Article
Food Science & Technology
Yudan Wang, Xiaomeng Ding, Yi Chen, Jianhua Xie, Bing Zheng, Xinxin Chang, Shiqi Liu, Xiaobo Hu, Qiang Yu
Summary: In this study, it was found that Ganoderma atrum polysaccharide (PSG-1) indirectly affects dendritic cells' immune function in the intestinal-like Caco-2/DCs co-culture model. The interaction between Caco-2 and DCs was regulated by PSG-1 through TNF-alpha and NF-kappa B signaling pathways of Caco-2 in the model. This suggests a potential mechanism for immune modulation in the gut environment through interactions between intestinal epithelial cells and immune cells.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Environmental Sciences
Oceane Reale, Antoine Huguet, Valerie Fessard
Summary: This study evaluated the toxic effects of four lipophilic phycotoxins on Caco-2/HT29-MTX co-cultured cells, revealing that these toxins can reduce cell viability, affect monolayer integrity, and have different impacts on cell types and mucus production. Cell models integrating multiple cell types may improve hazard characterization and provide more accurate descriptions of the modes of action of phycotoxins.
Article
Multidisciplinary Sciences
Isabella B. Metelmann, Sebastian Kraemer, Matthias Steinert, Stefan Langer, Peggy Stock, Olga Kurow
Summary: This study developed a 3D organotypic model of the pleural mesothelium and demonstrated its similarity to human pleura tissue in terms of morphology and microenvironment. The permeability test of the model indicated its ability to mimic physiological conditions in vivo.
Article
Biochemistry & Molecular Biology
Natalie Wagner, Armin Safaei, Jose Hurst, Pia A. Vogt, H. Burkhard Dick, Stephanie C. Joachim, Sven Schnichels
Summary: This study established a porcine organotypic co-cultivation model to investigate the interactions between photoreceptor and RPE cells. The results showed that co-cultivation had beneficial effects on the neuroretina, preserving photoreceptors and maintaining synaptic vesicles in vitro.
Article
Agriculture, Multidisciplinary
Yuhuan Chen, Hua Zhang, Wenyi Fan, Lili Mats, Ronghua Liu, Zeyuan Deng, Rong Tsao
Summary: The phenolic compounds derived from common beans can be metabolized and absorbed by intestinal epithelial cells, exhibiting antioxidant and anti-inflammatory effects against oxidative stress injury in vascular endothelial cells, thereby contributing to the amelioration of vascular diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Nutrition & Dietetics
Ivan Bogdanov, Ekaterina Finkina, Daria N. Melnikova, Rustam H. Ziganshin, Tatiana Ovchinnikova
Summary: The soybean allergen Gly m 4 has been found to potentially sensitize the immune system by crossing the epithelial barrier and inducing production of IL-4 and Th2-polarizing cytokines. Intercommunication between immunocompetent and epithelial cells may play a crucial role in this sensitization process.
Article
Public, Environmental & Occupational Health
Quyen T. L. Tran, Ha V. Nguyen, Huyen T. Pham, Tuan V. Mai, Quyen H. M. Nguyen, Dzung V. Le, Linh N. H. Bui, Lan T. H. Hoang, Trung Q. Hoang, Trung T. Trinh
Summary: This study evaluated the use of four ELISAs for the diagnosis of melioidosis. The combined WC/Hcp1 ELISA showed the highest sensitivity and specificity. The assay proved to be a reliable method for detecting underdiagnosed cases of melioidosis.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Article
Cardiac & Cardiovascular Systems
Rolando S. Matos, Davide Maselli, John H. McVey, Christian Heiss, Paola Campagnolo
Summary: The study designed and validated a novel, cost-efficient, and versatile perfusion system using 3D printing technology, which can sustain the viability and functionality of large porcine arteries after injury for early post-injury evaluations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Food Science & Technology
Li Peng, Fanghua Guo, Minjia Pei, Rong Tsao, Xiaoya Wang, Li Jiang, Yong Sun, Hua Xiong
Summary: In this study, the anti-inflammatory mechanism and impact on the intestinal barrier of lentil hulls were investigated. It was found that high doses of lentil hulls could inhibit the secretion of inflammatory mediators and downregulate the expression of inflammatory genes, as well as inhibit the activation of signaling pathways. Lentil hulls contain polyphenols, and the digestive products can be absorbed by the intestine and exert anti-inflammatory effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Immunology
Jurij Kiefer, Johannes Zeller, Balazs Bogner, Isabel A. Hoerbrand, Friederike Lang, Emil Deiss, Oscar Winninger, Mark Fricke, Sheena Kreuzaler, Eva Smudde, Markus Huber-Lang, Karlheinz Peter, Kevin J. Woollard, Steffen U. Eisenhardt
Summary: This paper presents a flow cytometry-based protocol for evaluating subset-specific activation and cytokine expression of circulating blood monocytes in humans and rats, offering an unbiased functional endpoint analysis for studying the differential regulation of monocytes in inflammatory and allogeneic immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Analytical
Chunlian Qin, Saisai Zhang, Qunchen Yuan, Mengxue Liu, Nan Jiang, Liujing Zhuang, Liquan Huang, Ping Wang
Summary: This study proposed a cell co-culture taste sensor using different proportions of Caco-2 cells and SH-SY5Y cells for bitter taste detection. The results showed that different mixtures at different ratios exhibited different response patterns after activation of taste receptors.
