Article
Pharmacology & Pharmacy
Irfan A. Rather, Mohammad Younus Wani, Majid Rasool Kamli, Jamal S. M. Sabir, Khalid Rehman Hakeem, Ahmad Firoz, Yong-Ha Park, Yan-Yan Hor
Summary: This study demonstrates the anti-biofilm and anti-virulence properties of Lactiplantibacillus plantarum KAU007 against Streptococcus pyogenes. The results show that Lactiplantibacillus plantarum KAU007 inhibits the growth and survival of S. pyogenes, as well as the formation of biofilm and the production of virulence-associated factors. This research provides a basis for further investigation into the use of Lactiplantibacillus plantarum KAU007 as an antibacterial agent to combat streptococcal infections.
Review
Medicine, General & Internal
Kamran Ghoreschi, Anna Balato, Charlotta Enerback, Robert Sabat
Summary: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population, characterized by sharply demarcated erythematous and scaly skin lesions. The disease results from hyperproliferation and disturbed differentiation of epidermal keratinocytes provoked by immune mediators of the IL-23 and IL-17 pathway. Therapeutics targeting IL-23, IL-17, and IL-17RA have shown excellent efficacy in treating psoriasis.
Article
Nutrition & Dietetics
Xinyan Huang, Jianhang Bao, Yan Zeng, Gina Meng, Xingyi Lu, Tong Tong Wu, Yanfang Ren, Jin Xiao
Summary: Ecological approaches can correct oral microbial dysbiosis and promote symbiotic oral microbiome for long-term dental caries control. The study found that prebiotics Galacto-oligosaccharide (GOS) inhibited the growth of Streptococcus mutans and Candida albicans and enhanced the anti-fungal performance of L. plantarum. GOS also resulted in a less acidic environment and reduced expression of virulence genes in S. mutans and C. albicans.
Article
Immunology
Yan Zeng, Ahmed Fadaak, Nora Alomeir, Tong Tong Wu, Elena Rustchenko, Shuang Qing, Jianhang Bao, Christie Gilbert, Jin Xiao
Summary: This study assessed the effects of four probiotic Lactobacillus strains on cariogenic bacteria-fungi biofilm formation and their interactions. Lactobacillus plantarum demonstrated superior inhibition on the growth of Candida albicans and Streptococcus mutans, disrupted virulent biofilm formation, and downregulated genes involved in metabolic pathways and antifungal resistance. These findings support further evaluation of L. plantarum for controlling cariogenic biofilms.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Matteo Vecellio, Vivien Xanath Hake, Connor Davidson, Maria Cristina Carena, B. Paul Wordsworth, Carlo Selmi
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis, with genetic predisposition playing a key role in its development. The IL-23/IL-17 axis is highlighted as important in the immunopathogenesis of PsA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino
Summary: IL-23 is a pro-inflammatory cytokine composed of two subunits and has a key role in protective immune response, but dysregulation can exacerbate chronic immune-mediated inflammation. Activation of the IL-23/IL-17 axis contributes to the development of various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Charlie Bridgewood, Darren Newton, Nicola Bragazzi, Miriam Wittmann, Dennis McGonagle
Summary: The IL-23/IL-17 cytokine axis is associated with spondyloarthropathy (SpA) pattern diseases that target the skin, eye, gut and joints, sharing some common characteristics with Th2 type or allergic diseases but also exhibiting distinct features. These findings suggest a dynamic Th2 and Th17 cytokine counter regulation in vivo in humans.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Allergy
Hao Li, George C. Tsokos
Summary: Inflammatory rheumatic disorders involve the immune system attacking connective tissues and internal organs. Advances in understanding the cellular and molecular mechanisms have led to targeting the IL-23/IL-17 axis therapeutically, resulting in clinical benefits. The complicated interrelationship between IL-23 and IL-17 may be uncoupled in certain disease settings.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Article
Microbiology
Hiroyuki Iuchi, Junichiro Ohori, Hisahiro Matsuzaki, Takeshi Tokushige, Sakiko Toge, Masaru Yamashita
Summary: This study investigates the role of phosphorylcholine (PC) in cell adhesion and invasion of Streptococcus pyogenes (S. pyogenes). The results show a negative correlation between PC expression level and bacterial adherence and invasion in S. pyogenes.
