Review
Cardiac & Cardiovascular Systems
Chiara Scrocco, Connie R. Bezzina, Michael J. Ackerman, Elijah R. Behr
Summary: Epidemiological studies have shown a genetic component to the risk of sudden cardiac death (SCD), especially in young individuals with rare, monogenic forms of heart disease. Despite comprehensive pathology and genetic evaluations, a proportion of SCD cases in young individuals remain unexplained, posing challenges in identifying family members at risk of SCD.
NATURE REVIEWS CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chien-Hsien Lo, Yu-Hsun Wang, Chin-Feng Tsai, Kuei-Chuan Chan, Li-Ching Li, Tse-Hsien Lo, James Cheng-Chung Wei, Chun-Hung Su
Summary: In patients with systemic lupus erythematosus, hydroxychloroquine treatment did not significantly increase the risk of cardiac arrhythmia or life-threatening ventricular arrhythmia regardless of the different hydroxychloroquine treatment duration, drug adherence rate, or daily dose.
Review
Emergency Medicine
Lauren B. Robison, William J. Brady, Robert A. Robison, Nathan Charlton
Summary: Prolongation of the QTc interval is associated with an increased risk of malignant ventricular dysrhythmias and sudden cardiac death. However, specific quantifiable risk rates in relation to specific QTc interval length remain unknown. Current literature is inadequate to provide a definitive answer, requiring further prospective research on this topic.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Fariba Ahmadizar, Negin Soroush, M. Arfan Ikram, Jan A. Kors, Maryam Kavousi, Bruno H. Stricker
Summary: This study aimed to investigate the effects of hydroxychloroquine and chloroquine on electrocardiographic measures and sudden cardiac death. The results showed that current use of these drugs was associated with an increased QTc-interval duration and a higher risk of sudden cardiac death. Therefore, cardiotoxicity is a strong argument against using these drugs to treat COVID-19 infections, in addition to the controversial efficacy against the virus.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Joanna Fishbein, Kristie M. Coleman, Amarbir Bhullar, Nikhil Sharma, Stefanos Zafeiropoulos, Umair Ansari, Tia Bimal, Yan Liu, Stavros E. Mountantonakis
Summary: This study retrospectively analyzed COVID-19 patients and identified independent factors associated with in-hospital mortality, which were incorporated into a risk score for prediction.
Review
Gastroenterology & Hepatology
Sara Massironi, Ilaria Fanetti, Chiara Vigano, Lorena Pirola, Maria Fichera, Laura Cristoferi, Gabriele Capurso, Pietro Invernizzi, Silvio Danese
Summary: This study is the first systematic review of the association between inflammatory bowel disease (IBD) and pancreatic diseases. The study found that pancreatic involvement in IBD commonly presents as acute pancreatitis and chronic pancreatitis, with factors such as gallstones, drugs, and autoimmune processes implicated. Additionally, the study suggests a potential association between IBD and pancreatic exocrine insufficiency, although data on this association is limited and conflicting.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Critical Care Medicine
Roi Bar Cohen, Matthew Dai, Anthony Aizer, Chirag Barbhaiya, Connor Peterson, Scott Bernstein, David S. Park, Michael Spinelli, Larry A. Chinitz, Lior Jankelson
Summary: The QTc/JTc interval is significantly and independently prolonged after sudden cardiac arrest, regardless of known QT prolonging triggers. Normalization of the QTc is expected only after day 6 of hospitalization. Assessment of the QTc for determining the etiology of arrest or monitoring the effect of QT prolonging medications may be unreliable.
Article
Multidisciplinary Sciences
Celinda M. Kofron, Tae Yun Kim, Fabiola Munarin, Arvin H. Soepriatna, Rajeev J. Kant, Ulrike Mende, Bum-Rak Choi, Kareen L. K. Coulombe
Summary: This study presents a novel human 3D in vitro pro-arrhythmic risk assessment platform using human induced pluripotent stem cell-derived cardiomyocytes and human cardiac fibroblasts in 3-dimensional microtissues, which effectively differentiates between high-risk and low-risk compounds and evaluates the impact of environmental toxicants such as bisphenol-A.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Magdalene M. Assimon, Patrick H. Pun, Lily (Chin-Hua) Wang, Sana M. Al-Khatib, M. Alan Brookhart, David J. Weber, Wolfgang C. Winkelmayer, Jennifer E. Flythe
Summary: In this study, respiratory fluoroquinolone antibiotics were found to be associated with a higher short-term risk of sudden cardiac death compared to amoxicillin-based antibiotics in patients with hemodialysis-dependent kidney failure. This suggests that the decision between using respiratory fluoroquinolones and amoxicillin-based antibiotics should be individualized, taking into account both the clinical benefits and potential cardiac risks. The findings indicate that treatment with respiratory fluoroquinolone antibiotics may carry a greater risk of sudden cardiac death in patients receiving hemodialysis.
Review
Biochemistry & Molecular Biology
Scalia Federica, Carini Francesco, David Sabrina, Giammanco Marco, Mazzola Margherita, Rappa Francesca, Bressan Noemi Irma, Maida Giorgio, Tomasello Giovanni
Summary: Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic idiopathic disorders in which abnormal immune interactions between the intestinal epithelium and the intestinal microbiota play a role. Heat shock proteins (HSPs) have been found to be differentially expressed in the intestinal tissues and sera of CD and UC patients. HSPs can have a dual role in the disease, supporting inflammation and fibrosis, but also acting as protective factors during disease progression or before the onset of colorectal cancer. Furthermore, HSPs mediate the interaction between the intestinal microbiota and intestinal epithelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Tarek Alsaied, Adriana H. Tremoulet, Jane C. Burns, Arwa Saidi, Audrey Dionne, Sean M. Lang, Jane W. Newburger, Sarah de Ferranti, Kevin G. Friedman
Summary: Multisystem inflammatory syndrome in children, triggered by SARS-CoV-2 infection, is a severe inflammatory disease with common symptoms of persistent fever and cardiac manifestations. Treatment mainly aims at reversing the inflammatory response with immunomodulatory medications.
Article
Pediatrics
Ana Barrios-Tascon, Masaru Miura, Sara Dominguez-Rodriguez, Elisa Fernandez-Cooke, Georgia Sarquella-Brugada, Alfredo Tagarro
Summary: The manually measured QTc interval may serve as a marker for coronary disease in the acute period of Kawasaki disease.
JOURNAL OF PEDIATRICS
(2021)
Review
Pediatrics
Mohamed Mutalib
Summary: Inflammatory bowel disease is a chronic inflammatory disorder that primarily affects the gastrointestinal tract and has a rising incidence in both children and adults. The symptoms are caused by inappropriate inflammatory response triggered by the interaction between the environment, gut microbiome and host immune system.
PEDIATRIC NEPHROLOGY
(2021)
Review
Gastroenterology & Hepatology
Noreen Singh, Charles N. Bernstein
Summary: This article reviews the impact of environmental risk factors, such as early life exposures, lifestyle and hygiene, vaccinations, surgeries, exposure to drugs and gastrointestinal pathogens, on the risk of developing IBD.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Medicine, General & Internal
Wei-Sheng Chung, Sunny Chung, Chung-Y Hsu, Cheng-Li Lin
Summary: The study suggests that regardless of the presence of appendicitis, appendectomy increases the risks of ulcerative colitis and Crohn's disease.
FRONTIERS IN MEDICINE
(2021)