Article
Pharmacology & Pharmacy
Ye Cai, Liu Liu, Mengqiu Xia, Chunling Tian, Wenqing Wu, Baoqi Dong, Xiaoqin Chu
Summary: SEDDS have potential applications in delivering hydrophobic components. The ability of CA-SEDDS to deliver cinnamaldehyde in rat mucus, mucin solution, Caco-2 and Caco-2/HT29 co-culture monolayer systems was investigated. CA-SEDDS exhibited excellent mucus permeability, 5.1- and 2.8-fold higher than the free CA group, in mucus and mucin solutions. The relative oral bioavailability of CA-SEDDS was 242% compared to CA without formulation, suggesting its great potential for hydrophobic oral applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Virology
Lise Lamoureux, Babu Sajesh, Jessy A. Slota, Sarah J. Medina, Matthew Mayor, Kathy L. Frost, Bryce Warner, Kathy Manguiat, Heidi Wood, Darwyn Kobasa, Stephanie A. Booth
Summary: Neurological syndromes associated with COVID-19 suggest an effect of the virus on neuronal function, but the direct infection of SARS-CoV-2 in the brain remains under debate. In this study, using brain slice culture, researchers found that while some glial cells were infected, there was no evidence of viral infection or replication in neurons. These findings support previous clinical studies on neurological involvement in COVID-19 patients.
Article
Biology
Svetlana V. Zubova, Ninel I. Kosyakova, Sergey V. Grachev, Isabella R. Prokhorenko
Summary: The investigation of common inflammation mechanisms caused by exogenic compounds of microbial origin and allergens is crucial in biomedical science. The activation of immune cells by pro-inflammatory agents leads to changes in receptor quantity and cytokine production by blood cells. The expression levels of TLR4, CD14, and CD11b in monocytes and neutrophils reflect their functional activities, while the composition and amount of cytokines produced reflect the biological activity of the studied agonists. Furthermore, the activity of Der p 2 allergen in whole blood samples is lower compared to isolated PBMC cells, and LPS R. capsulatus PG reduces the synthesis of cytokines activated by LPS and Der p 2, suggesting a unified mechanism of cell activation and protective action.
Article
Virology
Heike Hartel, Janine Theiss, Mohammed O. Abdelaziz, Martin J. Raftery, Gabriele Pecher, Elke Bogner
Summary: This study demonstrated the characteristics of colon carcinoma cells under HCMV infection and the anti-apoptotic effect of HCMV on cells. The findings suggest a potential role for proteasome inhibitors in colon carcinoma therapy.
Article
Biochemistry & Molecular Biology
Teresa R. Wagner, Daniel Schnepf, Julius Beer, Natalia Ruetalo, Karin Klingel, Philipp D. Kaiser, Daniel Junker, Martina Sauter, Bjoern Traenkle, Desiree Frecot, Matthias Becker, Nicole Schneiderhan-Marra, Annette Ohnemus, Martin Schwemmle, Michael Schindler, Ulrich Rothbauer
Summary: The study identified two high-affinity biparatopic nanobodies that can neutralize multiple emerging SARS-CoV-2 variants, providing protection against virus infection in vivo and demonstrating a significant reduction in disease progression.
