Article
Dentistry, Oral Surgery & Medicine
Chawan Manaspon, Chavin Jongwannasiri, Sujin Chumprasert, Noppadol Sa-Ard-Iam, Rangsini Mahanonda, Prasit Pavasant, Thantrira Porntaveetus, Thanaphum Osathanon
Summary: The study found that ProRoot(R) MTA and Biodentine(TM) have favorable in vitro biocompatibility and bioactive properties on human dental pulp stem cells, suggesting their superior regenerative potential compared with DyCal(R) and TheraCal(TM).
Article
Multidisciplinary Sciences
Thira Faruangsaeng, Sermporn Thaweesapphitak, Chompak Khamwachirapitak, Thantrira Porntaveetus, Vorasuk Shotelersuk
Summary: The molecular control of tooth development differs between the maxilla and mandible, with PITX1 gene expression significantly higher in mandibular posterior teeth compared to maxillary posterior teeth. These differences should be considered in molecular studies of dental pulp stem cells and may contribute to more precise treatments in regenerative dentistry.
SCIENTIFIC REPORTS
(2022)
Review
Materials Science, Ceramics
Sotoudeh Davaie, Tabassom Hooshmand, Sajjad Ansarifard
Summary: This study systematically reviewed the use of different types of bioceramics as direct dental pulp capping materials for dentin regeneration in permanent teeth. It found that calcium silicate-based materials, MTA, and Biodentine are currently the most effective bioceramics for this purpose, with calcium phosphates showing potential as future alternatives. Further well-designed in vitro and clinical studies are needed to confirm the most appropriate bioceramics for direct dental pulp capping procedures.
CERAMICS INTERNATIONAL
(2021)
Article
Health Care Sciences & Services
Shilpa Bhandi, Shankargouda Patil, Nezar Boreak, Hitesh Chohan, Abdulaziz S. AbuMelha, Mazen F. Alkahtany, Khalid H. Almadi, Thilla Sekar Vinothkumar, A. Thirumal Raj, Luca Testarelli
Summary: Different intracanal medicaments have varying effects on the viability and survival of dental pulp stem cells at different doses and exposure times. Calcium hydroxide and triamcinolone promote cell viability, while doxycycline, potassium iodide, and glutaraldehyde increase cell death.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mauricio Garrido, Diego Morales, Maria Paz Saldias, Christian Fernandez, Veronica Villalobos, Oscar Cerda, Monica Caceres
Summary: ProRoot (R) MTA and Biodentine (TM) exhibit a better cellular response of human apical papilla cells in vitro conditions compared to BioRoot (R) and calcium hydroxide diluted in sodium chloride.
Article
Dentistry, Oral Surgery & Medicine
Yu Liu, Nan Liu, Jing Na, Chiyu Li, Gan Yue, Yubo Fan, Lisha Zheng
Summary: This study investigated the role of the Wnt/β-catenin pathway in calcium hydroxide-induced proliferation, migration, osteogenic differentiation, and mineralization of human dental pulp stem cells (DPSCs). The results showed that calcium hydroxide promoted rapid proliferation and migration of DPSCs, while prolonged incubation negatively regulated osteogenic differentiation and mineralization.
INTERNATIONAL ENDODONTIC JOURNAL
(2023)
Article
Engineering, Environmental
Caitlin Courtney, Antoine Brison, Dyllon G. Randall
Summary: Stabilizing urine with calcium hydroxide can prevent enzymatic urea hydrolysis, allowing for maximum nitrogen recovery. Adding air and carbon dioxide to stabilized urine can effectively remove calcium ions as calcium carbonate, with air bubbling being the more cost-efficient option. The study found that calcium removal efficiency can reach up to 98% at certain air flow rates, and that even if the pH decreases, urine remains stabilized with no enzymatic urea hydrolysis.
