Article
Clinical Neurology
Panwen Zhang, Na Zhang, Shulin Fang, Jiayue He, Lejia Fan, Xingwei Luo, Jianghua Zhang, Yan Xiong, Fusheng Luo, Xiaosheng Wang, Shuqiao Yao, Xiang Wang
Summary: The study evaluated the psychometric properties of the Chinese version of SHAPS in non-clinical and clinical samples including MDD, schizophrenia, or personality disorders. The results showed good internal consistency, best fit structural model in both samples, and significant associations with TEPS and BDI.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Ahmet Gurcan, Koray Basar, Zumrut Duygu Sen, Ahmet Alp Karakasli
Summary: This study aimed to adapt and validate the Snaith-Hamilton Pleasure Scale Clinician Administered Turkish Form (SHAPS-C-TR) for measuring anhedonia in clinical and non-clinical samples. The results showed that the SHAPS-C-TR is a reliable and valid measurement tool for assessing anhedonia in both clinical and non-clinical individuals.
TURK PSIKIYATRI DERGISI
(2022)
Article
Psychology, Clinical
Maria Montoro, Elsa Arrua-Duarte, Belen Penalver-Argueso, Marta Migoya-Borja, Enrique Baca-Garcia, Maria Luisa Barrigon
Summary: This study aimed to investigate the equivalence between the traditional paper-and-pencil format and a digital version of the SHAPS. The results showed no significant differences between the two formats, indicating good levels of internal consistency.
JOURNAL OF HEALTH PSYCHOLOGY
(2022)
Article
Neurosciences
Ghorban Taghizadeh, Mohammad Taghi Joghataei, Sepideh Goudarzi, Merat Bakhsheshi, Sayed Amir Hasan Habibi, Maryam Mehdizadeh
Summary: The study confirmed the acceptability and efficacy of the Persian version of KPPS-P for assessing pain in patients with Parkinson's disease. Cut-off points for pain severity levels were identified as 0, 17, and 68, with high sensitivity and specificity.
NEUROSCIENCE LETTERS
(2021)
Article
Psychiatry
Phuong Le-Nguyen-Thuy, Trang Nguyen-Dao-Uyen, Anh Tran-Nguyen-Quynh, Truc Thanh Thai, Linh Ngo-Tich, Dung Do-Van, Sy Duong-Quy
Summary: This study aimed to evaluate the reliability and validity of the Vietnamese version of the Hamilton D-17 scale. The results showed that the scale had high levels of reliability and validity, and it can be used to assess symptoms of depression among Vietnamese patients.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Multidisciplinary
Sarah A. Wellan, Anna Daniels, Henrik Walter
Summary: The study validated the German version of the Dimensional Anhedonia Rating Scale (DARS) in a sample of healthy adults, showing good convergent and divergent validity as well as high internal consistency. The research also found that the COVID-19 pandemic had an impact on depressive symptoms, but did not affect state hedonic capacity.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Rehabilitation
Aysan Mahmoudi Asl, Maryam Mehdizadeh, Jaime Kulisevsky, Azar Sabet, Parvaneh Taghavi Azar Sharabiani, Hajar Mehdizadeh, Hassan Ashayeri, Ghorban Taghizadeh
Summary: The aim of this study was to investigate the reliability and validity of the Parkinson's Disease-Cognitive Rating Scale (PD-CRS) in Iranian patients with idiopathic Parkinson's disease (PD). The Persian version of PD-CRS showed excellent test-retest and inter-rater reliability, as well as internal consistency. It also exhibited high sensitivity and specificity in identifying mild cognitive impairment (MCI) and dementia in PD patients. Overall, the Persian version of PD-CRS is a reliable and valid measure for assessing cognitive function in patients with PD.
DISABILITY AND REHABILITATION
(2022)
Article
Clinical Neurology
Calum D. Moulton, Rebecca Strawbridge, Dimosthenis Tsapekos, Emanuella Oprea, Ben Carter, Chloe Hayes, Anthony J. Cleare, Lindsey Marwood, Tim Mantingh, Allan H. Young
Summary: This study aimed to validate the M3VAS as a measure of core depressive symptoms and suicidality. The results indicated good internal consistency and convergent validity of the M3VAS.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Jingjie Lu, Xiang Wang, Qian Liu, Quanhao Yu, Jie Fan, Xiongzhao Zhu
Summary: Social anhedonia, as a transdiagnostic symptom, has received increasing attention. This study explored the psychometric properties of the ACIPS in undergraduate and Chinese OCD patients. Findings indicated that depression and the severity of obsessive thoughts are significantly negatively correlated with social anhedonia in OCD patients. The ACIPS is a reliable tool for assessing social anhedonia.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Wen-Yi Xiao, Rui-Zhen Zhu, Zhao-Xi Lv, Juan Fan, Zheng-hui Yi, Jue Chen, Kang Ju, Chao Yan
Summary: The present study examined the reliability and validity of the Chinese version of the Dimensional Anhedonia Rating Scale in adolescents. The results showed that the scale had good internal consistency, test-retest reliability, concurrent, convergent, and divergent validity in typical adolescents. It also demonstrated excellent eligibility and validity in depressed adolescents.