Article
Multidisciplinary Sciences
Hanna Renk, Alex Dulovic, Alina Seidel, Matthias Becker, Dorit Fabricius, Maria Zernickel, Daniel Junker, Ruediger Gross, Janis Mueller, Alexander Hilger, Sebastian F. N. Bode, Linus Fritsch, Pauline Frieh, Anneke Haddad, Tessa Goerne, Jonathan Remppis, Tina Ganzemueller, Andrea Dietz, Daniela Huzly, Hartmut Hengel, Klaus Kaier, Susanne Weber, Eva-Maria Jacobsen, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Maximilian Stich, Burkhard Toenshoff, Georg F. Hoffmann, Barbara Mueller, Carolin Ludwig, Bernd Jahrsdoerfer, Hubert Schrezenmeier, Andreas Peter, Sebastian Hoerber, Thomas Iftner, Jan Muench, Thomas Stamminger, Hans-Juergen Gross, Martin Wolkewitz, Corinna Engel, Weimin Liu, Marta Rizzi, Beatrice H. Hahn, Philipp Henneke, Axel R. Franz, Klaus-Michael Debatin, Nicole Schneiderhan-Marra, Ales Janda, Roland Elling
Summary: This study compares the humoral immune response in children and adults following SARS-CoV-2 infection and finds that children are more likely to have asymptomatic infections and higher levels of specific antibodies that persist for a longer time. Symptomatic and asymptomatic infections induce similar humoral responses across all age groups.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Alex Dulovic, Barbora Kessel, Manuela Harries, Matthias Becker, Julia Ortmann, Johanna Griesbaum, Jennifer Juengling, Daniel Junker, Pilar Hernandez, Daniela Gornyk, Stephan Gloeckner, Vanessa Melhorn, Stefanie Castell, Jana-Kristin Heise, Yvonne Kemmling, Torsten Tonn, Kerstin Frank, Thomas Illig, Norman Klopp, Neha Warikoo, Angelika Rath, Christina Suckel, Anne Ulrike Marzian, Nicole Grupe, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Tobias Kerrinnes, Gerard Krause, Berit Lange, Nicole Schneiderhan-Marra, Monika Strengert
Summary: Recent increases in SARS-CoV-2 infections have raised questions about the duration and quality of vaccine-induced immune protection. This study analyzed samples from a large population-based seroprevalence study in Germany and found that mRNA-based or heterologous prime-boost vaccination resulted in higher antibody responses compared to vector-based homologous vaccination. Previously infected individuals had a robust immune response after vaccination, regardless of the vaccine received.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Daniel Junker, Alex Dulovic, Matthias Becker, Teresa R. Wagner, Philipp D. Kaiser, Bjoern Traenkle, Katharina Kienzle, Stefanie Bunk, Carlotta Struemper, Helene Haeberle, Kristina Schmauder, Natalia Ruetalo, Nisar Malek, Karina Althaus, Michael Koeppen, Ulrich Rothbauer, Juliane S. Walz, Michael Schindler, Michael Bitzer, Siri Gopel, Nicole Schneiderhan-Marra
Summary: This study developed a new serological multiplex assay to analyze ACE2 binding inhibition of SARS-CoV-2 VOCs and VOIs. The study found that ACE2 binding inhibition correlated with disease severity and antibody levels in COVID-19 patients.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Stefanie Lerche, Milan Zimmermann, Isabel Wurster, Benjamin Roeben, Franca Laura Fries, Christian Deuschle, Katharina Waniek, Ingolf Lachmann, Thomas Gasser, Meike Jakobi, Thomas O. Joos, Nicole Schneiderhan-Marra, Kathrin Brockmann
Summary: The study found limited correlations between central-nervous and peripheral inflammatory markers in Parkinson's disease patients, with important pro-inflammatory mediators associated with motor and cognitive decline as well as neurodegenerative/PD-specific biomarkers, and these results were more robust in cerebrospinal fluid. Sex-specific characteristics have significant implications for the design of clinical trials targeting the immune system for disease modification.
