Review
Medicine, Research & Experimental
Runze Liu, Song Qin, Wenjun Li
Summary: This review systematically summarizes the applications of phycocyanin in treating inflammatory diseases in the lung, liver, cardiovascular, and cerebrovascular systems. It also discusses the anti-inflammatory mechanisms of phycocyanin and proposes phycocyanobilin as a potential anti-inflammatory agent.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Sevinj Sultanli, Soni Ghumnani, Richa Ashma, Katharina F. Kubatzky
Summary: The effects of plumbagin on osteoclast formation can either trigger or inhibit depending on the model system used.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Yaping Zhou, Zuomin Hu, Fan Ye, Tianyi Guo, Yi Luo, Wenshen Zhou, Dandan Qin, Yiping Tang, Fuliang Cao, Feijun Luo, Qinlu Lin
Summary: MGV supplementation improved the health status of mice by inhibiting the expression of inflammatory factors in colonic tissues and reducing pro-inflammatory cytokines in cells. It exerts an anti-inflammatory effect by triggering the AMPK-PI3K/Akt/mTOR pathway in LPS-induced inflammation models.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Multidisciplinary Sciences
Eun-Young Lee, Su-Man Kim, Jung Hwan Hwang, Song Yee Jang, Shinhye Park, Sanghyeon Choi, Ga Seul Lee, Jungwon Hwang, Jeong Hee Moon, Paul L. Fox, Sunghoon Kim, Chul-Ho Lee, Myung Hee Kim
Summary: This study reveals the critical role of EPRS1 in coordinating AKT signaling for anti-inflammatory responses, shedding light on potential therapeutic targets for inflammatory diseases.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Stefan W. Ryter
Summary: The heme oxygenase-1 (HO-1) enzyme and its reaction products have beneficial effects in human diseases, including cardiovascular disease, metabolic conditions, and acute and chronic diseases of the liver, kidney, or lung. Modulating the HO-1 pathway, such as regulating HO-1 expression or using reaction products, has therapeutic potential in inflammatory conditions.
Article
Cell Biology
Eva Fige, Judi Szendrei, Laszlo Sos, Izabela Kraszewska, Laszlo Potor, Jozsef Balla, Zsuzsa Szondy
Summary: HO-1 plays a crucial role in the engulfment of heme-containing cells and is essential for regulating internal signaling pathways and anti-inflammatory responses during efferocytosis. The uptake of apoptotic cells and eryptotic red blood cells may involve different mechanisms, but both pathways are controlled by HO-1.
Article
Multidisciplinary Sciences
Johannes J. Kovarik, Andrea Bileck, Gerhard Hagn, Samuel M. Meier-Menches, Tobias Frey, Anna Kaempf, Marlene Hollenstein, Tarik Shoumariyeh, Lukas Skos, Birgit Reiter, Marlene C. Gerner, Andreas Spannbauer, Ena Hasimbegovic, Doreen Schmidl, Gerhard Garhofer, Mariann Gyongyosi, Klaus G. Schmetterer, Christopher Gerner
Summary: In order to understand the pathophysiology of long COVID-19 syndrome (LCS), an exploratory study was conducted using blood plasma samples from three groups: healthy vaccinated individuals without SARS-CoV-2 exposure, asymptomatic recovered patients at least three months after SARS-CoV-2 infection, and symptomatic patients at least three months after SARS-CoV-2 infection with LCS. The study found that recovered individuals had slightly elevated pro-inflammatory cytokine levels compared to patients with LCS. Additionally, LCS patients showed low levels of acute phase proteins and macrophage-derived secreted proteins, but high levels of anti-inflammatory oxylipins and osmolytes. The study proposes that alternatively polarized macrophages may be a major contributor to these molecular alterations.
