Article
Biochemistry & Molecular Biology
Carmen Vida, Carlos Oliva, Claudia Yuste, Noemi Ceprian, Paula Jara Caro, Gemma Valera, Ignacio Gonzalez de Pablos, Enrique Morales, Julia Carracedo
Summary: The study reveals the significant role of oxidative stress in CKD patients, with dialysis procedures helping to maintain the GSSG/GSH balance in PMNs. PD patients showed higher oxidative stress than HD patients, particularly in MNs. The assessment of redox state parameters in PMNs and MNs may serve as potential biomarkers for CKD progression.
Article
Agriculture, Dairy & Animal Science
Sicong Yu, Lepeng Gao, Yang Song, Xin Ma, Shuang Liang, Hainan Lan, Xin Zheng, Suo Li
Summary: In this study, a mitochondrial damage model was induced in porcine oocytes with the Bcl-2-specific antagonist ABT-199, and the protective effects of glycine (Gly) against ABT-199-induced mitochondrial dysfunction were investigated. Gly was found to significantly ameliorate mitochondrial dysfunction, oxidative stress, and apoptosis, as well as regulate intracellular calcium levels and IP(3)R1 cellular distribution, thereby protecting oocyte maturation.
JOURNAL OF ANIMAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Loretta Ferrera, Raffaella Barbieri, Cristiana Picco, Paolo Zuccolini, Alessia Remigante, Sara Bertelli, Maria Rita Fumagalli, Giovanni Zifarelli, Caterina A. M. La Porta, Paola Gavazzo, Michael Pusch
Summary: The response to oxidative stimulation in melanoma cells involves the activation of potassium currents and an increase in intracellular calcium levels, mediated by BK, KCa3.1, and TRPM2 channels. Differences in the expression levels of these channels in different cell lines may play a crucial role in melanoma progression. Targeting these ion channels pharmacologically could be a novel strategy to reduce the metastatic potential of melanoma cells alongside traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Bowei Jia, Yuan Li, Xiaoli Sun, Mingzhe Sun
Summary: This study summarizes the current knowledge of soybean calcium transporters in terms of structural features, expression characteristics, roles in stress response, and prospects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Vanessa Staldoni de Oliveira, Allisson Jhonatan Gomes Castro, Katiuska Marins, Ana Karla Bittencourt Mendes, Gabriel Adan Araujo Leite, Ariane Zamoner, Glen Van der Kraak, Fatima Regina Mena Barreto Silva
Summary: The study revealed that pyriproxyfen can affect the ionic balance in the testis of zebrafish through multiple pathways, leading to oxidative stress and impacting reproductive health. Pyriproxyfen may induce toxicity in the testis by causing calcium overload, increased lipid peroxidation, and diminished antioxidant capacity, thereby affecting spermatogenesis.
ENVIRONMENTAL POLLUTION
(2021)
Article
Fisheries
Ajay Guru, Christy Lite, Allen J. Freddy, Praveen Kumar Issac, Mukesh Pasupuleti, N. T. Saraswathi, Mariadhas Valan Arasu, Naif Abdullah Al-Dhabi, Aziz Arshad, Jesu Arockiaraj
Summary: The study showed that WL15 peptide possesses strong antioxidant properties, which were validated through in vitro and in vivo experiments. Results from zebrafish experiments demonstrated that WL15 peptide can reduce intracellular ROS levels and inhibit apoptotic responses induced by H2O2.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Microbiology
Christopher T. D. Price, Hannah E. Hanford, Aruna Vashishta, Mateja Ozanic, Marina Santic, Silvia Uriarte, Yousef Abu Kwaik
Summary: The Dot/Icm type IV secretion system of Legionella pneumophila is crucial for lysosomal evasion and macrophage permissiveness, but polymorphonuclear cells (PMNs) respond to this system by rapidly restricting the pathogen. This response is triggered by the injected amylase effector, LamA, which catalyzes glycogen degradation in PMNs and leads to immunometabolic reprogramming involving increased aerobic glycolysis. Activated PMNs utilize major microbicidal processes, including granule fusion and reactive oxygen species production, resulting in rapid killing of Legionella pneumophila.
