Article
Cardiac & Cardiovascular Systems
Simone Biscaglia, Andrea Erriquez, Matteo Serenelli, Fabrizio D'Ascenzo, Gaetano De Ferrari, Albert Ariza Sole, Juan Sanchis, Francesco Giannini, Francesco Gallo, Antonella Scala, Alberto Menozzi, Michele Pighi, Raul Moreno, Gianmarco Iannopollo, Mila Menozzi, Vincenzo Guiducci, Matteo Tebaldi, Gianluca Campo
Summary: The optimal revascularization strategy for older myocardial infarction (MI) patients with multivessel disease (MVD) is currently unknown. This study compared the outcomes of complete revascularization versus culprit-only treatment in older MI patients. The results showed that complete revascularization was associated with lower all-cause and cardiovascular mortality, as well as a lower incidence of myocardial infarction.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS
(2022)
Review
Cardiac & Cardiovascular Systems
Giorgio Benatti, Felice Gragnano, Luigi Vignali, Paolo Calabro, Filippo Luca Gurgoglione, Giampaolo Niccoli
Summary: Approximately half of the patients with ST-segment elevation myocardial infarction have additional atherosclerotic lesions in coronary segments other than the infarct-related artery. The optimal management of these residual lesions has been extensively studied, with evidence supporting the benefits of complete revascularization. However, controversies exist regarding the timing and strategy of treatment. This review provides a critical appraisal of the available literature, discussing areas of certainty, knowledge gaps, approaches for specific clinical subsets, and future research directions.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Denise Cristiana Faro, Claudio Laudani, Federica Giuseppa Agnello, Nicola Ammirabile, Simone Finocchiaro, Marco Legnazzi, Maria Sara Mauro, Placido Maria Mazzone, Giovanni Occhipinti, Carla Rochira, Lorenzo Scalia, Marco Spagnolo, Antonio Greco, Davide Capodanno
Summary: Multivessel disease (MVD) is common in patients with acute coronary syndromes (ACS) and is associated with poor outcomes and high mortality rates. Complete revascularization is beneficial for hemodynamically stable ACS patients with MVD, but there are still uncertainties regarding optimal timing and guidance strategies.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Federico Archilletti, Fabrizio Ricci, Francesco Pelliccia, George Dangas, Livio Giuliani, Francesco Radico, Matteo Perfetti, Serena Rossi, Sabina Gallina, Nicola Maddestra, Mohammed Y. Khanji, Marco Zimarino
Summary: This study aimed to identify the best strategy for complete revascularization in patients with multi-vessel disease and ST-elevation myocardial infarction. The results showed that complete revascularization significantly reduced the risk of all-cause death and new myocardial infarction compared to infarct-related artery-only percutaneous coronary intervention. There was no significant difference between angiography-guided and fractional flow reserve-guided complete revascularization in reducing the composite endpoint. Bayesian probability analysis ranked angiography-guided complete revascularization as the best intervention with the lowest risk of the composite endpoint, questioning the role of fractional flow reserve guidance in this setting.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Francesco Bruno, Giorgio Marengo, Ovidio De Filippo, Wojciech Wanha, Sergio Leonardi, Sergio Raposeiras Roubin, Enrico Fabris, Maja Popovic, Giuseppe Giannino, Alessandra Truffa, Zenon Huczek, Nicola Gaibazzi, Alfonso Ielasi, Bernardo Cortese, Andrea Borin, Ivan J. Nunez-Gil, Daniele Melis, Fabrizio Ugo, Matteo Bianco, Lucia Barbieri, Federico Marchini, Piotr Desperak, Claudio Montalto, Maria Melendo-Viu, Edoardo Elia, Massimo Mancone, Andrea Buono, Marcos Ferrandez-Escarabajal, Nuccia Morici, Marco Scaglione, Domenico Tuttolomondo, Gennaro Sardella, Mariusz Gasior, Maciej Mazurek, Guglielmo Gallone, Gianluca Campo, Wojciech Wojakowski, Emad Abu-Assi, Gianfranco Sinagra, Gaetano Maria De Ferrari, Fabrizio D'Ascenzo
Summary: The impact of complete revascularization on heart failure development in patients with acute coronary syndrome and multivessel coronary artery disease undergoing percutaneous coronary intervention is not clear. This study found that complete revascularization can reduce the risk of heart failure and cardiovascular death.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Joo Myung Lee, Hyun Kuk Kim, Keun Ho Park, Eun Ho Choo, Chan Joon Kim, Seung Hun Lee, Min Chul Kim, Young Joon Hong, Sung Gyun Ahn, Joon-Hyung Doh, Sang Yeub Lee, Sang Don Park, Hyun-Jong Lee, Min Gyu Kang, Jin-Sin Koh, Yun-Kyeong Cho, Chang-Wook Nam, Bon-Kwon Koo, Bong-Ki Lee, Kyeong Ho Yun, David Hong, Hyun Sung Joh, Ki Hong Choi, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Seung-Hyuk Choi, Hyeon-Cheol Gwon, Joo-Yong Hahn, FRAME AMI Invest
Summary: For patients with acute myocardial infarction and multivessel coronary artery disease, FFR-guided PCI is superior to angiography-guided PCI in reducing the risk of death or myocardial infarction.
