Review
Biochemistry & Molecular Biology
Hochung Jang, Eun Hye Kim, Sung-Gil Chi, Sun Hwa Kim, Yoosoo Yang
Summary: This review focuses on utilizing nanoparticles to target innate immune cells in tumor microenvironments. It emphasizes the immune-suppressive properties of some innate immune cells that limit clinical benefits, and the potential development of strategies by understanding the cross-talk between tumors and innate immune cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Zhengjia Zhang, Qingcai Huang, Liuchunyang Yu, Dongjie Zhu, Yang Li, Zeyu Xue, Zhenglai Hua, Xinyi Luo, Zhiqian Song, Cheng Lu, Ting Zhao, Yuanyan Liu
Summary: Tumor immune escape is a critical step in cancer progression and immunotherapy. miRNAs play important roles in regulating immune escape, and exosomes have emerged as effective carriers for delivering miRNAs. Understanding the role of miRNAs in tumor immune escape and utilizing exosomes for miRNA therapy is crucial for developing more effective tumor-fighting strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Su Xian, Magalie Dosset, Gonzalo Almanza, Stephen Searles, Paras Sahani, T. Cameron Waller, Kristen Jepsen, Hannah Carter, Maurizio Zanetti
Summary: Aneuploidy is associated with poor prognosis in cancer types, and the unfolded protein response (UPR) is proposed as a mechanistic link between aneuploidy and immune dysregulation in the tumor microenvironment, showing increased activity of multiple UPR branches in response to aneuploidy.
Review
Cell Biology
Alessandro Sacco, Anna Martina Battaglia, Cirino Botta, Ilenia Aversa, Serafina Mancuso, Francesco Costanzo, Flavia Biamonte
Summary: New insights have been gained into the impact of iron metabolism within the tumor microenvironment on cancer development. Iron promotes the production of reactive oxygen species, which can trigger cell death or malignant transformation, affecting tumor immunosurveillance. The potential and controversies of using iron metabolism as a target for anticancer treatments are discussed, particularly in the context of hot and cold tumors.
Article
Chemistry, Multidisciplinary
Jung Min Shin, Chan-Hyeong Lee, Soyoung Son, Chan Ho Kim, Jae Ah Lee, Hyewon Ko, Sol Shin, Seok Ho Song, Seong-Sik Park, Ju-Hyun Bae, Ju-Mi Park, Eun-Ji Choe, Moon-Chang Baek, Jae Hyung Park
Summary: Sulfisoxazole significantly decreases exosomal PD-L1 levels and reinvigorates exhausted T cells when orally administered, showing potential to improve the response rate of anti-PD-1 antibodies in cancer treatment.
Review
Oncology
Tian Yun, Zhenzhu Liu, Jianbo Wang, Rui Wang, Liang Zhu, Zheng Zhu, Xuejian Wang
Summary: This paper describes the mechanism of ferroptosis in tumor therapy and immunotherapy, as well as the application and benefits of nanotechnology in the combination of tumor immunotherapy and ferroptosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Chenglin Lu, Ying Liu, Nasra Mohamoud Ali, Bin Zhang, Xiaonan Cui
Summary: Innate immune cells in the tumor microenvironment determine the occurrence and development of tumors by secreting various factors. Understanding their role can improve therapeutic approaches and prognosis. This review provides an overview of the biology, role, and immunotherapy of innate immune cells, aiming to guide future research and clinical trials.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Johanna Waidhauser, Pia Nerlinger, Florian Sommer, Sebastian Wolf, Stefan Eser, Phillip Loehr, Andreas Rank, Bruno Maerkl
Summary: This study found that circulating lymphocytes, especially cytotoxic T cells, are associated with the local antitumor immune response in colorectal cancer patients. The results also demonstrate that the size of lymph nodes and the metastasis-to-lymph node size ratio have an impact on the immune response in these patients.
Review
Biochemistry & Molecular Biology
Lin Fu, Xiaotong Zhou, Qian Jiao, Xi Chen
Summary: As a member of the TRIM protein family, TRIM56 acts as an E3 ubiquitin ligase and exhibits deubiquitinase activity and RNA binding ability. Its role in innate immune response regulation, antiviral defense, and tumor development has attracted attention from researchers. However, there is a lack of systematic review on TRIM56.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Shiyan Fu, Ruihao Yang, Junjie Ren, Jiahui Liu, Lei Zhang, Zhigang Xu, Yuejun Kang, Peng Xue
Summary: The PEGylated CoFe2O4 nanoflowers (CFP) with multiple enzymatic activities are synthesized as bioreactors responsive to TME cues for augmented sonodynamic therapy (SDT) and chemodynamic therapy (CDT), eliciting a strong immune response.
