Article
Immunology
Riguo Lan, Zhixin Wan, Yuanyuan Xu, Zhenglei Wang, Shaodong Fu, Yuanyuan Zhou, Xinguang Lin, Xiangan Han, Zhenhua Luo, Jinfeng Miao, Yulong Yin
Summary: Streptococcus uberis is an important pathogen causing mastitis, and metabolic reprogramming during host immune responses is associated with infection-driven inflammation. The use of taurine can restore metabolic homeostasis and alleviate inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhenglei Wang, Riguo Lan, Yuanyuan Xu, Jiakun Zuo, Xiangan Han, Vanhnaseng Phouthapane, Zhenhua Luo, Jinfeng Miao
Summary: Taurine enhances PTEN activity, inhibits Akt/mTOR signaling, and activates autophagy to degrade intracellular S. uberis, reducing bacterial load, inhibiting over-activation of the NF-kappa B pathway, and alleviating inflammation and damage caused by S. uberis infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhixin Wan, Riguo Lan, Yilin Zhou, Yuanyuan Xu, Zhenglei Wang, Zhenhua Luo, Jinfeng Miao
Summary: In bacterial mastitis, lipid metabolism leads to the synthesis of fatty acids and production of lipid droplets, while taurine can reduce fatty acid synthesis, the abundance of lipid droplets, and the in vitro bacterial load. These changes are mediated, at least partly, by the E3 ubiquitin ligase IDOL associated with the degradation of low-density lipoprotein receptors (LDLRs).
INFECTION AND IMMUNITY
(2021)
Article
Immunology
Ming Li, Zhenglei Wang, Shaodong Fu, Naiyan Sun, Weizhen Li, Yuanyuan Xu, Xiangan Han, Jinqiu Zhang, Jinfeng Miao
Summary: Taurine plays a protective role in mastitis by modulating the immune network, inhibiting inflammation and oxidative damage to alleviate the damage caused by inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Anna Dobrut, Dagmara Wojcik-Grzybek, Agata Mlodzinska, Dorota Pietras-Ozga, Katarzyna Michalak, Aleksander Tabacki, Urszula Mroczkowska, Monika Brzychczy-Wloch
Summary: This study aimed to detect immunoreactive proteins related to bovine mastitis through in silico and in vitro methods. Thirteen proteins were identified, which showed immunoreactivity to antibodies present in serum from cows with diagnosed mastitis. These proteins have the potential to be used as targets in rapid immunodiagnostic assays for bovine mastitis, but further research is needed due to the limited sample size.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Virginia E. Sherwin, Martin J. Green, James A. Leigh, Sharon A. Egan
Summary: Streptococcus uberis is a major causative agent of bovine mastitis worldwide. The prevalence of S. uberis in feces and factors affecting gastrointestinal carriage were investigated in two longitudinal studies. Seasonality and management conditions were found to significantly influence the detection of S. uberis.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Veterinary Sciences
Virginia E. Sherwin, Sharon A. Egan, Martin J. Green, James A. Leigh
Summary: This study demonstrates the importance of bedding type and management on the environmental survival of S. uberis. Bacteria can survive and replicate on bedding materials such as straw and sand for at least 35 days, but not beyond 7 days on sawdust. The addition of feces and urine on used bedding materials promotes the replication of S. uberis.
VETERINARY JOURNAL
(2021)
Article
Immunology
Ming Li, Zhenglei Wang, Yawei Qiu, Shaodong Fu, Yuanyuan Xu, Xiangan Han, Vanhnaseng Phouthapane, Jinfeng Miao
Summary: Taurine was found to protect mammary health under S. uberis infection by reducing inflammatory responses and maintaining the integrity of the blood-milk barrier.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Veterinary Sciences
Zhixin Wan, Shaodong Fu, Zhenglei Wang, Yuanyuan Xu, Yuanyuan Zhou, Xinguang Lin, Riguo Lan, Xiangan Han, Zhenhua Luo, Jinfeng Miao
Summary: Foamy macrophages with lipid droplets play a role in the immune response to Streptococcus uberis-induced mastitis. The fatty acid synthesis pathway is enhanced during infection, leading to increased levels of lipid droplets and an intensified inflammatory response. This process is mediated by FABP4, a subtype of the fatty acid-binding protein family, and gene silencing of FABP4 decreases lipid droplet deposition and reduces inflammatory cytokine expression.