Review
Microbiology
Kathrin Stelzner, Nadine Vollmuth, Thomas Rudel
Summary: In this review, the authors summarize the current knowledge of Chlamydia trachomatis intracellular replication, metabolism, immune defense, and transition to a persistent state. Recent progress has been made in understanding how C. trachomatis establishes itself in the host cell and relies on the host for nutrients. The review focuses on the mechanistic understanding of these processes.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Immunology
Jeffrey S. Kavanaugh, Kevin G. Leidal, William M. Nauseef, Alexander R. Horswill
Summary: PMN can invade Staphylococcus aureus biofilms and phagocytose bacteria, largely depending on the activity of secreted cathepsin G.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Agriculture, Dairy & Animal Science
Hiroaki Okawa, Missaka M. P. Wijayagunawardane, Peter L. A. M. Vos, Osamu Yamato, Masayasu Taniguchi, Mitsuhiro Takagi
Summary: Intrauterine infusion of chitosan solution in early postpartum dairy cows can accelerate uterine recovery from endometritis, potentially serving as a replacement for prostaglandin F-2 alpha administration. The treatment has antimicrobial effects on the uterus and does not show adverse effects on fertility.
Article
Dermatology
Yushi Katsuyama, Yuki Sato, Yuri Okano, Hitoshi Masaki
Summary: This study elucidated the mechanism by which UVB and oxidative stress enhance phagocytosis in keratinocytes, showing that keratinocytes exposed to UVB or oxidative stress were in the S-phase of the cell cycle, leading to increased phagocytic abilities.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Giulia Fani, Chiara Ester La Torre, Roberta Cascella, Cristina Cecchi, Michele Vendruscolo, Fabrizio Chiti
Summary: Alzheimer's disease is characterized by the accumulation of amyloid beta (A beta) peptide in the brain, which leads to the formation of senile plaques. The aggregation process of A beta also generates smaller misfolded oligomers that contribute to disease progression. These oligomers interact with cell membranes, increasing intracellular Ca2+ levels and producing reactive oxygen species (ROS). Our study found that the increase in intracellular Ca2+ occurs faster than the increase in ROS levels after exposure to misfolded protein oligomers. Removing Ca2+ from the cell medium prevents the increase in intracellular Ca2+ and abolishes ROS production. Treating cells with antioxidant agents prevents ROS formation, but does not prevent the initial increase in Ca2+, allowing the cells to restore normal calcium levels. These findings suggest that Ca2+ influx triggers ROS production in cells challenged by aberrant protein oligomers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Plant Sciences
Sergio M. Borghi, Talita P. Domiciano, Fernanda S. Rasquel-Oliveira, Camila R. Ferraz, Allan J. C. Bussmann, Josiane A. Vignoli, Doumit Camilios-Neto, Sergio R. Ambrosio, Nilton S. Arakawa, Rubia Casagrande, Waldiceu A. Verri
Summary: The study indicated that kaurenoic acid can prevent antigen-induced asthma by down-regulating inflammatory pathways, promoting antioxidant effects, and regulating regulatory T cell markers, explaining the ethnopharmacological use of S. trilobata for the treatment of lung inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hiroki Yamamoto, Takuya Fujiwara, Takashi Funatsu, Makoto Tsunoda
Summary: This study developed a method for intracellular thiol quantification using HPLC-fluorescence detection. The method can separate six different SBD-thiols within 30 minutes and was used to quantify thiol concentrations in chronic myelogenous leukemia K562 cell samples, as well as the time-dependent effect of a thiol scavenger, N-ethyl maleimide, on intracellular thiol concentrations. This method is useful for elucidating the role of intracellular sulfur metabolism.