Review
Food Science & Technology
Cristina Valeria Bulgaru, Daniela Eliza Marin, Gina Cecilia Pistol, Ionelia Taranu
Summary: ZEA is an estrogenic fusariotoxin that affects reproductive health and immune response. It can cause reproductive disorders and impact immune response, with studies showing effects on different types of immune cells and immune organs. Despite the increasing research on the mechanisms of ZEA in modulating immune response, data are currently insufficient and further investigation is needed.
Review
Oncology
Lin Zhang, Chao Zhou, Songou Zhang, Xiaozhen Chen, Jian Liu, Fangming Xu, Wenqing Liang
Summary: New evidence suggests that the clinical success of chemotherapy is not solely due to its toxic effects on tumor cells, but also because it restores immunosurveillance, which has been largely overlooked in previous research. It is crucial to gain novel insights into molecular mechanisms and strategies that enhance the effectiveness of immunotherapy, as only a few cancer patients respond to immune checkpoint inhibitors (ICIs). Recent studies on combination therapy of chemotherapy and ICIs have shown promising results.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Evelien Hesemans, Neshat Saffarzadeh, Christy Maksoudian, Mukaddes Izci, Tianjiao Chu, Carla Rios Luci, Yuqing Wang, Hendrik Naatz, Sebastian Thieme, Cornelia Richter, Bella B. Manshian, Suman Pokhrel, Lutz Madler, Stefaan J. Soenen
Summary: Nanoparticle-mediated cancer immunotherapy holds great promise, but more efforts are needed to obtain nanoformulations that result in a full scale activation of innate and adaptive immune components that specifically target the tumors. Fine-tuning nanoparticle properties resulted in a formulation of 33% Cu-doped TiO2 which enabled short-lived hyperactivation of dendritic cells and hereby promoted immunotherapy. These nanoparticles result in highly efficient activation of dendritic cells ex vivo, which upon transplantation in tumor-bearing mice, exceeded the therapeutic outcomes obtained with classically stimulated dendritic cells.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Haina Tian, Yang Li, Jinyan Lin, Fukai Zhu, Zhenqing Hou, Peiyuan Wang, Xiaolong Liu
Summary: Researchers have successfully constructed GSH/pH-sensitive Mn2+/polydopamine-incorporated hollow mesoporous tetrasulfide-bridged organosilica nanoreactors loaded with l-arginine (l-Arg). These nanoreactors generate reactive oxygen species (ROS) and nitric oxide (NO) for photothermal-intensified chemodynamic therapy and gas therapy, and enhance the immune response by inducing immunogenic cell death (ICD) and converting macrophages into an M1 phenotype.
ACS MATERIALS LETTERS
(2023)
Article
Cell Biology
Federica Tomay, Kelsi Wells, Lelinh Duong, Jean Wei Tsu, Danielle E. Dye, Hannah G. Radley-Crabb, Miranda D. Grounds, Tea Shavlakadze, Pat Metharom, Delia J. Nelson, Connie Jackaman
IMMUNOLOGY AND CELL BIOLOGY
(2018)
Article
Oncology
Connie Jackaman, Joanne K. Gardner, Federica Tomay, Joshua Spowart, Hannah Crabb, Danielle E. Dye, Simon Fox, Stephen Proksch, Pat Metharom, Satvinder S. Dhaliwal, Delia J. Nelson
Article
Immunology
Jennifer L. Hope, Panagiota Spantidea, Caoimhe H. Kiernan, Christopher J. Stairiker, Laurine C. Rijsbergen, Marjan van Meurs, Inge Brouwers-Haspels, Yvonne M. Mueller, Delia J. Nelson, Linda M. Bradley, Joachim G. J. Aerts, Peter D. Katsikis
FRONTIERS IN IMMUNOLOGY
(2020)
Review
Geriatrics & Gerontology
L. Duong, H. G. Radley, B. Lee, D. E. Dye, F. J. Pixley, M. D. Grounds, D. J. Nelson, C. Jackaman
Summary: As individuals age, their health deteriorates, leading to an increased risk of diseases such as cancer. The process of immunosenescence is characterized by changes in immune function, including an imbalance between pro-inflammatory and anti-inflammatory factors. Macrophages, key inflammatory cells, play a significant role in aging processes, potentially impacting the severity of age-related diseases such as cancer and injury repair.
