Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 10, Issue 4, Pages 474-480Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.intimp.2010.01.008
Keywords
Asthma; Allantoin; IgE; IL-4; IL-5
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Funding
- Korea Research Council of Fundamental Science and Technology of the Republic of Korea [G09141]
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Asthma is characterized by difficulty in breathing because of the constriction of the smooth muscles of the bronchi, as a result of inflammation. In the present study, we focus on the protective effects of allantoin against ovalbumin (OVA)-induced lung inflammation in a murine allergic model, and assess cytokine release, eosinophilia, and mucus hypersecretion. Allantoin treatment led to significant reduction in the levels of Ig (immunoglobulin)E and T-helper-2-type cytokines, such as IL(interleukin)-4 and IL-5, in bronchoalveolar lavage (BAL) fluid. Airway inflammatory-cell infiltration was remarkably alleviated in allantoin-treated asthma groups, compared with the control group. Moreover, allantoin-treated asthma groups exhibited a marked decrease in cytokine mRNA expression in lung tissues, compared with the control group. The effectiveness of allantoin was similar to that of montelukast, used as a positive control. These results support the utility of allantoin as a protective agent against asthma. (C) 2010 Published by Elsevier B.V.
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