Article
Physics, Applied
Ryuhei Yamaguchi, Gaku Tanaka, Nadia Shaira Shafii, Kahar Osman, Yasutomo Shimizu, Khalid M. Saqr, Makoto Ohta
Summary: This study investigated the hemodynamics of an elastic aneurysm model using particle image velocimetry. The results showed that wall elasticity suppressed the magnitude of wall shear stress in the aneurysm and attenuated the flow fluctuation.
JOURNAL OF APPLIED PHYSICS
(2022)
Article
Engineering, Multidisciplinary
Zahra Sadeghi Nogourani, As'ad Alizadeh, Hayder Mahmood Salman, Tariq J. Al-Musawi, Pooya Pasha, Muhammad Waqas, Davood Domiri Ganji
Summary: Cardiovascular diseases are a leading cause of death in today's society. This study analyzes and models blood flow in the coronary vessels, with particular focus on the vessels on the left side. Changes in hematocrit and blood viscosity are found to affect the pressure distribution and shear stress on the vessel walls. The research suggests that a flexible vessel model reduces pressure distribution and an increase in blood viscosity leads to a significant increase in wall shear stress.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Computer Science, Interdisciplinary Applications
Harry J. Carpenter, Mergen H. Ghayesh, Anthony C. Zander, Peter J. Psaltis
Summary: This study investigates the relationship between twelve multi-directional/topological wall shear stress (WSS) derived metrics and the formation of coronary plaques using computational fluid dynamics (CFD) and dynamic fluid-structure interaction (FSI) frameworks. The results highlight the importance of multi-directional and topological WSS metrics in atherosclerosis related mechanotransduction and near-wall transport processes. Further research is needed to explore the mechanisms of atherosclerosis and longitudinal changes in coronary dynamics.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Giulio Russo, Daniela Pedicino, Claudio Chiastra, Ramona Vinci, Maurizio Lodi Rizzini, Lorenzo Genuardi, Mohammad Sarraf, Alessia d'Aiello, Marco Bologna, Cristina Aurigemma, Alice Bonanni, Antonio Bellantoni, Fabrizio D'Ascenzo, Pellegrino Ciampi, Aniello Zambrano, Luca Mainardi, Myriana Ponzo, Anna Severino, Carlo Trani, Massimo Massetti, Diego Gallo, Francesco Migliavacca, Francesco Maisano, Amir Lerman, Umberto Morbiducci, Francesco Burzotta, Filippo Crea, Giovanna Liuzzo
Summary: This study aimed to provide a comprehensive description of haemodynamic and biological characteristics of unstable and stable coronary artery plaques and investigate the correlation between wall shear stress (WSS) and molecular pathways. The results showed that nine genes were significantly overexpressed in unstable patients compared to stable patients, with four genes displaying different levels between intact fibrous cap (IFC) and ruptured fibrous cap (RFC) groups. Additionally, higher WSS was observed in the RFC group and significant correlations were found between certain genes and WSS values in the RFC group. These findings suggest the importance of WSS profiling in characterizing plaque instability.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Engineering, Mechanical
Ruturaj Badal, Shreeshan Jena, Meghna Pisupati, Erukala Kalyan Kumar, Vikash Kumar, Subrata Kumar Panda
Summary: This study utilized a CAD model of a stent based on the BX-Velocity design to analyze the flow parameters after its placement in the artery under different conditions. The results showed that position B was the most favorable for stent placement. The wall shear stress and shear stress gradient magnitudes indicated the potential development of neointimal hyperplasia for position B.