Review
Immunology
Angela Ceribelli, Francesca Motta, Matteo Vecellio, Natasa Isailovic, Francesco Ciccia, Carlo Selmi
Summary: Spondyloarthritis (SpA) is a group of inflammatory musculoskeletal diseases with common genetic backgrounds, and IL-17 and IL-23 have been identified as key cytokines in its pathogenesis. Treatment options for axial SpA differ significantly from peripheral arthritis, with new therapies targeting these cytokines showing promising results for both axial psoriatic arthritis and ankylosing spondylitis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jingheng Liang, Yan Zhou, Guihua Tang, Ruixue Wu, Huancai Lin
Summary: This study found that the cell-free supernatant of Lactobacillus plantarum has a strong antibiofilm effect on Streptococcus mutans, and the main antibiofilm substance is a mixture of lactic acid and valine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yu-Huei Huang, Lun-Ching Chang, Ya-Ching Chang, Wen-Hung Chung, Shun-Fa Yang, Shih-Chi Su
Summary: Alterations in gut microbiota composition and microbial-encoded metabolic pathways were observed in patients with psoriasis, and the impact of biologics on shaping gut microbiota was explored in this study. The results showed that the gut microbial compositions changed during the treatment period, and the relative abundance of individual taxa differed between patients receiving different inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Jia Sha, Jiajia Song, Yechuan Huang, Yuhong Zhang, Hongwei Wang, Yu Zhang, Huayi Suo
Summary: This study investigated the inhibitory effect and mechanism of 12 LAB strains isolated from Chinese fermented foods on dipeptidyl peptidase-4 (DPP-4) using the Caco-2 cell model. The results showed that the inhibitory effect of cell-free extracts (CFEs) collected from each LAB strain on DPP-4 was higher than that of the cell-free excretory supernatants. The CFEs from Lactobacillus plantarum YE4 (YE4-CFE) exhibited the strongest DPP-4 inhibitory activity (24.33% inhibition). Furthermore, YE4-CFE altered the TNF and MAPK signaling pathways, and the high proportion of adenine, acetylcholine, and L-phenylalanine in YE4-CFE contributed to its inhibitory effect on DPP-4.
Article
Biochemistry & Molecular Biology
Marija Stankovic, Katarina Veljovic, Nikola Popovic, Snezana Kojic, Sofija Dunjic Manevski, Dragica Radojkovic, Natasa Golic
Summary: Bronchial epithelial cells are exposed to environmental influences, microbiota, and pathogens and initiate inflammation. Recent studies have found that lung microbiota differ between inflammatory lung diseases and healthy lungs, indicating their contribution to lung immunity. This study investigated the anti-inflammatory effects of 21 natural LAB strains in LPS-stimulated human bronchial epithelial cells (BEAS-2B). The results showed that several LAB strains reduced the expression of pro-inflammatory cytokine and chemokine genes. Two LAB strains, Lactobacillus brevis BGZLS10-17 and Lb. plantarum BGPKM22, effectively attenuated LPS-induced NF-kappa B nuclear translocation and the activation of p38, ERK, and JNK signaling cascade, resulting in a reduction of pro-inflammatory mediator expressions in BEAS-2B cells. These LAB strains could be used to balance immune response in lungs and replenish diminished lung microbiota in chronic lung diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Pin Chen, Xiaoqian Chen, Wei Yu, Bo Zhou, Lihua Liu, Yuzhuo Yang, Peng Du, Libo Liu, Chun Li
Summary: This experiment investigated the effects of the antibiotic Ciprofloxacin on key enzymes and intracellular metabolites of Lactobacillus plantarum DNZ-4. The results showed that Ciprofloxacin significantly decreased the activity of certain enzymes and caused changes in intracellular fatty acids, carbohydrates, and amino acids. These findings are important for the development of effective probiotics preparation products.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Review
Medicine, Research & Experimental
Dardo Menditti, Luigi Laino, Marina Di Domenico, Giuseppe Troiano, Mario Guglielmotti, Sara Sava, Antonio Mezzogiorno, Alfonso Baldi
Article
Cell Biology
Marina Di Domenico, Daniela Pozzi, Sara Palchetti, Luca Digiacomo, Rosamaria Iorio, Carlo Astarita, Alfonso Fiorelli, Matteo Pierdiluca, Mario Santini, Marcella Barbarino, Antonio Giordano, Angelina Di Carlo, Luigi Frati, Morteza Mahmoudi, Giulio Caracciolo
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Serena Ricci, Federica Pinto, Adelaide Auletta, Antonio Giordano, Alfonso Giovane, Giuliana Settembre, Mariarosaria Boccellino, Silvia Boffo, Angelina Di Carlo, Marina Di Domenico
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Physics, Applied
Massimiliano Papi, Valentina Palmieri, Sara Palchetti, Daniela Pozzi, Luca Digiacomo, Elia Guadagno, Marialaura del Basso De Caro, Marina Di Domenico, Serena Ricci, Roberto Pani, Morteza Mahmoudi, Angelina Di Carlo, Giulio Caracciolo
APPLIED PHYSICS LETTERS
(2019)
Article
Cell Biology
Mariarosaria Boccellino, Federica Pinto, Vincenzo Ieluzzi, Alfonso Giovane, Lucio Quagliuolo, Chiara Fariello, Mario Coppola, Annalisa Carlucci, Mario Santini, Kenan Ferati, Arberesha Bexheti-Ferati, Antonio Giordano, Marina Di Domenico
