Article
Medicine, General & Internal
Ayano Maruyama, Risa Tamagawa-Mineoka, Hiromi Nishigaki, Koji Masuda, Norito Katoh
Summary: This is an important study exploring potential local and systemic biomarkers of AD, which will have clinical significance in discovering and assessing new biomarkers for AD.
Article
Allergy
Susumu Murata, Sakae Kaneko, Eishin Morita
Summary: The improvement of dermatitis in atopic dermatitis (AD) patients is correlated with a decrease in stratum corneum interleukin-8 (scIL-8) levels after topical corticosteroid treatment. The reduction in scIL-8 levels is associated with the improvement in local skin severity in AD, indicating that scIL-8 may be a suitable biomarker for monitoring therapeutic effects in AD patients.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2021)
Article
Dermatology
Masataka Ota, Takashi Sasaki, Tamotsu Ebihara, Emiko Yokosawa, Yumi Murakami, Hiroshi Matsunaka, Yuko Chinuki, Masayuki Amagai, Eishin Morita
Summary: The study found that loss-of-function mutations of the filaggrin (FLG) gene do not affect the severity of atopic dermatitis (AD) or skin barrier function, and have little impact on the amount of FLG protein and total amino acids in the stratum corneum of lesional skin. The results suggest that the production of FLG in skin lesions is influenced by the activation of Th2-dominant inflammatory cells along with FLG abnormalities.
JOURNAL OF DERMATOLOGY
(2021)
Review
Allergy
F. L. de Boer, H. F. van Der Molen, S. Kezic
Summary: Dysfunction of the skin barrier is crucial in inflammatory skin diseases, and epidermal biomarkers can aid in evaluating its functionality. This review provides an overview of recent studies on epidermal biomarkers associated with the skin barrier's function and integrity and their application in research on atopic dermatitis and contact dermatitis. Potential biomarkers include lipids, natural moisturizing factors, structural proteins, corneocyte surface topography, and elasticity. While these biomarkers show promise, their validation for specific diseases is still needed.
CONTACT DERMATITIS
(2023)
Article
Dermatology
Mads Almose Ropke, Anna Mekulova, Christian Pipper, Maigi Eisen, Kristi Pender, Pieter Spee, Sanja Kezic
Summary: This study evaluated the use of the non-invasive patch technique by FibroTx for skin biomarker analysis in AD patients. The results demonstrated that this method can detect key biomarkers on lesional and non-lesional skin, which can reflect changes based on treatment. These findings support the effectiveness of using patch sampling for non-invasive assessment of inflammatory processes in AD skin.
SKIN RESEARCH AND TECHNOLOGY
(2021)
Article
Allergy
Evgeny Berdyshev, Jihyun Kim, Byung Eui Kim, Elena Goleva, Taras Lyubchenko, Irina Bronova, Anna Sofia Bronoff, Olivia Xiao, Jiwon Kim, Sukyung Kim, Mijeong Kwon, Sungjoo Lee, Yu Jeong Seo, Kyunga Kim, Suk-Joo Choi, Soo-Young Oh, Seung Hwan Kim, So Yeon Yu, Seung Yong Hwang, Kangmo Ahn, Donald Y. M. Leung
Summary: A study found that the risk of developing atopic dermatitis in the future can be predicted by analyzing the skin surface of infants at the age of two months, and identified potential biomarkers.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Adrienn Jenei, Gergo Kallo, Zsolt Dajnoki, Krisztian Gaspar, Andrea Szegedi, Aniko Kapitany, Eva Csosz
Summary: This study developed a novel approach for examining AMPs in the outer layer of the epidermis, with hexane-free processing producing higher protein yield. Among the investigated peptides, 9 could be detected in healthy or inflamed skin, and significant topographical differences were observed in the amount of certain peptides among different regions of healthy skin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Sagar Shukla, Annette L. Bunge, Hazem E. Hassan, Audra L. Stinchcomb
Summary: The study evaluated the impact of different investigators in studies using a tape stripping protocol to minimize investigator variability. The results showed that the measurements of different investigators are reproducible within the limitations of measurement variability, which can be managed by increasing volunteer numbers.
