Journal
INTERNATIONAL IMMUNOLOGY
Volume 25, Issue 3, Pages 139-143Publisher
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxs113
Keywords
Foxp3; gut lamina propria; intestinal tolerance; mesenteric lymph nodes
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Funding
- Deutsche Forschungsgemeinschaft [PA921/1-1, PA921/2-1]
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Intestinal tolerance toward dietary antigens and the microbiota critically depends on regulatory T cells (T-reg cells). To exert their function, T-reg cells need to get into the proximity of their target cells foremost within lymphoid organs and the lamina propria in the small and large intestines. Thus, T-reg-cell-mediated immunosuppression is intrinsically linked to cell migration and localization. However, the gut lamina propria not only constitutes an effector site but also actively influences T-reg-cell function. In particular, gut-resident macrophages take an active role in shaping the T-reg-cell pool. Here, the author summarizes recent observations to suggest that T-reg-cell migration not only directs cells to sites of immunosuppression but also allows for the coordinated shaping of the T-reg-cell population.
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