JOURNAL OF VIBRATION ENGINEERING & TECHNOLOGIES
(2023)
Article
Biotechnology & Applied Microbiology
Pratik Kandangwa, Ryo Torii, Peter D. Gatehouse, Spencer J. Sherwin, Peter D. Weinberg
Summary: The distribution of atherosclerosis is affected by hemodynamic wall shear stress. This study examined the influence of dynamic motion and non-Newtonian blood rheology on the transverse wall shear stress in coronary arteries. The results showed that dynamic motion had little effect on time average wall shear stress, but significantly affected oscillatory wall shear stress. Additionally, changes in curvature caused time-varying vortical structures, which further influenced transverse wall shear stress. Non-Newtonian rheology also played a significant role. Incorporating dynamic geometry and non-Newtonian rheology into models can improve the accuracy of transverse wall shear stress maps in coronary arteries.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Vincenzo Tufaro, Ryo Torii, Emrah Erdogan, Pieter Kitslaar, Bon-Kwon Koo, Roby Rakhit, Grigoris Karamasis, Christos Costa, Patrick Serruys, Daniel A. Jones, Anthony Mathur, Andreas Baumbach, Jean-Paul Aben, Christos Bourantas
Summary: A user-friendly software for real-time calculation of wall shear stress (WSS) showed high accuracy and reproducibility in assessing WSS distribution. The software significantly reduced simulation time compared to conventional methods.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
M. Yousuf Salmasi, Selene Pirola, Sumesh Sasidharan, Serena M. Fisichella, Alberto Redaelli, Omar A. Jarral, Declan P. O'Regan, Aung Ye Oo, James E. Moore, Xiao Yun Xu, Thanos Athanasiou
Summary: The study found that elevated values of WSS in ATAA patients were associated with aortic wall degradation, indicating a potential relationship between WSS and the progression of ATAA disease. Further research may help in identifying threshold values to predict acute aortic events.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biology
Peshala T. Gamage, Pengfei Dong, Juhwan Lee, Yazan Gharaibeh, Vladislav N. Zimin, Luis A. P. Dallan, Hiram G. Bezerra, David L. Wilson, Linxia Gu
Summary: In this study, hemodynamic alterations in heavily calcified coronary arteries following stent deployment and post-dilations were quantified using in silico and ex-vivo approaches. Results showed that post-dilations are necessary for lumen gain and hemodynamic restoration towards hemostasis, mitigating risks associated with in-stent restenosis and stent thrombosis. Additionally, computational fluid dynamics simulations indicated that areas near malapposed stent struts are more prone to in-stent restenosis.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Engineering, Mechanical
Sina Ebrahimi, Famida Fallah
Summary: This study investigated the effects of different patterns of coronary artery tortuosity (CAT) on the stress concentration of plaques and blood flow patterns. The results showed an increase in stress and risk of plaque rupture and progression.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2022)
Article
Mechanics
Navid Freidoonimehr, Maziar Arjomandi, Anthony Zander, Rey Chin
Summary: The study emphasizes the significant impact of artery curvature on pressure drop and Fractional Flow Reserve. It indicates that an accurate evaluation of pressure drop and FFR inside a curved coronary artery can only be achieved by accounting for curvature parameters, and neglecting these parameters could result in an underestimation of 25%-35%.
Article
Engineering, Biomedical
Lahcen Akerkouch, Haneesh Jasuja, Kalpana Katti, Dinesh Katti, Trung Le
Summary: We studied the relationship between fluid shear stress and the proliferation of bone prostate cancer cells on nanoclay-based scaffolds in a perfusion bioreactor. Human mesenchymal stem cells (hMSCs) were seeded on the scaffolds to initiate bone growth. Prostate cancer cells (MDAPCa2b) were then cultured on top of the differentiated hMSCs. The experiments showed significant differences in cell growth patterns between static and dynamic conditions, and computational results indicated that dynamic flow had a drastic impact on cell morphology and tumorous distribution.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Biology
Romana Perinajova, Joe F. Juffermans, Jos J. M. Westenberg, Roel L. F. van der Palen, Pieter J. van den Boogaard, Hildo J. Lamb, Sasa Kenjeres
Summary: The study reveals that aortic aneurysm is associated with aberrant blood flow and wall shear stress, which can be studied through MRI and CFD. Attention should be paid to the effect of MRI segmentation variations on wall shear stress in patient-specific simulations. Comparing mean and maximal values of WSS in different segments of the thoracic aorta shows good to excellent correlation for rescan, while voxel-to-voxel comparison yields poorer results.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Clinical Neurology
Weiying Zhong, Yiming Du, Hong Kuang, Ming Liu, Feng Xue, Xue Bai, Donghai Wang, Wandong Su, Yunyan Wang
Summary: This study found that low wall shear stress, low aneurysm pressure, and increased low shear area were significantly associated with aneurysm wall enhancement on vessel wall magnetic resonance imaging in unruptured cerebral aneurysms.