Article
Multidisciplinary Sciences
Fateme Mohammadi, Seyed Amin Kouhpayeh, Mostafa Bijani, Mojtaba Farjam, Amir Faghihi, Zohreh Badiyepeymaiejahromi
Summary: Nurses play a key role in medication safety and patient safety. This study translated and assessed a Persian version of the Medication Safety Competence Scale (MSCS) for clinical nurses in Iran. The psychometric properties of the MSCS were evaluated using COSMIN criteria. The Persian version of the MSCS demonstrated satisfactory validity and reliability, making it a useful tool for measuring medication safety competence in nurses.
SCIENTIFIC REPORTS
(2023)
Article
Psychology, Multidisciplinary
Nelson Andrade-Gonzalez, Irene Rodrigo-Holgado, Jesus Fernandez-Rozas, Pablo F. Cancer, Guillermo Lahera, Alberto Fernandez-Liria, Gabriel Rubio, Scott D. Miller
Summary: The research aimed to determine the reliability and validity of the Outcome Rating Scale (ORS) and Session Rating Scale (SRS) in a sample of Spanish patients, with both measures showing good internal consistency, convergent and discriminant validity, as well as sensitivity to changes in patients' symptoms.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Food Science & Technology
Nikoline Bach Hyldelund, Chanette Frederiksen, Derek Victor Byrne, Barbara Vad Andersen
Summary: Psychological stress is associated with altered eating behavior and anhedonic traits. A study conducted with Danish consumers found that high levels of stress resulted in loss of appetite and anhedonia, while moderate stress led to changes in meal patterns. These findings contribute to our understanding of the impact of stress on individual and public health.
Article
Clinical Neurology
David Morley, Sarah Dummett, Laura Kelly, Crispin Jenkinson
Summary: Exercise is an important component in managing Parkinson's disease, but there is no specific self-report measure for exercise. This study developed a Parkinson's-specific patient-reported outcome measure (PROM) through cognitive interviews and online surveys. Results show that the PDQ-Exercise is an acceptable, reliable, and valid PROM, with further assessment of its psychometric properties ongoing.
MOVEMENT DISORDERS
(2021)
Article
Psychology, Clinical
Lu Yang, Shuangxin Zhang, Jiaqi Leng, Zhiguang Fan, Yi Luo
Summary: This study developed the Nurse Occupational Stigma Scale (NOSS) and tested its reliability and validity in the Chinese context. The results indicated that NOSS has good internal consistency and split-half reliability, making it an effective tool for assessing occupational stigma towards nurses.
PSYCHOLOGY RESEARCH AND BEHAVIOR MANAGEMENT
(2022)
Article
Clinical Neurology
Aya Ogura, Kazuya Kawabata, Hirohisa Watanabe, Shao Wei Choy, Epifanio Bagarinao, Toshiyasu Kato, Kazunori Imai, Michihito Masuda, Reiko Ohdake, Kazuhiro Hara, Ryoichi Nakamura, Naoki Atsuta, Tomohiko Nakamura, Masahisa Katsuno, Gen Sobue
Summary: In this study, a novel framework for diffusion-weighted imaging analysis called Fixel-based analysis (FBA) was used to investigate white matter changes in ALS patients. The findings showed reduced fiber density and morphology in the bilateral corticospinal tracts and corpus callosum of ALS patients. Clinical scores were negatively correlated with fiber density values in the corticospinal tracts.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Genki Tohnai, Ryoichi Nakamura, Naoki Atsuta, Masahiro Nakatochi, Naoki Hayashi, Daisuke Ito, Hazuki Watanabe, Hirohisa Watanabe, Masahisa Katsuno, Yuishin Izumi, Akira Taniguchi, Kazuaki Kanai, Mitsuya Morita, Osamu Kano, Satoshi Kuwabara, Masaya Oda, Koji Abe, Masashi Aoki, Ikuko Aiba, Koichi Okamoto, Kouichi Mizoguchi, Tomohiko Ishihara, Akihiro Kawata, Takanori Yokota, Kazuko Hasegawa, Isao Nagano, Ichiro Yabe, Fumiaki Tanaka, Satoshi Kuru, Nobutaka Hattori, Kenji Nakashima, Ryuji Kaji, Gen Sobue
Summary: This study aimed to determine the frequencies and characteristics of DNAJC7 gene variants in a Japanese ALS cohort. Rare missense variants and one splice-site variant of DNAJC7 were detected in 807 Japanese patients with sporadic ALS. The variants were located around the TPR domain and the estimated frequency of DNAJC7 variants in Japanese ALS patients was 0.87%.
