Article
Endocrinology & Metabolism
Guanlin Li, Wei Wei, Lingge Suo, Chun Zhang, Haiyan Yu, Hui Liu, Qing Guo, Xiumei Zhen, Yang Yu
Summary: The study demonstrated that aspirin treatment can effectively improve renal failure and pathological changes induced by preeclampsia, attenuating tubular injury and reducing kidney inflammation. It also suppresses renal cell apoptosis and oxidative stress. The mechanism involves inhibition of the WNT5A/NF-kappa B signaling pathway.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei Gao, Ying Zhang
Summary: Inflammation is crucial in the pathogenesis of acute lung injury, and lncRNA MINCR may exacerbate ALI/ARDS progression by inducing alveolar epithelial cell injury and inflammation through the miR-146b-5p and TRAF6/NF-κB pathways, serving as a potential therapeutic target.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ji Cao, Qian Li, Xuehuai Shen, Yao Yao, Longlong Li, Haitian Ma
Summary: DHEA suppresses inflammatory responses through the activation of Nrf2 and inhibition of NF-kappa B in LPS-stimulated macrophages.
MOLECULAR IMMUNOLOGY
(2021)
Article
Plant Sciences
Weiwei Zhu, Wu Luo, Jibo Han, Qiuyan Zhang, Lijun Ji, Aleksandr V. Samorodov, Valentin N. Pavlov, Zaishou Zhuang, Daona Yang, Lina Yin, Lijiang Huang, Guang Liang, Joo Young Huh, Yi Wang
Summary: This study investigated the anti-inflammatory mechanism of Schisandrin B (Sch B) in macrophages and an animal model of acute lung injury (ALI) and found that Sch B directly binds to MyD88 to regulate inflammatory responses and inhibit the expression of inflammatory factors. The study suggests that Sch B has therapeutic potential for ALI and other MyD88-dependent inflammatory diseases.
Article
Environmental Sciences
Xinwen Dong, Lvfei Deng, Yaguang Su, Xiaofeng Han, Sanqiao Yao, Weidong Wu, Jia Cao, Linqiang Tian, Yichun Bai, Guizhi Wang, Wenjie Ren
Summary: Gas explosions are a common cause of traumatic brain injury in coal miners. This study investigated the effects of curcumin on gas explosion-induced brain injury in rats. The results showed that curcumin treatment improved histological abnormalities, mitochondrial structure, and neuroinflammatory signaling molecules in the brain tissue. Curcumin also reshaped the gut microbiota and reduced serum lipopolysaccharide levels, showing potential therapeutic effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Medicinal
Qing Tu, Yabing Zhu, Yuan Yuan, Long Guo, Lu Liu, Liangfang Yao, Yun Zou, Jinbao Li, Feng Chen
Summary: The study demonstrated that GPs significantly alleviated lung injury in ALI mice by inhibiting NF-kappa B and TNF-alpha pathways, providing potential strategies for ALI prevention and therapy.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Qhaweni Dhlamini, Wei Wang, Guifeng Feng, Aiping Chen, Lei Chong, Xue Li, Quan Li, Jin Wu, Depu Zhou, Jie Wang, Hailin Zhang, Jin-San Zhang
Summary: This study demonstrates the protective effects of FGF1 pretreatment against acute lung injury (ALI) and its potential mechanisms involving anti-inflammatory and antioxidant effects.
MOLECULAR MEDICINE
(2022)
Article
Immunology
Qiao Zhou, Ding-Xiu He, Yi-Ling Deng, Chun-Li Wang, Lan-Lan Zhang, Fa-Ming Jiang, Laurent Irakoze, Zong-An Liang
Summary: This study found that miR-124-3p has a protective effect on acute lung injury (ALI) by inhibiting the TLR4/NF-kappa B signaling pathway, and miR-124-3p directly targets PDE4B to suppress this signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kiran Kumar Reddi, Hanxuan Li, Wei Li, Sarada D. Tetali
Summary: Berberine has been shown to possess therapeutic properties in various health conditions, including anti-inflammatory effects by inhibiting NF-kappa B translocation in activated monocytes. This suggests its potential for treating chronic inflammatory disorders.
Article
Biochemistry & Molecular Biology
Shih-Ming Ou, Yin-Chieh Hsu, Shu-Ling Fu, Lie-Chwen Lin, Chao-Hsiung Lin
Summary: Galgravin has anti-inflammatory effects, it can suppress NF-kappa B activation and reduce the expression of proinflammatory molecules, suggesting its potential application in inflammation diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Chemistry, Medicinal
Shan Han, Siyuan Li, Jilang Li, Jia He, Qin-Qin Wang, Xiang Gao, Shilin Yang, Jingjing Li, Renyikun Yuan, Guoyue Zhong, Hongwei Gao
Summary: Acute kidney injury (AKI) is a common clinical condition with high incidence and mortality rates. This study found that Hederasaponin C (HSC) has a protective effect against lipopolysaccharide (LPS)-induced renal inflammation by inhibiting the expression of TLR4 and the activation of NF-kappa B and PIP2 signaling pathways, as well as suppressing the activation of the NLRP3 inflammasome.
