Journal
INTERNATIONAL IMMUNOPHARMACOLOGY
Volume 10, Issue 9, Pages 1003-1009Publisher
ELSEVIER
DOI: 10.1016/j.intimp.2010.05.012
Keywords
Flavonoids; Lipoteichoic acid; Endocarditis; Mitogen-activated protein kinases; IL-1 beta; Rat heart embryonic cells
Categories
Funding
- Direccion General de Asuntos del Personal Academico (DGAPA) [PAPITT-IN218609-3]
Ask authors/readers for more resources
Dental focal infections are infections in the mouth that cause subsequent infection and symptoms in other parts of the body. Dental conditions such as periodontitis have been associated with coronary heart disease. In this study, we investigated the effect of flavonoids on activation of mitogen-activated protein kinase (MAPK) family members, protein kinase B (AKT), and IL-1 beta expression by rat heart embryonic (H9c2) cells upon stimulation with LTA. Pretreatment with four flavonoids, including quercetin, genistein, quercetagetin, and luteolin diminished LTA-induced ERK1/2, JNK, p38, and AKT phosphorylation and IL-1 beta gene expression. Our findings indicate that flavonoids interfere with LTA signal transduction. Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available