor A. Steffens, Gabi Krczal, Michael Wassenegger
Summary: Transitivity in plants relies on RDR6-mediated dsRNA synthesis and DCL endonuclease activity to reinforce target RNA cleavage through the formation of an RNA-induced silencing complex. This study found that the primary target site influences gene silencing and transitivity, with dsRNA synthesis generally initiated at the 3MODIFIER LETTER PRIME-end of the target RNA.
Article
Entomology
Jing-Hang Zhang, Ling Li, Na Li, Yan-Yan Li, Bao-Ping Pang
Summary: In this study, odorant receptor genes of Galeruca daurica were identified and their expression and function in the antennae were investigated. It was found that the majority of these odorant receptor genes were expressed in the antennae, and their expression levels were influenced by age. Silencing specific odorant receptor genes through RNA interference significantly decreased the electrophysiological responses of Galeruca daurica to host plant volatiles. This study provides a necessary foundation for understanding the mechanism of host plant identification in Galeruca daurica.
Review
Immunology
Jolieke G. van Oosterwijk, Stephen K. Wikel
Summary: The medical and veterinary public health importance of ticks and tick-borne pathogens is increasing due to the expansion of geographic ranges, increasing populations, and growing incidence of diseases. The immune-mediated control of tick infestations and pathogen transmission through vaccines has become more prominent. Research on resistance mechanisms, host immune defenses, genomics, and proteomics have contributed to the development of new anti-tick vaccine antigens. Targeting pathogen reservoirs with vaccines has the potential to disrupt disease cycles and reduce exposure in humans and animals.
Article
Cell Biology
Lingfeng Yu, Gentao Fan, Qingyan Wang, Yan Zhu, Hao Zhu, Jiang Chang, Zhen Wang, Shoubin Zhan, Xianming Hua, Diankun She, Jianhao Huang, Yicun Wang, Jianning Zhao, Chen-Yu Zhang, Xi Chen, Guangxin Zhou
Summary: This study presents a synthetic biological strategy for efficient in vivo delivery of VEGFR2 siRNA by remolding the host liver with genetic circuits. The results show that this strategy is superior to the positive medicine in terms of therapeutic efficacy and toxic adverse effects, providing a feasible therapeutic solution for lung metastatic OS.
CELL DEATH & DISEASE
(2023)
Review
Agriculture, Dairy & Animal Science
Luis Fernando Parizi, Naftaly Wang'ombe Githaka, Carlos Logullo, Jinlin Zhou, Misao Onuma, Carlos Termignoni, Itabajara da Silva Vaz Jr
Summary: Developing vaccines against different tick species faces challenges in selecting suitable antigens and controlling the expanding population of ticks. This review discusses the progress made and future directions in the search for universal tick vaccines.
Review
Biochemistry & Molecular Biology
Muhammad Nadeem Abbas, Mohamed Amine Jmel, Imen Mekki, Ingrid Dijkgraaf, Michail Kotsyfakis
Summary: Ticks can cause serious damage to human and animal health worldwide and result in significant economic losses annually. Chemical acaricides are commonly used for tick control but have negative impacts on the environment and contribute to the emergence of acaricide-resistant tick populations. Vaccines are considered a better alternative for tick control and have been developed using antigen-based approaches, with some already commercially available.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Sushama Jadhav, Prajakta Makar, Vijay Nema
Summary: HIV-1 viral proteins activate astrocytes and microglia, leading to the development of HIV-associated neurocognitive disorder. This study demonstrates that HIV-1 Nef upregulates IL-6, IP-10, and TNF-alpha levels in normal human astrocytes. RNA interference can downregulate inflammatory cytokines and is associated with the upregulation of kynurenine pathway metabolites. The findings suggest the potential of combining RNA interference with current antiretroviral therapy to prevent neurotoxicity development.
