Article
Pediatrics
Ya-Lan Lin, Yi-Li Hung, Chung-Min Shen, Yung-Chuan Chen, Wu-Shiun Hsieh
Summary: This study conducted a prospective, single-center, observational study on preterm infants. It found that although NT-proBNP levels decreased significantly after birth, a serum level of 9248 pg/mL could be helpful for early detection of reduced ejection fraction in preterm infants, with the optimal timing for assessment being after 2 days of life.
Article
Cardiac & Cardiovascular Systems
Vasileios Kouranos, Rajdeep S. Khattar, Joseph Okafor, Raheel Ahmed, Alessia Azzu, John Arun Baksi, Kshama Wechalekar, Martin R. Cowie, Athol Umfrey Wells, Thomas F. Luscher, Rakesh Sharma
Summary: This study describes the baseline characteristics of a sizable and deeply phenotyped contemporary cohort of cardiac sarcoidosis (CS) patients and investigates the predictors of poor outcomes. The study found that CS is associated with significant morbidity and mortality, particularly in those with cardiac involvement as the first manifestation. Serum brain natriuretic peptide levels, left ventricular ejection fraction, and myocardial inflammation were identified as independent predictors of outcomes.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Lisha Zhang, Yixuan Wan, Bo He, Lei Wang, Dongyong Zhu, Fabao Gao
Summary: This study aimed to evaluate LV function in HCM patients with preserved LVEF using LV strain patterns based on CMR-FT. The results showed that almost all global and segmental strains were significantly worse in the HCM group compared to healthy controls. Some strains were significantly correlated with NT-proBNP and cTnT levels in HCM patients, and the best correlations were observed for GRS and MRS. The study also found that GRS and MRS had greater diagnostic accuracy for predicting elevated NT-proBNP and abnormal cTnT levels. Overall, LV strain patterns can be used to assess subclinical cardiac function and predict elevated biomarkers in HCM patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Arsalan Hamid, Wondwosen K. Yimer, Adebamike A. Oshunbade, Daisuke Kamimura III, Donald Clark, Ervin R. Fox, Yuan- Min, Paul Muntner, Daichi Shimbo, Ambarish Pandey, Amil M. Shah, Robert J. Mentz, Daniel W. Jones, Alain G. Bertoni, John E. Hall, Adolfo Correa, Javed Butler, Michael E. Hall
Summary: This study aimed to assess the independent effects of diabetes and hypertension on left ventricular (LV) remodeling in Black adults. Through a cross-sectional analysis of Black adults, it was found that diabetes was only associated with changes in LV structure and function when accompanied by hypertension. These findings suggest that hypertension is the main contributor to cardiac structural and functional changes in Black adults with diabetes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Biochemistry & Molecular Biology
Songling Tang, Ruixin Li, Wen Ma, Liu Lian, Jiuyu Gao, Yu Cao, Lu Gan
Summary: Adipose tissue plays a crucial role in maintaining metabolic homeostasis and dysfunction poses a risk for cardiovascular diseases. The heart, traditionally seen as a pump, is now recognized as a coordinator of interorgan cross-talk through peripheral signals known as cardiokines. These molecules regulate various processes including lipid metabolism, energy expenditure, and adipokine production, and they also participate in pathological conditions such as obesity, diabetes, and ischemic heart injury.
CELL AND BIOSCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Charlotte Van Edom, Steven Jacobs, Libera Fresiello, Katrien Vandersmissen, Christophe Vandenbriele, Walter Droogne, Bart Meyns
Summary: The study found a decrease in NT-proBNP levels and improvement in submaximal and maximal exercise capacity in LVAD recipients. There was also an inverse correlation between NT-proBNP levels and exercise test results.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Infectious Diseases
Bruno Oliveira de Figueiredo Brito, Zachi I. Attia, Larissa Natany A. Martins, Pablo Perel, Maria Carmo P. Nunes, Ester Cerdeira Sabino, Clareci Silva Cardoso, Ariela Mota Ferreira, Paulo R. Gomes, Antonio Luiz Pinho Ribeiro, Francisco Lopez-Jimenez
Summary: This study demonstrated the ability of artificial intelligence to recognize LVSD in Chagas disease patients, showing that AI-ECG could rapidly identify patients with left ventricular systolic dysfunction.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Olivier Huttin, Masatake Kobayashi, Joao Pedro Ferreira, Stefano Coiro, Erwan Bozec, Christine Selton-Suty, Laura Filipetti, Zohra Lamiral, Patrick Rossignol, Faiez Zannad, Nicolas Girerd
Summary: The combination of multiple biomarkers with clinical variables can effectively predict LVH and DD, with Gal3, P3NP, and ST2 significantly improving the predictive value for DD.
