Article
Immunology
Matthew J. Bottomley, Paul N. Harden, Kathryn J. Wood, Joanna Hester, Fadi Issa
Summary: The monocytic HLA-DR density remains stable in long-term renal transplant recipients and is associated with myeloid-derived suppressor-like cells accumulation. Decreased HLA-DR density is linked to a higher risk of subsequent malignancy, indicating a potential novel marker for excess immunosuppression. Further research is needed to understand the underlying mechanism behind this association.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Fan Fei, Liang Rong, Nan Jiang, Alan S. Wayne, Jianming Xie
Summary: In this study, an anti-HLA-DR inhibitory CAR (iCAR) was developed to effectively suppress NK cell activation against HLA-DR-expressing cells. Dual CAR-NK cells, which co-express the anti-CD19 or CD33 activating CAR and the anti-HLA-DR iCAR, were found to preferentially target HLA-DR-negative cells over HLA-DR-positive cells in vitro. The HLA-DR-mediated inhibition was positively correlated with both iCAR and HLA-DR densities. HLA-DR-positive cells were resistant to dual CAR-NK cell-mediated killing in a xenograft mouse model, confirming the potential of this approach to enhance CAR-NK and CAR-T cell specificity against malignancies with HLA-DR loss.
Article
Immunology
Malte Deseke, Francesca Rampoldi, Inga Sandrock, Eva Borst, Heike Boning, George Liam Ssebyatika, Carina Jurgens, Nina Pluckebaum, Maleen Beck, Ahmed Hassan, Likai Tan, Abdi Demera, Anika Janssen, Peter Steinberger, Christian Koenecke, Abel Viejo-Borbolla, Martin Messerle, Thomas Krey, Immo Prinz
Summary: Deseke et al. identified HLA-DR as the cognate TCR ligand of a CMV-induced V delta 1(+) gamma delta T cell clone using soluble gamma delta TCRs and CRISPR/Cas9-mediated screening. This study provides insights into the potential role of HLA-DR in adaptive immune responses of gamma delta T cells.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jordi Miatello, Anne-Claire Lukaszewicz, Michael J. Carter, Valerie Faivre, Stephane Hua, Kim Z. Martinet, Christine Bourgeois, Lluis Quintana-Murci, Didier Payen, Michele Boniotto, Pierre Tissieres
Summary: This study demonstrates that the G-286A*rs3037456 polymorphism in the promoter III of CIITA is associated with mHLA-DR expression and mortality in patients with septic shock. GG genotype is associated with increased 28-day mortality and persistently low mHLA-DR expression, while AA or AG genotype is associated with increased mHLA-DR expression.
Article
Multidisciplinary Sciences
Jake R. Thomas, Anna Appios, Emily F. Calderbank, Nagisa Yoshida, Xiaohui Zhao, Russell S. Hamilton, Ashley Moffett, Andrew Sharkey, Elisa Laurenti, Courtney W. Hanna, Naomi McGovern
Summary: The human placenta is an additional site of primitive haematopoiesis, where placental erythro-myeloid progenitors (PEMPs) generate HBC-like cells lacking expression of HLA-class II. This is mediated through epigenetic silencing of the CIITA gene, which regulates HLA-class II expression.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Noriaki Tsuji, Kohei Hosokawa, Ryota Urushihara, Mikoto Tanabe, Takamasa Katagiri, Tatsuhiko Ozawa, Hiroyuki Takamatsu, Ken Ishiyama, Hirohito Yamazaki, Hiroyuki Kishi, Seishi Ogawa, Shinji Nakao
Summary: This study demonstrates that antigens presented by HSPCs on HLA-DR15 may lead to abnormal activation of CD4(+) T cells and immune escape in the development of AA. Immune response-related gene expression is downregulated in DR(-) cells compared to HLA-I(-) HSPCs.
