Article
Respiratory System
Joan M. Teno, Donald R. Sullivan, Jen Bunker, Pedro Gozalo
Summary: In patients with advanced dementia hospitalized with pneumonia or septicemia with pneumonia, the use of invasive mechanical ventilation (IMV) compared to noninvasive ventilation (NIV) showed improved 30-day survival but did not provide a benefit in 1-year survival and had significantly higher healthcare costs.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Review
Medicine, General & Internal
Jean-Paul Janssens, Chloe Cantero, Patrick Pasquina, Marjolaine Georges, Claudio Rabec
Summary: This article summarized the current knowledge in the field of monitoring during home ventilation and emphasized the effectiveness of long term noninvasive ventilation (LTNIV) for chronic hypercapnic respiratory failure (CHRF). By remotely adjusting ventilator settings and combining with other monitoring tools, patient comfort and tolerance can be improved, and hospital admissions can be reduced.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ewert Ralf, Alexander Heine, Anne Obst, Karoline Koerner, Veit Hustig-Kittler, Michael Boesche, Mohamed Elhadad, Beate Stubbe, Michael Westhoff
Summary: The establishment of guidelines for long-term noninvasive ventilation treatment in acute hypercapnic exacerbations of chronic obstructive pulmonary disease (AECOPD) has been elusive. Most studies have shown no mortality benefit of this treatment. However, our retrospective analysis of patient data from 2012 to 2019 demonstrated higher survival rates in the group receiving long-term noninvasive ventilation compared to those who didn't. This study provides evidence of the mortality benefit of long-term NIV therapy for AECOPD patients in real-world conditions.
SCIENTIFIC REPORTS
(2023)
Article
Respiratory System
Mihaela S. Stefan, Aruna Priya, Penelope S. Pekow, Jay S. Steingrub, Nicholas S. Hill, Tara Lagu, Karthik Raghunathan, Anusha G. Bhat, Peter K. Lindenauer
Summary: This study aimed to develop and validate a clinical risk prediction score for noninvasive ventilation (NIV) failure in non-surgical patients. Factors such as organ failure, principal diagnosis group, and prior use of invasive ventilation were found to be strong independent predictors for intubation after a trial of NIV. The constructed risk scoring model provides quantitative guidance for decision-making in patients who are started on NIV.
BMC PULMONARY MEDICINE
(2021)
Review
Critical Care Medicine
Brett N. Hryciw, Nicole Hryciw, Alexandre Tran, Shannon M. Fernando, Bram Rochwerg, Karen E. A. Burns, Andrew J. E. Seely
Summary: The objective of this study was to identify factors associated with failure of noninvasive ventilation (NIV) in the post-extubation period. The study found that higher critical illness severity and a diagnosis of pneumonia were illness-related factors associated with increased odds of post-extubation NIV failure. Additionally, higher respiratory rate, higher heart rate, lower Pao(2):Fio(2) 1-hour after NIV initiation, and higher rapid shallow breathing index prior to NIV start were clinical and biochemical factors associated with an increased risk of NIV failure. Elevated body mass index may have a protective effect. The study highlights the importance of these factors in guiding clinical decision-making, but further prospective studies are needed to confirm their predictive value.