FRONTIERS IN NEUROLOGY
(2022)
Article
Critical Care Medicine
Tobias Sinnberg, Christa Lichtensteiger, Omar Hasan Ali, Oltin T. Pop, Ann-Kristin Jochum, Lorenz Risch, Silvio D. Brugger, Ana Velic, David Bomze, Philipp Kohler, Pietro Vernazza, Werner C. Albrich, Christian R. Kahlert, Marie-Therese Abdou, Nina Wyss, Kathrin Hofmeister, Heike Niessner, Carl Zinner, Mara Gilardi, Alexandar Tzankov, Martin Rocken, Alex Dulovic, Srikanth Mairpady Shambat, Natalia Ruetalo, Philipp K. Buehler, Thomas C. Scheier, Wolfram Jochum, Lukas Kern, Samuel Henz, Tino Schneider, Gabriela M. Kuster, Maurin Lampart, Martin Siegemund, Roland Bingisser, Michael Schindler, Nicole Schneiderhan-Marra, Hubert Kalbacher, Kathy D. McCoy, Werner Spengler, Martin H. Brutsche, Boris Macek, Raphael Twerenbold, Josef M. Penninger, Matthias S. Matter, Lukas Flatz
Summary: COVID-19 can cause severe respiratory distress syndrome, and dysregulated immune responses, including autoimmunity, play a key role. This study investigated the presence of IgA autoantibodies targeting lung-specific proteins and their effects on pulmonary surfactant in severe COVID-19 cases.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Immunology
Daniel Junker, Matthias Becker, Teresa R. Wagner, Philipp D. Kaiser, Sandra Maier, Tanja M. Grimm, Johanna Griesbaum, Patrick Marsall, Jens Gruber, Bjoern Traenkle, Constanze Heinzel, Yudi T. Pinilla, Jana Held, Rolf Fendel, Andrea Kreidenweiss, Annika Nelde, Yacine Maringer, Sarah Schroeder, Juliane S. Walz, Karina Althaus, Gunalp Uzun, Marco Mikus, Tamam Bakchoul, Katja Schenke-Layland, Stefanie Bunk, Helene Haeberle, Siri Goepel, Michael Bitzer, Hanna Renk, Jonathan Remppis, Corinna Engel, Axel R. Franz, Manuela Harries, Barbora Kessel, Berit Lange, Monika Strengert, Gerard Krause, Anne Zeck, Ulrich Rothbauer, Alex Dulovic, Nicole Schneiderhan-Marra
Summary: Using a large diverse cohort, this study found that the Omicron variant can bind to ACE2 more efficiently than inhibitory antibodies. Antibodies elicited by infection or immunization showed reduced binding capacities and ACE2 binding inhibition compared to wild type. Both Omicron variants are able to evade control by preexisting antibodies.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Matthias Becker, Anne Cossmann, Karsten Luerken, Daniel Junker, Jens Gruber, Jennifer Juengling, Gema Morillas Ramos, Andrea Beigel, Eike Wrenger, Gerhard Lonnemann, Metodi Stankov, Alexandra Dopfer-Jablonka, Philipp D. Kaiser, Bjoern Traenkle, Ulrich Rothbauer, Gerard Krause, Nicole Schneiderhan-Marra, Monika Strengert, Alex Dulovic, Georg M. N. Behrens
Summary: Haemodialysis patients have poor response to vaccination, but their immune protection can be improved by receiving a fourth COVID-19 vaccine dose. This study provides longitudinal vaccination response data in dialysis patients and controls after triple BNT162b2 vaccination and subsequent fourth full-dose mRNA-1273 vaccination. The results show that the fourth dose significantly enhances the immune response against various SARS-CoV-2 variants in dialysis patients. Therefore, a four-dose COVID-19 immunisation scheme is recommended for haemodialysis patients to prevent severe COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Anneke Haddad, Ales Janda, Hanna Renk, Maximilian Stich, Pauline Frieh, Klaus Kaier, Florens Lohrmann, Alexandra Nieters, Anna Willems, Daniela Huzly, Alex Dulovic, Nicole Schneiderhan-Marra, Eva-Maria Jacobsen, Dorit Fabricius, Maria Zernickel, Thomas Stamminger, Sebastian F. N. Bode, Theda Himpel, Jonathan Remppis, Corinna Engel, Andreas Peter, Tina Ganzenmueller, Georg Friedrich Hoffmann, Bettina Haase, Hans-Georg Krausslich, Barbara Muller, Axel R. Franz, Klaus-Michael Debatin, Burkhard Tonshoff, Philipp Henneke, Roland Elling
Summary: Long COVID symptoms were examined in a cohort of infected children, adolescents, and adults and their exposed but non-infected household members approximately 1 year after infection. The study found a higher prevalence of moderate or severe persistent symptoms in infected women, men, and adolescent girls compared to their exposed counterparts. Clustering of persistent symptoms within households was also observed.
