Article
Biochemistry & Molecular Biology
Yusuke Ohnaka, Satoshi Tsukamoto, Yuna Iwai, Michiko Hamada-Kanazawa, Ryusho Kariya, Masaoki Takano
Summary: Bradykinin plays various physiological roles, including vasodilation and blood pressure reduction. Mutant mice experiments indicated that plasma LKNG is the source of KNG in the vascular kallikrein-kinin system, and it contributes significantly to maintaining lower systolic blood pressure.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Michal B. Ponczek
Summary: Kininogens are multidomain glycoproteins with important roles in the intrinsic pathway of coagulation and the generation of the vasoactive peptide bradykinin. Despite previous failures to crystallize kininogen, new advancements in cryo-electron microscopy offer opportunities to study its structure at an atomic level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Guacyara Motta, Luiz Juliano, Jair Ribeiro Chagas
Summary: This review summarizes the history and evolution of human plasma kallikrein, and explores its role in cell biology and inflammatory processes. It also examines the development of natural plasma protein inhibitors.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
P. Vishnyakova, A. Poltavets, E. Karpulevich, A. Maznina, V. Vtorushina, L. Mikhaleva, E. Kananykhina, A. Lokhonina, S. Kovalchuk, A. Makarov, A. Elchaninov, G. Sukhikh, T. Fatkhudinov
Summary: Macrophages play a crucial role in innate immunity and are activated by various factors. This study found that macrophages derived from CD14+ monocytes exhibit higher sensitivity to pro-inflammatory induction, showing increased levels of pro-inflammatory and anti-inflammatory cytokines compared to CD16+-derived macrophages. This data may be valuable for macrophage-based cell therapy applications, providing insights for manipulating donor monocytes for transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Clinical Neurology
Anan Shtaya, Leslie R. Bridges, Rebecca Williams, Sarah Trippier, Liqun Zhang, Anthony C. Pereira, James A. R. Nicoll, Delphine Boche, Atticus H. Hainsworth
Summary: The study identified an anti-inflammatory process occurring alongside neuroinflammation post-sICH in clinical patients, involving native microglia and blood monocytes. This novel pathway offers therapeutic targets and a treatment opportunity window for delivering therapeutics through invading monocytes during 3-5 days post-sICH.
Review
Immunology
Marco Orecchioni, Hiroaki Matsunami, Klaus Ley
Summary: Olfactory receptors in macrophages play a significant role in inflammation regulation and pathological processes. By triggering specific receptors and their ligand binding, the formation of inflammasomes and the release of inflammatory mediators can be induced.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Alona A. Merkulova, Sarah Abdalian, Sadiq Silbak, Alessandro Pinheiro, Alvin H. Schmaier
Summary: This study found that the activation of prekallikrein and cleavage of high-molecular-weight kininogen on human microvascular endothelial cells were regulated by the ambient concentration of C1 inhibitor and prolylcarboxypeptidase. These findings are important for understanding the function of endothelial cells and related diseases.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Hematology
Zu-Lin Chen, Pradeep K. Singh, Katharina Horn, Marissa R. Calvano, Shigeru Kaneki, Keith R. McCrae, Sidney Strickland, Erin H. Norris
Summary: A dysregulated plasma contact system is involved in various pathological conditions. 3E8 anti-HK antibody blocks HK cleavage and bradykinin generation in human and mouse plasma, and inhibits contact system-induced bradykinin generation. It also inhibits the activation of factor XI, prekallikrein, and FXII, providing a novel strategy to treat contact system dysregulation-related diseases.