Article
Cell Biology
Edward J. Calabrese, Evgenios Agathokleous, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese
Summary: This study represents the first assessment of hormetic dose responses by human dental pulp stem cells, focusing on cell renewal and differentiation. The study found that hormetic dose responses are commonly observed in this model, involving a wide range of chemicals including pharmaceuticals, dietary supplements/extracts from medicinal plants, and endogenous agents. The study evaluated the mechanistic foundations, study design considerations, and therapeutic implications of the hormetic dose responses in hDPSCs.
AGEING RESEARCH REVIEWS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Nevin Cobanoglu, Tuncay Alptekin, Haruaki Kitagawa, Markus B. Blatz, Satoshi Imazato, Fusun Ozer
Summary: This study found that direct pulp capping with Clearfil Protect Bond (CPB) self-etching adhesive containing an antibacterial monomer MDPB induced an acceptable healing response, with no severe inflammation or soft tissue disorganization observed in the CPB group compared to other control groups.
DENTAL MATERIALS JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Cihan Kuden, Seda Nur Karakas, Sevde Gul Batmaz
Summary: The study compared the cytotoxicity, residual monomer release, degree of conversion, calcium ion release, and crystal structure of TheraCal PT (ThPT), TheraCal LC (ThLC), and mineral trioxide aggregate (MTA). The results showed that MTA had lower cytotoxicity and higher calcium ion release compared to ThLC and ThPT.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
A. Abou ElReash, H. Hamama, M. Grawish, M. Saeed, A. M. Zaen El-Din, M. A. Shahin, W. Zhenhuan, X. Xiaoli
Summary: In a laboratory setting, ACTIVA, MTA-HP, and iRoot-BP-Plus demonstrated significant promotion of hDPSCs proliferation, mineralization, and attachment compared to the control group. iRoot-BP-Plus surfaces showed the highest cellular attachment, followed by MTA-HP, while ACTIVA group exhibited the lowest attachment. Significant differences were observed in mineralizing nodule formation among different experimental groups.
INTERNATIONAL ENDODONTIC JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Duaa Abuarqoub, Nazneen Aslam, Rand Zaza, Hanan Jafar, Suzan Zalloum, Renata Atoom, Walhan Alshaer, Mairvat Al-Mrahleh, Abdalla Awidi
Summary: This study investigates the immune-inflammatory effect of Biodentine capping material on dental pulp stem cells (DPSCs) and macrophages. The results show that Biodentine stimulates the upregulation of anti-inflammatory cytokines and the downregulation of proinflammatory cytokines in DPSCs and macrophages. Biodentine also enhances the migration potential of treated DPSCs. These findings suggest that Biodentine has tissue repair properties and promotes dentine-pulp regeneration.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Jingsong Wang, Sally Roberts, Weiping Li, Karina Wright
Summary: This study identifies and characterizes progenitor cell populations in different regions of the human meniscus. Progenitor cells from the vascular region show enhanced proliferative and fibrochondrogenic characteristics compared to those from the avascular region. These findings indicate that meniscal progenitors may be a promising cell therapy strategy for meniscal regeneration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ahmed Mahmoud, Sybel Moussa, Rania El Backly, Reem El-Gendy
Summary: This study evaluated the indirect effects of residual silver nanoparticles gel on human dental pulp stromal cells (DPSCs). The results showed that dentin discs treated with concentrations of AgNPs gel for 7 days allowed more than 90% DPSCs cell attachment after 24 hours. The cytotoxicity and proliferation of DPSCs in response to AgNPs gel were comparable to those with calcium hydroxide. This suggests that AgNPs gel may be a promising candidate for clinical use in regenerative endodontics.
Article
Engineering, Environmental
Caitlin Courtney, Dyllon G. Randall
Summary: The research examined the addition of carbonate salts to precipitate CaCO3 before RO concentration, finding that dosing of NaHCO3 or Na2CO3 effectively reduced calcium concentration while maintaining pH. Conductivity measurement was found to be an effective method for determining the required salt dose, with NH4HCO3 identified as a cost-effective alternative to NaHCO3.
WATER SCIENCE AND TECHNOLOGY
(2021)