Article
Obstetrics & Gynecology
Erin J. Henshaw, Marie Cooper, Teresa Wood, Stacey N. Doan, Sanchita Krishna, Marie Lockhart
Summary: This study aims to evaluate the role of stress, relationship satisfaction, and co-parent mood in predicting depressive and anxious symptoms in mothers and partners during the postpartum period. The results indicate that stress, relationship satisfaction, and co-parent mood are associated with depressive and anxious symptoms in both mothers and partners.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Psychiatry
Chang Liang, Pingrun Chen, Yu Tang, Chuheng Zhang, Na Lei, Ying Luo, Shihao Duan, Yan Zhang
Summary: This study conducted a clinical trial and found that adding venlafaxine therapy improved the quality of life, mental health, and disease activity in patients with Inflammatory Bowel Disease (IBD) with comorbid anxious or depressive symptoms, providing better treatment outcomes.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Gaby S. Pell, Tal Harmelech, Sam Zibman, Yiftach Roth, Aron Tendler, Abraham Zangen
Summary: Deep TMS is effective in treating comorbid anxiety in patients with MDD, and high baseline anxiety levels do not adversely affect treatment outcomes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Eric T. Dobson, Paul E. Croarkin, Heidi K. Schroeder, Sara T. Varney, Sarah A. Mossman, Kim Cecil, Jeffrey R. Strawn
Summary: This study found that in adolescents with GAD, certain symptoms not directly related to anxiety can bridge anxiety and depression, while patients with a heavier burden of depressive symptoms showed alterations in cortical thickness, indicating a unique neurostructural fingerprint. Additionally, youth with high depressive symptoms in GAD had reduced age-cortical thickness correlations, suggesting bidirectional neurobiological relationships between early GAD and cortical development.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Ma-Li Wong, Mauricio Arcos-Burgos, Sha Liu, Alice W. Licinio, Chenglong Yu, Eunice W. M. Chin, Wei-Dong Yao, Xin-Yun Lu, Stefan R. Bornstein, Julio Licinio
Summary: Rare functional variants were identified in antidepressant drug response, serving as potential genetic markers for predicting drug response. Limitations include small sample size and inability to use antidepressant blood level as a covariate. Further studies with larger cohorts are warranted.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
History & Philosophy Of Science
Troy Jollimore
Summary: Anxiety, often seen as negative, can actually serve as a positive alert for potential problems or threats. Friends' proxy anxiety can also contribute to our well-being by playing a similar role in our functioning. Friends are in a good position to help regulate deficient or excessive anxieties due to their close but relatively objective perspective.
Article
Endocrinology & Metabolism
Lauren A. Harasymiw, Scott D. Grosse, Kathryn R. Cullen, Rebecca H. Bitsko, Ruth Perou, Kyriakie Sarafoglou
Summary: A study found that adolescents with congenital adrenal hyperplasia (CAH) have a higher risk of depressive and anxiety disorders, indicating the need for screening and attention to this population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
History & Philosophy Of Science
Juliette Vazard
Summary: This article examines the role of anxiety in motivating us to reassess our epistemic states. It takes Levy's proposal that anxiety is responsible for our ruminations and worries about threatening possibilities as a starting point. The author agrees with Levy's claim but believes that further explanation is needed regarding the nature of anxiety and the mechanisms through which it generates doubts. The paper attempts to clarify the role of anxiety in these phenomena and revise assumptions about the interactions between anxiety and higher-level cognitive processes.
Article
Clinical Neurology
Yuelee Khoo, Ilya Demchenko, Benicio N. Frey, Roumen Milev, Arun Ravindran, Sagar Parikh, Keith Ho, Susan Rotzinger, Wendy Lou, Raymond W. Lam, Sidney H. Kennedy, Venkat Bhat
Summary: Early improvement in anxiety and depression during the first two weeks of treatment significantly predicts the eventual treatment outcomes for anxiety and depression. Baseline anxiety severity is a strong predictor of anxiety outcomes at weeks 2 and 8. The study suggests that focusing on early improvement in anxiety may be more beneficial in predicting treatment outcomes for anxiety depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Clinical
Noah T. Kreski, Katherine M. Keyes, Michael J. Parks, Megan E. Patrick
Summary: The SARS-CoV-2 pandemic is strongly associated with depressive and anxious symptoms among young adults, highlighting the need for improved mental health treatment infrastructure and stronger structural support.