PHARMACEUTICAL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Konstantin Simon, Gila Oberender, Alexander Roloff
Summary: Tape stripping is a common method used in studies on drug penetration through the skin, but the amount of stratum corneum removed by each tape strip is still under debate. Some studies suggest that the amount of stratum corneum decreases with increasing depth, while others find a constant removal rate.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biology
Trinidad Montero-Vilchez, Carlos Cuenca-Barrales, Juan-Angel Rodriguez-Pozo, Pablo Diaz-Calvillo, Jesus Tercedor-Sanchez, Antonio Martinez-Lopez, Alejandro Molina-Leyva, Salvador Arias-Santiago
Summary: This study investigated the changes in skin barrier function with age in patients with atopic dermatitis (AD). The results showed that as age increased, AD patients had higher transepidermal water loss (TEWL), lower stratum corneum hydration (SCH), and reduced elasticity compared to healthy individuals. There was a negative correlation between age and elasticity, which was stronger in AD patients than in controls. Linear regression analyses revealed that age and disease severity had a significant impact on elasticity in AD patients. These findings suggest that age plays a role in impairing skin barrier function in AD patients, particularly in terms of elasticity.
Article
Biochemistry & Molecular Biology
Tu Hu, Tanja Todberg, Daniel Andersen, Niels Banhos Danneskiold-Samsoe, Sofie Boesgaard Neestrup Hansen, Karsten Kristiansen, David Adrian Ewald, Susanne Brix, Joel Correa da Rosa, Ilka Hoof, Lone Skov, Thomas Litman
Summary: This study used BRB-seq technique to analyze the transcriptome of tape-stripped skin samples from atopic dermatitis patients and healthy controls. An AD signature consisting of genes related to skin barrier and inflammatory response was identified. However, the low and highly variable transcript counts in tape-stripped samples were a limiting factor for epidermal transcriptome profiling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Risa Tamagawa-Mineoka
Summary: The skin acts as a physical barrier and toll-like receptors (TLRs) play a role in both infectious and non-infectious inflammatory diseases. In atopic dermatitis (AD), skin barrier dysfunction allows stimuli to penetrate the skin and activate the innate immune system, leading to inflammation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mihaela Gorcea, Majella E. Lane, David J. Moore
Summary: The purpose of this in vivo exploratory study was to investigate the conformational order and chain packing of human stratum corneum lipids in healthy face skin as a function of depth. The study found that the lipid order of the stratum corneum increases with depth in face skin, but shows significant differences compared to arm skin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Yu Zhang, Nina Heinemann, Franziska Rademacher, Maxim E. Darvin, Christian Raab, Cornelia M. Keck, Henning Vollert, Joachim W. Fluhr, Regine Glaser, Jurgen Harder, Martina C. Meinke
Summary: This study investigates the effects of a natural extract rich in antioxidants on signaling inflammatory molecules and skin barrier enhancement in human epidermal keratinocytes, and analyzes its influence on lesion severity, barrier function, and pruritus in mild to moderate atopic dermatitis patients through both cell assays and a clinical study.
Article
Dermatology
Masataka Suehiro, Tomofumi Numata, Emi Murakami, Masakazu Takahashi, Ryo Saito, Satoshi Morioke, Akiko Kamegashira, Shunsuke Takahagi, Michihiro Hide, Akio Tanaka
Summary: The topical Janus kinase inhibitor, delgocitinib (DEL) ointment, has been shown to be effective in treating atopic dermatitis (AD). It is as effective as topical corticosteroids in maintaining remission, especially for patients with dry skin.
