Review
Obstetrics & Gynecology
Joanne Michelle D. Gomez, Katherine VanHise, Nina Stachenfeld, Jessica L. Chan, Noel Bairey Merz, Chrisandra Shufelt
Summary: Polycystic ovary syndrome (PCOS) affects approximately 6%-10% of women worldwide, with features of hyperandrogenism, irregular menses, infertility, and polycystic appearing ovaries on ultrasound. PCOS is also associated with endocrine and metabolic disorders that increase the risk for subclinical cardiovascular disease.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Meri-Maija Ollila, Riikka K. Arffman, Elisa Korhonen, Laure Morin-Papunen, Stephen Franks, Juhani Junttila, Terhi T. Piltonen
Summary: Polycystic ovary syndrome (PCOS) is associated with various cardiovascular disease (CVD) risk factors, including obesity, type 2 diabetes mellitus, and hypertension. However, it is still unclear whether the presence of multiple CVD risk factors leads to an increased risk of CVD events.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jolanta Nawrocka-Rutkowska, Iwona Szydlowska, Katarzyna Jakubowska, Maria Olszewska, Dariusz Chlubek, Malgorzata Szczuko, Andrzej Starczewski
Summary: This study evaluated oxidative stress parameters in patients with PCOS and found that the severity of oxidative stress is associated with the risk of cardiovascular diseases. Assessing additional cardiovascular disease parameters can help identify risk groups for cardiometabolic disease among PCOS patients. Early preventive examinations should be conducted when PCOS patients have additional risk factors such as hyperandrogenism and insulin resistance.
Article
Gastroenterology & Hepatology
Alessandro Mantovani, Graziana Petracca, Giorgia Beatrice, Herbert Tilg, Christopher D. Byrne, Giovanni Targher
Summary: This meta-analysis shows that patients with NAFLD have a significantly increased risk of developing diabetes, and this risk rises with the severity of NAFLD. The risk is independent of age, sex, adiposity measures, and other metabolic risk factors.
Review
Biochemistry & Molecular Biology
Anastasia Poznyak, Larisa Litvinova, Paolo Poggio, Donato Moschetta, Vasily Nikolaevich Sukhorukov, Alexander N. Orekhov
Summary: Atherosclerosis is a complex cardiovascular disease caused by multiple molecular mechanisms, such as endothelial dysfunction, inflammation, mitochondrial dysfunction, oxidative stress, and lipid metabolism disorders. Metformin, a medication commonly used for diabetes, holds promise as a therapeutic option for atherosclerosis due to shared mechanisms with diabetes. This review summarizes the mechanisms of action of metformin and presents available data from clinical trials on its efficacy in reducing cardiovascular risks.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Justin B. Echouffo-Tcheugui, Alexander Turchin, Robert S. Rosenson, Gregg C. Fonarow, Abhinav Goyal, James A. de Lemos, Suzanne V. Arnold
Summary: The study found that patients with isolated cerebrovascular disease had lower rates of attainment of secondary cardiovascular prevention goals, indicating a need for more focus on secondary prevention in this patient population.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Elizabeth Y. Liu, Mohammed E. Al-Sofiani, Hsin-Chieh Yeh, Justin B. Echouffo-Tcheugui, Joshua J. Joseph, Rita R. Kalyani
Summary: This study revealed that preventive aspirin use was more common among older adults with diabetes compared to those without diabetes, with approximately 9.9 million older adults in the US previously taking aspirin for primary prevention now not recommended to continue its use.
Article
Endocrinology & Metabolism
Han Han, Yaying Cao, Chengwu Feng, Yan Zheng, Klodian Dhana, Shu Zhu, Cong Shang, Changzheng Yuan, Geng Zong
Summary: The study found that adopting a healthy lifestyle can reduce mortality rates in individuals with type 2 diabetes.
Article
Endocrinology & Metabolism
Han Han, Yaying Cao, Chengwu Feng, Yan Zheng, Klodian Dhana, Shu Zhu, Cong Shang, Changzheng Yuan, Geng Zong
Summary: This study evaluates the association between a healthy lifestyle and all-cause mortality and cause-specific mortality among individuals with type 2 diabetes. The results show that a healthy lifestyle, involving seven low-risk factors, is significantly associated with a lower risk of all-cause mortality and mortality due to cardiovascular disease, cancer, respiratory disease, and digestive disease among individuals with type 2 diabetes.