FRONTIERS IN NEUROLOGY
(2022)
Article
Mechanics
Ahmed Elhanafy, Yasser Abuouf, Samir Elsagheer, Shinichi Ookawara, Mahmoud Ahmed
Summary: Diagnostic technology based on magnetic fields is commonly used in medicine, but exposure to strong electromagnetic fields has adverse effects on patients. This study investigates the effects of external uniform magnetic fields on blood flow in healthy and diseased cases, and determines safe values for field strength. A three-dimensional non-Newtonian flow model is developed to investigate the effects of the magnetic field on shear rate and hematocrit. Numerical simulations are conducted at different field strengths and orientations, and results demonstrate the dominant effect of the magnetic field in the Y-direction.
Article
Engineering, Chemical
Silvia Lorente-Bailo, Inigo Etayo, Maria L. Salvador, Ana Ferrer-Mairal, Miguel A. Martinez, Begona Calvo, Jorge Grasa
Summary: An axisymmetric model for transient heat and mass transfer during pancake cooking on a domestic induction hob was developed, taking into account the variable thermal contact conductance resulting from crust formation at the bottom of the batter. The model introduced a normalized relationship between batter viscosity and temperature to quantify the heat flow variation due to changes in batter structure. The model successfully predicted weight loss and average surface temperature of the batter using parameters related to rheological properties and composition.
JOURNAL OF FOOD ENGINEERING
(2021)
Article
Food Science & Technology
Jara Moya, Silvia Lorente-Bailo, Ana Ferrer-Mairal, Miguel A. Martinez, Begona Calvo, Jorge Grasa, Maria L. Salvador
Summary: The kinetics of heat-induced color changes in beef meat were studied and implemented in a numerical model for double-sided pan cooking of steak. The CIELab color space was used to obtain lightness and reddish tone of the cooked meat. The model successfully verified experimental data for different cooking degrees and determined the optimum turn over time for achieving a similar color profile on both sides of the meat.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Patricia Hernandez-Lopez, Myriam Cilla, Miguel Martinez, Estefania Pena
Summary: This study presents a mechanobiological atheroma growth model modulated by a new haemodynamic stimulus, which showed improved prediction of plaques compared to traditional methods. However, there are cases where haemodynamics alone cannot accurately predict plaque locations, indicating the importance of other biological or genetic factors in atherosclerosis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Mathematics
Itziar Rios-Ruiz, Myriam Cilla, Miguel A. Martinez, Estefania Pena
Summary: The study proposes a methodology for obtaining dissection parameters in aortic tissue through computational modelling, aiming to understand the mechanisms and progression of aortic dissection. By conducting two different experimental tests and calibrating the dissection properties of each interface, the study aims to contribute to the development of reliable numerical tools for simulating aortic dissection and aortic aneurysm rupture.
Article
Engineering, Multidisciplinary
Gabriel Valdes-Alonzo, Christophe Binetruy, Benedikt Eck, Alberto Garcia-Gonzalez, Adrien Leygue
Summary: This paper presents a new methodology to extend the Data-Driven Identification (DDI) to heterogeneous samples made of multiple elastic materials. By using the Correspondence Analysis (CA) technique to post-process DDI, the study is able to identify representative material databases for each phase and localize the different phases in the sample. It shows that the method is effective for estimating stresses and identifying different phases in the sample, and it can be improved by iterating between DDI and CA when input data is limited.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2022)
Article
Biophysics
Juan A. Pena, M. Cilla, Miguel A. Martinez, Estefania Pena
Summary: This study analyzes the residual stresses and mechanical properties of layer-dissected infrarenal abdominal aorta. The results show that the residual stresses are layer dependent, with the media layer being the softest and the intima and adventitia exhibiting considerable stiffness. The GOH model provides the best fitting to the experimental data.
JOURNAL OF BIOMECHANICS
(2022)
Article
Biophysics
Alba Muixi, Sergio Zlotnik, Pere Calvet, Montserrat Espanol, Irene Lodoso-Torrecilla, Maria-Pau Ginebra, Pedro Diez, Alberto Garcia-Gonzalez
Summary: Scaffolds are microporous structures that provide material support for cell proliferation and tissue formation. Computational simulation can assist in studying the performance of scaffolds and their impact on cell differentiation. We propose a computational parametric reduced-order model to study the distribution of calcium ions in the interstitial fluid flowing through scaffolds.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Mathematics, Applied
Marc Rocas, Alberto Garcia-Gonzalez, Xabier Larrayoz, Pedro Diez
Summary: The article discusses the uncertainty quantification analysis for nonlinear crash models and the challenges it faces, proposing the use of kernel principal component analysis technique to improve the efficiency of metamodels.