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Meng-Jin Hu, Yue-Jin Yang, Jin-Gang Yang
Summary: Based on the results of our meta-analysis, we found that among patients with STEMI and multivessel disease, staged MV-PCI may be the optimal revascularization strategy compared to immediate MV-PCI.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Lingyue Zhao, Wenqin Guo, Weichao Huang, Lili Wang, Fanrui Mo, Xiehui Chen, Chaoyang Li, Siquan Huang
Summary: In patients with ST-segment elevation myocardial infarction and multivessel disease, angiography-guided complete revascularization appears to be more effective and associated with lower risk compared to culprit-only revascularization. Additionally, angiography-guided complete revascularization showed lower risk compared to FFR-guided complete revascularization for the primary outcome and myocardial infarction. Further studies directly comparing the effectiveness of these two complete revascularization strategies are warranted to draw more conclusive results.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Medicine, General & Internal
Raffaele Piccolo, Lina Manzi, Fiorenzo Simonetti, Attilio Leone, Domenico Angellotti, Maddalena Immobile Molaro, Nicola Verde, Plinio Cirillo, Luigi Di Serafino, Anna Franzone, Carmen Anna Maria Spaccarotella, Giovanni Esposito
Summary: Multivessel disease is common in STEMI patients undergoing primary PCI. Complete revascularization improves outcomes by reducing reinfarction and urgent revascularization risks. The timing and modality of non-culprit lesions revascularization remain debated. This review summarizes the evidence on managing non-culprit lesions in STEMI patients with or without cardiogenic shock.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Tobias F. S. Pustjens, Marijke J. C. Timmermans, Saman Rasoul, Arnoud W. J. van't Hof
Summary: The study found that NSTE-ACS patients with MVD undergoing MV-PCI and CO-PCI had similar mortality rates at long-term follow-up, but the MV-PCI group showed improved event-free survival in terms of fewer coronary reinterventions.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Roberto Diletti, Wijnand K. den Dekker, Johan Bennett, Carl E. Schotborgh, Rene van der Schaaf, Manel Sabate, Raul Moreno, Koen Ameloot, Rutger van Bommel, Daniele Forlani, Bert van Reet, Giovanni Esposito, Maurits T. Dirksen, Willem P. T. Ruifrok, Bert R. C. Everaert, Carlos Van Mieghem, Jacob J. Elscot, Paul Cummins, Mattie Lenzen, Salvatore Brugaletta, Eric Boersma, Nicolas M. Van Mieghem
Summary: Immediate complete revascularisation is non-inferior to staged complete revascularisation in patients with acute coronary syndrome and multivessel disease, and it is associated with a reduction in myocardial infarction and unplanned ischaemia-driven revascularisation.
Review
Cardiac & Cardiovascular Systems
Yujia Feng, Shu Li, Sihan Hu, Jing Wan, Hua Shao
Summary: This study suggests that complete revascularization should be performed in STEMI patients with multivessel coronary artery disease, and complete revascularization at the index procedure is superior to staged revascularization in reducing the risk of MACE events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Xacobe Flores-Rios, Ramon A. Calvino-Santos, Rodrigo Estevez-Loureiro, Jesus Peteiro-Vazquez, Jorge Salgado-Fernandez, Alejandro Rodriguez-Vilela, Raul Franco-Gutierrez, Alberto Bouzas-Mosquera, Jose Angel Rodriguez-Fernandez, Raquel Marzoa-Rivas, Carlos Gonzalez-Juanatey, Guillermo Aldama-Lopez, Pablo Pinon-Esteban, Nicolas Vazquez-Gonzalez, Javier Muniz-Garcia, Jose Manuel Vazquez-Rodriguez
Summary: An economic evaluation of the CROSS-AMI trial showed that SelR may be more efficient than ComR in patients with ST-segment elevation acute coronary syndrome and multivessel disease, as the costs during follow-up were lower in the SelR group.