Article
Biology
Ayeisha Milligan Armstrong, Tenielle Porter, Hazel Quek, Anthony White, John Haynes, Connie Jackaman, Victor Villemagne, Kylie Munyard, Simon M. Laws, Giuseppe Verdile, David Groth
Summary: Chronic psychosocial stress is recognized as a risk factor for sporadic Alzheimer's disease. Factors such as dysregulation of the HPA axis and elevated levels of cortisol may contribute to the disease process. Individual differences in sensitivities to glucocorticoid and stress responses could also impact an individual's risk of developing AD.
BIOLOGICAL REVIEWS
(2021)
Article
Pathology
Jessica Gaff, Connie Jackaman, John Papadimitriou, Shelley Waters, Catriona McLean, Patricia Price
Summary: The study found that P2X7R, P2X4R, and CaMKK2 proteins are expressed in neurons of older individuals, but their expression is not associated with Alzheimer's disease (AD). There were marginally fewer neurons in sections from individuals with AD, but no significant differences in the percentage of positive neurons for P2X7R, P2X4R, or CaMKK2.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Veterinary Sciences
Stephen Francis Proksch, Clinton Petrus Matthysen, John E. Jardine, Ken Mark Wyatt, Jessica Renee Finlay, Delia Jane Nelson
Summary: Human and canine sarcomas are challenging soft tissue malignancies with high recurrence and metastasis rates. In a study using genetically identical mice, intra-tumoral delivery of IL-2 and an anti-CD40 antibody showed promising curative responses. The same approach was then tested in domestic dogs with naturally occurring sarcomas, resulting in tumor regression and minimal side effects. These findings provide encouraging proof-of-concept data for developing immunotherapeutic strategies in both veterinary and human medicine.
VETERINARY AND COMPARATIVE ONCOLOGY
(2022)
Article
Immunology
Peter T. Graham, Anna K. Nowak, Scott M. J. Cornwall, Irma Larma, Delia J. Nelson
Summary: We evaluated the potential of the murine Stimulator of Interferon Genes (STING) agonist, DMXAA, against mesothelioma using a mouse model. Our results showed that careful dosing and treatment protocols of DMXAA induced tumor regression, long-term survival, and protective memory in mice with mesothelioma. DMXAA also had direct cytotoxic effects on mesothelioma cell lines and improved tumor-antigen presentation. However, combining DMXAA with other immunotherapies reduced its efficacy. These findings suggest that mesothelioma patients could benefit from treatment with a STING agonist, but caution should be exercised when combining it with other immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Arlene Chan, Jespal Gill, HuiJun Chih, Delia J. Nelson
Summary: This study investigated the impact of immune biomarkers on the prognosis of luminal breast cancer patients. The results showed no statistically significant differences in immune biomarkers between patients with relapse and those without relapse. However, tumor-infiltrating lymphocytes were found to be higher in patients without relapse, and GAL-9 expression was consistently detected in these patients. Further research on these trends in checkpoint molecule expression is warranted.
Article
Biochemistry & Molecular Biology
Gaewyn Ellison, Lelinh Duong, Ashley Hollings, Daryl Howard, Connie Jackaman, Mark J. Hackett
Summary: Metal ion homeostasis in the aging brain is important for healthy brain function. This study investigates the association between elevated brain iron and brain inflammation during natural aging using various imaging techniques. The results show an accumulation of iron in the corpus callosum white matter and highlight the need for further research on different forms of iron in relation to brain metabolism and inflammation.
Article
Chemistry, Inorganic & Nuclear
Nurshadrina Akabar, Vishal Chaturvedi, Georgina E. Shillito, Bradley J. Schwehr, Keith C. Gordon, Gregory S. Huff, Joshua J. Sutton, Brian W. Skelton, Alexandre N. Sobolev, Stefano Stagni, Delia J. Nelson, Massimiliano Massi
DALTON TRANSACTIONS
(2019)
Article
Immunology
Jenjira Mountford, Fitri Octaviana, Riwanti Estiasari, Denise Dewanto Setiawan, Ibnu Ariyanto, Silvia Lee, Jessica Gaff, Constance Chew, Connie Jackaman, Peter Kamerman, Catherine Cherry, Patricia Price
Article
Medicine, General & Internal
Joanne K. Gardner, Connie Jackaman, Cyril D. S. Mamotte, Delia J. Nelson
FRONTIERS IN MEDICINE
(2018)