Article
Food Science & Technology
Gaby Andersen, Kristin Kahlenberg, Dietmar Krautwurst, Veronika Somoza
Summary: The study investigates the role of TRPV1 channels in human neutrophils and finds that activation of the channel with [6]-gingerol enhances cellular immune response. This research is significant in understanding the function of TRP channels in non-sensory tissues.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Cell Biology
Miriam S. Giambelluca, Marc Pouliot
JOURNAL OF LEUKOCYTE BIOLOGY
(2017)
Article
Physiology
Korbinian Boesl, Miriam Giambelluca, Markus Haug, Marit Bugge, Terje Espevik, Richard K. Kandasamy, Bjarte Bergstrom
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Chemistry, Analytical
Pablo J. Lebed, Jaiver Osorio Grisales, Sonia Keunchkarian, Javier Gotta, Miriam Giambelluca, Cecilia Castells
ANALYTICAL METHODS
(2011)
Article
Biochemistry & Molecular Biology
Miriam S. Giambelluca, Oscar A. Gende
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2011)
Article
Cell Biology
Miriam S. Giambelluca, Maria C. Ciancio, Alejandro Orlowski, Oscar A. Gende, Marc Pouliot, Ernesto A. Aiello
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Miriam S. Giambelluca, Genevieve Bertheau-Mailhot, Cynthia Laflamme, Emmanuelle Rollet-Labelle, Marc J. Servant, Marc Pouliot
Article
Genetics & Heredity
C. Laflamme, G. Bertheau-Mailhot, M. S. Giambelluca, N. Cloutier, E. Boilard, M. Pouliot
GENES AND IMMUNITY
(2014)
Article
Biochemistry & Molecular Biology
Miriam S. Giambelluca, Nathalie Cloutier, Emmanuelle Rollet-Labelle, Eric Boilard, Marc Pouliot
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2013)
Article
Critical Care Medicine
Miriam S. Giambelluca, Oscar A. Gende
Article
Cell Biology
Birgitta Ehrnstrom, June F. Kojen, Miriam Giambelluca, Liv Ryan, Siv H. Moen, Zhenyi Hu, Hang Yin, Tom E. Mollnes, Jan K. Damas, Terje Espevik, Jorgen Stenvik
JOURNAL OF LEUKOCYTE BIOLOGY
(2020)
Article
Immunology
Sneha M. Pinto, Hera Kim, Yashwanth Subbannayya, Miriam S. Giambelluca, Korbinian Bosl, Liv Ryan, Animesh Sharma, Richard K. Kandasamy
Summary: The study demonstrated the impact of variations in PMA concentration and post-stimulation rest duration on the protein expression and cellular signaling processes in macrophage-like cells, leading to altered inflammatory responses and cytokine expression levels. This provides valuable insights into the dynamics of protein expression with common in vitro macrophage models, significantly expanding knowledge in immune and inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Hera Kim, Yashwanth Subbannayya, Fiachra Humphries, Astrid Skejsol, Sneha M. Pinto, Miriam Giambelluca, Terje Espevik, Katherine A. Fitzgerald, Richard K. Kandasamy
Summary: This study investigated the gene expression changes in THP1-derived macrophages upon TLR4 activation and identified several interferon-stimulated genes, including CMPK2. The in-depth characterization of CMPK2 expression revealed its significant induction upon TLR4 and TLR3 ligand stimulation, suggesting its potential role in anti-bacterial and antiviral responses mediated by IRF3-type I interferon signaling.
Article
Cell Biology
Apsana Lamsal, Sonja Benedikte Andersen, Ida Johansson, Marina Vietri, Ansooya Avinash Bokil, Natalie Jayne Kurganovs, Felicia Rylander, Geir Bjorkoy, Kristine Pettersen, Miriam S. S. Giambelluca
Summary: Solid tumors rely on suppressed local immune reactions in the tumor microenvironment, and the formation of immunosuppressive tumor microenvironments is still not fully understood. This study found that the type I interferon response is dampened in tumors with metastatic ability, and decreased expression of IFN-I-related genes predicts poor prognosis in breast cancer patients.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Mathieu Le Boulvais Borkja, Miriam S. Giambelluca, Borgny Ytterhus, Wenche S. Prestvik, Geir Bjorkoy, Anna M. Bofin
Summary: 20% of breast cancer patients have increased S100A8 copy number in their tumors, 15% of patients have overexpressed S100A8 protein in their tumors, and 19% of patients have more than 10 infiltrating S100A8+ polymorphonuclear cells in their tumors. These are associated with high Ki67 status, high mitotic count, and high histopathological grade. Only S100A8 protein expression in tumor cells is associated with poorer prognosis.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