DERMATOLOGIC THERAPY
(2022)
Article
Microbiology
Itaru Dekio, Renata Culak, Raju Misra, Tom Gaulton, Min Fang, Mitsuo Sakamoto, Moriya Ohkuma, Kenshiro Oshima, Masahira Hattori, Hans-Peter Klenk, Dunstan Rajendram, Saheer E. Gharbia, Haroun N. Shah
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2015)
Article
Dermatology
Yuichi Nodake, Said Matsumoto, Ryoko Miura, Hidetoshi Honda, Genji Ishibashi, Shuzo Matsumoto, Itaru Dekio, Ryuzo Sakakibara
JOURNAL OF DERMATOLOGICAL SCIENCE
(2015)
Editorial Material
Dermatology
Anna Sadayasu, Yoshifumi Maumi, Yuka Hayashi, Itaru Dekio, Sumiko Ishizaki, Mariko Fujibayashi, Masaru Tanaka
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2017)
Letter
Dermatology
Sumiko Ishizaki, Masaru Tanaka, Itaru Dekio, Mizuki Sawada, Mariko Fujibayashi, Satoru Shimizu
JOURNAL OF DERMATOLOGICAL SCIENCE
(2016)
Letter
Dermatology
O. A. Alexeyev, I. Dekio, A. M. Layton, H. Li, H. Hughes, T. Morris, C. C. Zouboulis, S. Patrick
BRITISH JOURNAL OF DERMATOLOGY
(2018)
Article
Dermatology
Itaru Dekio, Shingo Matsuki, Eishin Morita
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2014)
Article
Microbiology
Itaru Dekio, Andrew McDowell, Mitsuo Sakamoto, Shuta Tomida, Moriya Ohkuma
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2019)
Article
Microbiology
Takao Iino, Shigeru Kawai, Masahiro Yuki, Itaru Dekio, Moriya Ohkuma, Shin Haruta
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Microbiology
Itaru Dekio, Mitsuo Sakamoto, Tomo Suzuki, Masahiro Yuki, Shigeru Kinoshita, Yoshiyuki Murakami, Moriya Ohkuma
INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY
(2020)
Article
Microbiology
Itaru Dekio, Yuki Sugiura, Susumu Hamada-Tsutsumi, Yoshiyuki Murakami, Hiroto Tamura, Makoto Suematsu
Summary: The researchers utilized proteogenomic approaches to assign high-intensity peaks in MALDI-TOF spectra of two bacterial genera, Cutibacterium and Staphylococcus, based on genome data and mass spectrometry technology, successfully confirming peak assignments for the species.
Article
Microbiology
Itaru Dekio, Akihiko Asahina, Haroun N. Shah
Summary: In 2016, a new species named Cutibacterium acnes was created for the well-known species Propionibacterium acnes, with the proposal of two new species and three subspecies. These changes have made it challenging for non-specialists to correlate previous research with current findings. The five recognized species in the genus have unique genetic makeups and pathogenic properties, residing in different niches.
Review
Dermatology
Brigitte Dreno, Itaru Dekio, Hilary Baldwin, Anne Laure Demessant, Marie-Ange Dagnelie, Amir Khammari, Stephane Corvec
Summary: Acne vulgaris is a chronic inflammatory skin disease caused by altered sebum production, inflammation, excess keratinization, and dysbiosis. Recent studies have shown that Cutibacterium acnes and Staphylococcus epidermidis play important roles in acne development. The use of antibiotics, a common treatment for acne, disrupts the skin microbiota, highlighting the need for alternative management strategies that positively affect the skin microbiome.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Michie Katsuta, Yozo Ishiuji, Minako Ogawa-Tominaga, Kaoru Chiba, Itaru Dekio, Yoshimasa Nobeyama, Akihiko Asahina
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Letter
Dermatology
Soko Watanabe, Masaru Tanaka, Itaru Dekio, Sumiko Ishizaki, Mizuki Sawada
AUSTRALASIAN JOURNAL OF DERMATOLOGY
(2018)