DEPRESSION AND ANXIETY
(2022)
Article
Clinical Neurology
Frank Iorfino, Ciro Marangoni, Lihong Cui, Daniel F. Hermens, Ian B. Hickie, Kathleen Ries Merikangas
Summary: The study found that anxiety-related temperamental traits show familial specificity, but these traits cannot fully explain the shared heritability between anxiety subtypes and mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Multidisciplinary Sciences
Maximilian Hinse, Anja Thronicke, Anne Berghoefer, Harald Matthes
Summary: The study found that AMT can improve the quality of life for IBS patients and the effects are particularly significant for patients without psychological comorbidities. Therefore, future IBS therapies should incorporate psychological therapy, especially for patients with depression and anxiety.
Article
Biochemistry & Molecular Biology
Christine Lalonde, Shayenthiran Sreetharan, Alyssa Murray, Lisa Stoa, Mary Ellen Cybulski, Allison Kennedy, Nicholas Landry, Amy Stillar, Sandhya Khurana, Sujeenthar Tharmalingam, Joanna Wilson, Neelam Khaper, Simon J. Lees, Douglas Boreham, T. C. Tai
Summary: This study investigated the effects of low dose and sublethal dose ionizing radiation exposure during late gestation in mice. The results showed that behavioral tasks measuring anxiety and stress-management were not significantly affected, but some dysregulation in gene expression was observed in specific brain regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Antonio Armario
Summary: The forced swim test is a commonly used method for evaluating antidepressant treatments and depression-like states in rodents, but its theoretical and predictive validity have been questioned. The test mainly assesses coping strategies in an inescapable situation, and proper interpretation of the behavior depends on its relationship with other behavioral traits.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Multidisciplinary Sciences
Tomer Mevorach, Michal Taler, Shira Dar, Maya Lebow, Irit Schorr Sapir, Ron Rotkopf, Alan Apter, Silvana Fennig, Alon Chen, Abraham Weizman, Maya Amitai
Summary: Recent studies suggest immune function dysregulation in depression and anxiety disorders, with elevated pro-inflammatory cytokines potentially being a marker for immune system dysregulation. This study found a positive correlation between IL-1 beta levels in depressed/anxious boys and their mothers, indicating potential familial vulnerability to depression and anxiety. The observation also highlights the need for a better understanding of sexual dimorphism in inflammatory responses to stress.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Clinical
Joshua E. Curtiss, David Mischoulon, Lauren B. Fisher, Cristina Cusin, Szymon Fedor, Rosalind W. Picard, Paola Pedrelli
Summary: This study investigates whether rises in different 'early warning signals' (auto-correlation, temporal variance, network connectivity) are associated with changes in depressive symptoms. Results indicate that rises in auto-correlation are significantly associated with worsening future changes in depression symptoms among patients with MDD.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
David Eddie, Kate H. Bentley, Richard Bernard, David Mischoulon, John W. Winkelman
Summary: This study found that HRV is non-stationary across sleep stage epochs, highlighting the importance of not aggregating HRV indices across sleep stages to avoid obscuring transient effects.
Article
Medicine, Research & Experimental
Felipe A. Jain, Olivia Okereke, Laura Gitlin, Paola Pedrelli, Jukka-Pekka Onnela, Maren Nyer, Liliana A. Ramirez Gomez, Michael Pittman, Abu Sikder, D. J. Ursal, David Mischoulon
Summary: More than 50 million people worldwide live with dementia, and most are cared for by family members. Family caregivers often experience chronic stress and insomnia, resulting in decreased mental and physical health. This study aims to investigate the effectiveness of delivering mentalizing imagery therapy (MIT) through a smartphone application in reducing caregiver stress and improving caregiving skills. Additionally, passive smartphone data will be used to study behavioral changes and predict health outcomes in older adults.