Article
Infectious Diseases
Julia Haring, Max J. Hassenstein, Matthias Becker, Julia Ortmann, Daniel Junker, Andre Karch, Klaus Berger, Tatia Tchitchagua, Olaf Leschnik, Manuela Harries, Daniela Gornyk, Pilar Hernandez, Berit Lange, Stefanie Castell, Gerard Krause, Alex Dulovic, Monika Strengert, Nicole Schneiderhan-Marra
Summary: A multiplex Borrelia immunoassay was developed in this study, which showed high sensitivity and specificity in detecting antibodies against multiple Borrelia species. This assay provides a cost-effective and time-saving method for the diagnosis and identification of Lyme borreliosis.
BMC INFECTIOUS DISEASES
(2022)
Article
Virology
Guenalp Uzun, Rebecca Mueller, Karina Althaus, Matthias Becker, Patrick Marsall, Daniel Junker, Stefanie Nowak-Harnau, Nicole Schneiderhan-Marra, Harald Klueter, Hubert Schrezenmeier, Peter Bugert, Tamam Bakchoul
Summary: This study investigated the relationship between clinical donor characteristics and neutralizing anti-SARS-CoV-2 antibodies in COVID-19 convalescent plasma (CCP) donors. Time since symptom onset, BMI, and fever were found to be associated with neutralizing capacity. These clinical parameters can be easily incorporated into the preselection of CCP donors.
Article
Neurosciences
Stefanie Lerche, Milan Zimmermann, Benjamin Roeben, Isabel Wurster, Franca Laura Fries, Christian Deuschle, Katharina Waniek, Ingolf Lachmann, Meike Jakobi, Thomas O. Joos, Thomas Knorpp, Nicole Schneiderhan-Marra, Kathrin Brockmann
Summary: Inflammation is linked to the incidence and progression of Parkinson's disease (PD). A study found that certain inflammatory markers in the cerebrospinal fluid (CSF) were associated with clinical scores and neurodegenerative CSF biomarkers in PD and dementia with Lewy bodies (DLB) patients. The presence of GBA mutations did not significantly affect the levels of inflammatory markers in PD patients. The study also showed that higher levels of TNF-alpha, VEGF, and MIP-1 beta were associated with the development of cognitive impairment in PD patients.
NPJ PARKINSONS DISEASE
(2023)
Article
Gastroenterology & Hepatology
Simon Woelfel, Joel Duetschler, Marius Koenig, Alex Dulovic, Nicole Graf, Daniel Junker, Vasileios Oikonomou, Claudia Krieger, Samuel Truniger, Annett Franke, Annika Eckhold, Kristina Forsch, Seraina Koller, Jacqueline Wyss, Niklas Krupka, Melanie Oberholzer, Nicola Frei, Nora Geissler, Peter C. Schaub, Matthias STAR SIGN Study Investigator, Werner Albrich, Matthias Friedrich, Nicole Schneiderhan-Marra, Benjamin J. Misselwitz, Wolfgang Korte, Justus Buergi, Stephan Brand
Summary: This study aimed to assess the immunization efficacy against the novel omicron sublineages BQ.1.1 and XBB.1.5 in immunosuppressed patients with IBD. The results showed that anti-TNF biologic-treated patients with IBD had impaired neutralization and inadequate surrogate neutralization against the tested sublineages compared to non-anti-TNF biologic-treated patients and healthy controls. Therefore, these patients may benefit from prioritization for future variant-adapted vaccines.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Multidisciplinary Sciences
Julia Haering, Tanja Michel, Matthias Becker, Daniel Junker, Tatia Tchitchagua, Olaf Leschnik, Berit Lange, Stefanie Castell, Gerard Krause, Monika Strengert, Alex Dulovic, Nicole Schneiderhan-Marra
Summary: To monitor infectious diseases, it is important to assess immunoreactivity and measure different antibody isotypes at different stages of the immune response. Lyme borreliosis can be caused by various Borrelia species, so correct classification of samples requires evaluating immunoreactivity against different antigens. This study demonstrates a dual-reporter multiplex immunoassay that allows simultaneous evaluation of IgG and IgM immunoreactivity against different bacterial antigens, providing more serological information in less time.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2023)
Article
Multidisciplinary Sciences
Serafina Calarco, B. Leticia Fernandez-Carballo, Thomas Keller, Stephan Weber, Meike Jakobi, Patrick Marsall, Nicole Schneiderhan-Marra, Sabine Dittrich
Summary: This study compared the analytical performance of 17 commercially available POC CRP tests and found that two quantitative tests performed better than the others, while the performance of semi-quantitative tests was unstable. Quantitative tests may be the best choice for different CRP ranges.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)