Article
Cardiac & Cardiovascular Systems
Eric J. Hall, Soumojit Pal, Michael S. Glennon, Puneeth Shridhar, Sidney L. Satterfield, Beth Weber, Qinkun Zhang, Guy Salama, Hind Lal, Jason R. Becker
Summary: Cardiac natriuretic peptides play a crucial role in regulating cardiovascular physiology. Deficiency in either atrial natriuretic peptide (ANP) or B-type natriuretic peptide (BNP) can cause adverse effects on the structure and function of the heart. This study shows that ANP and BNP exert non-redundant functions in maintaining myocardial cGMP levels, which in turn regulate the activity of cardiomyocyte p38 mitogen-activated protein kinase (p38 MAPK) and cAMP response element-binding protein (CREB). Deficiency in cardiac natriuretic peptides increases the risk of stress-induced ventricular arrhythmias.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Zhixia An, Zhichun Gao, Luyu Wang, Changchun Hou, Liying Zhang, Siming Gong, Rongsheng Rao, Chun Li, Zhexue Qin
Summary: This study found that B-type natriuretic peptide (BNP) level is significantly associated with all-cause mortality in patients with left ventricular thrombus (LVT), and elevated BNP levels indicate a higher risk of LVT.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Urology & Nephrology
Theerasak Tangwonglert, Andrew Davenport
Summary: The study revealed that changes in left ventricular mass index in peritoneal dialysis patients were mainly associated with changes in extracellular water per height ratio and serum N-terminal pro-brain natriuretic peptide levels, rather than with blood pressure or other factors.
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Medicine, General & Internal
Anthony H. Kashou, Jose R. Medina-Inojosa, Peter A. Noseworthy, Richard J. Rodeheffer, Francisco Lopez-Jimenez, Itzhak Zachi Attia, Suraj Kapa, Christopher G. Scott, Alexander T. Lee, Paul A. Friedman, Paul M. McKie
Summary: The study validated the effectiveness of an AI-ECG algorithm in detecting LVSD, showing high sensitivity and specificity, making it a potential screening tool.
MAYO CLINIC PROCEEDINGS
(2021)
Article
Multidisciplinary Sciences
Masayuki Shiba, Takao Kato, Takeshi Morimoto, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Yuta Seko, Erika Yamamoto, Yusuke Yoshikawa, Takeshi Kitai, Yugo Yamashita, Moritake Iguchi, Kazuya Nagao, Yuichi Kawase, Takashi Morinaga, Mamoru Toyofuku, Yutaka Furukawa, Kenji Ando, Kazushige Kadota, Yukihito Sato, Yasuaki Nakagawa, Koichiro Kuwahara, Takeshi Kimura
Summary: This study investigated the association between changes in brain natriuretic peptide (BNP) levels and clinical outcomes in patients with acute heart failure (AHF). The results showed that the percent change in BNP was associated with an increased risk of all-cause death or hospitalization for HF. Therefore, monitoring changes in BNP levels can help in the management of patients with heart failure.
Review
Pharmacology & Pharmacy
Koichiro Kuwahara
Summary: Natriuretic peptides, such as ANP and BNP, are important in cardioprotection in heart failure by antagonizing the effects of angiotensin II, while CNP plays a role in regulating vascular tone and blood pressure. These peptides are also being studied for their potential as biomarkers and therapeutics in cardiovascular disease.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Peripheral Vascular Disease
Liyue Xu, Brendan T. Keenan, David Maislin, Thorarinn Gislason, Bryndis Benediktsdottir, Sigrun Gudmundsdottir, Marianna Gardarsdottir, Bethany Staley, Frances M. Pack, Xiaofeng Guo, Yuan Feng, Jugal Chahwala, Pritika Manaktala, Anila Hussein, Maheshwara Reddy-Koppula, Zeba Hashmath, Jonathan Lee, Raymond R. Townsend, Richard J. Schwab, Allan Pack, Samuel T. Kuna, Julio A. Chirinos
Summary: This study investigated the impact of obesity on the effectiveness of PAP therapy and the levels of NT-proBNP in adults with and without OSA. The results indicated that obesity modified the effects of PAP treatment on NT-proBNP and left atrial volume index, suggesting potential differences in cardiac remodeling in obese individuals with OSA.