Article
Medicine, General & Internal
Lee-Ling Lim, Eric S. H. Lau, Amy W. C. Fu, Subir Ray, Yi-Jen Hung, Alexander T. B. Tan, Parinya Chamnan, Wayne H. H. Sheu, Manoj S. Chawla, Yook-Chin Chia, Lee-Ming Chuang, Duc-Cong Nguyen, Aravind Sosale, Banshi D. Saboo, Uday Phadke, Jothydev Kesavadev, Su-Yen Goh, Neeru Gera, Thi Thanh Huyen Vu, Ronald C. W. Ma, Vanessa Lau, Andrea O. Y. Luk, Alice P. S. Kong, Juliana C. N. Chan
Summary: The study showed that using information and communications technology, along with nurse involvement, for quality improvement intervention in low- and middle-income countries did not reduce clinical events but did decrease cardiometabolic risk factors among patients with type 2 diabetes.
Article
Medicine, Research & Experimental
Ching Chen, Ting-Ting Chang, Jaw-Wen Chen
Summary: Chemokines, through modulating inflammation process, have a potential role in the development of cardiovascular disease, diabetes mellitus, and kidney disease. Among them, CXCL5, a chemokine with bidirectional promiscuity, may be involved in various inflammatory diseases, but its specific mechanistic roles in each disease need further investigation. Recent evidence suggests differential effects of CXCL5 in cardiovascular disease, diabetes mellitus, and renal disease, but its potential as a therapeutic target in these diseases requires further validation.
Article
Multidisciplinary Sciences
Elisabeth Buur Stougaard, Signe Abitz Winther, Hanan Amadid, Marie Frimodt-Moller, Frederik Persson, Tine Willum Hansen, Peter Rossing
Summary: The study aimed to assess the associations between PBR, PBR-hf, and MVHS with cardio-renal risk factors in individuals with type 1 diabetes, as well as compare these dimensions with controls. Results showed that the endothelial glycocalyx dimension was impaired in individuals with T1D compared to controls, but there was no association with albuminuria levels or cardio-renal risk factors. The use of the GlycoCheck device may not contribute significantly to cardio-renal risk stratification in T1D.
Article
Endocrinology & Metabolism
Thorsten Otto, Joanna Diesing, Julia Borchert, Elke Heitmann, Nanette C. Schloot, Jeremie Lebrec, Dirk Mueller-Wieland, Dennis Haeckl
Summary: This study assessed the prevalence of type 2 diabetes mellitus (T2DM) in Germany, particularly in patients at risk for or with established cardiovascular disease (CVD), and their treatments. Using claims data, T2DM prevalence was estimated at 11.9%, higher in older patients. The majority of T2DM patients had at least one cardiovascular risk factor, and about half had established CVD. Early prevention of CVD in T2DM patients, especially in older individuals, is crucial. Furthermore, the use of insulin in older T2DM patients needs further evaluation.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Anna Syreeni, Emma H. Dahlstrom, Stefanie Hagg-Holmberg, Carol Forsblom, Marika I. Eriksson, Valma Harjutsalo, Jukka Putaala, Per-Henrik Groop, Niina Sandholm, Lena M. Thorn
Summary: This study aimed to investigate the relationship between the haptoglobin Hp1/2 genotype and stroke in individuals with type 1 diabetes. The results showed that the haptoglobin genotypes had no association with the risk of stroke or survival after stroke in this cohort.
Article
Multidisciplinary Sciences
Gudrun Hoskuldsdottir, Stefan Franzen, Katarina Eeg-Olofsson, Bjorn Eliasson
Summary: This study aimed to explore the development risk of comorbidities in type 2 diabetes patients and evaluate the impact of common risk factors. The study found that all comorbidities gradually increased over time, with women having a lower risk compared to men.
SCIENTIFIC REPORTS
(2022)