Review
Biotechnology & Applied Microbiology
Jiarong Xu, Hui Shi, Jun Luo, Haiyan Yao, Pei Wang, Zhihua Li, Junchao Wei
Summary: This article discusses the importance of enamel remineralization and the application of advanced materials, pointing out that remineralization treatment can effectively control the progression of caries and restore the structure and hardness of the enamel.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Anne Carolin Bingoel, Memduh Bingoel, Nikolaos Pandis, Simone Stolz, Skadi Beblo, Paul-Georg Jost-Brinkmann, Eberhard Moench, Theodosia Bartzela
Summary: This study compared the prevalence of oral diseases (caries, periodontal disease, enamel defects) in phenylketonuria (PKU) patients, their siblings, and a control group. The results showed that PKU patients had higher rates of caries, enamel defects, and periodontal problems compared to the control group. However, the siblings of PKU patients had fewer enamel defects but no significant differences in caries and periodontal parameters compared to PKU patients.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Engineering, Multidisciplinary
Andrea Butera, Carolina Maiorani, Simone Gallo, Maurizio Pascadopoli, Martina Quintini, Marco Lelli, Fabrizio Tarterini, Ismaela Foltran, Andrea Scribante
Summary: Biomimetic zinc-carbonate hydroxyapatite technology was developed to mimic the natural hydroxyapatite of enamel and dentin and possess strong affinity to adhere to these biological tissues. The literature review showed that oral care products with this technology provide benefits such as remineralization, prevention of enamel demineralization, and reduction of dentinal hypersensitivity.
Article
Dentistry, Oral Surgery & Medicine
M. Bulut, M. Tokuc, M. N. Aydin, H. Ayyildiz Civan, E. Polat, G. Dogan, C. Altuntas, N. A. Bayrak, O. F. Beser
Summary: This study evaluated the nutritional and oral health status of children with previously diagnosed celiac disease (CD) who follow a gluten-free diet, as well as recently diagnosed CD patients. The results showed significant differences between the previously diagnosed patients and recently diagnosed patients in terms of toothpaste preference, frequency of dental visits, and types of dental treatment received. Therefore, children with CD should be directed to a pediatric dentist to improve oral and dental health, alleviate symptoms of oral mucosal lesions, inform about enamel defects, and encourage the use of gluten-free oral care products.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Engineering, Biomedical
Yinghui Wang, Shuting Zhang, Peiwen Liu, Fan Li, Xu Chen, Haorong Wang, Zhangyi Li, Xi Zhang, Xiangyu Zhang, Xu Zhang
Summary: The aim of this study was to develop a stable calcium-phosphorus system for remineralizing early enamel caries lesions. A nanocomplex solution of carboxymethyl chitosan/L-serine/amorphous calcium phosphate (CMC-Ser-ACP) was synthesized and transformed into hydroxyapatite (HAP) crystals using sodium hypochlorite (NaClO). The CMC-Ser-ACP nanocomplexes preserved their stability for 45 days and regenerated aprismatic enamel-like crystals. This novel remineralization system has great solution stability and shows promising therapeutic effects against early enamel caries.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2023)
Article
Materials Science, Ceramics
Marta Kalbarczyk, Aleksandra Szczes
Summary: Polyphasic calcium phosphates were synthesized using raw non-calcined eggshells as a source of calcium via low-cost precipitation method. The material composition, morphology, calcium release profile, and enamel remineralization potential were influenced by the initial pH value.
CERAMICS INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
A. Chaiwat, E. Chunhacheevachaloke, P. Kidkhunthod, P. Pakawanit, O. Ajcharanukul
Summary: Early caries lesions are noncavitated subsurface demineralizations that cannot be effectively remineralized by conventional treatment. This study investigated the structural and compositional characteristics of enamel caries and the remineralizing effect of fluoride iontophoresis with different polarities. The results showed that iontophoresis significantly promoted subsurface remineralization, with cathodal iontophoresis leading to increased mineral density and a stronger crystal structure, while anodal iontophoresis resulted in an increase in mineral density but no change in structure. The study concluded that cathodal iontophoresis is an ideal method for rapid enamel remineralization and recrystallization.
JOURNAL OF DENTAL RESEARCH
(2023)
Review
Dentistry, Oral Surgery & Medicine
Wen Zhou, Hong Chen, Michael D. Weir, Thomas W. Oates, Xuedong Zhou, Suping Wang, Lei Cheng, Hockin H. K. Xu
Summary: This review provides an overview of cutting-edge research on the development of new bioactive restorations to inhibit secondary caries in enamel and dentin under biofilms. Novel bioactive materials are categorized based on their remineralization and antibacterial biofunctions. However, there is still a need for new intelligent and pH-responsive materials, and the evaluation should be performed using more clinically relevant biofilm-based secondary caries models.
