Article
Biochemistry & Molecular Biology
Maria Auladell, Hoang Vu Mai Phuong, Le Thi Quynh Mai, Yeu-Yang Tseng, Louise Carolan, Sam Wilks, Pham Quang Thai, David Price, Nguyen Thanh Duong, Nguyen Le Khang Hang, Le Thi Thanh, Nguyen Thi Hong Thuong, Tran Thi Kieu Huong, Nguyen Thi Ngoc Diep, Vu Thi Ngoc Bich, Arseniy Khvorov, Luca Hensen, Tran Nhu Duong, Katherine Kedzierska, Dang Duc Anh, Heiman Wertheim, Scott D. Boyd, Kim L. Good-Jacobson, Derek Smith, Ian Barr, Sheena Sullivan, H. Rogier van Doorn, Annette Fox
Summary: Recent prior influenza A infection enhances antibody responses to subsequent influenza vaccination and broadens the reactivity to different strains. Immunological memory induced by prior infection plays an important role in vaccine responses.
Article
Immunology
Mikel J. Ruterbusch, Brian D. Hondowicz, Kennidy K. Takehara, Kurt B. Pruner, Thomas S. Griffith, Marion Pepper
Summary: CD4(+) lung-resident memory T cells generated in response to influenza infection can be altered by subsequent exposure to allergens, leading to changes in their function and impact on disease outcomes upon reinfection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Fabio Sallustio, Angela Picerno, Francesca Montenegro, Maria Teresa Cimmarusti, Vincenzo Di Leo, Loreto Gesualdo
Summary: The human virome, consisting of prokaryotes, viruses, fungi, and parasites, is intricately connected with the human host. Different viral community states have been identified as indicators of health or undesirable outcomes for the host. The virome can collaborate with the human host in maintaining mutualistic functions and preserving human health. This Review explores the role of viruses in health and disease, the relationship between the virobiota and immune system control, and the potential molecular mechanisms linking viruses to glomerulonephritis and IgA nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Kevin R. McCarthy, Tarra A. Von Holle, Laura L. Sutherland, Thomas H. Oguin, Gregory D. Sempowski, Stephen C. Harrison, M. Anthony Moody
Summary: Immune memory established by initial infection with influenza virus has a lasting imprint on later responses, which differ from those induced by early childhood immunization. A study comparing immune imprints from vaccination and infection in non-human primates found that initial exposure by infection led to strong but limited antibody responses, while initial vaccination elicited weaker but broader binding responses to different HA strains. This suggests that the mode of initial exposure affects the strength and breadth of the immune response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Immunology
Yuying Liang
Summary: Influenza viruses continuously evolve, giving rise to new variants and strains, and causing epidemics, zoonotic infections, and pandemics. The possibility of avian influenza viruses acquiring airborne transmission in humans through viral evolution is of great concern for the next pandemic. Severe influenza disease is caused by both direct viral cytopathic effects and host immune response against high viral loads. This review summarizes the viral determinants of influenza virulence and pathogenicity, the protective and immunopathogenic aspects of host immune responses, and the roles of host factors and cellular signaling pathways in antiviral and proviral functions. Understanding these molecular mechanisms is crucial for the development of preventive and therapeutic measures against influenza diseases.
Article
Cell Biology
Phillip A. Swanson, Marcelino Padilla, Wesley Hoyland, Kelly McGlinchey, Paul A. Fields, Sagida Bibi, Saul N. Faust, Adrian B. McDermott, Teresa Lambe, Andrew J. Pollard, Nicholas M. Durham, Elizabeth J. Kelly
Summary: AZD1222 vaccine induces effective T cell responses in adults of all age groups, mainly of T(H)1 type, covering the SARS-CoV-2 spike protein. Vaccination with AZD1222 promotes immune responses and demonstrates broad immunological protection coverage across age groups.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Microbiology
Song Wang, Ning Jiang, Wenhao Shi, Hang Yin, Xiaojuan Chi, Yanhui Xie, Jingyun Hu, Yanwei Zhang, Huangping Li, Ji-Long Chen
Summary: This study using a mouse model revealed that co-infection of H9N2 AIV and E. coli leads to more severe lung lesions and a cytokine storm, increasing harm to the host. Co-infection also increases pathogen loads and significantly enhances NOS2 expression, promoting rapid bacterial proliferation.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Nutrition & Dietetics
Kenji Gonda, Hideto Kanazawa, Goki Maeda, Chisa Matayoshi, Naoto Hirose, Yukiteru Katsumoto, Koji Kono, Seiichi Takenoshita
Summary: Regular consumption of Okinawan vegetables is associated with higher levels of immunoglobulins, potentially preventing influenza infections. In contrast, individuals who do not consume Okinawan vegetables have lower immunoglobulin levels and are more susceptible to influenza. Additionally, there is a positive correlation between immunoglobulins and soluble interleukin-2 receptor levels in both groups.