Article
Cardiac & Cardiovascular Systems
Sooyong Park, Ja-Yoon Gu, Hyun Kyung Kim
Summary: This study investigates the relationship between the activation of the contact system and the progression of disseminated intravascular coagulation (DIC). The results show that the activity levels of prekallikrein and high-molecular-weight kininogen (HMWK) are linearly correlated with DIC score and antithrombin level. Additionally, the consumption of prekallikrein and HMWK contributes to the formation of microvascular thrombosis in DIC. Therefore, measurements of prekallikrein and HMWK activity could serve as potential diagnostic markers for the progression of overt-DIC.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Immunology
Nadeem Akhter, Shihab Kochumon, Amal Hasan, Ajit Wilson, Rasheeba Nizam, Ashraf Al Madhoun, Fatema Al-Rashed, Hossein Arefanian, Fawaz Alzaid, Sardar Sindhu, Fahd Al-Mulla, Rasheed Ahmad
Summary: The co-stimulation of IFN-gamma and LPS can enhance the expression of CCL2 through the acetylation of H3K27, leading to augmented inflammation in obesity. These findings contribute to a better understanding of the regulatory mechanisms of CCL2 in the pathogenesis of obesity.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Himangshu Sonowal, Ashish Saxena, Sumin Qiu, Sanjay Srivastava, Kota V. Ramana
Summary: The study demonstrates that fidarestat can attenuate Dox-induced immune and inflammatory responses by upregulating mitochondrial biogenesis markers, providing potential evidence for using fidarestat in combination with anthracycline drugs to prevent chemotherapy-induced inflammation and toxicity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jingxuan Liu, Yueying Yang, Xiao Liu, Andy Samuel Widjaya, Baohong Jiang, Yanyan Jiang
Summary: The study suggests that utilizing nanotherapy, such as PM/TN-CCLP, can significantly prevent and treat aortic dissection by reducing the rupture rate, preventing loss of elastic fibers, and decreasing inflammation at the lesion site.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Immunology
Delphine C. Malherbe, Ilhem Messaoudi
Summary: Drinking alcohol, even in moderation, can have disproportionate effects on the immune system, particularly on myeloid cells. These effects depend on the pattern of alcohol exposure, with acute drinking dampening inflammatory mediators and chronic drinking enhancing their production. Alcohol's impact on myeloid cells is thought to be mediated by oxidative stress and changes in cellular epigenetic landscapes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Marina Fandaros, Kusumam Joseph, Allen P. Kaplan, David A. Rubenstein, Berhane Ghebrehiwet, Wei Yin
Summary: Angioedema is characterized by swelling of skin or mucous membranes due to the overproduction of the vasodilator bradykinin. Endothelial cells are sensitive to blood-flow-induced shear stress, and a monoclonal antibody targeting gC1qR may be an effective therapeutic reagent for angioedema.
Review
Biochemistry & Molecular Biology
Melanie A. Kimm, Christopher Klenk, Marianna Alunni-Fabbroni, Sophia Kaestle, Matthias Stechele, Jens Ricke, Michel Eisenblaetter, Moritz Wildgruber
Summary: This review provides an overview of the origin of tumor-associated macrophages, their polarization into different subtypes, and how characteristic markers of the subtypes can be used as targets for molecular imaging and theranostic approaches.
Article
Chemistry, Physical
Anna Barbasz, Agnieszka Czyzowska
MOLECULAR SIMULATION
(2019)
Article
Biochemistry & Molecular Biology
Agnieszka Czyzowska, Anna Barbasz
ACTA BIOCHIMICA POLONICA
(2019)
Review
Environmental Sciences
Agnieszka Czyzowska, Anna Barbasz
Summary: Modern nanotechnology has made it possible to obtain zinc oxide nanomaterials with unique properties for a wide range of commercial applications. The toxicity of these nanoparticles to humans and plants is a subject of concern, but their use also has potential benefits depending on concentration and synthesis methods.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Environmental Sciences
Anna Barbasz, Barbara Kreczmer, Magdalena Skorka, Agnieszka Czyzowska
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2020)
Article
Chemistry, Multidisciplinary
Magdalena Ocwieja, Anna Barbasz
JOURNAL OF NANOPARTICLE RESEARCH
(2020)
Article
Toxicology
Agnieszka Czyzowska, Barbara Dyba, Elzbieta Rudolphi-Szydlo, Anna Barbasz
