Review
Hematology
Ibadete Bytyci, Rafik Shenouda, Per Wester, Michael Y. Henein
Summary: The meta-analysis revealed a linear relationship between coronary and carotid atherosclerosis, with carotid plaque features associated with coronary artery disease. Moderate correlations were found between carotid intima-media thickness and the severity of CAD, as well as carotid and coronary stenosis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Weronika Frak, Armanda Wojtasinska, Wiktoria Lisinska, Ewelina Mlynarska, Beata Franczyk, Jacek Rysz
Summary: Cardiovascular diseases (CVDs) are disorders associated with the heart and circulatory system, with atherosclerosis as its underlying cause. CVDs are the leading cause of morbidity and mortality globally, creating a significant public health concern. This review summarizes the pathophysiological implications of CVDs, focusing on coronary artery disease and atherosclerosis. Inflammatory factors and genetic risk factors have been identified in association with CVDs.
Article
Biology
Yash T. Katakia, Satyadevan Kanduri, Ritobrata Bhattacharyya, Srinandini Ramanathan, Ishan Nigam, Bhanu Vardhan Reddy Kuncharam, Syamantak Majumder
Summary: The angle of blood vessel bifurcation is an important determinant of atherosclerosis and endothelial dysfunction, as it can alter hemodynamics and impact endothelial structure and function.
COMMUNICATIONS BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kiyotaka Hao, Jun Takahashi, Yoku Kikuchi, Akira Suda, Koichi Sato, Jun Sugisawa, Satoshi Tsuchiya, Tomohiko Shindo, Kensuke Nishimiya, Shohei Ikeda, Ryuji Tsuburaya, Takashi Shiroto, Yasuharu Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Satoshi Yasuda, Hiroaki Shimokawa
Summary: The study found that while the incidence of major adverse cardiovascular events was low among patients with vasospastic angina (VSA), those with significant coronary stenosis in the low-FFR group had a poor prognosis. The combination treatment of calcium channel blockers and percutaneous coronary intervention significantly improved the outcomes for VSA patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Liu Yang, Peng Peng Xu, U. Joseph Schoepf, Christian Tesche, Balakrishnan Pillai, Rock H. Savage, Chun Xiang Tang, Fan Zhou, Hao Dong Wei, Zhong Qiang Luo, Qing Gen Wang, Chang Sheng Zhou, Meng Jie Lu, Guang Ming Lu, Long Jiang Zhang
Summary: Fractional flow reserve and plaque progression assessed by serial coronary CT angiography predicted the risk of future major adverse cardiovascular events (MACE), demonstrating better accuracy compared to traditional assessment markers.
EUROPEAN RADIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Diana Jhoseline Medina-Leyte, Oscar Zepeda-Garcia, Mayra Dominguez-Perez, Antonia Gonzalez-Garrido, Teresa Villarreal-Molina, Leonor Jacobo-Albavera
Summary: The development of coronary artery disease (CAD) is closely tied to endothelial dysfunction and inflammation activation. Identifying new biomarkers and therapeutic strategies is crucial in preventing atherosclerosis and CAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Environmental Sciences
Karl Kilbo Edlund, Gerd Sallsten, Peter Molnar, Eva M. Andersson, Mikael Ogren, David Segersson, Erika Fagman, Bjorn Fagerberg, Lars Barregard, Goran Bergstrom, Leo Stockfelt
Summary: Long-term exposure to low levels of air pollution, particularly traffic-related pollutants, is positively associated with larger carotid artery plaque area, indicating the role of atherosclerosis as a main pathway between air pollution and cardiovascular disease. These associations are stronger in men and participants with cardiovascular risk factors.
ENVIRONMENTAL RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Ruijun Liu, Jing Shao
Summary: The article reviews the reasons for the increasing number of cardiovascular and cerebrovascular disease patients in recent years, as well as the related risk factors, providing a theoretical basis for early detection and treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Daniel Bos, Banafsheh Arshi, Quirijn J. A. van den Bouwhuijsen, M. Kamran Ikram, Mariana Selwaness, Meike W. Vernooij, Maryam Kavousi, Aad van der Lugt
Summary: This study found that hemorrhage in carotid atherosclerotic plaque is an independent risk factor for stroke and coronary heart disease.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yoichi Miura, Hidenori Suzuki
Summary: Both fasting and non-fasting hypertriglyceridemia are risk factors for atherosclerotic disease, but it is uncertain whether they increase the risks of carotid artery stenosis progression. Statins can prevent carotid plaque progression and improve plaque stability. However, there is currently no evidence that combining non-statin lipid-lowering drugs with statins provides additional benefits in preventing cerebrovascular events and stenosis progression in patients with carotid artery stenosis. This article explores the relationship between hypertriglyceridemia and carotid artery stenosis, as well as the potential role of lipid-lowering drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Multidisciplinary
Jia-Lu Hu, Zhi-Feng Yao, Min-Na Tang, Chun Tang, Xiao-Fan Zhao, Xi Su, Dan-Bo Lu, Qiu-Rong Li, Zhang-Sheng Wang, Yan Yan, Zeneng Wang
Summary: In this study, 78 human subjects were recruited and their gut microbiota compositions were analyzed. Specific microbial taxa associated with coronary artery disease (CAD) risks were identified, but the reproducibility of enriched taxa across different cohorts limited their use in early diagnosis and prevention of CAD. Only decreased Bacteroides abundance was found to be a reliable marker for indicating CAD progression.
Article
Cardiac & Cardiovascular Systems
Michelle Cristina-Oliveira, Kamila Meireles, Saulo Gil, Fabio Cavalcante Assis, Joao Carlos Geber-Junior, Samuel Katsuyuki Shinjo, Heraldo Possolo de Souza, Alfredo Nicodemos Cruz Santana, Paul A. Swinton, Luciano F. Drager, Bruno Gualano, Hamilton Roschel, Tiago Pecanha
Summary: This study examined whether brachial flow-mediated dilation (FMD) and carotid intima-media thickness (cIMT) are associated with acute in-hospital outcomes in patients hospitalized with COVID-19. The results suggest that cIMT and FMD are not independent predictors of clinical outcomes in these patients.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Anurag Mehta, Joseph Rigdon, Matthew C. Tattersall, Charles A. German, Thomas A. Barringer, Parag H. Joshi, Laurence S. Sperling, Matthew J. Budoff, Alain Bertoni, Erin D. Michos, Michael J. Blaha, James H. Stein, Michael D. Shapiro
Summary: This study found that the presence and extent of carotid plaque were associated with long-term coronary heart disease risk and incident CAC in middle-aged asymptomatic individuals with initial CAC score of 0.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Chemistry, Multidisciplinary
Min-chun Jiang, Huan-yu Ding, Yu-hong Huang, Chak Kwong Cheng, Chi Wai Lau, Yin Xia, Xiao-qiang Yao, Li Wang, Yu Huang
Summary: Atherosclerotic diseases are a major cause of adult mortality and strain healthcare systems worldwide. A study found that the drug thioridazine can inhibit YAP activity and alleviate endothelial inflammation and atherosclerosis. Thioridazine was shown to have anti-inflammatory effects mediated by inhibiting YAP and regulating RhoA. Furthermore, thioridazine reduced atherosclerosis in two mouse models. This research suggests the potential of repurposing thioridazine for treating atherosclerotic diseases.
ACTA PHARMACOLOGICA SINICA
(2023)