Article
Immunology
Desmond O. Agwunobi, Ningmei Wang, Lei Huang, Yefei Zhang, Guomin Chang, Kuang Wang, Mengxue Li, Hui Wang, Jingze Liu
Summary: This study analyzed the phosphorylated proteins in the saliva of Haemaphysalis longicornis ticks and identified 262 phosphorylated tick saliva proteins. Functional annotation and enrichment analysis revealed that these proteins are involved in cellular and metabolic processes, particularly in transport-oriented processes. Knockdown of certain proteins resulted in various effects on tick feeding and reproduction. These findings demonstrate the importance of salivary phosphoproteins in facilitating tick feeding.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Parasitology
Christoph Krull, Bettina Boehme, Peter-Henning Clausen, Ard M. Nijhof
PARASITES & VECTORS
(2017)
Article
Parasitology
Abdul Rehman, Ard M. Nijhof, Carola Sauter-Louis, Birgit Schauer, Christoph Staubach, Franz J. Conraths
PARASITES & VECTORS
(2017)
Article
Parasitology
Peter L. Venjakob, Gerhard Thiele, Peter-Henning Clausen, Ard M. Nijhof
PARASITOLOGY RESEARCH
(2017)
Article
Infectious Diseases
B. C. Roy, J. Kruecken, J. S. Ahmed, S. Majumder, M. P. Baumann, P. -H. Clausen, A. M. Nijhof
TRANSBOUNDARY AND EMERGING DISEASES
(2018)
Review
Parasitology
Hein Sprong, Tal Azagi, Dieuwertje Hoornstra, Ard M. Nijhof, Sarah Knorr, M. Ewoud Baarsma, Joppe W. Hovius
PARASITES & VECTORS
(2018)
Article
Parasitology
Bettina Boehme, Christoph Krull, Peter-Henning Clausen, Ard M. Nijhof
PARASITOLOGY RESEARCH
(2018)
Article
Parasitology
Peter-Henning Clausen, Sandra Stelzer, Ard Nijhof, Juergen Kruecken, Georg von Samson-Himmelstjerna
VETERINARY PARASITOLOGY
(2018)
Article
Infectious Diseases
Babul Chandra Roy, Agustin Estrada-Pena, Juergen Kruecken, Abdul Rehman, Ard Menzo Nijhof
TICKS AND TICK-BORNE DISEASES
(2018)
Article
Infectious Diseases
Amira AL-Hosary, Laila Ahmed, Jabbar Ahmed, Ard Nijhof, Peter-Henning Clausen
TICKS AND TICK-BORNE DISEASES
(2018)
Editorial Material
Immunology
Sarah I. Bonnet, Ard M. Nijhof, Jose de la Fuente
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Zerihun Hailemariam, Juergen Kruecken, Maximilian Baumann, Jabbar S. Ahmed, Peter-Henning Clausen, Ard M. Nijhof
Article
Infectious Diseases
Abdul Rehman, Franz J. Conraths, Carola Sauter-Louis, Juergen Kruecken, Ard M. Nijhof
TRANSBOUNDARY AND EMERGING DISEASES
(2019)
Article
Physiology
Sarah Knorr, Juan Anguita, Julen T. Cortazar, Ondrej Hajdusek, Petr Kopacek, Jos J. Trentelman, Olivia Kershaw, Joppe W. Hovius, Ard M. Nijhof
FRONTIERS IN PHYSIOLOGY
(2018)
Review
Parasitology
Ryan O. M. Rego, Jos J. A. Trentelman, Juan Anguita, Ard M. Nijhof, Hein Sprong, Boris Klempa, Ondrej Hajdusek, Julen Tomas-Cortazar, Tal Azagi, Martin Strnad, Sarah Knorr, Radek Sima, Marie Jalovecka, Sabina Fumacova Havlikova, Martina Lickova, Monika Slavikova, Petr Kopacek, Libor Grubhoffer, Joppe W. Hovius
PARASITES & VECTORS
(2019)
Article
Parasitology
Peter Lennart Venjakob, Corinna Vogel, Peter-Henning Clausen, Ard M. Nijhof
PARASITOLOGY RESEARCH
(2019)