Article
Immunology
Cassandra Ballou, Franca Barton, Elizabeth H. Payne, Thierry Berney, Jean Villard, Raphael P. H. Meier, David Baidal, Rodolfo Alejandro, Mark Robien, Thomas L. Eggerman, Malek Kamoun, Yannick D. Muller
Summary: The exact contribution of HLA matching to graft survival in pancreatic islet transplantation remains unclear. This study evaluated the impact of HLA-DR matching, including the presence of diabetogenic HLA-DR3 or HLA-DR4 matches, on long-term islet survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Bo Peng, Min Yang, Quan Zhuang, Junhui Li, Pengpeng Zhang, Hong Liu, Ke Cheng, Yingzi Ming
Summary: This study standardized the measurement of nCD64 and mHLA-DR using MESF, and evaluated their role in immune monitoring for kidney transplant recipients (KTRs) with infection. The standardized values of nCD64 and mHLA-DR showed good diagnostic performance for infection and sepsis, respectively, and could contribute to individualized treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Hiroki Yamada, Takanori Sasaki, Kotaro Matsumoto, Katsuya Suzuki, Masaru Takeshita, Shuhei Tanemura, Noriyasu Seki, Hideto Tsujimoto, Tsutomu Takeuchi
Summary: The study found that HLA-DR+ Tph cells were correlated with DAS28-ESR, while HLA-DR- Tph cells accurately reflected disease activity during treatment. MTX treatment independently reduced the proportion of HLA-DR+ Tph cells.
Article
Gastroenterology & Hepatology
Chien-Hao Huang, Jian-He Fan, Wen-Juei Jeng, Shu-Ting Chang, Chan-Keng Yang, Wei Teng, Tsung-Han Wu, Yi-Chung Hsieh, Wei-Ting Chen, Yi-Cheng Chen, I-Shyan Sheen, Yung-Chang Lin, Chun-Yen Lin
Summary: This study found that CD38(+)HLA-DR(+)CD8(+) T cells are present in patients with CHC. These cells have higher levels of effector memory and proinflammatory chemokine molecules, and produce higher levels of interferon-gamma compared to CD38(-)HLA-DR(-)CD8 T cells. They are mainly composed of non-HCV-specific CD8(+) T cells and have strong cytotoxicity. Furthermore, these CD8(+) T cells play an important role in liver injury and fibrosis, and their percentage decreases significantly after successful antiviral treatment.
Article
Immunology
Sylvain Raimbault, Guillaume Monneret, Morgane Gossez, Fabienne Venet, Alexandre Belot, Franck Zekre, Solene Remy, Etienne Javouhey
Summary: In this study, the researchers examined the use of monocyte human leucocyte antigen (mHLA)-DR as a potential diagnostic marker for secondary HLH (sHLH). They found that levels of mHLA-DR were significantly higher in patients with sHLH compared to healthy children and those with septic shock. Additionally, mHLA-DR levels decreased after treatment initiation. The findings suggest that elevated mHLA-DR could aid in the diagnosis of sHLH and distinguish it from septic shock.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Oncology
Sylvain Simon, Grace Bugos, Stanley R. Riddell
Summary: The study presents a novel chimeric receptor design that enhances the antigen sensitivity of CAR T cells towards tumor cells expressing low antigen levels.
Article
Biochemistry & Molecular Biology
Kenji Tanimura, Shigeru Saito, Sayaka Tsuda, Yosuke Ono, Hajime Ota, Shinichiro Wada, Masashi Deguchi, Mikiya Nakatsuka, Takeshi Nagamatsu, Tomoyuki Fujii, Gen Kobashi, Hisashi Arase, Hideto Yamada
Summary: The anti-beta 2-glycoprotein I/HLA-DR antibody is associated with antiphospholipid syndrome and recurrent pregnancy loss. This study demonstrates that the antibody is significantly associated with adverse obstetric outcomes and recurrent pregnancy loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Olaf Holz, Meike Mueller, Saskia Carstensen, Anna-Carin Olin, Jens M. Hohlfeld
Summary: In this study, we used the endotoxin challenge model to monitor particles in exhaled air (PEx) and demonstrated that PEx can be used to monitor inflammatory changes in the lung. We were able to detect a cytokine response in PEx during the early phase of LPS-induced inflammation.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Ila Joshi, Walter P. Carney, Edwin P. Rock
Summary: Sepsis is a heterogeneous clinical syndrome characterized by a systemic inflammatory response to tissue injury or infection, accompanied by reduced immune responsiveness. Immunoparalysis, characterized by reduced lymphocyte numbers and downregulation of class II human leukocyte antigens (HLA), is associated with worsened outcomes and increased mortality. Measures such as mHLA-DR expression on peripheral blood monocytes have shown promise in identifying sepsis immunoparalysis. Experimental immunotherapies, including sargramostim, have demonstrated clinical benefit by reducing hospitalization duration and lowering infection risk. However, the lack of a standardized method has limited widespread adoption of these approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)