CONTEMPORARY CLINICAL TRIALS
(2022)
Letter
Medicine, General & Internal
Olivia Okereke, David Mischoulon, JoAnn E. Manson
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Letter
Medicine, General & Internal
Olivia Okereke, David Mischoulon, JoAnn E. Manson
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Psychology, Clinical
Mi Jin Park, Juhwan Yoo, Kyungdo Han, Dong Wook Shin, Maurizio Fava, David Mischoulon, Hong Jin Jeon
Summary: This study found that high body weight variability (BWV) is associated with an increased risk of depression. Even after adjusting for other factors, the association between high BWV and depression remains. This suggests that BWV may be an important risk factor for depression.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Mayron Piccolo, Emily L. Belleau, Laura M. Holsen, Madhukar H. Trivedi, Ramin V. Parsey, Patrick J. McGrath, Myrna M. Weissman, Diego A. Pizzagalli, Kristin N. Javaras
Summary: This study found that hyperphagic MDD may be associated with altered activity and connectivity between interoceptive and reward regions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Junjie Lu, Jingyang Liang, Jiarui Yang, David Mischoulon, Maren Nyer
Summary: This study used data from National Health and Nutrition Examination Survey 2009-2014 to investigate the relationship between HSV-2 infection and depression, considering gender and sexual orientation as potential modifiers. The results showed that sexual minority status did not have a significant effect on the association, while biological sex assigned at birth did. Females with HSV-2 infection had a higher risk for depressive symptoms. Further longitudinal investigations are needed to validate these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Stefania Lamon-Fava, Minying Liu, Boadie W. Dunlop, Becky Kinkead, Pamela J. Schettler, Jennifer C. Felger, Thomas R. Ziegler, Maurizio Fava, David Mischoulon, Mark Hyman Rapaport
Summary: Chronic inflammation is related to major depressive disorder (MDD). Activating inflammation resolution through omega-3 fatty acid supplementation may be an effective treatment for MDD. In a 12-week randomized trial, patients with MDD were treated with EPA supplementation, and it was found that those who showed an increase in 18-HEPE synthesis had reduced symptoms of depression and inflammation.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Fernando Vizcaino, Paolo Cassano, Aura Hurtado, David Mischoulon
Summary: Cranial electrotherapy stimulation (CES) is a noninvasive neuromodulation technique that has potential for treating psychiatric diseases. While the unequivocal efficiency of CES for major depressive disorder (MDD) has not been demonstrated, some data suggest it could be an effective therapy. CES devices allow patients to self-administer treatment at home.
PSYCHIATRIC ANNALS
(2022)
Article
Public, Environmental & Occupational Health
Junjie Lu, Jiarui Yang, Jingyang Liang, David Mischoulon, Maren Nyer
Summary: Sexual minorities, especially those with sexual orientation uncertainty, are at a higher risk of suffering from depressive symptoms. Little research has been conducted on the conditions of having depressive symptoms among different sexual minority groups, as well as the difference in mean white blood cell count between depressed and non-depressed individuals in these groups.
Article
Psychology, Multidisciplinary
Liliana Ramirez-Gomez, Julene K. Johnson, Christine Ritchie, Ashley K. Meyer, Emily Tan, Saira Madarasmi, Paulina Gutierrez-Ramirez, Cecilianna Aldarondo-Hernandez, David Mischoulon, Sreya Banerjee, Felipe A. Jain
Summary: Spanish-speaking family caregivers of people with dementia have limited supportive resources in their own language. This study examined the feasibility of a Spanish language adaptation of a virtual Mentalizing Imagery Therapy (MIT) program. Results showed that participating caregivers experienced a reduction in depressive symptoms and improvements in mindfulness, caregiver burden, and well-being. The adapted MIT program was found to be feasible, acceptable, and potentially beneficial for this population. Further research is needed to validate the efficacy of MIT in larger, randomized controlled trials.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychiatry
Albert Yeung, Doga Cetinkaya, David Mischoulon
Summary: Culture plays a role in shaping the understanding and expression of mood disorders, such as anxiety and depression. To provide culturally sensitive treatment and recognize depression in diverse populations, it is important to understand patients' illness beliefs, including their perception of illness onset, cause, severity, impact, and appropriate treatment. Clinicians who have insight into a patient's illness beliefs can effectively communicate medical management. This article explores the illness beliefs of Chinese Americans with depression, the existing treatment gap, and strategies to improve recognition and engagement in treatment, along with considerations for psychological and pharmacological interventions.
PSYCHIATRIC ANNALS
(2023)
Article
Psychiatry
Hyewon Kim, Jin Hyung Jung, Kyungdo Han, Dong-Yun Lee, Maurizio Fava, David Mischoulon, Hong Jin Jeon
Summary: A retrospective cohort study in South Korea examined the association between female reproductive factors and the risk of depression in postmenopausal women. The study found that late menarche, early menopause, and long-term use of menopausal hormone therapy were associated with an increased risk of depression.
GENERAL HOSPITAL PSYCHIATRY
(2023)
Article
Psychiatry
Chirag M. Vyas, David Mischoulon, Grace Chang, Charles F. Reynolds, Nancy R. Cook, Alison Weinberg, Trisha Copeland, Vadim Bubes, Gary Bradwin, I-Min Lee, Julie E. Buring, Samia Mora, Nader Rifai, JoAnn E. Manson, Olivia I. Okereke
Summary: This study examined the relationship between serum brain-derived neurotrophic factor (BDNF) and late-life depression (LLD) both cross-sectionally and longitudinally. It also investigated the effects of vitamin D3 and omega-3s on changes in BDNF and explored the role of BDNF in the effects of these supplements on LLD. The results showed significant cross-sectional associations between serum BDNF levels and LLD, but no longitudinal associations. Neither vitamin D3 nor omega-3s had an effect on serum BDNF levels over a 2-year period.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)