Summary: The study aimed to assess the toxic effects of ZnO-NPs on model human immune cells, focusing on their interaction with membrane lipids and the role of zinc ions. Results showed disruption in cell metabolism and lipid peroxidation, with zinc ions not being the main causative factor of toxicity. Using Langmuir technique, the interaction of nanoparticles with lipids was evaluated to understand the early stages of toxicity mechanism for a complete risk assessment and safer synthesis of nanomaterials.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Toxicology
Agnieszka Czyzowska, Anna Barbasz
Summary: This study assessed the toxicity of zinc oxide nanoparticles with two diameters on human immune cells, finding that they induce cell death, mitochondrial damage, membrane lipid peroxidation, and inflammation induction.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Biophysics
Ditta Ungor, Anna Barbasz, Agnieszka Czyzowska, Edit Csapo, Magdalena Ocwieja
Summary: This study focused on the comparative cytotoxicity investigations of protein-stabilized gold nanoclusters on lymphocytes B and T cells. It was found that gamma G-Au NCs induced the highest disorders in mitochondrial activity, while LYZ- and gamma G-Au NCs enhanced the secretion of malonic dialdehyde. Despite minor effects on cell viability, all Au NCs caused oxidative stress and could stimulate undesirable cellular processes.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Toxicology
Anna Barbasz, Magdalena Ocwieja, Natalia Piergies, Dorota Duraczynska, Anna Nowak
Summary: The study investigated the toxicity of silver nanoparticles synthesized using antioxidants on human cells, finding that GAAgNPs were more toxic than AAgNPs, with the presence of stabilizing agents being the main factor influencing toxicity.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Barbara Dyba, Elzbieta Rudolphi-Szydlo, Anna Barbasz, Agnieszka Czyzowska, Konrad Kamil Hus, Vladimir Petrilla, Monika Petrillova, Jaroslav Legath, Aleksandra Bocian
Summary: The study aimed to determine the effects of exogenous application of three-finger toxins on monocytes (U-937) and promyelocytes (HL-60) cells, focusing on membrane modifications under the influence of various doses of 3FTx protein fraction. The results showed that protein-lipid interactions depended on the presence of lipid polar parts and the degree of membrane saturation. Biochemical indicators reflecting the tested cells confirmed the results obtained from the model.
Article
Chemistry, Physical
Agnieszka Czyzowska, Anna Barbasz, Lilianna Szyk-Warszynska, Magdalena Ocwieja, Edit Csapo, Ditta Ungor
Summary: This study investigated the comprehensive toxicity mechanism of protein-stabilized gold nanoclusters (Au NCs) on HL-60 cells, revealing a minor toxic effect and enhanced apoptosis, especially with LYZ-stabilized Au NCs having the most negative impact on the cells.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Toxicology
Agnieszka Czyzowska, Anna Barbasz, Elzbieta Rudolphi-Szydlo, Barbara Dyba
Summary: Studies have shown that zinc oxide nanoparticles exhibit toxicity towards cell membranes, with different cell lines showing varying reactions to the nanoparticles. Analysis using a model membrane revealed that interaction with zinc oxide nanoparticles results in changes in the model membrane.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Barbara Kreczmer, Barbara Dyba, Anna Barbasz, Elzbieta Rudolphi-Szydlo
Summary: Quercetin, a polyphenolic compound, exhibits potential anticancer, antiinflammatory, and antioxidant properties, but may also have pro-oxidative and cytotoxic effects. Research suggests that quercetin's action in cells may be primarily through altering the stiffness/elasticity of cell membranes, impacting cellular processes associated with membrane functions.
Article
Toxicology
Anna Barbasz, Agnieszka Czyzowska, Natalia Piergies, Magdalena Ocwieja
Summary: Silver nanoparticles prepared and stabilized by various bioactive substances, particularly antioxidants, exhibit different toxicity levels on melanoma cells. Human skin melanoma cells are more sensitive to AgNPs than murine melanoma cells when exposed to different combinations of antioxidants.
JOURNAL OF APPLIED TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Waldemar Tejchman, Bartosz Orwat, Izabela Korona-Glowniak, Anna Barbasz, Ireneusz Kownacki, Gniewomir Latacz, Jadwiga Handzlik, Ewa Zeslawska, Anna Malm
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)