JOURNAL OF DENTISTRY
(2023)
Article
Medicine, General & Internal
Fatma Sarac, Sera Simsek Derelioglu, Fatih Sengul, Fuat Laloglu, Naci Ceviz
Summary: The purpose of this study is to compare the oral and dental health status in children with congenital heart disease (CHD) and healthy children, and determine the effects of CHD on oral and dental health. The results showed that children with CHD are more prone to enamel defects and periodontal diseases, which highlights the importance of multidisciplinary collaboration for prevention and treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shouq Sharar Bsesa, Samir Srour, Mayssoon Dashash
Summary: This study aimed to investigate the oral health status and quality of life of Syrian children with congenital heart disease (CHD) and compare them with healthy controls aged 4-12 years. The results showed that CHD patients were more prone to periodontitis, dental caries, and dental abnormalities. Additionally, there were significant differences in the four domains of the Child Oral Health-Related Quality of Life Questionnaire (COHRQoL) between CHD children and controls.
Article
Chemistry, Physical
Flavia Vitiello, Vincenzo Tosco, Riccardo Monterubbianesi, Giulia Orilisi, Maria Laura Gatto, Scilla Sparabombe, Lucia Meme, Paolo Mengucci, Angelo Putignano, Giovanna Orsini
Summary: This study qualitatively and quantitatively compared the remineralizing effectiveness of four commercially available agents on artificial enamel lesions. The results showed that two of the agents (G1 and G2) exhibited better surface remineralization compared to the other two agents (G3 and G4).
Article
Dentistry, Oral Surgery & Medicine
Mohammed Nadeem Bijle, Mohamed Mahmoud Abdalla, Usman Ashraf, Manikandan Ekambaram, Cynthia Kar Yung Yiu
Summary: The arginine-fluoride (Arg-NaF) varnishes demonstrated enhanced enamel fluoride uptake and remineralization potential, showing promise as a caries-preventive regimen. Increasing arginine concentration improved the effectiveness of the varnish while reducing plaque fluoride uptake.
JOURNAL OF DENTISTRY
(2021)
Article
Multidisciplinary Sciences
Yue Huang, Yuan Liu, Nil Kanatha Pandey, Shrey Shah, Aurea Simon-Soro, Jessica C. Hsu, Zhi Ren, Zhenting Xiang, Dongyeop Kim, Tatsuro Ito, Min Jun Oh, Christine Buckley, Faizan Alawi, Yong Li, Paul J. M. Smeets, Sarah Boyer, Xingchen Zhao, Derk Joester, Domenick T. Zero, David P. Cormode, Hyun Koo
Summary: This study shows that the combination of iron oxide nanoparticles (ferumoxytol) with stannous fluoride (SnF2) effectively inhibits biofilm accumulation and enamel damage. The stability of SnF2 is enhanced when mixed with ferumoxytol in aqueous solutions, increasing the catalytic activity of ferumoxytol. In vivo experiments demonstrate that the combination of ferumoxytol and SnF2 is exceptionally effective in controlling dental caries, even at lower concentrations, without adverse effects on host tissues or oral microbiome. This research reveals a potent therapeutic synergism using approved agents and provides a method for facile SnF2 stabilization to prevent a widespread oral disease with reduced fluoride exposure.
NATURE COMMUNICATIONS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Sonia Nath, Brianna Faye Poirier, Xiangqun Ju, Kostas Kapellas, Dandara Gabriela Haag, Pedro Henrique Ribeiro Santiago, Lisa M. Jamieson
Summary: This systematic review and meta-analysis aimed to investigate the disparity in dental caries experiences among indigenous and nonindigenous populations globally. The study found that indigenous populations have a higher prevalence and severity of dental caries compared to nonindigenous populations, with a higher number of decayed teeth, slightly more missing teeth, and fewer filled teeth. These findings highlight the need to explore the factors contributing to such inequities.
Article
Dentistry, Oral Surgery & Medicine
Farah A. Alsadat, Najlaa M. Alamoudi, Azza A. El-Housseiny, Osama M. Felemban, Faisal M. Dardeer, Omar Saadah
Summary: This study compared the oral manifestations of children with celiac disease (CD) against healthy controls in Saudi Arabia. Children with CD had more recurrent aphthous stomatitis (RAS) and dental enamel defects (DEDs) compared to healthy controls. Pediatric dentists should consider the possibility of CD in child patients presenting with RAS or DEDs.