FINITE ELEMENTS IN ANALYSIS AND DESIGN
(2022)
Article
Pharmacology & Pharmacy
Javier Escuer, Andre Fensterseifer Schmidt, Estefania Pena, Miguel A. Martinez, Sean McGinty
Summary: The most common treatment for obstructive coronary artery disease is the implantation of a permanent drug-eluting stent, but it has drawbacks such as delayed healing and challenges in treating re-narrowing. Drug-coated balloons provide a potential solution. This paper presents a computational model that compares drug delivery from drug-coated balloons and drug-eluting stents, and suggests the potential of designing drug-coated balloons with similar safety and efficacy to commercial drug-eluting stents.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Mathematics
Belen Bonet-Sanchez, Iulen Cabeza-Gil, Begona Calvo, Jorge Grasa, Carlos Franco, Sergio Llorente, Miguel A. Martinez
Summary: This study analyzes the influence of the vessel on thermal efficiency during the cooking process. By designing a numerical model and conducting experimental tests, it was found that thermal conductivity and the thermal contact between the vessel and the glass are the two most influential factors in the heating process. Cooking efficiency can be improved by using a vessel with low thermal conductivity and high concavity.
Article
Biophysics
Itziar Rios-Ruiz, Miguel Angel Martinez, Estefania Pena
Summary: Proper characterisation of biological tissue is crucial for understanding the impact of the biomechanical environment on the cardiovascular system. For aortic dissection, location and dissected layer play significant roles in its development and outcome. A study on healthy porcine aortas has revealed that dissection forces and requirements vary across different locations and layers, emphasizing the importance of characterising aortic tissue specifically.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Aroa Ruiz Munoz, Andrea Guala, Myriam Cilla, Miguel Martinez, Lydia Dux-Santoy, Gisela Teixido-Tura, Juan Garrido-Oliver, Laura Galian, Augusto Sao-Aviles, Arturo Evangelista, Ignacio Ferreira-Gonzalez, Estefania Pena, Jose Rodriguez-Palomares
CARDIOVASCULAR RESEARCH
(2022)
Article
Materials Science, Multidisciplinary
Alba Muixi, Sergio Zlotnik, Alberto Garcia-Gonzalez, Pedro Diez
Summary: This study analyzes the inverse problem in the field of bone regeneration and solves the problem of determining the best-fitting parameter values in a 3D-printed scaffold. A hyper-reduction method is proposed to reduce computational costs.
FRONTIERS IN MATERIALS
(2022)
Article
Engineering, Biomedical
Sara Bridio, Giulia Luraghi, Francesco Migliavacca, Sanjay Pant, Alberto Garcia-Gonzalez, Jose F. Rodriguez Matas
Summary: This study proposes a low-dimensional surrogate model to estimate the evolution of maximum first principal strain in thrombus during the mechanical thrombectomy procedure. The surrogate model was built using a parametric finite-element model and validated with experimental simulations. The results show that the model provides highly correlated predictions with the actual strain curves and has a maximum error of 28% with an error below 20% in 60% of the test cases. The surrogate model is a valuable tool for assessing the risk of thrombus rupture during pre-operative planning for acute ischemic stroke treatment.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Mathematics
Stephan Gahima, Pedro Diez, Marco Stefanati, Jose Felix Rodriguez Matas, Alberto Garcia-Gonzalez
Summary: This manuscript presents a novel formulation for a linear elastic model of a heterogeneous arterial section undergoing uniform pressure in a quasi-static regime. The novelties are twofold. First, an elastic bed support on the external boundary (elastic bed boundary condition) replaces the classical Dirichlet boundary condition for elastic solids to ensure a solvable problem. Secondly, an unfitted strategy based on the Immersed Boundary (IB) framework is devised to study different geometrical configurations corresponding to different patients. It provides results equivalent to the standard finite elements (FE) with dimensionality reduction.