REVISTA ESPANOLA DE CARDIOLOGIA
(2021)
Article
Cardiac & Cardiovascular Systems
Jiachun Lang, Chen Wang, Le Wang, Jingxia Zhang, Yuecheng Hu, Huajun Sun, Hongliang Cong, Yin Liu
Summary: Staged PCI is superior to culprit-only PCI in elderly patients with STEMI and MVD.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Myunhee Lee, Dae-Won Kim, Mahn-Won Park, Kyusup Lee, Sung-Ho Her, Kiyuk Chang, Wook Sung Chung, Myung Ho Jeong, Seung-Woon Rha, Hyo-Soo Kim, Hyeon Cheol Gwon, In Whan Seong, Kyung Kuk Hwang, Shung Chull Chae, Kwon-Bae Kim, Young Jo Kim, Kwang Soo Cha, Seok Kyu Oh, Jei Keon Chae, Ji-Hoon Jung
Summary: This study compared the long-term outcomes of IRA-only PCI and multivessel PCI in patients with NSTEMI and MVD complicated by severe LVSD, finding that multivessel PCI was associated with a significantly lower MACE risk, driven by a significantly lower risk of all-cause death.
Editorial Material
Surgery
Chong-Chi Chiu, Po-Huang Lee, Chen-Fuh Lam, Li-Ren Yeh, Cheuk-Kwan Sun
INTERNATIONAL JOURNAL OF SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Shu-Yuan Hsu, Chih-Hung Chen, Sujira Mukda, Steve Leu
Summary: Cerebral stroke is one of the leading causes of death worldwide. Pnn deficiency increases oxidative stress in neurons and exacerbates cerebral ischemia/reperfusion injury.
Review
Anesthesiology
Kuo-Chuan Hung, Ching-Chung Ko, Chih-Wei Hsu, Yu-Li Pang, Jen-Yin Chen, Cheuk-Kwan Sun
Summary: This systematic review and meta-analysis investigated the impact of peripheral nerve blocks (PNBs) on patient-reported quality of recovery (QoR) following breast cancer surgery. The results showed that patients who received PNBs had higher QoR scores at 24 hours after surgery, as well as higher scores on all subscales of the QoR-40 scale except for psychological support. Sensitivity analysis confirmed the stability of the results. The use of PNBs was associated with lower opioid consumption and a lower risk of postoperative nausea and vomiting.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2022)
Letter
Immunology
Renin Chang, Hui Yuan Chen, Yao-Min Hung, Cheuk Kwan Sun
CLINICAL INFECTIOUS DISEASES
(2022)
Letter
Medicine, General & Internal
W-B Yeh, W-K Lee, R. Chang, C-K Sun
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Letter
Medicine, General & Internal
W-B Yeh, W-K Lee, R. Chang, C-K Sun
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Review
Anesthesiology
I-Chia Teng, Cheuk-Kwan Sun, Chun-Ning Ho, Li-Kai Wang, Yao-Tsung Lin, Ying-Jen Chen, Jen-Yin Chin, Chin-Chen Chu, Chung-Hsi Hsing, Kuo-Chuan Hung
Summary: This meta-analysis found that combined epidural anaesthesia/analgesia (EAA) did not have a significant impact on the incidence of postoperative delirium/cognitive dysfunction (POD/POCD) in patients following major non-cardiac surgery. However, it was associated with lower pain scores at postoperative 24 hours and a decreased risk of postoperative nausea/vomiting (PONV).