PHYTOTHERAPY RESEARCH
(2023)
Article
Immunology
SangJoon Mo, Eun Young Kim, Yi-Suk Kwon, Min Young Lee, Jin Chul Ahn
Summary: Inflammation is the body's response to harmful agents. Macrophages play a key role in this process and can modulate the immune response. Organic light-emitting diodes (OLEDs) show potential for treating inflammatory conditions by reducing morphological changes and inflammatory cytokine expression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jin-Fang Luo, Lan Yue, Tian-Tai Wu, Chen-Liang Zhao, Jiang-Hai Ye, Kang He, Juan Zou
Summary: The aim of this study was to identify the active components of Astilbe grandis and verify their pharmacological activity. A novel triterpenoid compound (astigranlactone) and a known coumarin compound (11-O-galloyl bergenin) were isolated from this plant. Both compounds exhibited anti-inflammatory effects by inhibiting the NF-kappa B signaling pathway.
Article
Immunology
Hongling Yin, Yajing Feng, Yi Duan, Shaolin Ma, Zhongliang Guo, Youzhen Wei
Summary: The study demonstrated that hydrogen gas protects against lipopolysaccharide-induced acute lung injury by reducing lung damage, inflammatory cytokine release, and oxidative stress. In vitro experiments also showed that hydrogen gas has a protective effect on macrophages by regulating the TLR4-NF-kappa B pathway.
JOURNAL OF INFLAMMATION-LONDON
(2022)
Article
Biotechnology & Applied Microbiology
Xin Li, Chao Pan, Zhicheng Liu, Peng Sun, Xiaoting Hua, Erling Feng, Yunsong Yu, Jun Wu, Li Zhu, Hengliang Wang
Summary: This study developed a conjugate vaccine against A. baumannii, demonstrating its ability to induce immune responses and provide protection against infection, ultimately proving its promising potential as a candidate vaccine.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Engineering, Environmental
Xinghang Liu, Zhicheng Liu, Debesh Devadutta Mishra, Zihe Chen, Jing Zhao, Chaoquan Hu
Summary: The solar-driven 3D wavy evaporator, combining carbon nanotubes and airlaid paper, achieves high evaporation rate and can continuously evaporate for 24 hours in natural environment without salt deposition.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Veterinary Sciences
Chaosi Li, Zhicheng Liu, Kai Chen, Jie Qian, Yulong Hu, Shuhe Fang, Zhi Sun, Chunhong Zhang, Lv Huang, Jianfeng Zhang, Nian Huang
Summary: This study evaluated the cross-protective efficacy of different PRRSV vaccines and found that the live-attenuated vaccine provides significant cross-protection against the NADC30-like strain, while the killed vaccine as a booster provides minimal additional protection.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Physical
Zhicheng Liu, Yingang Gui, Lingna Xu, Xianping Chen
Summary: In this study, the adsorption of SF6 decomposition products on transition metal modified WSe2 was explored. The results showed that while certain modified systems were sensitive to gases, the five modified systems studied were not suitable for gas-sensing equipment in relation to SF6 decomposition products. Other modified systems can be used to detect gases by measuring the change in conductivity after adsorption.
APPLIED SURFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Yingang Gui, Zhicheng Liu, Chang Ji, Lingna Xu, Xianping Chen
Summary: This study systematically investigated the adsorption behavior of CuO-GeSe, NiO-GeSe, and Ag2O-GeSe towards CO, CH4, C2H2, and C2H4 in transformer oil using DFT. The results provide insights into the interaction between modified monolayers and gases, and offer a theoretical basis for the application of gas sensors in DGA.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Immunology
Songqi Wang, Haiyan Shen, Qijie Lin, Jun Huang, Chunhong Zhang, Zhicheng Liu, Minhua Sun, Jianfeng Zhang, Ming Liao, Yugu Li, Jianmin Zhang
Summary: In this study, a new detection method for African swine fever virus (ASFV) was established using cleaved probe-based loop-mediated isothermal amplification (CP-LAMP). The method achieved specific identification and visual detection of ASFV with high sensitivity and rapidity. By combining smartphone quantitation and a self-designed 3D-printed visualization function cassette, the CP-LAMP assay became a user-friendly, cost-effective, portable, rapid, and accurate point-of-care testing (POCT) platform for ASFV.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Editorial Material
Chemistry, Multidisciplinary
Renyang Zheng, Zhicheng Liu, Zaiku Xie
Summary: This article introduces three Chinese scientists with rich research experience. They have unique research interests in the fields of industrial catalysis and metal catalysis, C1 chemistry catalysis and CO2 utilization, as well as industrial catalysis and zeolite catalysis.