Article
Engineering, Biomedical
Chaowang Huang, Qianyi You, Jing Xu, Di Wu, Huaping Chen, Yuhang Guo, Jiancheng Xu, Mingdong Hu, Hang Qian
Summary: This study proposes and demonstrates an anti-inflammatory dual therapy strategy that uses self-assembled DNA nanostructures as nontoxic, programmable delivery vehicles, achieving anti-inflammatory effects by regulating macrophage polarization and promoting macrophage autophagy.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Plant Sciences
Ting-Ting Chang, Yi-An Chen, Szu-Yuan Li, Jaw-Wen Chen
Summary: The study showed that Ginkgo biloba extract (GbE) prevented diabetic nephropathy (DN) by activating heme oxygenase (HO)-1, improving renal function, decreasing glomerular hypertrophy, proteinuria, and kidney/body weight ratio, reducing inflammatory factors in the glomeruli, and protecting podocytes against the effects of high glucose.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wangsheng Jiang, Wenfeng Ruan, Zhengqiang Wang
Summary: This study found that Dendrobium officinale polysaccharide (DOP) can alleviate vascular calcification in patients with chronic kidney disease (CKD) by suppressing inflammation and apoptosis through the activation of heme oxygenase-1 (HMOX-1). These results provide a promising treatment approach for vascular calcification in CKD.
Article
Biochemistry & Molecular Biology
Guennadi Kozlov, Sandy Mattijssen, Jianning Jiang, Samuel Nyandwi, Tara Sprules, James R. Iben, Steven L. Coon, Sergei Gaidamakov, Anne M. Noronha, Christopher J. Wilds, Richard J. Maraia, Kalle Gehring
Summary: In this study, the La-module of LARP1 was characterized, and it was found that unlike other LARPs, the La-module of LARP1 does not contain an RRM domain. The La-module alone is capable of binding poly(A) RNA with high specificity for the RNA 3'-end. This study provides insights into the functional relevance of LARP1 RNA binding in cells.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Plant Sciences
Pengfei Tang, Qiurong Li, Shanting Liao, Shanshan Wei, Letian Cui, Wenjun Xu, Dongrong Zhu, Jun Luo, Lingyi Kong
Summary: Shizukaol A from Sarcandra glabra targets HMGB1 to regulate the Nrf2/HO-1 signaling pathway, showing promising anti-inflammatory effects and potential therapeutic applications for inflammatory diseases.
Article
Biochemistry & Molecular Biology
Ji Ae Lee, Young-Won Kwon, Hye Ri Kim, Nari Shin, Hyo Jin Son, Chan Seong Cheong, Dong Jin Kim, Onyou Hwang
Summary: KKC080096 upregulated HO-1, suppressed inflammatory factors, and regulated multiple signaling pathways, showing potential therapeutic effects on neuroinflammation-related diseases such as Parkinson's disease.
MOLECULES AND CELLS
(2022)
Article
Fisheries
Bo-Rong Peng, Ngoc Bao An Nguyen, Lo-Yun Chen, Mohamed El-Shazly, Tsong-Long Hwang, Jui-Hsin Su, Kuei-Hung Lai
Summary: Recent advancements in the discovery of natural products have led to the rapid identification of known compounds using advanced spectroscopic technologies. In a study focused on lead discovery from a sustainable medicinal source, a powerful method called MS/MS molecular networking (MN) was used to identify and prioritize novel compounds with unique MS/MS fragments. The study successfully isolated and characterized two novel compounds with anti-inflammatory properties from an aquaculture soft coral.
AQUACULTURE REPORTS
(2023)
Article
Chemistry, Medicinal
Lingling Dong, Hongling Du, Minyue Zhang, Haiting Xu, Xiulan Pu, Qiyan Chen, Ruifeng Luo, Yichen Hu, Yitao Wang, He Tu, Jinming Zhang, Fei Gao
Summary: The study showed that Rhein had therapeutic effects on ulcerative colitis by inhibiting the production of pro-inflammatory cytokines, alleviating UC-associated symptoms, and modulating the PI3K/Akt/mTOR signaling pathway and gut microbiota.
PHYTOTHERAPY RESEARCH
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)