Article
Immunology
Johanna Raffetseder, Robert Lindau, Sigrid van der Veen, Goran Berg, Marie Larsson, Jan Ernerudh
Summary: During pregnancy, MAIT cells play dual roles in immune modulation and antimicrobial defense, requiring strict regulation to prevent pregnancy complications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Kang Mi Lee, Qiang Fu, Guoli Huai, Kevin Deng, Ji Lei, Lisa Kojima, Divyansh Agarwal, Peter van Galen, Shoko Kimura, Naoki Tanimine, Laura Washburn, Heidi Yeh, Ali Naji, Charles G. Rickert, Christian LeGuern, James F. Markmann
Summary: B lymphocytes play important roles in adaptive immunity and self-tolerance. Activated B cells through TLR4/TLR9 receptors acquire regulatory properties, inhibiting T cell proliferation and preventing allograft rejection.
Article
Cell Biology
Sophia Papaioannou, Jia-Xiang See, Mingeum Jeong, Carolina De La Torre, Volker Ast, Philipp-Sebastian Reiners-Koch, Ankita Sati, Carolin Mogler, Michael Platten, Adelheid Cerwenka, Ana Stojanovic
Summary: Liver sinusoidal endothelial cells (LSECs) respond to LPS and immune-derived signals, producing chemokines CCL2 and CXCL10. NK cells exposed to LSECs in vitro are primed for higher production of IFN-g in response to IL-12 and IL-18. In inflamed livers, NK cells are the major producers of IFN-g. This positive feedback loop of immune cell attraction and activation is regulated by LSECs and is important in liver inflammation.
Article
Geriatrics & Gerontology
Hisato Iriki, Miho Mukai, Yasuhiko Asahina, Yoko Kubo, Hiromi Ito, Masayuki Amagai, Hayato Takahashi
Summary: Autoimmune responses increase with age, but the mechanism behind it is unclear. This study used CD4(+) T cells to investigate how immunological tolerance against autoreactive CD4(+) T cells changes with age. It was found that in aged mice, Dsg3-specific T cells were not deleted and produced higher levels of proinflammatory cytokine IFN-gamma compared to young mice. Understanding this mechanism may help in evaluating the risk and preventing onset of autoimmune diseases in the elderly.
Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Tucker J. Piergallini, Julia M. Scordo, Anna Allue-Guardia, Paula A. Pino, Hao Zhang, Hong Cai, Yufeng Wang, Larry S. Schlesinger, Jordi B. Torrelles, Joanne Turner
Summary: Inflammation plays a crucial role in lung infection, including tuberculosis caused by Mycobacterium tuberculosis. However, the specific impact of inflammation on regulating lymphocyte function is not well understood. To address this knowledge gap, the researchers used an acute lipopolysaccharide (LPS) treatment in young mice to study how inflammation affects CD8 T cell subsets. The findings show that acute inflammation can affect CD8 T cells, potentially impacting immune control in various disease states.
JOURNAL OF LEUKOCYTE BIOLOGY
(2023)
Review
Immunology
Xiaoqing Chen, Xue Liu, Yichao Jiang, Ningshao Xia, Chao Liu, Wenxin Luo
Summary: Chronic hepatitis B virus (HBV) infection is a major public health challenge, with over 250 million people worldwide infected. Priming of naive HBV-specific CD8 T cells is hindered, and this is closely related to abnormalities in the complex immune microenvironment. In this article, we summarize recent progress in understanding the abnormal priming of HBV-specific CD8 T cells and discuss corresponding immunotherapies to facilitate their functional recovery. We also highlight the importance of balancing viral clearance and pathological liver injury induced by CD8 T-cell activation during drug development.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Feiya Ma, Jensen Vayalil, Grace Lee, Yuqi Wang, Guangyong Peng
Summary: Tumor-derived extracellular vesicles (EVs) are a major factor inducing T cell dysfunction in the tumor microenvironment, playing a crucial role in cancer immunity. By carrying immune suppressive signals, tumor-derived EVs can drive T cell dysfunction and promote tumor immunity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Natalia M. Krajewska, Remi Fiancette, Ye H. Oo
Summary: Immune-mediated cholangiopathies are characterized by the destruction of bile ducts, leading to liver inflammation and fibrosis. Regulatory T cells (Tregs) play a crucial role in these diseases, but their function can be impaired by the inflamed microenvironment. Mast cells (MCs) are also involved in the pathogenesis by releasing pro-inflammatory mediators. MCs can indirectly influence Treg function and there are also direct interactions between MCs and Tregs. Understanding the crosstalk between Tregs and MCs is important for the progression of autoimmune cholangiopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dennis Merk, Johannes Ptok, Philipp Jakobs, Florian von Ameln, Jan Greulich, Pia Kluge, Kathrin Semperowitsch, Olaf Eckermann, Heiner Schaal, Niloofar Ale-Agha, Joachim Altschmied, Judith Haendeler
Summary: The study showed that APEX1(1-20) can inhibit EC apoptosis, and identified SELENOT as a potential regulator gene to reduce LPS-induced EC activation and apoptosis. SELENOT, along with APEX1(1-20), can protect EC from activation and apoptosis effects, providing new therapeutic approaches for sepsis.
Article
Medicine, Research & Experimental
Rubia Isler Mancuso, Juliana Hofstatter Azambuja, Sara Teresinha Olalla Saad
Summary: This study demonstrates that ART pretreatment effectively prevents inflammation induced by LPS, protecting the body from inflammatory damage by regulating various immune cell types, reducing inflammatory cytokines and chemokines.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Shafat Ali, Sabhiya Majid, Md. Niamat Ali, Shahnaz Taing, Muneeb U. Rehman, Azher Arafah
Summary: Recurrent pregnancy loss (RPL) is a reproductive disease that involves two or more successive spontaneous abortions, with causes often related to dysfunction of endometrial cytokines and dysregulation of decidual cytokines. Cytokine modulatory therapies are considered promising for preventing RPL.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Daniel F. Zegarra-Ruiz, Dasom V. Kim, Kendra Norwood, Myunghoo Kim, Wan-Jung H. Wu, Fatima B. Saldana-Morales, Andrea A. Hill, Shubhabrata Majumdar, Stephanie Orozco, Rickesha Bell, June L. Round, Randy S. Longman, Takeshi Egawa, Matthew L. Bettini, Gretchen E. Diehl
Summary: Humans and their microbiota have a mutually beneficial relationship, where microbiota provides nutritional benefits and protection, and humans provide a hospitable environment. Maintaining this relationship requires immune balance to contain commensal microorganisms and limit inflammatory responses. Intestinal microorganisms can be recognized by T cells with antigen-specificity.
Article
Immunology
H. Hackstein, A. Kalina, B. Dorn, I. S. Keil, N. Baal, G. Michel, C. Brendel, A. Neubauer, T. Jakob, G. Bein
Summary: Extracorporeal photopheresis (ECP) acts through antigen-presenting dendritic cells (DC) and is influenced by CD11c(+) DC, demonstrating antigen specificity and showing the critical importance of CD11c(+) DC for ECP activity.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Review
Immunology
Aikaterini Hatzioannou, Athina Boumpas, Miranta Papadopoulou, Iosif Papafragkos, Athina Varveri, Themis Alissafi, Panayotis Verginis
Summary: Treg cell plasticity plays a significant role in autoimmunity and cancer, characterized by loss of Foxp3 expression. It has great therapeutic potential through destabilizing Treg cells to promote anti-tumor immunity or enhancing Treg cell stability to attenuate chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)