NEUROBIOLOGY OF AGING
(2022)
Article
Clinical Neurology
Kai Takahashi, Hiroshi Nishiwaki, Mikako Ito, Kazuhiro Iwaoka, Kenta Takahashi, Yoshio Suzuki, Keita Taguchi, Kanako Yamahara, Yoshio Tsuboi, Kenichi Kashihara, Masaaki Hirayama, Kinji Ohno, Tetsuya Maeda
Summary: The study revealed that the relative abundance of gut microbiota is associated with motor complications in Parkinson's disease patients, with differences in effects between wearing-off and dyskinesia. Age, disease duration, and wearing-off were identified as independent risk factors for microbiota changes.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Neurosciences
M. Judith Peterschmitt, Hidemoto Saiki, Taku Hatano, Thomas Gasser, Stuart H. Isaacson, Sebastiaan J. M. Gaemers, Pascal Minini, Stephane Saubadu, Jyoti Sharma, Samantha Walbillic, Roy N. Alcalay, Gary Cutter, Nobutaka Hattori, Gunter U. Hoeglinger, Kenneth Marek, Anthony H. Schapira, Clemens R. Scherzer, Tanya Simuni, Nir Giladi, Sergio Pablo Sardi, Tanya Z. Fischer
Summary: This study evaluated the pharmacology, safety, and tolerability of the glucosylceramide synthase inhibitor venglustat in patients with Parkinson's disease and GBA mutations. The results showed favorable safety and tolerability of venglustat in both Japanese and non-Japanese participants, with target engagement achieved in cerebrospinal fluid.
JOURNAL OF PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Haruka Takeshige-Amano, Taku Hatano, Koji Kamagata, Christina Andica, Wataru Uchida, Masahiro Abe, Takashi Ogawa, Yasushi Shimo, Genko Oyama, Atsushi Umemura, Masanobu Ito, Masaaki Hori, Shigeki Aoki, Nobutaka Hattori
Summary: This study comprehensively assessed white matter microstructures in PD patients with ICBs using advanced diffusion MRI and MT-sat imaging. The results showed that compared with healthy controls, PD-nICBs had significant alterations in many major white matter tracts in most parameters. Compared with PD-ICBs, PD-nICBs had more prominent myelin and axonal changes in fibers related to the reward system and visual emotional recognition.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Clinical Neurology
Mayuko Ogawa, Genko Oyama, Satoko Sekimoto, Taku Hatano, Nobutaka Hattori
Summary: In a specific cohort in Japan, patients with Parkinson's disease and their caregivers were mostly satisfied with the telemedicine service, finding it effective in reducing travel burden.
JOURNAL OF MOVEMENT DISORDERS
(2022)
Review
Clinical Neurology
Conor Fearon, Sapna Rawal, Diana Olszewska, Paula Alcaide-Leon, Drew S. Kern, Soumya Sharma, Shyam K. Jaiswal, Jagarlapudi M. K. Murthy, Ainhi D. Ha, Raymond S. Schwartz, Victor S. C. Fung, Chauncey Spears, Tracy Tholanikunnel, Leonardo Almeida, Taku Hatano, Yutaka Oji, Nobutaka Hattori, Shantanu Shubham, Hrishikesh Kumar, Roongroj Bhidayasiri, Christopher Laohathai, Anthony E. Lang
Summary: The MDS Video Challenge is one of the most attended sessions at the International Congress. In addition to presenting complex case videos, over the years, there have been cases with unusual or important neuroimaging findings. This review compiles a selection of such cases and presents them in two anthologies based on whether the underlying diagnosis is genetic or acquired.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2022)
Review
Clinical Neurology
Hirohisa Watanabe, Sayuri Shima, Yasuaki Mizutani, Akihiro Ueda, Mizuki Ito
Summary: This review summarizes the improvements in understanding the pathophysiology and early clinical symptoms of multiple system atrophy (MSA), as well as advancements in diagnostic methods and disease-modifying therapies for the condition. The introduction of new diagnostic criteria in 2022 and the use of artificial intelligence and machine learning in neuroimaging have significantly improved diagnostic accuracy. Treatment advancements, including immunotherapy against alpha-synuclein and stem cell therapies, show promise in targeting different aspects of the disease.