Article
Immunology
Ji Cheng Han, Qiu Xuan Li, Jin Bo Fang, Jin Yong Zhang, Yi Quan Li, Shan Zhi Li, Cheng Cheng, Chang Zhan Xie, Fu Long Nan, He Zhang, Zhuo Xin Li, Ning Yi Jin, Guang Ze Zhu, Hui Jun Lu
Summary: Norovirus is a zoonotic virus causing diarrhea in humans and animals, with the emergence of GII.P16-GII.2 recombinant genotype posing a potential pandemic threat. Immunization with VLPs induced specific cellular and humoral responses in mice, revealing the antigen presentation mechanism and providing insights for vaccine development.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Megan M. Dunagan, Kala Hardy, Toru Takimoto
Summary: The study found that the host shutoff protein NS1 of Influenza A virus plays a key role in suppressing host immune responses, leading to a reduction in the ability of the host to generate protective immunity against IAV infection.
Article
Immunology
Erin E. West, Nicolas S. Merle, Marcin M. Kaminski, Gustavo Palacios, Dhaneshwar Kumar, Luopin Wang, Jack A. Bibby, Kirsten Overdahl, Alan K. Jarmusch, Simon Freeley, Duck-Yeon Lee, J. Will Thompson, Zu-Xi Yu, Naomi Taylor, Marc Sitbon, Douglas R. Green, Andrea Bohrer, Katrin D. Mayer-Barber, Behdad Afzali, Majid Kazemian, Sabine Scholl-Buergi, Daniela Karall, Martina Huemer, Claudia Kemper
Summary: Induction of Arg1 expression in lung CD4+ T cells during mouse in vivo influenza infection accelerates the resolution of virus-specific Th1 effector responses, leading to efficient viral clearance and reduced lung pathology.
Article
Immunology
Jenna M. Kastenschmidt, Suhas Sureshchandra, Aarti Jain, Jenny E. Hernandez-Davies, Rafael de Assis, Zachary W. Wagoner, Andrew M. Sorn, Mahina Tabassum Mitul, Aviv I. Benchorin, Elizabeth Levendosky, Gurpreet Ahuja, Qiu Zhong, Douglas Trask, Jacob Boeckmann, Rie Nakajima, Algimantas Jasinskas, Naresha Saligrama, D. Huw Davies, Lisa E. Wagar
Summary: This study investigated the effects of different antigen formats on mucosal adaptive immune responses using a human tonsil organoid model. The results showed significant differences in the B and T cell responses elicited by different antigen formats, which led to changes in the corresponding antibody response. The ability of antigen formats to recruit naive and memory B and T cells to the response was identified as a major source of variability.
Article
Cell Biology
Bo Zhang, Shuai Xu, Minxuan Liu, Yanli Wei, Qian Wang, Wentao Shen, Cao-Qi Lei, Qiyun Zhu
Summary: Mitophagy, a type of autophagy, plays a crucial role in maintaining the stability of functional mitochondria in the cell. This study identified the nucleoprotein (NP) of H1N1 virus as a regulator of mitophagy. The NP-mediated mitophagy leads to the degradation of MAVS, a protein anchored to mitochondria, which then blocks antiviral signaling and promotes virus replication. The interaction between NP, MAVS, and the cargo receptor TOLLIP is required for the NP-mediated mitophagy. Furthermore, a specific mutation in NP significantly reduces virus-induced mitophagy and virus replication in vitro and in vivo. Overall, this study uncovers a novel mechanism in which the NP of influenza virus induces mitophagy to attenuate innate immunity.
Article
Immunology
Rhiannon R. Penkert, Nehali Patel, Richard J. Webby, Ted M. Ross, Julia L. Hurwitz
Summary: Research has shown that the timing of vaccination significantly impacts the immune response to influenza vaccines, as changes in host lifestyles and viral infection frequencies throughout different seasons can alter vaccine immunogenicity. Therefore, routine assessment of inoculation month in clinical studies is recommended to inform data interpretation and expedite successful vaccine development within and beyond the field of influenza virus.
Review
Immunology
Piyush Dey, Akanksha Ahuja, Jaishal Panwar, Poonam Choudhary, Shital Rani, Mandeep Kaur, Akanksha Sharma, Jatinder Kaur, Ashok Kumar Yadav, Vikas Sood, Adukamparai Suresh R. Babu, Sanjay K. Bhadada, Gurpal Singh, Ravi Pratap Barnwal
Summary: The avian influenza A virus (AIV) is a naturally prevalent virus in aquatic birds, which infects various avian species and can transmit to humans. Both the H5N1 and H7N9 viruses have the potential to cause acute influenza in humans and pose a possible pandemic threat. Understanding the disease pathogenesis and the host's immune response is crucial for the development of control and prevention strategies.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)