Article
Pharmacology & Pharmacy
Tianhua Hou, Manshi Yang, Kun Yan, Xiaoye Fan, Xinxin Ci, Liping Peng
Summary: Amentoflavone (AMF) protects against pleurisy and lung injury by activating Nrf2, reducing inflammatory effusion and pathological injury. AMF also decreases oxidative stress markers and modulates proinflammatory pathways while increasing anti-inflammatory cytokines levels, all in a Nrf2-dependent manner.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tiziana Genovese, Andrea Duranti, Ramona D'Amico, Roberta Fusco, Daniela Impellizzeri, Alessio Filippo Peritore, Rosalia Crupi, Enrico Gugliandolo, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Marika Cordaro
Summary: Acute lung injury (ALI) is a lung disease characterized by severe inflammation without treatment. This study investigated the role of fatty acid amide hydrolase (FAAH) inhibition in an ALI mouse model and found that it could counteract the inflammatory response and histological changes caused by the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Rania A. Abdel-Emam, Ahmed M. Abd-Eldayem
Summary: This study compared the effects of Egb-761 and dexamethasone on carrageenan-induced hind paw inflammation in rats, showing that both treatments significantly reduced paw edema and tissue levels of MDA, NO, and TNF-alpha. Dexamethasone demonstrated slightly superior anti-inflammatory and antioxidant efficacy compared to Egb-761.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cell Biology
Saeed Mehrzadi, Hamidreza Khalili, Iman Fatemi, Alireza Malayeri, Amir Siahpoosh, Mehdi Goudarzi
Summary: The study evaluated the beneficial effects of Zingerone in an acute inflammation model, showing that high doses of Zing significantly reduced paw swelling and increased antioxidant levels while decreasing levels of inflammation-related factors.
Article
Plant Sciences
Jae-Hun Ahn, Yae-Lyeon Park, A-Young Song, Wan-Gyu Kim, Chang-Yun Je, Do-Hyeon Jung, Yeong-Jun Kim, Jisu Oh, Jeong-Yong Cho, Dong-Jae Kim, Jong-Hwan Park
Summary: The water extract of Artemisia scoparia demonstrated potent anti-inflammatory properties in both in vitro and in vivo experiments, significantly reducing the production of inflammatory cytokines and recruitment of immune cells. This suggests the potential of A. scoparia as a functional food targeting inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Goeun Jang, Seulah Lee, Joonho Hong, Boram Park, Dokyung Kim, Chunsung Kim
Summary: 4,5-diCQA demonstrates anti-inflammatory properties by inhibiting inflammatory markers in vitro and reducing inflammation-induced edema in vivo, through suppression of nuclear factor-kappa B and MAPK pathways. This natural compound shows potential as an alternative to non-steroidal anti-inflammatory drugs.
Article
Pharmacology & Pharmacy
Luana Eloisa Leal, Evelyn Silva Moreira, Bruna Lopes Correia, Paulo Sergio Alves Bueno, Jurandir Fernando Comar, Anacharis Babeto de Sa-Nakanishi, Roberto Kenji Nakamura Cuman, Adelar Bracht, Ciomar Aparecida Bersani-Amado, Livia Bracht
Summary: The aim of this study was to compare the anti-inflammatory and antioxidant effects of three natural coumarins: 1,2-benzopyrone, umbelliferone, and esculetin. Various assays were used to evaluate their antioxidant capacity, and in vitro and in vivo experiments were conducted to investigate their anti-inflammatory activity. The results showed that esculetin had the highest antioxidant capacity and effectively reduced mitochondrial ROS generation. In terms of anti-inflammatory effects, 1,2-benzopyrone was the most efficient and enhanced the actions of dexamethasone, while umbelliferone and esculetin did not reduce pleural exudate volume. Overall, these findings suggest that these plant secondary metabolites have promising effects in preventing and treating inflammation and oxidative stress-related diseases, although the specificities of the inflammatory process and pharmacokinetics should be considered.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ioana Boarescu, Raluca Maria Pop, Paul-Mihai Boarescu, Ioana Corina Bocsan, Dan Gheban, Ruxandra-Mioara Rajnoveanu, Armand Rajnoveanu, Adriana Elena Bulboaca, Anca Dana Buzoianu, Sorana D. Bolboaca