JOURNAL OF MOVEMENT DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Naoto Sugeno, Takafumi Hasegawa
Summary: Alpha-synuclein (aS) is a protein encoded by the SNCA gene that is involved in Parkinson's disease (PD). Mutations and multiplication of the SNCA gene lead to familial forms of PD. Misfolded aS is cytotoxic and forms Lewy bodies, a hallmark of PD. The expression of SNCA and epigenetic alterations play a role in the pathogenesis of sporadic PD. RNA sequencing and informatic analysis of human midbrain-like organoids can provide insights into novel pathways for the development of PD therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Clinical Neurology
Toshiharu Nagatsu, Akira Nakashima, Hirohisa Watanabe, Shosuke Ito, Kazumasa Wakamatsu, Fabio A. Zucca, Luigi Zecca, Moussa Youdim, Maximilian Wulf, Peter Riederer, Johannes M. Dijkstra
Summary: The dark pigment neuromelanin (NM) is abundant in dopamine (DA) neurons in the substantia nigra (SN) and norepinephrine (NE) neurons in the locus coeruleus (LC) in the human brain. During the progression of Parkinson's disease (PD), NM levels in these neurons decrease. The synthesis pathway involves conversion of tyrosine to L-DOPA, then to DA or NE, followed by autoxidation and conversion to eumelanic or pheomelanic NM.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Clinical Neurology
Naoya Yamazaki, Takafumi Hasegawa, Kensuke Ikeda, Ako Miyata, Shin-ichiro Osawa, Kuniyasu Niizuma, Shigenori Kanno, Teiji Tominaga, Masashi Aoki
Summary: Disturbance of smell is often associated with neurodegenerative diseases and can also be caused by head trauma, intracranial tumors, and hydrocephalus. Olfactory dysfunction is often overlooked due to the prominence of motor symptoms. This case report highlights that hydrocephalus can cause olfactory dysfunction and that it can be improved with surgical treatment.
CASE REPORTS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Yoko Sugimura, Toru Baba, Michinori Ezura, Akio Kikuchi, Takafumi Hasegawa, Isao Nagano, Kyoko Suzuki, Atsushi Takeda
Summary: Corticobasal syndrome is characterized by asymmetric akinetic rigidity and higher cortical dysfunction. Predicting its pathology is challenging, but clinical and neuroimaging findings can provide clues. Visuospatial dysfunction and language impairment indicate Alzheimer's disease-related pathology, aiding in distinguishing it from other types. Early diagnosis based on clinical features and biomarkers is crucial for successful intervention in corticobasal syndrome associated with Alzheimer's disease.
ALZHEIMER DISEASE & ASSOCIATED DISORDERS
(2023)
Review
Medicine, General & Internal
Takafumi Kubota, Tomomi Shijo, Kensho Ikeda, Yoshihiko Mitobe, Shu Umezawa, Tatsuro Misu, Takafumi Hasegawa, Masashi Aoki
Summary: We report a rare case of distal chronic inflammatory demyelinating polyneuropathy (CIDP) following COVID-19 vaccination. A 39-year-old woman developed general weakness after receiving the Pfizer-BioNTech COVID-19 vaccine, which progressed over 3 months. The patient was diagnosed with distal CIDP based on neurological examination and serological tests. Treatment with immunoglobulin, methylprednisolone, prednisolone, and plasma exchange resulted in gradual improvement. Physicians should be aware of CIDP as a rare complication of COVID-19 vaccination.
Article
Medicine, General & Internal
Gakusuke Umezawa, Takafumi Hasegawa, Kensuke Ikeda, Genichi Saito, Masashi Aoki
Summary: Painful legs and moving toes syndrome (PLMTS) is a rare movement disorder characterized by spontaneous abnormal toe movements and leg pain. It mainly affects middle-aged or older women. The cause of PLMTS is often unknown, but it can be related to peripheral neuropathy, trauma history, or nerve root damage. Treatment for PLMTS includes medication such as anticonvulsants and antidepressants, as well as therapeutic interventions like botulinum toxin injection and epidural block. We report a case where low doses of pramipexole, a non-ergot dopamine agonist, significantly improved both abnormal toe movement and leg pain.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Makiko Yoshida, Naoki Ishizuka, Masanori Mizuno, Manami Maeta, Tetsuya Maeda
Summary: We report a rare case of tuberculous hypertrophic pachymeningitis in a patient with abdominal tuberculous lymphadenopathy. Systematic investigation of tuberculosis is crucial for the diagnosis of pachymeningitis.
SAGE OPEN MEDICAL CASE REPORTS
(2022)