Article
Biochemistry & Molecular Biology
Sadiya Bi Shaikh, Mohd Altaf Najar, Ashwini Prabhu, D. A. B. Rex, Jaikanth Chanderasekaran, Santosh Kumar Behera, Prashant Kumar Modi, Thottethodi Subrahmanya Keshava Prasad, Yashodhar Prabhakar Bhandary
Summary: The study utilized a quantitative proteomics approach to identify protein targets of curcumin in BLM or TGF-beta 1-treated cells, revealing its effects on related pathways and cellular processes. It also discovered that curcumin can reverse the expression of specific proteins in lung injury.
Article
Biochemistry & Molecular Biology
Zixuan Liu, Mingming Chen, Yini Sun, Xu Li, Liu Cao, Xiaochun Ma
Summary: Heparin-binding protein (HBP), secreted by neutrophils, plays a role in the pathophysiology of sepsis. Our studies showed that HBP binds to transforming growth factor-beta receptor type 2 (TGF-beta-R2) and triggers acute lung injury and vascular leakage through the TGF-beta/SMAD2/3 signaling pathway. The role of HBP and TGF-beta-R2 in HBP-related acute lung injury at the blood-gas barrier was also defined.
Article
Chemistry, Medicinal
Shuo Wang, Ping Zhao, Ying Zhang, Lianhua Zhu, Jianing Zhu, Yukun Luo, Qiuyang Li
Summary: Curcumin has shown potential as a novel therapeutic agent for alleviating sepsis-induced AKI in rats by improving renal microcirculatory perfusion and reducing inflammatory response.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Microbiology
Xin Zhou, Youxia Liao
Summary: The pathogenesis of septic ALI/ARDS is complex and multifactorial, mainly due to systemic and local inflammatory responses caused by various factors disrupting immune homeostasis, which can initiate and exacerbate ALI/ARDS.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Jianmin Ling, Shanshan Yu, Feng Xiong, Tingting Xu, Shusheng Li
Summary: This study found that melatonin can regulate mitophagy in sepsis-induced acute lung injury (ALI) by influencing the expression of OPTN, a mitophagy adaptor. Treatment with melatonin alleviated ALI and normalized mitophagy, thereby reducing epithelial barrier damage and inflammation. These findings suggest that manipulating mitophagy through melatonin could be a potential treatment for sepsis-associated lung injury.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Wenfang Xia, Zhou Pan, Huanming Zhang, Qingshan Zhou, Yu Liu
Summary: This study investigates the role of estrogen-related receptor alpha (ERRα) in sepsis-induced acute lung injury (ALI). The results show that overexpression of ERRα can ameliorate LPS-induced endothelial hyperpermeability, apoptosis, and inhibit autophagy, while knockdown of ERRα exacerbates these effects. Administration of an ERRα agonist can alleviate pathological damage, increase the levels of junctional proteins, and decrease apoptosis-related protein expression. Promoting ERRα expression enhances autophagy and reduces sepsis-induced ALI. ERRα is essential for maintaining the integrity of adherens junctions by regulating the balance between autophagy and apoptosis.
MOLECULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Baisheng Sun, Mingxing Lei, Jiaqi Zhang, Hongjun Kang, Hui Liu, Feihu Zhou
Summary: Sepsis is a systemic inflammatory disease caused by severe infections, often resulting in acute lung injury (ALI). The exact pathological process of ALI caused by sepsis is not fully understood. This article reviews the research advances in the pathogenesis of ALI caused by sepsis and the treatment regimens adopted in clinical practice, providing new insights for theoretical understanding and treatment strategies.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Zhong Xiao, Juan Long, Jie Zhang, Zhimin Qiu, Chen Zhang, Hongbing Liu, Xinyong Liu, Kang Wang, Yahui Tang, Longwang Chen, Zhongqiu Lu, Guangju Zhao
Summary: This study found that protopine (PTP) has a protective effect on septic acute lung injury (ALI), reducing inflammation, oxidative stress, apoptosis, and mitophagy damage, and improving survival rate. This suggests that PTP may have potential role in the treatment of sepsis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Ya Lv, Deming Chen, Xinyi Tian, Ji Xiao, Congcong Xu, Linan Du, Jiacong Li, Siyu Zhou, Yuxiang Chen, Rong Zhuang, Yuqiang Gong, Binyu Ying, Fang Gao-Smith, Shengwei Jin, Ye Gao
Summary: This study suggests that PCTR1 suppresses LPS-induced ferroptosis via the ALX/PKA/CREB signaling pathway, which may offer promising therapeutic prospects in sepsis-related ALI.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Jing Zhang, Yongping Zheng, Yun Wang, Jin Wang, Aming Sang, Xuemin Song, Xinyi Li
Summary: YAP1 can inhibit ferroptosis and alleviate sepsis-induced acute lung injury (ALI) by disrupting ferritinophagy and regulating key genes and pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Critical Care Medicine
Huang Liu, Qingqiang Shi, Ling Tang, Hanghang Wang, Daoxin Wang
Summary: The pathophysiology of ARDS involves cytokine storms, alveolar-capillary barrier destruction, and fibrotic progression. Apelin-13, an endogenous active polypeptide, shows promise in attenuating EndMT and post-ALI pulmonary fibrosis by suppressing the Smad signaling pathway. Elevated levels of apelin-13 were found in sepsis-associated ARDS patients, suggesting it may be a novel biomarker. These findings provide insights into potential therapeutic strategies for ARDS.
Article
Chemistry, Multidisciplinary
Wu Luo, Li-bin Yang, Chen-chen Qian, Bao Ma, Gloria M. Manjengwa, Xiao-min Miao, Jie Wang, Cheng-hong Hu, Bo Jin, Ling-xi Zhang, Chao Zheng, Guang Liang, Yi Wang
Summary: This study identified the natural compound flavokawain B (FKB) as a potential therapeutic option for acute lung injury (ALI). FKB demonstrated anti-inflammatory activity by reducing pro-inflammatory cytokine secretion in immune cells and protecting against lung injury in mice, leading to increased survival and reduced mortality in the ALI model.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Immunology
Youdong Wan, Shuya Wang, Yifan Niu, Boyang Duo, Yinshuang Liu, Zhenzhen Lu, Ruixue Zhu
Summary: This study aimed to investigate the effect of metformin on gut microbiota and SALI in aged rats with sepsis. The results showed that metformin could improve the pathological changes in the lungs of aged rats and relieve SALI inflammation and damage. The composition of gut microbiota in aged SALI rats was also different, and metformin could increase the proportion of beneficial bacteria.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Immunology
Wei Wang, Rongli Xu, Ping He, Yuqing Xiong, Haomiao Zhao, Xuewei Fu, Jie Lin, Lijiao Ye
Summary: The study reveals the association between ferroptosis and sepsis-induced acute lung injury (ALI), suggesting that ferroptosis exacerbates ALI. The findings provide new mechanistic insights into sepsis-induced ALI and indicate potential therapeutic targets.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Zhe Jin, Meng-Yun Li, Lijuan Tang, Yufeng Zou, Kai Chen
Summary: This study found that ulinastatin (UTI) can effectively reduce acute lung injury (ALI) induced by diabetic sepsis in rats by inhibiting inflammatory response, reducing oxidative stress, regulating hypoxia response pathway, and improving pulmonary microvascular permeability.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)