CRITICAL CARE MEDICINE
(2023)
Article
Urology & Nephrology
Steven D. Pearson, Jay L. Koyner, Bhakti K. Patel
Summary: This review provides an overview of the basic principles of invasive and noninvasive mechanical ventilation, including modes of ventilation, respiratory mechanics and waveform interpretation, strategies for initial settings, indications and contraindications for noninvasive ventilation, and the impact of ventilation on kidney function.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Pediatrics
Jennifer A. Blumenthal, Melody G. Duvall
Summary: There is a lack of research on the best practices in managing pediatric severe COVID-19 with respiratory failure, highlighting the urgent need for more studies as the pandemic continues to impact children and as vaccination efforts progress. Management of acute respiratory failure in children with COVID-19 requires individualized approach based on lung conditions.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Critical Care Medicine
Jun Duan, Lijuan Chen, Xiaoyi Liu, Suha Bozbay, Yuliang Liu, Ke Wang, Antonio M. Esquinas, Weiwei Shu, Fuxun Yang, Dehua He, Qimin Chen, Bilin Wei, Baixu Chen, Liucun Li, Manyun Tang, Guodan Yuan, Fei Ding, Tao Huang, Zhongxing Zhang, ZhiJun Tang, Xiaoli Han, Lei Jiang, Linfu Bai, Wenhui Hu, Rui Zhang, Bushra Mina
Summary: This study aimed to update and improve the HACOR score by considering baseline data for better prediction of noninvasive ventilation failure.
Review
Critical Care Medicine
Kimberley Lewis, Joshua Piticaru, Dipayan Chaudhuri, John Basmaji, Eddy Fan, Morten Hylander Moller, John W. Devlin, Waleed Alhazzani
Summary: Dexmedetomidine usage in patients with acute respiratory failure undergoing noninvasive ventilation in the ICU can reduce the risk of intubation, delirium, and ICU length of stay, while increasing the risk of bradycardia and hypotension. However, the results are limited by uncertainty and further large randomized clinical trials are needed.
Article
Critical Care Medicine
Guillaume Dumas, Virginie Lemiale, Nisha Rathi, Andrea Cortegiani, Frederic Pene, Vincent Bonny, Jorge Salluh, Guillermo M. Albaiceta, Marcio Soares, Ayman O. Soubani, Emmanuel Canet, Tarik Hanane, Achille Kouatchet, Djamel Mokart, Pia Lebiedz, Melda Turkoglu, Remi Coudroy, Kyeongman Jeon, Alexandre Demoule, Sangeeta Mehta, Pedro Caruso, Jean-Pierre Frat, Kuang-Yao Yang, Oriol Roca, John Laffey, Jean-Francois Timsit, Elie Azoulay, Michael Darmon
Summary: This study examined survival trends in immunocompromised patients receiving invasive mechanical ventilation, showing improved survival rates over time. Delayed intubation after ICU admission was found to be significantly associated with higher mortality rates.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Nicholas S. Hill, Gerard J. Criner, Richard D. Branson, Bartolome R. Celli, Neil R. MacIntyre, Amen Sergew
Summary: This document summarizes the work of the COPD Technical Expert Panel working group, making key recommendations for optimal access to noninvasive ventilation for patients with COPD. These recommendations include removal of overnight oximetry testing requirements, ability to initiate therapy using bilevel devices with backup rate capability, and increased duration of time to meet adherence criteria. Emphasis is placed on the need for adequate clinical support during initiation and maintenance of home noninvasive ventilation in such patients.
Article
Medicine, General & Internal
Daisuke Kasugai, Masayuki Ozaki, Kazuki Nishida, Hiroaki Hiraiwa, Naruhiro Jingushi, Atsushi Numaguchi, Norihito Omote, Yuichiro Shindo, Yukari Goto
Summary: This study characterized the time course of severe COVID-19 parameters and outcomes in relation to liberation from mechanical ventilation, where early liberation was associated with better activities of daily living at discharge compared to prolonged ventilation. Differences in respiratory mechanics and laboratory data trends were observed based on liberation timing, providing insight into the pathophysiology of COVID-19 in critical care settings.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Abigail Macias Paredes, Jose Manuel Alvarez, Noelia Perez, Carme Puy, Patricia Penacoba, Maracena Segura, Antonio Anton
Summary: Controlled cycles are common during home mechanical ventilation and depend on the patient's ventilatory pattern and the level of ventilatory assistance.