VETERINARY RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Larissa Martins, Juliano L. Goncalves, Renata F. Leite, Tiago Tomazi, Vera L. M. Rall, Marcos Santos
Summary: This study aimed to evaluate the association between antimicrobial use and antimicrobial resistance in relation to Streptococcus uberis causing clinical mastitis in dairy herds. The findings showed high resistance of Strep. uberis isolates to macrolides, tetracycline, and penicillin G, while lower resistance was observed for ceftiofur and enrofloxacin.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Immunology
Ming Li, Yabing Gao, Zhenglei Wang, Binfeng Wu, Jinqiu Zhang, Yuanyuan Xu, Xiangan Han, Vanhnaseng Phouthapane, Jinfeng Miao
Summary: This study investigated the molecular mechanisms of S. uberis-induced NETs formation and the regulatory role of taurine. The results showed that taurine can protect mammary epithelial cells and barriers from damage by reducing S. uberis-induced NETs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Jie Zang, Felix Peters, Yves Cambet, Eugenia Cifuentes-Pagano, Munira Mohamed Shishay Hissabu, Christopher M. Dustin, Lars Henrik Svensson, Martin Mariboe Olesen, Mathias Feldt Lomholt Poulsen, Stig Jacobsen, Pernille Sonderby Tuelung, Dilip Narayanan, Annette Eva Langkilde, Michael Gajhede, Patrick J. Pagano, Vincent Jaquet, Frederik Vilhardt, Anders Bach
Summary: In this study, we optimized and explored bivalent small-molecule drugs targeting the NOX2 subunit p47phox and identified compounds with high binding affinities and cellular activities, demonstrating the potential of p47phox as an effective small-molecule target. This has important implications for the research and development of therapeutic drugs for related diseases.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Veterinary Sciences
Jayedul Hassan, Md. Abdus Sattar Bag, Md. Wohab Ali, Ajran Kabir, M. Nazmul Hoque, Muhammad Maqsud Hossain, Md. Tanvir Rahman, Md. Shafiqul Islam, Md. Shahidur Rahman Khan
Summary: This study aimed to determine the diversity of Streptococcus spp. isolated from clinical mastitis of cattle in Bangladesh. The results showed that out of 105 samples, 59 samples tested positive for Streptococcus, 18 samples tested positive for Staphylococcus, 10 samples tested positive for Enterococcus faecalis, and 24 samples tested positive for E. coli. Through 16S rRNA sequencing, it was identified that approximately 55.6% of the Streptococcus isolates were Streptococcus uberis, 33.3% were Streptococcus agalactiae, 5.6% were Streptococcus hyovaginalis, and 5.6% were Streptococcus urinalis. Additionally, two novel ST types of S. uberis were identified through whole genome sequencing.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Petr Slama, Terezie Zavadilova, Ales Pavlik, Pavel Horky, Sylvie Skalickova, Jiri Skladanka, Shubhadeep Roychoudhury, Simona Baldovska, Adriana Kolesarova, Roman Konecny, Vladimir Tancin, Monika Zouharova
Summary: Bovine mastitis is a significant issue for dairy farmers with antibiotic treatment needing to be minimized due to resistance. Streptococcus uberis is a common pathogen, with research indicating that gamma delta T cells may play a key role in resolving inflammation in mammary glands.
Article
Agriculture, Dairy & Animal Science
B. G. Alves, L. Martins, J. N. Ribeiro, F. M. S. Tavares, M. dos Santos
Summary: Streptococcus uberis is a major cause of environmental mastitis, with potential contagious transmission. The study evaluated the diversity of S. uberis isolates, identifying different hybridization patterns and high prevalence of virulence genes. This suggests diversity within the population and importance of certain virulence factors for intramammary infections.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)