Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 22, Issue 1, Pages 51-58Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2014.06.009
Keywords
Dieckol; HO-1; Inflammation; Murine macrophages
Categories
Ask authors/readers for more resources
Eisenia bicyclis is edible brown algae recognized as a rich source of bioactive derivatives mainly phlorotannins reported for their anti-oxidant properties. Of all phlorotannins identified so far, dieckol has shown the most potent effect in anti-inflammatory, radical scavenging and neuroprotective functions. However, whether dieckol up-regulates hemeoxygenase 1 (HO-1) and this mediates its anti-inflammatory effect in murine macrophages remains poorly understood. Dieckol (12.5-50 mu M) inhibited nitric oxide production and attenuated inducible nitric oxide synthase, phospho (p)-PI-3 K, p-Akt, p-IKK-alpha/beta, p-I kappa B-alpha and nuclear p-NF-kappa Bp65 protein expressions, and NF-kappa B transcriptional activity in LPS (0.1 mu g/ml) stimulated murine macrophages. On the other hand, dieckol up-regulated HO-1 which partly mediated its anti-inflammatory effect in murine macrophages. Thus, dieckol appeared to be a potential therapeutic agent against inflammation through HO-1 up-regulation. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available