Article
Engineering, Multidisciplinary
Tao Zhang, Zhi-Cheng Liu, Ying-Chun Ye, Yu Wang, He-Qin Yang, Huan-Xin Gao, Wei -Min Yang
Summary: This study reveals the strong metal-support interaction (SMSI) effect on FeNi/Al-Ce-O catalysts, where the introduction of Al significantly improves the catalytic performance for dry reforming of ethane (DRE). The optimal DRE performance is achieved with a 50% Al content in the catalyst.
Article
Chemistry, Physical
Zhicheng Liu, Yingang Gui, Lingna Xu, Xianping Chen
Summary: In this study, density functional theory calculations were used to investigate the adsorption of toxic gases (NH3, NO2, and SO2) on Aun (n = 1-3) doped MoTe2 monolayer. The results showed that the conductivity of MoTe2 monolayer was improved after doping Au atoms. The adsorption capacity of Aun-MoTe2 for these gases was significantly improved compared to pristine MoTe2. These findings provide a theoretical basis for the preparation of gas sensors based on Aun-MoTe2 for industrial toxic gases detection.
SURFACES AND INTERFACES
(2022)
Article
Chemistry, Physical
Jialei Li, Zhicheng Liu, Weihua Chang, Bin Pei, Shuai Ning, Ruizeng Liu
Summary: This study aimed to investigate the adverse effects of humic substances on molybdenite flotation and propose a feasible method to eliminate these effects. The results showed that humic substances in process water can reduce the flotation recovery of molybdenite by adsorbing onto its surface. Pre-removal of humic substances using polyferric sulfate (PFS) coagulation was found to effectively eliminate their adverse effects and improve the flotation recovery of molybdenite. The study highlights the importance of achieving a high removal rate of humic substances in order to enhance the flotation recovery of molybdenite.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Microbiology
Haiyan He, Xuelei Fan, Haiyan Shen, Hongchao Gou, Chunhong Zhang, Zhicheng Liu, Bin Zhang, Nile Wuri, Jianfeng Zhang, Ming Liao, Letu Geri
Summary: In this study, it was found that butyrate has antiviral effects in porcine intestinal epithelial cells by inducing GPR43-mediated interferon production.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Wei He, Tao Li, Bixin Mou, Yuxue Lei, Jinhui Song, Zhicheng Liu
Summary: This study investigated the petrology and lithofacies of the shale samples from the Wufeng Formation-Member 1 of the Longmaxi Formation in the Xichang Basin. It identified nine lithofacies and determined the lithofacies that are favorable for shale gas accumulation. This study is important for the exploration and development evaluation of shale gas.
Article
Veterinary Sciences
Nile Wuri, Hongchao Gou, Bin Zhang, Menglu Wang, Songqi Wang, Weixiao Zhang, Haiyan He, Xuelei Fan, Chunhong Zhang, Zhicheng Liu, Letu Geri, Haiyan Shen, Jianfeng Zhang
Summary: Porcine epidemic diarrhea virus (PEDV) is a deadly pathogen causing significant economic losses in pig herds worldwide. This study reveals the key role of glucose, glutamine, and lactate in PEDV replication, independent of genotype and MOI. The findings suggest lactate as a promising cell culture additive to improve vaccine production and develop novel antiviral strategies.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Xiaoliang Liu, Chuanming Wang, Jian Zhou, Chang Liu, Zhicheng Liu, Jing Shi, Yangdong Wang, Jiawei Teng, Zaiku Xie
Summary: Increasing social sustainability contributes to the advancement of industrial catalysis through the use of zeolite catalysts. However, the diffusion regulations within the pores and channels of zeolites are often overlooked. Understanding the structure-transport-reactivity relationships can provide guidelines for designing high-performance catalysts.
CHEMICAL SOCIETY REVIEWS
(2022)
Article
Immunology
Peng Sun, Xin Li, Chao Pan, Zhicheng Liu, Jun Wu, Hengliang Wang, Li Zhu
Summary: This study demonstrates that the trimeric autotransporter protein Ata(α) of Acinetobacter baumannii is a promising vaccine target for A. baumannii infections. The fusion protein CTB-Ata(α) induces immune responses, reduces bacterial loads, and provides broad protection in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