Summary: This study confirmed the significant anti-inflammatory and analgesic effects of conventional curcumin and curcumin nanoparticles combined with diclofenac sodium in acute inflammation. The combination treatment effectively reduced pain, improved mechanical pressure and heat thresholds, and decreased levels of inflammatory cytokines and histological changes. Overall, the combination of curcumin nanoparticles with diclofenac sodium showed the best results in reducing inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Joao de Sousa Valente, Khadija M. Alawi, Sabah Bharde, Ali A. Zarban, Xenia Kodji, Dibesh Thapa, Fulye Argunhan, Brentton Barrett, Istvan Nagy, Susan D. Brain
Summary: The study found that Englerin A has anti-inflammatory and analgesic effects via the TRPC4/5 pathway in the carrageenan model. It inhibited thermal hyperalgesia and mechanical allodynia, reduced paw oedema, and induced cobalt uptake in DRG neurons. Furthermore, Englerin A showed TRPC4/5-independent effects in vivo, indicating further research is needed to understand its mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Zhe Ma, Lin Peng, Wenhui Chu, Pan Wang, Yongqian Fu
Summary: In this study, it was found that osthole has a protective effect against D-galactose-induced liver injury through the TLR4/MAPK/NF-kappa B pathway. These findings suggest that osthole could be developed as a candidate bioactive component for functional food.
Article
Physiology
Qing Dai, Deqiong Xie, Chenli Zhang, Lei Zhu, Ying Xu, Kui Li, Wen Hao, Hefei Yin
Summary: Renal ischemia-reperfusion (IR) injury is a major cause of kidney injury, and its clinical treatment is challenging. Research has shown that osthole can protect the kidneys by inhibiting inflammatory responses and reducing cell apoptosis. This protective effect has drawn significant attention in recent years.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Chemistry, Applied
Juanjuan Guo, Xuke Shang, Peilin Chen, Xiaozhou Huang
Summary: This review discusses the pathogenesis of carrageenan-induced colitis, highlighting two pathways: carrageenan alters the composition of intestinal microbiota, leading to an inflammatory immune response, and carrageenan directly activates the NF-kappa B inflammatory pathway through contact with receptors on epithelial cells. The findings provide guidance for exploring the treatment of carrageenan-induced colitis and emphasize the importance of safe processing and utilization of carrageenan in the food industry.
CARBOHYDRATE POLYMERS
(2023)
Article
Integrative & Complementary Medicine
Lusi Putri Dwita, Ni Putu Ermi Hikmawanti, Yeni, Supandi
Summary: The study found that Kaempferia galanga exhibited significant anti-inflammatory activity in both the granuloma air pouch and pleurisy models, showing potential for inhibiting LOX and reducing LTB4 levels.
JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE
(2021)
Article
Immunology
Mohammad Saleem, Muhammad Asif, Anum Parveen, Hafiza Sidra Yaseen, Malik Saadullah, Asiya Bashir, Jawaria Asif, Mehwish Arif, Ikram Ullah Khan, Rizwan Ullah Khan
Summary: Melilotus indicus demonstrates potential anti-inflammatory and anti-angiogenic properties, showing significant inhibition in acute and chronic inflammation models and downregulation of TNF-alpha levels in serum samples.
INFLAMMOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Tayyba Saher, Rizwana Manzoor, Khizar Abbas, Jahanzeb Mudassir, M. Asif Wazir, Ejaz Ali, Faheem Ahmad Siddique, Akhtar Rasul, Muhammad Imran Qadir, Ambreen Aleem, Naeem Qaiser, Adeel Usman, Muhammad Romman, Muhammad Sajid Ali
Summary: The present study evaluated the analgesic and anti-inflammatory potential of a polyherbal extract and its hydrogel formulation. The results showed significant effects and good appearance and stability.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)