Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 10, Issue 12, Pages 1595-1601Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2010.09.015
Keywords
Complement and pentraxins; Acute phase response; Photodynamic therapy; Glucocorticoid hormones; Corticosterone
Categories
Funding
- National Cancer Institute of Canada
- Canadian Cancer Society
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Treatment of solid tumors by photodynamic therapy (PDT) was recently shown to trigger a strong acute phase response. Using the mouse Lewis lung carcinoma (LLC) model, the present study examined complement and pentraxin proteins as PDT-induced acute phase reactants. The results show a distinct pattern of changes in the expression of genes encoding these proteins in the tumor, as well as host liver and spleen, following PDT mediated by photosensitizer Photofrin (TM). These changes were influenced by glucocorticoid hormones, as evidenced by transcriptional activation of glucocorticoid receptor and the upregulation of gene encoding this receptor. The expression of gene for glucocorticoid-induced zipper (GILZ) protein, whose activity is particularly susceptible to glucocorticoid regulation, was also changed in PDT-treated tumors. A direct demonstration that tumor PDT induces glucocorticoid hormone upregulation is provided by documenting elevated levels of serum corticosterone in mice bearing PDT-treated LLC tumors. Tumor response to PDT was negatively affected by blocking glucocorticoid receptor activity, which suggests that glucocorticoid hormones have a positive impact on the therapeutic outcome with this therapy. (C) 2010 Elsevier B.V. All rights reserved.
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