Journal
INTERNATIONAL DAIRY JOURNAL
Volume 23, Issue 1, Pages 24-29Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.idairyj.2011.09.005
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Funding
- Consejo Superior de Investigaciones Cientificas (CSIC) [200570F0111, 200520F0113]
- Ministerio de Ciencia e Innovacion (MICIIN), Espana [AGL2007-60256/ACU, AGL2008-01713, CSD 2007-0063]
- Comunidad de Madrid [P2009/AGR1469]
- MICIIN
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The aim of this work was to evaluate the antiviral properties of a number of milk proteins and enzymatic hydrolysates thereof on fish cell monolayers against the infectious pancreatic necrosis virus (IPNV) and infectious hematopoietic necrosis virus (IHNV). Results showed that the most potent antiviral activities against IHVN corresponded to the bovine lactoferrin-derived peptide lactoferricin, 3 h-total bovine casein peptic hydrolysate and 3 h-alpha(s2)-casein peptic hydrolysate of ovine and bovine origin, for which a therapeutic index (cytotoxic concentration(50)/MIC50) of approximately 30 was recorded. These studies are useful not only as a starting point for the search of specific active peptides from milk proteins, but also for a better understanding of the virus-cell interactions. Proteins and peptides from milk could have attractive applications in the control of viruses affecting fish species. (C) 2011 Elsevier Ltd. All rights reserved.
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