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Review
Endocrinology & Metabolism
Marina Di Domenico, Federica Pinto, Lucio Quagliuolo, Maria Contaldo, Giuliana Settembre, Antonio Romano, Mario Coppola, Kenan Ferati, Arbereska Bexheti-Ferati, Antonella Sciarra, Giovanni Francesco Nicoletti, Giuseppe Andrea Ferraro, Mariarosaria Boccellino
FRONTIERS IN ENDOCRINOLOGY
(2019)
Editorial Material
Oncology
Alfonso Fiorelli, Fabiana Vitiello, Floriana Morgillo, Mario Santagata, Chiara Spuntarelli, Marina Di Domenico, Mario Santini, Andrea Bianco
TRANSLATIONAL CANCER RESEARCH
(2019)
Review
Dentistry, Oral Surgery & Medicine
M. Contaldo, V Luzzi, G. Ierardo, E. Raimondo, M. Boccellino, K. Ferati, A. Bexheti-Ferati, F. Inchingolo, M. Di Domenico, R. Serpico, A. Polimeni, M. Bossu
JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY
(2020)
Article
Endocrinology & Metabolism
Ciro Gargiulo Isacco, Andrea Ballini, Danila De Vito, Kieu Cao Diem Nguyen, Stefania Cantore, Lucrezia Bottalico, Lucio Quagliuolo, Mariarosaria Boccellino, Marina Di Domenico, Luigi Santacroce, Roberto Arrigoni, Gianna Dipalma, Francesco Inchingolo
Summary: The current treatment and prevention procedures of oral disorders focus on maintaining oral bacteria and hygiene levels separately from systemic microbial homeostasis, which may impact the diagnosis and progression of complex systemic diseases. Imbalance in oral and gut microbiota can lead to various diseases, highlighting the need for a novel philosophical approach in the treatment of oral diseases that considers the interconnectedness of oral and systemic health.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Review
Cell & Tissue Engineering
Ioannis Alexandros Charitos, Andrea Ballini, Stefania Cantore, Mariarosaria Boccellino, Marina Di Domenico, Elisa Borsani, Riccardo Nocini, Michele Di Cosola, Luigi Santacroce, Lucrezia Bottalico
Summary: Stem cells have potential applications in replacing damaged cells and regenerating organs, but their use is limited by issues such as tumor growth in animal models, rejection in transplant cases, and ethical and social concerns related to the use of embryonic cells. There is ongoing debate and research on the ethical implications and religious perspectives surrounding the use of stem cells, highlighting the diverse viewpoints and challenges in this field.
STEM CELLS INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Antonio Vitiello, Francesco Ferrara, Amogh M. Auti, Marina Di Domenico, Mariarosaria Boccellino
Summary: This review provides an overview of the molecular profile, epidemiology, transmissibility, impact on vaccines, and pharmacological agents related to the Omicron variant of SARS-CoV-2. Omicron has multiple mutations, including changes in the spike protein, which contribute to its high transmissibility and potential immune escape. Current vaccination provides limited protection against Omicron, while booster doses offer significant protection against mild illness. New oral antiviral agents are emerging as important alternatives for treatment. Further research is needed to determine the infectiousness of Omicron and the effectiveness of available vaccines, monoclonal antibodies, and antiviral drugs.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Elisa Borsani, Andrea Ballini, Barbara Buffoli, Lorenzo Lo Muzio, Marina Di Domenico, Mariarosaria Boccellino, Salvatore Scacco, Riccardo Nocini, Vittorio Dibello, Rita Rezzani, Stefania Cantore, Luigi Fabrizio Rodella, Michele Di Cosola
Summary: This study investigated alterations in the nitroxidergic system at the brainstem level and the role of peripheral P2 purinergic receptors in pediatric inflammatory orofacial pain. The results suggest a relationship between orofacial pain and the nitroxidergic system in the spinal trigeminal nucleus, as well as a role for peripheral P2 receptors in pain transmission.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Cardiac & Cardiovascular Systems
Francesco Ippoliti, Fernando Piscioneri, Patrizio Sartini, Mariangela Peruzzi, Marina Di Domenico, David Dannhauser, Domenico Rossi, Filippo Causa, Paolo Antonio Netti, Fabio Miraldi, Ernesto Greco, Antonino Marullo, Alessandra Iaccarino, Elena Cavarretta, Giuseppe Biondi Zoccai, Sebastiano Sciarretta, Giacomo Frati
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2019)
Article
Pharmacology & Pharmacy
M. Boccellino, D. Di Stasio, G. Dipalma, S. Cantore, P. Ambrosio, M. Coppola, L. Quagliuolo, A. Scarano, G. Malcangi, E. Borsani, B. Rinaldi, M. Nuzzolese, E. Xhajanka, A. Ballini, F. Inchingolo, M. Di Domenico
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2019)
Article
Chemistry, Physical
Giulio Caracciolo, Reihaneh Safavi-Sohi, Reza Malekzadeh, Hossein Poustchi, Mahdi Vasighi, Riccardo Zenezini Chiozzi, Anna Laura Capriotti, Aldo Lagana, Mohammad Hajipour, Marina Di Domenico, Angelina Di Carlo, Damiano Caputo, Haniyeh Aghaverdi, Massimiliano Papi, Valentina Palmieri, Angela Santoni, Sara Palchetti, Luca Digiacomo, Daniela Pozzi, Kenneth S. Suslick, Morteza Mahmoudi
NANOSCALE HORIZONS
(2019)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)