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2022)
Article
Medicine, General & Internal
Lin-Lin Pan, Hsiu-Chen Yu, Ching-Hui Lee, Kuo-Chuan Hung, I-Ting Tsai, Cheuk-Kwan Sun
Summary: The aim of this study was to identify the factors impacting the accuracy of reticulocyte enumeration and compare the results of different staining techniques. The results showed that the BCB stain was the most reliable, senior technologists had a higher bias in counting, and repeated counting also affected the results. However, inter-observer consistency was high, and inter-/intra-observer variations were non-significant.
Article
Medicine, General & Internal
Yu-Wen Chen, Wei-Chieh Lee, Hsiu-Yu Fang, Cheuk-Kwan Sun, Jiunn-Jye Sheu
Summary: This study compared the outcomes of percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG) for revascularization in patients with reduced ejection fraction (EF) and severe coronary artery disease (CAD). The results showed that compared to PCI, CABG was associated with a lower incidence of heart failure (HF) hospitalization but worse survival outcomes.
Review
Psychology, Developmental
Kuo-Chuan Hung, Jen-Yin Chen, Chung-Hsi Hsing, Chih-Wei Hsu, Ping-Hsin Liu, Ying-Jen Chang, Jui-Yi Chen, Sheng-Fu Chiu, Cheuk-Kwan Sun
Summary: This meta-analysis investigated the association between labor epidural analgesia exposure and the risk of autism spectrum disorder in offspring. The results showed a slightly increased risk of autism spectrum disorder in children with exposure to labor epidural analgesia compared to those without. This finding was consistent in subgroup analysis focusing on sibling data and children delivered vaginally. However, no increased risk of autism spectrum disorder was observed in children exposed to labor epidural analgesia for less than 4 hours or more than 8 hours.
Review
Medicine, General & Internal
Kuo-Chuan Hung, Yu-Yu Li, Yen-Ta Huang, Ping-Hsin Liu, Chih-Wei Hsu, Chun-Ning Ho, I-Yin Hung, Fu-Sheng Chang, Cheuk-Kwan Sun
Summary: A meta-analysis found a positive correlation between blood urea nitrogen (BUN)/albumin ratio and poor outcome in patients with COVID-19. High BUN/Albumin ratio is associated with increased risk of poor prognosis.
Letter
Endocrinology & Metabolism
Yu-Hsuan Pai, Renin Chang, Cheuk-Kwan Sun, Wen-Bin Yeh
DIABETES & METABOLISM
(2023)
Review
Psychiatry
Hsien-Jane Chiu, Cheuk-Kwan Sun, Yu-Shian Cheng, Ming Yu Wang, Ruu-Fen Tzang, Feng-Li Lin, Ying-Chih Cheng, Weilun Chung
Summary: A meta-analysis of nine randomized controlled trials demonstrated that psychostimulants may be effective in treating symptoms of ADHD in preschool children, especially hyperactivity/impulsivity as observed by teachers. However, the quality of the evidence was low, and further research is needed to confirm the true magnitude of the effect.
EUROPEAN PSYCHIATRY
(2023)
Review
Medicine, General & Internal
Kuo-Chuan Hung, Chun-Ning Ho, Wei-Cheng Liu, Ming Yew, Ying-Jen Chang, Yao-Tsung Lin, I-Yin Hung, Jen-Yin Chen, Ping-Wen Huang, Cheuk-Kwan Sun
Summary: This study aimed to provide updated evidence on the association between intraoperative lidocaine and the risk of postcardiac surgery cognitive deficit. The results suggested a prophylactic effect of intravenous lidocaine against cognitive deficit in the early postoperative period, but insufficient evidence to support this conclusion. In the late postoperative period, intravenous lidocaine did not reduce the risk of cognitive deficit. Intravenous lidocaine may be associated with a shortened length of stay in the intensive care unit/hospital, but the evidence is weak. Further large-scale studies are needed to evaluate the use of lidocaine for the prevention of cognitive deficit and enhancement of recovery.
Review
Medicine, General & Internal
I-Wen Chen, Yu-Yu Li, Kuo-Chuan Hung, Ying-Jen Chang, Jen-Yin Chen, Ming-Chung Lin, Kuei-Fen Wang, Chien-Ming Lin, Ping-Wen Huang, Cheuk-Kwan Sun
Summary: By comparing the outcomes of video-stylets and conventional laryngoscopes in tracheal intubation of patients with cervical immobilization, the study found no significant differences in intubation success rate, time, and risk of tissue damage between the two, but video-stylets had a lower risk of causing sore throat.