RESPIRATORY MEDICINE
(2022)
Article
Critical Care Medicine
George L. Anesi, Vincent X. Liu, Marzana Chowdhury, Dylan S. Small, Wei Wang, M. Kit Delgado, Brian Bayes, Erich Dress, Gabriel J. Escobar, Scott D. Halpern
Summary: This study examines the impact of hospital admission decisions during the emergency department process on patients with sepsis and acute respiratory failure. The results indicate that initial admission to the general ward, compared to the ICU, is associated with shorter hospital stays and improved survival for patients with sepsis, while triage to the ICU, compared to the general ward, is associated with improved survival for patients with acute respiratory failure.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Daniel Oliveira Silva, Patricia Nery de Souza, Mayson Laercio de Araujo Sousa, Caio Cesar Araujo Morais, Juliana Carvalho Ferreira, Marcelo Alcantara Holanda, Wellington Pereira Yamaguti, Laerte Pastore Junior, Eduardo Leite Vieira Costa
Summary: The display of the estimated inspiratory muscle pressure (P-mus) waveform can improve healthcare providers' ability to identify patient-ventilator asynchronies, leading to improved diagnostic accuracy.
Article
Critical Care Medicine
David Schnell, Benjamin Planquette, Asael Berger, Sybille Merceron, Julien Mayaux, Lucas Strasbach, Stephane Legriel, Sandrine Valade, Michael Darmon, Ferhat Meziani
JOURNAL OF INTENSIVE CARE MEDICINE
(2019)
Editorial Material
Critical Care Medicine
Michael Darmon, Emmanuel Canet, Marlies Ostermann
INTENSIVE CARE MEDICINE
(2019)
Review
Critical Care Medicine
Michael Darmon, Aurelie Bourmaud, Quentin Georges, Marcio Soares, Kyeongman Jeon, Sandra Oeyen, Chin Kook Rhee, Pascale Gruber, Marlies Ostermann, Quentin A. Hill, Pieter Depuydt, Christelle Ferra, Anne-Claire Toffart, Peter Schellongowski, Alice Mueller, Virginie Lemiale, Djamel Mokart, Elie Azoulay
INTENSIVE CARE MEDICINE
(2019)
Letter
Hematology
Vincent Rebiere, Jean-Jacques Tudesq, Aurelie Chauveau, Jean-Richard Eveillard, Eric Lippert, Mickael Darmon, Jean-Christophe Ianotto
BRITISH JOURNAL OF HAEMATOLOGY
(2020)
Review
Critical Care Medicine
Peter Pickkers, Michael Darmon, Eric Hoste, Michael Joannidis, Matthieu Legrand, Marlies Ostermann, John R. Prowle, Antoine Schneider, Miet Schetz
Summary: AKI is now recognized as a complex and heterogeneous syndrome that not only impacts acute morbidity and mortality, but also long-term prognosis of patients. This review provides updates on various aspects of AKI in critically ill patients, focusing on prediction and early detection, pathophysiology, different phenotypes of AKI, nephrotoxicity and organ cross-talk, prevention, supportive treatment, and long-term risks post-AKI.
INTENSIVE CARE MEDICINE
(2021)
Article
Critical Care Medicine
Anastasia Saade, Giulia Moratelli, Guillaume Dumas, Asma Mabrouki, Jean-Jacques Tudesq, Lara Zafrani, Elie Azoulay, Michael Darmon
Summary: This study evaluated the frequency of infections, community and hospital-acquired infections, and risk factors for infections and mortality in severe COVID-19 patients. Results showed a high risk of infections in COVID-19 patients with underlying immune defects, with mechanical ventilation and steroid use independently associated with infection rate. Dexamethasone was associated with hospital-acquired infections but had no impact on mortality in this population.
ANNALS OF INTENSIVE CARE
(2021)
Editorial Material
Critical Care Medicine
Michael Darmon, David Schnell, Antoine Schneider
INTENSIVE CARE MEDICINE
(2022)
Letter
Hematology
Adrien Mirouse, Michael Darmon, Lara Zafrani, Etienne Lengline, Elie Azoulay
BRITISH JOURNAL OF HAEMATOLOGY
(2020)